Clarification of molecular mechanisms of pharmacological effects/adverse events in the coadministration of various immunosuppressants

• Project/Area Number: 18689016
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Applied pharmacology
• Research Institution: Kyoto University
• Principal Investigator: MASUDA Satohiro Kyoto University, 医学研究科, 講師 (90303825)
• Project Period (FY): 2006 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000); Fiscal Year 2008: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2006: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
• Keywords: 臨床薬理学 / トランスポータ / 代謝酵素 / MDR1 / NR3C1 / タクロリムス / 薬物相互作用 / 薬物感受性 / 免疫抑制薬 / 免疫抑制剤 / ステロイド薬 / CYP3A5 / FKBP1A / 相互作用

Research Abstract

臓器移植治療は、他人の肝臓や腎臓を移植することから、自己とは異なる(非自己)異物に対する攻撃(免疫反応)を抑制する必要があります。免疫抑制剤は、移植臓器を非自己として拒絶するのを防ぐために障害服用せねばなりません。しかし、実際に用いられている免疫抑制剤の効き具合、副作用の頻度には個人差があります。本研究では、免疫抑制剤の使用による効果、副作用の出方を左右する原因の一部を突き止めることができ、今後の移植医療に対して大いに貢献できると考えられます。

Research Products

• [Journal Article] Larger dosage required for everolimus than sirolimus to maintain same blood concentration in two pancreatic islet transplant patients with tacrolimus. (2009)
  • Author(s): Sato E
  • Journal Title: Drug Metab Pharmacokinet 24 Pages: 175-179
  • Peer Reviewed
• [Journal Article] Absence of influence of concomitant administration of rabeprazole on the pharmacokinetics of tacrolimus in adult living-donor liver transplant patients : a case-control study (2009)
  • Author(s): Hosohata K
  • Journal Title: Drug Metab Pharmacokinet 24 Pages: 458-463
  • Peer Reviewed
• [Journal Article] MDR1 haplotypes conferring an increased expression of intestinal CYP3A4 rather than MDR1 in female living-donor liver transplant patients (2009)
  • Author(s): Hosohata K
  • Journal Title: Pharm Res 26 Pages: 1590-1595
  • Peer Reviewed
• [Journal Article] Impact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole, but not lansoprazole, in adult living-donor liver transplant patients (2009)
  • Author(s): Hosohata K
  • Journal Title: Drug Metab Dispos 37 Pages: 821-826
  • Peer Reviewed
• [Journal Article] Risk factors for recurrence of primary sclerosing cholangitis after living donor liver transplantation : a single center experience (2009)
  • Author(s): Egawa H
  • Journal Title: Dig Dis Sci 54 Pages: 1347-1354
  • Peer Reviewed
• [Journal Article] Identification and functional characterization of a novel human and rat riboflavin transporter (2008)
  • Author(s): Yonezawa A, Masuda S, Katsura T, Inui K
  • Journal Title: RFT1. Am J Physiol Cell Physiol 295(3)
  • Peer Reviewed
• [Journal Article] Significance of organic cation transporter 3 (SLC22A3) expression for the cytotoxic effect of oxaliplatin in colorectal cancer. (2008)
  • Author(s): Yokoo S, Masuda S, Yonezawa A, Terada T, Katsura T, Inui K
  • Journal Title: Drug Metab Dispos 36(11) Pages: 2299-2306
  • Peer Reviewed
• [Journal Article] Effect of intestinal and hepatic first-pass extraction on the pharmacokinetics of everolimus in rats. (2008)
  • Author(s): Yokomasu A, Yano I, Sato E, Masuda S, Katsura T, Inui K
  • Journal Title: Drug Metab Pharmacokinet 23(6) Pages: 469-475
  • NAID: 10025722222
  • Peer Reviewed
• [Journal Article] Required transient dose escalation of tacrolimus in living-donor liver transplant recipients with high concentrations of a minor metabolite M-II in bile. (2008)
  • Author(s): Shimomura M, Masuda S, Goto M, Katsura T, Kiuchi T, Ogura Y, Oike F, Takada Y, Uemoto S, Inui K
  • Journal Title: Drug Metab Pharmacokinet 23(5) Pages: 313-317
  • NAID: 10024384504
  • Peer Reviewed
• [Journal Article] Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1. (2008)
  • Author(s): Sato T, Masuda S, Yonezawa A, Tanihara Y, Katsura T, Inui K
  • Journal Title: Biochem Pharmacol 76(7) Pages: 894-903
  • Peer Reviewed
• [Journal Article] Interaction between tacrolimus and lansoprazole, but not rabeprazole in living-donor liver transplant patients with defects of CYP2C19 and CYP3A5. (2008)
  • Author(s): Hosohata K, Masuda S, Ogura Y, Oike F, Takada Y, Katsura T, Uemoto S, Inui K
  • Journal Title: Drug Metab Pharmacokinet 23(2) Pages: 134-138
