Analysis of a regulatory function of a novel MHC class I receptor, PIR, in inflammatory disorders
| Project/Area Number |
18689015
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKAMURA Akira Tohoku University, 加齢医学研究所, 准教授 (20344723)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2007: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2006: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
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| Keywords | 感染症 / 免疫学 |
|---|
| Research Abstract |
生体においてウイルス除去に重要な役割を果たすとされるプラズマサイト樹状細胞を採取し、刺激を行なったところ、抑制型受容体PIR-Bを欠損したプラズマサイト樹状細胞は、野性型と比較してサイトカイン産生が高値であった。これらの結果よりPIR-Bが、感染炎症を制御する重要な抑制分子であることが判明した。一方、PIR-Bタンパクを用いた感染炎症の制御は困難であることが判明し、今後の検討課題となった。
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development2008
Author(s)
Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Nakamura A, Takayanagi H, Itoi E, Takai T
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Journal Title
Journal of Immunology 181
Pages: 4742-4751
Related Report
Peer Reviewed
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[Journal Article] Fcγ receptor regulation of Citrobacter rodentium infection2008
Author(s)
Masuda A, Yoshida M, Shiomi H, Ikezawa S, Takagawa T, Tanaka H, Chinzei R, Ishida T, Morita Y, Kutsumi H, Inokuchi H, Wang S, Kobayashi K, Mizuno S, Nakamura A, Takai T, Blumberg RS, Azuma T
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Journal Title
Infection and Immunity 76
Pages: 1728-1737
Related Report
Peer Reviewed
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[Journal Article] Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast develonment2008
Author(s)
Mori Y, Tsuji S, Inui M, Sakamoto Y, Endo S, Ito Y, Fujimura S, Koga T, Na kamura A, Takavanagi H, Itoi E, Takai
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Journal Title
Journal of Immunology 181
Pages: 4742-4751
Related Report
Peer Reviewed
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[Presentation] B細胞におけるPirb遺伝子の転写調節因子の同定2008
Author(s)
Arita Kojo, Endo Shota, Nakamura Akira, Kohu Kazuyoshi, Satake Masanobu, Toshiyuki Takai
Organizer
第38回日本免疫学会総会
Place of Presentation
京都
Year and Date
2008-12-03
Related Report
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[Presentation] B細胞におけるPfrb遺伝子の転写調節因子の同定2008
Author(s)
Arita Kojo, Endo Shota, Nakamura Akira, Kohu Kazuyoshi, Satake Mas anobu, Toshiyuki Takai
Organizer
第38回日本免疫学会総会
Place of Presentation
京都
Year and Date
2008-12-03
Related Report
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