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Relationship between chemical exposure and the minimal brain dysfunction examined by new associative learning behavioral tests in rodents.

Research Project

Project/Area Number 18681008
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Risk sciences of radiation/Chemicals
Research InstitutionThe University of Tokyo

Principal Investigator

KAKEYAMA Masaki  The University of Tokyo, 大学院・医学系研究科, 助教 (30353535)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2006: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Keywords有害化学物質 / 脳神経疾患 / 社会医学 / 環境 / 神経科学 / 学習機能 / 行動
Research Abstract

発達期の脳は脆弱であり、化学物質影響科学のターゲットとして極めて重要である。ラットにおいて連合学習と行動異常の両面を検出する新たな行動毒性試験法を確立し、ダイオキシン等環境化学物質の低用量曝露を陽性条件として、胎児期から出生直後にかけての環境中有害化学物質が高次脳機能の発達に及ぼす影響について解析した。ダイオキシン等化学物質の比較的低用量の曝露により、軽度発達障害を引き起こす可能性が示唆された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (14 results)

All 2009 2008 2007 2006 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Learning behavior in rat offspring after in utero and lactational exposure to either TCDD or PCB126.2008

    • Author(s)
      Hojo R, Kakeyama M, Kurokawa Ym Aoki Y, Yonemoto J, Tohyama C
    • Journal Title

      Environ. Health Prevent. Med (印刷中)(掲載確定)

    • NAID

      10026957322

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perinatal Exposure of Female Rats to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Central Precocious Puberty in the Offspring.2008

    • Author(s)
      Kakeyama M, Sone H and Tohyama C.
    • Journal Title

      Journal of Endocrinology (印刷中)(掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Schemas and memory consolidation.2007

    • Author(s)
      Tse D, Langston RF, Kakeyama M, Bethus I, Spooner PA, Wood E, Morris RGM
    • Journal Title

      Science 316

      Pages: 76-82

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Toluene induces rapid and reversible rise of hippocampal glutamate and taurine neurotransmitter levels in mice.2007

    • Author(s)
      Win-Shwe TT, Mitsushima D, Nakajima D, Ahmed S, Yamamoto S, Tsukahara S, Kakeyama M, Goto S, Fujimaki H
    • Journal Title

      Toxicol Lett. 168

      Pages: 75-82

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Sex differences in the level of Bcl-2 family proteins and caspase-3 activation in the sexually dimorphic nuclei of the preoptic area in postnatal rats.2006

    • Author(s)
      Tsukahara S, Kakeyama M, Toyofuku Y.
    • Journal Title

      J Neurobiol. 66

      Pages: 1411-1419

    • Related Report
      2006 Annual Research Report
  • [Presentation] ダイオキシンによる脳の発達異常-性行動、学習行動、情動行動2009

    • Author(s)
      掛山正心
    • Organizer
      第16回生殖・発生毒性学東京セミナー
    • Place of Presentation
      東京、国立オリンピック記念青少年総合センター
    • Year and Date
      2009-03-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] 発達期のダイオキシン類曝露による高次脳機能のかく乱2009

    • Author(s)
      掛山正心
    • Organizer
      第20回環境ホルモン学会講演会
    • Place of Presentation
      東京、江戸東京博物館
    • Year and Date
      2009-02-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 集団型全自動行動解析装置を用いた胎仔期授乳期の低用量ダイオキシン曝露マウスの行動影響評価2008

    • Author(s)
      遠藤俊裕, 掛山正心, 遠山千春
    • Organizer
      環境ホルモン学会第11回研究発表会
    • Place of Presentation
      東京、星陵会館
    • Year and Date
      2008-12-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemically-induced attention deficit hyperactivity disorder-like behavior in juvenile rats detected by a newly developed behavioral test2008

    • Author(s)
      Kakeyama M, Hojo R, Tohyama C
    • Organizer
      The 38th annual meeting of the Society for Ne uroscience (SfN2008)
    • Place of Presentation
      Washington D.C., 米国
    • Year and Date
      2008-11-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of novel behavioral tests for rodents to study the high-order brain function altered by in utero and lactational exposure to dioxins2008

    • Author(s)
      Kakeyama M, Endo T, Zhang Y, Miyazaki W, Tohyama C
    • Organizer
      28th International Symposium on Halogen ated Persistent Organic Pollutants(DIOXIN2008)
    • Place of Presentation
      Birmingham, 英国
    • Year and Date
      2008-08-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 環境化学物質の発達期曝露によるラット脳高次機能への影響2008

    • Author(s)
      掛山 正心
    • Organizer
      日本薬学会第128年会シンポジウム若手が切り開くMolecular Toxicology 3〜化学物質の脳神経毒性とそのメカニズム〜
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] IN UTERO AND LACTATIONAL EXPOSURE TO A LOW DOSE OF TCDD OR TBDD PERTURBS PAIRED ASSOCIATIVE LEARNING OF MALE RAT OFFSPRING.2008

    • Author(s)
      Endo T, Kakeyama M, Tohyama C.
    • Organizer
      47th Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Seattle,米国
    • Year and Date
      2008-03-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] MATERNAL EXPOSURE TO A LOW DOSE DIOXIN AFFECTS THE PAIRED ASSOCIATIVE LEARNING BEHAVIOR OF OFFSPRING OF LONG-EVANS RATS2007

    • Author(s)
      Kakeyama M, Endo T, Yamanouchi K, Tohyama C.
    • Organizer
      27th International Symposium on Halogenated Persistent Organic Pollutants-DIOXIN 2007.
    • Place of Presentation
      東京
    • Year and Date
      2007-09-04
    • Related Report
      2007 Annual Research Report
  • [Remarks] 日経バイオテク、Biotechnology Japan

    • URL

      http://biotech.nikkeibp.co.jp/fsn/kiji.jsp?kiji=1155

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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