Relationship between chemical exposure and the minimal brain dysfunction examined by new associative learning behavioral tests in rodents.

• Project/Area Number: 18681008
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: The University of Tokyo
• Principal Investigator: KAKEYAMA Masaki The University of Tokyo, 大学院・医学系研究科, 助教 (30353535)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000); Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2007: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2006: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
• Keywords: 有害化学物質 / 脳神経疾患 / 社会医学 / 環境 / 神経科学 / 学習機能 / 行動

Research Abstract

発達期の脳は脆弱であり、化学物質影響科学のターゲットとして極めて重要である。ラットにおいて連合学習と行動異常の両面を検出する新たな行動毒性試験法を確立し、ダイオキシン等環境化学物質の低用量曝露を陽性条件として、胎児期から出生直後にかけての環境中有害化学物質が高次脳機能の発達に及ぼす影響について解析した。ダイオキシン等化学物質の比較的低用量の曝露により、軽度発達障害を引き起こす可能性が示唆された。

Research Products

• [Journal Article] Learning behavior in rat offspring after in utero and lactational exposure to either TCDD or PCB126. (2008)
  • Author(s): Hojo R, Kakeyama M, Kurokawa Ym Aoki Y, Yonemoto J, Tohyama C
  • Journal Title: Environ. Health Prevent. Med (印刷中)(掲載確定)
  • NAID: 10026957322
  • Peer Reviewed
• [Journal Article] Perinatal Exposure of Female Rats to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Central Precocious Puberty in the Offspring. (2008)
  • Author(s): Kakeyama M, Sone H and Tohyama C.
  • Journal Title: Journal of Endocrinology (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Schemas and memory consolidation. (2007)
  • Author(s): Tse D, Langston RF, Kakeyama M, Bethus I, Spooner PA, Wood E, Morris RGM
  • Journal Title: Science 316 Pages: 76-82
• [Journal Article] Toluene induces rapid and reversible rise of hippocampal glutamate and taurine neurotransmitter levels in mice. (2007)
  • Author(s): Win-Shwe TT, Mitsushima D, Nakajima D, Ahmed S, Yamamoto S, Tsukahara S, Kakeyama M, Goto S, Fujimaki H
  • Journal Title: Toxicol Lett. 168 Pages: 75-82
• [Journal Article] Sex differences in the level of Bcl-2 family proteins and caspase-3 activation in the sexually dimorphic nuclei of the preoptic area in postnatal rats. (2006)
  • Author(s): Tsukahara S, Kakeyama M, Toyofuku Y.
  • Journal Title: J Neurobiol. 66 Pages: 1411-1419
• [Presentation] ダイオキシンによる脳の発達異常-性行動、学習行動、情動行動 (2009)
  • Author(s): 掛山正心
  • Organizer: 第16回生殖・発生毒性学東京セミナー
  • Place of Presentation: 東京、国立オリンピック記念青少年総合センター
  • Year and Date: 2009-03-07
• [Presentation] 発達期のダイオキシン類曝露による高次脳機能のかく乱 (2009)
  • Author(s): 掛山正心
  • Organizer: 第20回環境ホルモン学会講演会
  • Place of Presentation: 東京、江戸東京博物館
  • Year and Date: 2009-02-24
• [Presentation] 集団型全自動行動解析装置を用いた胎仔期授乳期の低用量ダイオキシン曝露マウスの行動影響評価 (2008)
  • Author(s): 遠藤俊裕, 掛山正心, 遠山千春
  • Organizer: 環境ホルモン学会第11回研究発表会
  • Place of Presentation: 東京、星陵会館
  • Year and Date: 2008-12-13
• [Presentation] Chemically-induced attention deficit hyperactivity disorder-like behavior in juvenile rats detected by a newly developed behavioral test (2008)
  • Author(s): Kakeyama M, Hojo R, Tohyama C
  • Organizer: The 38th annual meeting of the Society for Ne uroscience (SfN2008)
  • Place of Presentation: Washington D.C., 米国
  • Year and Date: 2008-11-19
• [Presentation] Development of novel behavioral tests for rodents to study the high-order brain function altered by in utero and lactational exposure to dioxins (2008)
  • Author(s): Kakeyama M, Endo T, Zhang Y, Miyazaki W, Tohyama C
  • Organizer: 28th International Symposium on Halogen ated Persistent Organic Pollutants(DIOXIN2008)
  • Place of Presentation: Birmingham, 英国
  • Year and Date: 2008-08-20
• [Presentation] 環境化学物質の発達期曝露によるラット脳高次機能への影響 (2008)
  • Author(s): 掛山 正心
  • Organizer: 日本薬学会第128年会シンポジウム若手が切り開くMolecular Toxicology 3〜化学物質の脳神経毒性とそのメカニズム〜
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] IN UTERO AND LACTATIONAL EXPOSURE TO A LOW DOSE OF TCDD OR TBDD PERTURBS PAIRED ASSOCIATIVE LEARNING OF MALE RAT OFFSPRING. (2008)
  • Author(s): Endo T, Kakeyama M, Tohyama C.
  • Organizer: 47th Annual Meeting of the Society of Toxicology
  • Place of Presentation: Seattle,米国
  • Year and Date: 2008-03-19
• [Presentation] MATERNAL EXPOSURE TO A LOW DOSE DIOXIN AFFECTS THE PAIRED ASSOCIATIVE LEARNING BEHAVIOR OF OFFSPRING OF LONG-EVANS RATS (2007)
  • Author(s): Kakeyama M, Endo T, Yamanouchi K, Tohyama C.
  • Organizer: 27th International Symposium on Halogenated Persistent Organic Pollutants-DIOXIN 2007.
  • Place of Presentation: 東京
  • Year and Date: 2007-09-04
• [Remarks] 日経バイオテク、Biotechnology Japan
  • URL: http://biotech.nikkeibp.co.jp/fsn/kiji.jsp?kiji=1155