  • NAID: 10024188057
  • Peer Reviewed
• [Journal Article] Relation between mRNA expression level of multidrug resistance 1/ABCB1 in blood cells and required level of tacrolimus in pediatric living-donor liver transplantation. (2008)
  • Author(s): Goto M, Masuda S, Kiuchi T, Ogura Y, Oike F, Tanaka K, Uemoto S, Inui K
  • Journal Title: J Pharmacol Exp Ther 325(2) Pages: 610-616
  • Peer Reviewed
• [Journal Article] Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients. (2008)
  • Author(s): Fukudo M, Yano I, Yoshimura A, Masuda S, Uesugi M, Hosohata K, Katsura T, Ogura Y, Oike F, Takada Y, Uemoto S, Inui K
  • Journal Title: Pharmacogenet Genomics 18(5) Pages: 413-423
  • Peer Reviewed
• [Journal Article] Effect of intestinal and hepatic first-pass extraction on the pharmacokinetics of everolimus in rats (2008)
  • Author(s): Yokomasu A
  • Journal Title: Drug Metab Pharmacokinet 23 Pages: 469-475
  • Peer Reviewed
• [Journal Article] Required transient dose escalation of tacrolimus in living-donor liver transplant recipients with high concentrations of a minor metabolite M-II in bile (2008)
  • Author(s): Shimomura M
  • Journal Title: Drug Metab Pharmacokinet 23 Pages: 313-317
  • Peer Reviewed
• [Journal Article] Interaction between tacrolimus and lansoprazole, but not rabeprazole in living-donor liver transplant patients with defects of CYP2C19 and CYP3A5 (2008)
  • Author(s): Hosohata K
  • Journal Title: Drug Metab Pharmacokinet 23 Pages: 134-138
  • Peer Reviewed
• [Journal Article] Relation between mRNA expression level of multidrug resistance 1/ABCB1 in blood cells and required level of tacrolimus in pediatric living-donor liver transplantation (2008)
  • Author(s): Goto M
  • Journal Title: J Pharmacol Exp Ther 325 Pages: 610-616
  • Peer Reviewed
• [Journal Article] Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients (2008)
  • Author(s): Fukudo M
  • Journal Title: Pharmacogenet Genomics 18 Pages: 413-423
  • Peer Reviewed
• [Journal Article] INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system and cyclosporine A augments its in vivo activity. (2007)
  • Author(s): Yokota A, Kimura S, Masuda S, Ashihara E, Kuroda J, Sato K, Kamitsuji Y, Kawata E, Deguchi Y, Urasaki Y, Terui Y, Ruthardt M, Ueda T, Hatake K, Inui K, Maekawa T
  • Journal Title: Blood 109(1) Pages: 306-314
  • Peer Reviewed
• [Journal Article] Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity. (2007)
  • Author(s): Yokoo S, Yonezawa A, Masuda S, Fukatsu A, Katsura T, Inui K
  • Journal Title: Biochem Pharmacol 74(3) Pages: 477-487
  • Peer Reviewed
• [Journal Article] Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. (2007)
  • Author(s): Tanihara Y, Masuda S, Sato T, Katsura T, Ogawa O, Inui K
  • Journal Title: Biochem Pharmacol 74(2) Pages: 359-371
  • Peer Reviewed
• [Journal Article] Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats. (2007)
  • Author(s): Nishihara K, Masuda S, Ji L, Katsura T, Inui K
  • Journal Title: Biochem Pharmacol 73(9) Pages: 1482-1490
  • Peer Reviewed
• [Journal Article] Pharmacokinetics and pharmacodynamics of paclitaxel with carboplatin or gemcitabine, and effects of CYP3A5 and MDR1 polymorphisms in patients with urogenital cancers. (2007)
  • Author(s): Jiko M, Yano I, Sato E, Takahashi K, Motohashi H, Masuda S, Okuda M, Ito N, Nakamura E, Segawa T, Kamoto T, Ogawa O, Inui K
  • Journal Title: Int J Clin Oncol 12(4) Pages: 284-290
  • NAID: 10020000038
  • Peer Reviewed
• [Journal Article] Decreased renal accumulation and toxicity of a new VCM formulation in rats with chronic renal failure. (2007)
  • Author(s): Hodoshima N, Masuda S, Inui K
  • Journal Title: Drug Metab Pharmacokinet 22(6) Pages: 419-427
  • NAID: 10020163561
  • Peer Reviewed
• [Journal Article] EMIT法によるミコフェノール酸血中濃度測定とHPLC法との比較による血中濃度評価 (2007)
  • Author(s): 古俵孝明、吉田優子、澤田京子、増田智先、矢野育子、乾賢一
  • Journal Title: 医療薬学 33(9) Pages: 804-808
  • NAID: 110006390977
  • Peer Reviewed
• [Journal Article] INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system and cyclosporine A augments its in vivo activity (2007)
  • Author(s): Yokota A, et al.
