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Regulation of mesenchymal cell differentiation by mechanical stress via PGC-1a

Research Project

Project/Area Number 18680047
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionThe University of Tokyo

Principal Investigator

AKIMOTO Takayuki  The University of Tokyo, 大学院・医学系研究科, 講師 (00323460)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥28,600,000 (Direct Cost: ¥22,000,000、Indirect Cost: ¥6,600,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2006: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Keywords筋肉 / 軟骨 / 骨 / 運動 / 細胞内シグナル伝達 / 物理的ストレス / 細胞分化 / 分化 / 細胞内カルシウム
Research Abstract

本研究では筋,骨,軟骨,脂肪などの間葉系組織の分化についてPGC-1αを中心にメカニカルストレス(物理的刺激)によるその制御を検討した.結果,メカニカルストレス誘導性の細胞内シグナル伝達経路を複数同定した.この研究を通じて,ある程度メカニカルストレス誘導性のシグナル伝達経路を特定できたことは,メカニカルストレスによって間葉系細胞の分化・成熟を制御するうえで有意義であると考えられる.研究最終年度の総括としては,研究機関3年間で,原著論文5編(加えて投稿中準備中3編),総説4編,学会発表16件,特許出願1件は十分な成果だったと考える.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (44 results)

All 2009 2008 2007 2006 Other

All Journal Article (19 results) (of which Peer Reviewed: 10 results) Presentation (23 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] 物理刺激2009

    • Author(s)
      秋本崇之, 牛田多加志
    • Journal Title

      遺伝子医学MOOK別冊 (in press)掲載確定

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Functional interaction of regulatory factors with the Pgc-1α promoter in response to exercise by in vivo imaging2008

    • Author(s)
      T. Akimoto, P. Li, Z. Yan
    • Journal Title

      Am J Physiol Cell Physiol 295(1)

      Pages: 288-292

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of the PKA/PKG target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle2008

    • Author(s)
      A. A. Wooldridge, C. N. Fortner, B. Lontay, T. Akimoto, R. L. Neppl, C. Facemire, M. B. Datto, A. Kwon, E. McCook, P. Li, S. Wang, R. J. Thresher, S. E. Miller, J. Perriard, T. P. Gavin, R. C. Hickner, T. M. Coffman, A. V. Somlyo, Z. Yan, T. A. Haystead
    • Journal Title

      J Biol Chem 283(17)

      Pages: 11850-11859

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical stress and tissue engineering2008

    • Author(s)
      T. Akimoto, M. Kawanishi, T. Ushida
    • Journal Title

      Clin Calcium 18(9)

      Pages: 1313-1320

    • Related Report
      2008 Final Research Report
  • [Journal Article] Functional interaction of regulatory factors with the Pgc-1 α promoter in response to exercise by in vivo imaging2008

    • Author(s)
      T. Akimoto, P. Li, Z. Yan
    • Journal Title

      Am J Physiol Cell Physiol 295

      Pages: 288-292

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of the PKA/PKG target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle2008

    • Author(s)
      A. A. Wooldridge, C. N. Fortner, B. Lontay, T. Akimoto, R. L. Neppl, C. Facemire, M. B. Datto, A. Kwon, E. McCook, P. Li , S. Wang, R. J. Thresher, S. E . Miller, J. Perriard, T. P. Gavin, R. C. Hickner, T. M. Coffman, A. V. Somlyo, Z. Yan, T. A. Haystead
    • Journal Title

      J Biol Chem 23

      Pages: 11850-11859

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanical stress and tissue engineering2008

    • Author(s)
      T. Akimoto, M. Kawanishi, T. Ushida
    • Journal Title

      Clin Calcium 18

      Pages: 1313-1320

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Deletion of the PKA/PKG target SMTNL1 promotes an exercise-adapted phenotype in vascular smc2008

    • Author(s)
      A. A. Wooldridge, C. N. Fortner, B. Lon
    • Journal Title

      J Biol Chem (印刷中)(掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨格筋のミトコンドリア・バイオジェネシスとPGC-1α2007

    • Author(s)
      秋本崇之, 和田正吾
    • Journal Title

      体育の科学 57(5)

      Pages: 345-350

    • Related Report
      2008 Final Research Report
  • [Journal Article] Transcriptional control of the Pgc-1α gene in skeletal muscle in vivo2007

    • Author(s)
      Z. Yan, P. Li, T. Akimoto
    • Journal Title

      Exerc Sport Sci Rev. Jul ; 35(3)

      Pages: 97-101

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eccentric muscle contraction induces greater oxidative stress in skeletal muscle than concentric contraction2007

    • Author(s)
      M. Kon, K. Tanabe, F. Kimura, H. S. Lee, T. Akimoto, I. Kono
    • Journal Title

      Appl Physiol, Nutrition Metabolism 32(2)

      Pages: 273-281

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Coenzyme Q10 supplementation on exercise-induced muscular injury of rats2007

    • Author(s)
      M. Kon, F. Kimura, T. Akimoto, K. Tanabe, Y. Murase, S. Ikemune, I. Kono
    • Journal Title

