Studies on the signaling network that regulates dendritic fields.

• Project/Area Number: 18687901
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: National Institute of Genetics
• Principal Investigator: EMOTO Kazuo National Institute of Genetics, 新分野創造センター, 准教授 (80300953)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥27,680,000 (Direct Cost: ¥23,900,000、Indirect Cost: ¥3,780,000); Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000); Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2006: ¥11,300,000 (Direct Cost: ¥11,300,000)
• Keywords: Ndrキナーゼ / 樹状突起 / ニューロン / 受容領域 / タイル化 / リン酸化酵素 / 脂質代謝酵素 / 感覚ニューロン / ショウジョウバエ / 反発作用 / 脳神経回路

Research Abstract

樹状突起は、他の神経細胞もしくは感覚受容器からの情報入力を担っており、外部情報を的確に受容する為には、樹状突起が適切な空間に配置されることにより、受容領域を正確にカバーすることが重要である。申請者は、リン酸化酵素Ndrキナーゼ・ファミリーが、樹状突起の維持・管理機構において中心的な役割を果たしていることを世界に先駆けて示した。さらに、ダウン症原因因子の1つである接着分子Dscam (Down's Syndrome-associated Adhesion Molecule)がNdrキナーゼと協調して機能することを見出した。

Research Products

• [Journal Article] 「神経突起のパターン形成」特集 : 神経系の発生とその異常 (2008)
  • Author(s): 榎本和生
  • Journal Title: BRAIN and NERVE 60 Pages: 351-364
• [Journal Article] The molecular and cellular basis for dendrite morphogenesis (2008)
  • Author(s): Kazuo EMOTO
  • Journal Title: BRAIN and NERVE 60 Pages: 351-364
• [Journal Article] リン脂質分子の膜動態による細胞骨格制御 (2008)
  • Author(s): 榎本和生
  • Journal Title: 生化学 80 Pages: 811-819
• [Journal Article] 脂質代謝物による細胞分裂の時空間制御 (2008)
  • Author(s): 金森崇浩・榎本和生
  • Journal Title: ファルマシア 44 Pages: 1157-1160
• [Journal Article] Drosophila sensory neurons require Dscam for dendrite self avoidance and proper dendritic organization (2007)
  • Author(s): Soba, P., Zhu, S., Emoto, K., Younger, S., Yang, S. J., Yu, H.H., Lee, T., Jan, L. Y., and Jan, Y. N.
  • Journal Title: Neuron 54 Pages: 403-416
  • Peer Reviewed
• [Journal Article] Polycomb genes interact with the tumor suppressor hippo and warts in the maintenance of Drosophila sensory neuron dendrites. (2007)
  • Author(s): Parrish, J. Z., Emoto, K., Jan, L., and Jan, Y. N.
  • Journal Title: Genes Dev. 21 Pages: 956-972
  • Peer Reviewed
• [Journal Article] Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. (2007)
  • Author(s): Parrish, J. Z.* Emoto, K.*, Kim, M. D., and Jan, Y. N.
  • Journal Title: Annu. Rev. Neurosci. 30 Pages: 399-423
  • Peer Reviewed
• [Journal Article] Special Review「ニューロン受容領域のタイル化を制御するリン酸化シグナルネットワーク」 (2007)
  • Author(s): 榎本和生・小池(熊谷)牧子
  • Journal Title: 細胞工学 26 Pages: 806-810
• [Journal Article] ニューロンはいかにして固有の受容領域を獲得し、それを維持・管理するのか? (2007)
  • Author(s): 榎本和生
  • Journal Title: 蛋白質核酸酵素 54 Pages: 842-852
• [Journal Article] Drosophila sensory neurons require Dscam for dendrite self avoidance and proper dendritic organization. (2007)
  • Author(s): Soba, P., et. al.
  • Journal Title: Neuron 54 Pages: 403-416
  • Peer Reviewed
• [Journal Article] Polycomb genes interact with the tumor suppressor hippo and warts in the maintenance of Drosophila sensory neuron dendrites. (2007)
  • Author(s): Parrish, J. Z., et. al.
  • Journal Title: Genes Dev. 21 Pages: 956-972
  • Peer Reviewed
• [Journal Article] Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. (2007)
  • Author(s): Parrish, J. Z., et. al.
  • Journal Title: Annu. Rev. Neurosci. 30 Pages: 399-423
  • Peer Reviewed
• [Journal Article] Polycomb genes interact with the tumor suppressor hippo and warts in the maintenance of Drosophila sensory neuron dendrites. (2007)
  • Author(s): Parrish, J.
  • Journal Title: Genes and Development 21 Pages: 956-972
• [Journal Article] The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance (2006)
  • Author(s): Emoto, K., Parrish, J. Z., Jan, L., and Jan, Y. N.
  • Journal Title: Nature 443 Pages: 210-213
  • Peer Reviewed
• [Journal Article] 癌抑制遺伝子群の新たな神経機能の発見 : ニューロンの受容領域を維持・管理する分子メカニズム (2006)
  • Author(s): 榎本和生
  • Journal Title: 実験医学 24 Pages: 2985-2988
• [Journal Article] The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. (2006)
  • Author(s): Emoto, K.
  • Journal Title: Nature 443 Pages: 210-213
• [Presentation] How do neurons establish and aintain their unique dendritic fields? (2008)
  • Author(s): Emoto, K.
  • Organizer: NAIST International Symposium "Cell Signaling"
  • Place of Presentation: Nara
• [Presentation] The cellular and molecular basis or membrane morphogenesis. (2008)
  • Author(s): Emoto, K.
  • Organizer: UK-Japan Frontier of Science Symposium
  • Place of Presentation: Tokyo
• [Presentation] Dendrite remodeling in adult Drosophila sensory neurons (2008)
  • Author(s): Emoto, K., Yasunaga, K.-I., Suzuki, E.
  • Organizer: 第31回日本神経科学会年会(Neuro2008)
  • Place of Presentation: 東京
• [Presentation] The molecular mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields (2008)
  • Author(s): Emoto, K.
  • Organizer: The 1st iCeMS Symposium
  • Place of Presentation: Kyoto
• [Presentation] How does neurons establish and maintain their unique dendritic fields (2008)
  • Author(s): Kazuo Emoto
  • Organizer: NAIST International Symposium "Cell signaling"
  • Place of Presentation: Nara
• [Presentation] ニューロン受容領域を形成・維持する分子基盤 (2007)
  • Author(s): 榎本和生
  • Organizer: 日本生化学会・分子生物学会合同年会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] ニューロン受容領域を決定・維持するキナーゼシグナル・ネットワーク (2007)
  • Author(s): 榎本和生
  • Organizer: 第80回日本生化学会・第30会日本分子生物学会合同年会(BMB2007)ワークショップ「From shape to function : ニューロンの形態形成と可塑的変化を司る分子基盤」
  • Place of Presentation: 横浜
• [Presentation] The kinase signaling network that regulates establishment and maintenance of dendritic fields (2007)
  • Author(s): Kazuo Emoto
  • Organizer: 第30回日本神経科学会年会(Neuro2007)
  • Place of Presentation: 横浜
• [Remarks]
  • URL: http://www.nig.ac.jp/section/emoto/emoto-j.html