  • Journal Title: Blood 109 Pages: 306-314
  • Peer Reviewed
• [Journal Article] Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity (2007)
  • Author(s): Yokoo, et al.
  • Journal Title: Biochem Pharmacol 74 Pages: 477-487
  • Peer Reviewed
• [Journal Article] Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters (2007)
  • Author(s): Tanihara, et al.
  • Journal Title: Biochem Pharmacol 74 Pages: 359-371
  • Peer Reviewed
• [Journal Article] Pharmacokinetic significance of luminal multidrug and toxin extrusion 1 in chronic renal failure rats. (2007)
  • Author(s): Nishihara K et al.
  • Journal Title: Biochem Pharmacol 73・9 Pages: 1482-1490
• [Journal Article] Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agents-induced nephrotoxicity (2007)
  • Author(s): Yokoo S et al.
  • Journal Title: Biochem Pharmacol (印刷中)
• [Journal Article] Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H+-organic cation antiporters (2007)
  • Author(s): Tanihara Y et al.
  • Journal Title: Biochem Pharmacol (印刷中)
• [Journal Article] Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and MATE family). (2006)
  • Author(s): Yonezawa A, Masuda S, Yokoo S, Katsura T, Inui K
  • Journal Title: J Pharmacol Exp Ther 319(2) Pages: 879-886
  • Peer Reviewed
• [Journal Article] Improved cyclosporine absorption and immunosuppression by a once daily dosing in living-donor liver transplant patients. (2006)
  • Author(s): Yano I, Fukudo M, Masuda S, Katsura T, Ogura Y, Oike F, Takada Y, Tanaka K, Inui K
  • Journal Title: Liver Transplantation 12(5)
  • Peer Reviewed
• [Journal Article] Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients. (2006)
  • Author(s): Uesugi M, Masuda S, Katsura T, Oike F, Takada Y, Inui K
  • Journal Title: Pharmacogenet Genomics 16(2) Pages: 119-127
  • Peer Reviewed
• [Journal Article] Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1. (2006)
  • Author(s): Terada T, Masuda S, Asaka JI, Tsuda M, Katsura T, Inui K
  • Journal Title: Pharm Res 23(8) Pages: 1696-1701
  • Peer Reviewed
• [Journal Article] Evaluation of Calvert's formula for dosage adjustment of carboplatin in Japanese patients with hormone refractory prostate cancer. (2006)
  • Author(s): Sato E, Yano I, Jiko M, Takahashi K, Motohashi H, Masuda S, Katsura T, Nishiyama H, Segawa T, Ito N, Kamoto T, Ogawa O, Inui K
  • Journal Title: Biol Pharm Bull 29(7) Pages: 1441-1444
  • NAID: 110005602318
  • Peer Reviewed
• [Journal Article] Temporal decline in sirolimus elimination immediately after pancreatic islet transplantation. (2006)
  • Author(s): Sato E, Shimomura M, Masuda S, Yano I, Katsura T, Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Inui K
  • Journal Title: Drug Metab Pharmacokinet 21(6) Pages: 492-500
  • NAID: 10018659035
  • Peer Reviewed
• [Journal Article] Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. (2006)
  • Author(s): Masuda S, Terada T, Yonezawa A, Tanihara Y, Kishimoto K, Katsura T, Ogawa O, Inui K
  • Journal Title: J Am Soc Nephrol 17(8) Pages: 2127-2135
  • Peer Reviewed
• [Journal Article] An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients. (2006)
  • Author(s): Masuda S, Inui K
  • Journal Title: Pharmacol Ther 112(1) Pages: 184-198
  • Peer Reviewed
• [Journal Article] Intestinal MDR1/ABCB1 level at surgery as a risk factor of acute cellular rejection in living-donor liver transplant patients. (2006)
  • Author(s): Masuda S, Goto M, Fukatsu S, Uesugi M, Ogura Y, Oike F, Kiuchi T, Takada Y, Tanaka K, Inui K
  • Journal Title: Clin Pharmacol Ther 79(1) Pages: 90-102
  • Peer Reviewed