      Exerc Immunol Rev 13

      Pages: 76-88

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional control of the Pgc-1α gene in skeletal muscle in vivo.2007

    • Author(s)
      Z. Yan, P. Li, T. Akimoto.
    • Journal Title

      Exerc Sport Sci Rev 35

      Pages: 97-101

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨格筋のミトコンドリア・バイオジェネシスとPGC-1α2007

    • Author(s)
      秋本崇之, 和田正吾.
    • Journal Title

      体育の科学 57

      Pages: 345-350

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Transcriptional control of the Pgc-1α gene in skeletal muscle in vivo.2007

    • Author(s)
      Z. Yan, P. Li, T. Akimoto
    • Journal Title

      Exer Sci Rev 35(3)

      Pages: 97-101

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Eccentric muscle contraction induces greater oxidative stress in skeletal muscle than concentric contraction.2007

    • Author(s)
      M. Kon, K. Tanabe, F. Kimura, H. S. Lee, T. Akimoto, I. Kono
    • Journal Title

      Appl Physiol, Nutrition Metabolism 32(2)

      Pages: 273-281

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Resident stem cells are not required for exercise-induced fiber type-switching and angiogenesis, but required for activity-dependent muscle growth2006

    • Author(s)
      P. Li, T. Akimoto, M. Zhang, R. S. Williams, Z. Yan
    • Journal Title

      Am J Physiol Cell Physiol 290(6)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resident stem cells are not required for exercise-induced fiber type-switching and angiogenesis, but required for activity-dependent muscle growth.2006

    • Author(s)
      P. Li, T. Akimoto, M. Zhang, R. S. Williams, Z. Yan.
    • Journal Title

      Am J Physiol Cell Physiol 290(6)

      Pages: 1461-1468

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 物理刺激

    • Author(s)
      秋本崇之, 牛田多加志
    • Journal Title

      遺伝子医学MOOK別冊 (in press)

    • Related Report
      2008 Final Research Report
  • [Presentation] Exercise stimulates local bioactive androgen metabolism in skeletal muscle2008

    • Author(s)
      K. Aizawa, M. Iemitsu, S. Maeda, K. Sato, T. Otsuki, T. Ushida, N. Mesaki, T. Akimoto
    • Organizer
      APS Meeting Integrative Biology of Exercise
    • Place of Presentation
      Hilton Head
    • Year and Date
      2008-09-27
    • Related Report
      2008 Final Research Report
  • [Presentation] Stress responsive miR-23a attenuates skeletal muscle atrophy by targeting MAFbx/Atrogin2008

    • Author(s)
      S. Wada, Y. Kato, M. Okutsu, S. Miyaki, K. Suzuki, H. Asahara, T. Ushida, T. Akimoto
    • Organizer
      APS Meeting Integrative Biology of Exercise
    • Place of Presentation
      Hilton Head
    • Year and Date
      2008-09-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Functional interaction of regulatory factors with the Pgc-1α promoter in response to exercise by in vivo imaging2008

    • Author(s)
      T. Akimoto, P. Li, Z. Yan
    • Organizer
      APS Meeting Integrative Biology of Exercise
    • Place of Presentation
      Hilton Head
    • Year and Date
      2008-09-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Stress responsive miR-23a attenuates skeletal muscle atrophy by targe ting MAFbx /Atrogin2008

    • Author(s)
      S. Wada, Y. Kato, M. Okutsu, S. Miyaki, K. Suzuki, H. Asahara, T. Ushida, T. Akimoto
    • Organizer
      APS Meeting Integrative Biology of Exercise
    • Place of Presentation
      Hilton Head, SC, USA
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Functional interaction of regulatory factors with the Pgc-1 α promoter in response to exercise by in vivo imaging2008

    • Author(s)
      T. Akimoto, P. Li, Z. Yan
    • Organizer
      APS Meeting Integrative Biology of Exercise
    • Place of Presentation
      Hilton Head, SC, USA
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Exercise stimulates local bioactive androgen metabolism in skeletal muscle2008

    • Author(s)
      K. Aizawa, M. Iemitsu, S. Maeda, K. Sato, T. Otsuki, T. Ushida, N. Mesaki, T. Akimoto
    • Organizer
      APS Meeting Integrative Biology of Exercise
    • Place of Presentation
      Hilton Head, SC, USA
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] ストレス誘導性miR-23aはatrogin-1の転写後制御を介して骨格筋萎縮を抑制する2008

    • Author(s)
      和田正吾, 奥津光晴, 鈴木克彦, 牛田多加志, 秋本崇之
    • Organizer
      第63回日本体力医学会学術総会
    • Place of Presentation
      ビーコンプラザ, 別府
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 筋収縮/メカニカルストレスによるPGC-1a転写活性化のメカニズム2008

    • Author(s)
      秋本崇之, 和田正吾, 相澤勝治, 牛田多加志
    • Organizer
      第63回日本体力医学会学術総会
    • Place of Presentation
      ビーコンプラザ, 別府
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] ストレス誘導性miR-23aはatrogin-1の転写後制御を介して骨格筋萎縮を抑制する2008

