Preparation of stimuli-responsive nano particles consisting of cello-oligosaccharides and dynamic control of their functions

• Project/Area Number: 18688009
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: 林産科学・木質工学
• Research Institution: Kyoto University
• Principal Investigator: KAMITAKAHARA Hiroshi Kyoto University, 大学院・農学研究科, 助教 (10293911)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000); Fiscal Year 2008: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2007: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2006: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
• Keywords: セルロース / メチルセルロース / セロオリゴ糖 / ナノ粒子 / 両親媒性

Research Abstract

ブロック的にメチル化されたジブロック型、トリブロック型セロオリゴ糖の一般的合成法を確立し、水中での会合構造を明らかにした。すなわち、水中での会合構造は、ブロック的メチル化セロオリゴ糖の一次構造に依存することが判明した。また、温度刺激により粒径が変化することも明らかとなり、その温度依存性もセロオリゴ糖の一次構造に依存することが判った。

Research Products

• [Journal Article] Synthesis and thermal properties of poly(methyl methacrylate)- graft -(cellobiosylamine-C15) (2009)
  • Author(s): Enomoto-Rogers, Y.; Kamitakahara, H.; Nakayama K.; Takano, T.; Nakatsubo, F.
  • Journal Title: Cellulose 16(3) Pages: 519-530
  • Peer Reviewed
• [Journal Article] Synthesis and thermal properties of poly(methyl methacrylate)- graft -(cellobiosylamine-C15) (2009)
  • Author(s): Enomoto-Rogers Y., Kamitakahara H., Nakayama K., Takano T., and Nakatsubo F.
  • Journal Title: Cellulose 16 Pages: 519-530
  • Peer Reviewed
• [Journal Article] New approach to unravel the structure-property relationship of methylcellulose. Self-assembly of amphiphilic block-like methylated cello-oligosaccharides. (2008)
  • Author(s): Kamitakahara H., Yoshinaga A., Aono H., Nakatsubo F., Klemm D. and Burchard W.
  • Journal Title: Cellulose 15 (6) Pages: 797-801
  • Peer Reviewed
• [Journal Article] New approach to unravel the structure-property relationship of methylcellulose. Self-assembly of amphiphilic block-like methylated cello-oligosaccharides (2008)
  • Author(s): Kamitakahara H., Yoshinaga A., Aono H., Nakatsubo F., Klemm D.
  • Journal Title: Cellulose 15 Pages: 797-801
  • Peer Reviewed
• [Journal Article] New class of carbohydrate-based nonionic surfactants: Block co-oligomers of tri-O-methylated and unmodified cello-oligosaccharides. (2007)
  • Author(s): Kamitakahara H., Nakatsubo F. and Klemm D.
  • Journal Title: Cellulose 14 (5) Pages: 513-528
  • Peer Reviewed
• [Journal Article] New class of carbohydrate-based nonionic surfactants: diblock co-oligomers of tri-O-methylated and unmodified cello-oligosaccharides (2007)
  • Author(s): Hiroshi Kamitakahara, Fumiaki Nakatsubo, and Dieter Klemm
  • Journal Title: CELLULOSE 14 Pages: 513-528
  • Peer Reviewed
• [Journal Article] Block cooligomers of tri-O-methylated and unmodified cello-oligosaccharides as model compounds for methylcellulose and its dissolution/gelation behavior. (2006)
  • Author(s): Kamitakahara, H.; Nakatsubo, F.; Klemm, D.
  • Journal Title: Cellulose 13 (4) Pages: 375-392
  • Peer Reviewed
• [Journal Article] Block co-oligomers of tri-O-methylated and unmodified cello-oligosaccharides as model compounds for (2006)
  • Author(s): Hiroshi Kamitakahara, Fumiaki Nakatsubo, Dieter Klemm
  • Journal Title: Cellulose 13(4) Pages: 375-392
• [Presentation] Water-soluble nano capsules based on blockwise methylated cello-oligosaccharides(Invited lecture) (2009)
  • Author(s): Hiroshi Kamitakahara and Fumiaki Nakatsubo
  • Organizer: 237th ACS National Meeting & Exposition
  • Place of Presentation: Salt Lake City, UT, USA
  • Year and Date: 2009-03-26
• [Presentation] Water-soluble nano capsules based on blockwise methylated cello-oligosaccharides (2009)
  • Author(s): Hiroshi Kamitakahara and Fumiaki Nakatsubo
  • Organizer: 237th ACS National Maeeting & Exposition
  • Place of Presentation: Salt Lake City, UT, USA
  • Year and Date: 2009-03-26
• [Presentation] Self-assembly of blockwise methylated cello-oligosaccharides in aqueous solution (2008)
  • Author(s): Hiroshi Kamitakahara and Fumiaki Nakatsubo
  • Organizer: 8th International Symposium Alternative Cellulose Manufacturing, Forming and Properties
  • Place of Presentation: Rudolstsdt, Germany
  • Year and Date: 2008-09-04
• [Presentation] セルロース学会奨励賞受賞講演 (2008)
  • Author(s): 上高原浩
  • Organizer: セルロース学会第15回年次大会2008 Cellulose R&D
  • Place of Presentation: 京都大学桂キャンパスローム記念館
  • Year and Date: 2008-07-10
• [Presentation] Regioselective functionalization of cellulose with two kinds of alkyl groups and the structure-property relationships(Invited lecture) (2008)
  • Author(s): Hiroshi Kamitakahara, Toshihiro Funakoshi, Shinji Nakai, Toshiyuki Takano, Fumiaki Nakatsubo
  • Organizer: 235^<th> ACS meeting in New Orleans, Anselme Payen Award Symposium honoring Prof. Fumitaka Horii
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2008-04-06
• [Presentation] Regioselective functionalization of cellulose with two kinds of alkyl groups and the structure-property (2008)
  • Author(s): Hiroshi Kamitakahara, Toshihiro Funakoshi, Shinji Nakai, Toshiyuki Takano, Fumiaki Nakatsubo
  • Organizer: 235th ACS National Meeting & Exposition
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2008-04-06
• [Presentation] Thermal behavior of aqueous solutions of blockwise methylated cello-oligosaccharide derivatives (2008)
  • Author(s): Hiroshi Kamitakahara, Fumiaki Nakatsubo
  • Organizer: 2^<nd> International Cellulose Conference, 2007
  • Place of Presentation: Tower Hall Funabashi, Tokyo, Japan
• [Presentation] Self-assembly of blockwise methylated cello-oligosaccharides in aqueous solution(Invited lecture) (2008)
  • Author(s): Hiroshi Kamitakahara and Fumiaki Nakatsubo
  • Organizer: ^<8th> International Symposium "Alternative Cellulose . Manufacturing, Forming and Properties"
  • Place of Presentation: Rudolstadt, Germany
• [Presentation] セルロース系コポリマーの調製とその会合構造 (2007)
  • Author(s): 上高原浩(代理 ロジャース(榎本)有希子)
  • Organizer: 第5回積水化学 自然に学ぶものづくりフォーラム
  • Year and Date: 2007-10-17
• [Presentation] ブロック的メチル化セロオリゴ糖誘導体水溶液の熱挙動 (2007)
  • Author(s): 上高原浩、中坪文明
  • Organizer: セルロース学会
  • Place of Presentation: 静岡大学 大学会館
  • Year and Date: 2007-07-20
• [Presentation] Synthesis strategy for functional cello-oligosaccharides to develop innovative cellulosic materials(Invited lecture) (2007)
  • Author(s): Hiroshi Kamitakahara, Arata Yoshinaga, Hajime Aono, Fumiaki Nakatsubo, Dieter O. Klemm
  • Organizer: 233^<rd> ACS meeting in Chicago, Anselme Payen Award Symposium honoring Dr. Charles Buchanan
  • Place of Presentation: USA
• [Presentation] 自己組織化する両親媒性セロオリゴ糖誘導体の合成とその性質 (2006)
  • Author(s): 上高原浩
  • Organizer: 第4回積水化学 自然に学ぶものづくりフォーラム
  • Year and Date: 2006-10-12
• [Presentation] ブロック的にメチル化されたセロオリゴ糖誘導体の構造-物性相関 (2006)
  • Author(s): 上高原浩、中坪文明、Dieter Klemm
  • Organizer: セルロース学会第13回年次大会
  • Place of Presentation: 東京
• [Book] セルロース利用技術の最先端 第6章(分担) セルロースの化学合成と特徴(磯貝明監修) (2008)
  • Author(s): 上高原浩
  • Total Pages: 405
  • Publisher: シーエムシー出版
• [Remarks] 上高原浩、中坪文明 (2008) セルロース系ポリマーのFDP分野への応用の可能性を探る、月刊マテリアルステージ、8 (6), 43-45.
• [Patent(Industrial Property Rights)] セロオリゴ糖誘導体およびその製造方法
  • Inventor(s): 上高原浩、中坪文明、Dieter Klemm