    • Author(s)
      和田正吾, 奥津光晴, 鈴木克彦, 牛田多加志, 秋本崇之
    • Organizer
      第63回日本体力医学会学術総会
    • Place of Presentation
      別府
    • Year and Date
      2008-09-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 筋収縮/メカニカルストレスによるPGC-1a転写活性化のメカニズム2008

    • Author(s)
      秋本崇之, 和田正吾, 相澤勝治, 牛田多加志
    • Organizer
      第63回日本体力医学会学術総会
    • Place of Presentation
      別府
    • Year and Date
      2008-09-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Exercise-induced transcriptional control of PGC-1a in skeletal muscle2008

    • Author(s)
      T. Akimoto
    • Organizer
      9th Annual Meeting of Korean Association of Certificated Exercise Professionals Daegu
    • Year and Date
      2008-06-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 筋収縮/メカニカルストレスによるPGC-1a転写活性化のメカニズム2008

    • Author(s)
      秋本崇之
    • Organizer
      名取禮二記念 筋肉の構造と機能のシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-03-24
    • Related Report
      2008 Final Research Report
  • [Presentation] 筋収縮/メカニカルストレスによるPGC-1a転写活性化のメカニズム2008

    • Author(s)
      秋本崇之
    • Organizer
      名取禮二記念筋肉の構造と機能のシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-03-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling2008

    • Author(s)
      T. Akimoto, T. Ushida, S. Miyaki, H. Aka
    • Organizer
      54th Annual Meeting of the Orthopedic Research Society
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2008-03-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] ストレッチによる脂肪分化抑制の新たな分子メカニズム2007

    • Author(s)
      秋本崇之, 牛田多加志, 味八木茂, 赤荻博, 槌谷宏平, Z. Yan, R. S. Williams, 立石哲也
    • Organizer
      第34回日本臨床バイオメカニクス学会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-07
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Eccentric muscle contraction induces greater oxidative stress in skeletal muscle than concentric contraction2007

    • Author(s)
      M. Kon, K. Tanabe, F. Kimura, H. S. Lee, T. Akimoto, I. Kono
    • Organizer
      8th symposium of International Society of Exercise and Immunology
    • Place of Presentation
      Sendai
    • Year and Date
      2007-10-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 関節内靭帯の網羅的遺伝子発現解析2007

    • Author(s)
      秋本崇之, 槌谷宏平, 味八木茂, 浅原弘嗣, 牛田多加志
    • Organizer
      第62回日本体力医学会学術総会
    • Place of Presentation
      秋田
    • Year and Date
      2007-09-16
    • Related Report
      2008 Final Research Report
  • [Presentation] ストレッチによる脂肪分化抑制の新たな分子メカニズム. シンポジウム10「生活習慣病に対する運動の効用-そのメカニズムを分子レベルで紐解く-」2007

    • Author(s)
      秋本崇之
    • Organizer
      第62回日本体力医学会学術総会
    • Place of Presentation
      秋田
    • Year and Date
      2007-09-15
    • Related Report
      2008 Final Research Report
  • [Presentation] コエンザイムQ10投与が高強度運動後の酸化ストレスに及ぼす影響2007

    • Author(s)
      今有礼, 木村文律, 田辺解, 秋本崇之, 河野一郎
    • Organizer
      第62回日本体力医学会学術総会
    • Place of Presentation
      秋田
    • Year and Date
      2007-09-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 熱ストレスが骨格筋萎縮に与える影響2007

    • Author(s)
      和田正吾, 奥津光晴, 鈴木克彦, 牛田多加志, 秋本崇之
    • Organizer
      第62回日本体力医学会学術総会
    • Place of Presentation
      秋田
    • Year and Date
      2007-09-15
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Exercise stimulates PGC-1α transcription in skeletal muscle through activation of the p38 MAPK pathway2006

    • Author(s)
      T. Akimoto , S. C. Pohnert, P. Li, M. Zhang, C. E. Gumbs, P. B. Rosenberg, R. S. Williams, Z. Yan
    • Organizer
      14th Meeting of International Research Group of Biochemistry of Exercise
    • Place of Presentation
      Seoul
    • Year and Date
      2006-10-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨格筋の有酸素運動適応におけるp38 MAPKの役割. シンポジウム10「分子でみる骨格筋の適応メカニズム」2006

    • Author(s)
      秋本崇之
    • Organizer
      第61回日本体力医学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2006-09-24
    • Related Report
      2008 Final Research Report
  • [Presentation] コエンザイムQ10摂取が合宿期における大学剣道選手の筋損傷と酸化ストレスに及ぼす影響2006

    • Author(s)
      今有礼, 田辺解, 谷村祐子, 清水和弘, 木村文律, 秋本崇之, 河野一郎
    • Organizer
      第61回日本体力医学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2006-09-24
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 抗筋萎縮剤2009

    • Inventor(s)
      秋本崇之, 牛田多加志, 和田正吾
    • Industrial Property Rights Holder
      早稲田大学, 東京大学
    • Industrial Property Number
      2009-028836
    • Filing Date
      2009-02-10
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 秋本崇之, 牛田多加志, 和田正吾

    • Inventor(s)
      抗筋萎縮剤
    • Industrial Property Number
      2009-028836
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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