• [Journal Article] Cyclosporine exposure and calcineurin phosphatase activity in living-donor liver transplant patients: twice daily vs. once daily dosing (2006)
  • Author(s): Fukudo M, Yano I, Masuda S, Katsura T, Ogura Y, Oike F, Takada Y, Tanaka K, Inui K
  • Journal Title: Liver Transpl 12(2) Pages: 292-300
  • Peer Reviewed
• [Journal Article] Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients. (2006)
  • Author(s): Fukudo M, Yano I, Masuda S, Goto M, Uesugi M, Katsura T, Ogura Y, Oike F, Takada Y, Egawa H, Uemoto S, Inui K
  • Journal Title: Clin Pharmacol Ther 80(4) Pages: 331-345
  • Peer Reviewed
• [Journal Article] Delayed effect of grapefruit juice on pharmacokinetics and pharmacodynamics of tacrolimus in a living-donor liver transplant recipient. (2006)
  • Author(s): Fukatsu S, Fukudo M, Masuda S, Yano I, Katsura T, Ogura Y, Oike F, Takada Y, Inui K
  • Journal Title: Drug Metab Pharmacokinet 21(2) Pages: 122-125
  • NAID: 10017423156
  • Peer Reviewed
• [Journal Article] カルシニューリン阻害剤のpharmacodynamicsと至適投与設計 (2006)
  • Author(s): 福土将秀、矢野育子、増田智先、桂敏也、小倉靖弘、尾池文隆、高田泰次、上本伸二、田中紘一、乾賢一
  • Journal Title: 今日の移植 19(6) Pages: 658-660
  • Peer Reviewed
• [Journal Article] 膵頭移植患者におけるラパマイシンの体内動態と薬効・副作用に関する検討 (2006)
  • Author(s): 佐藤栄里子、下村昌寛、増田智先、矢野育子、土生康司、桂敏也、松本慎一、興津輝、岩永康裕、野口洋文、永田英生、米川幸秀、田中紘一、乾賢一
  • Journal Title: TDM研究 23(2) Pages: 85-86
  • Peer Reviewed
• [Journal Article] 小児造血幹細胞移植におけるシクロスポリン間歇点滴法の血中濃度モニタリング (2006)
  • Author(s): 澤田京子、小谷敦子、増田智先、桂敏也、矢野育子、松原央、平松英文、小林道弘、中畑龍俊、乾賢一
  • Journal Title: TDM研究 23(2) Pages: 87-88
  • Peer Reviewed
• [Journal Article] NONMEMを活用したTDM解析支援ソフトウェアの開発 (2006)
  • Author(s): 石橋徹、矢野育子、増田智先、桂敏也、乾 賢一
  • Journal Title: TDM研究 23(2) Pages: 153-154
  • Peer Reviewed
• [Journal Article] Intestinal MDR1/ABCB1 Level at Surgery As a Risk Factor of Acute Cellular Rejection in Living-donor Liver Transplant Patients. (2006)
  • Author(s): Masuda S et al.
  • Journal Title: Clin Pharmacol Ther 79・1 Pages: 90-102
• [Journal Article] Effect of intestinal CYP3A5 on postoperative tacrolimus trough levels in living-donor liver transplant recipients. (2006)
  • Author(s): Uesugi M et al.
  • Journal Title: Pharmacogenet Genomics 16・2 Pages: 119-127
• [Journal Article] Cyclosporine exposure and calcineurin phosphatase activity in living-donor liver transplant patients : twice daily versus once daily dosing. (2006)
  • Author(s): Fukudo M et al.
  • Journal Title: Liver Transpl 12・2 Pages: 292-300
• [Journal Article] Population pharmacokinetic and pharmacogenomic analysis of tacrolimus in pediatric living-donor liver transplant recipients (2006)
  • Author(s): Fukudo M et al.
  • Journal Title: Clin Pharmacol Ther 80・4 Pages: 331-345
• [Journal Article] An up-date review on individualized, dosage adjustment of calcineurin inhibitors in organ transplant patients (2006)
  • Author(s): Masuda S, Inui K
  • Journal Title: Pharmacol Ther 112・1 Pages: 184-198
• [Journal Article] Delayed effect of grapefruit juice on pharmacokinetics and pharmacodynamics of tacrolimus in a living-donor liver transplant recipient (2006)
  • Author(s): Fukatsu S et al.
  • Journal Title: Drug Metab Pharmacokinet 21・2 Pages: 122-125
• [Journal Article] Temporal decline in sirolimus elimination immediately after pancreatic islet transplantation (2006)
  • Author(s): Sato E et al.
  • Journal Title: Drug Metab Pharmacokinet 21・6 Pages: 492-500
• [Journal Article] Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. (2006)
  • Author(s): Masuda S et al.
  • Journal Title: J Am Soc Nephrol 17・8 Pages: 2127-2135
• [Journal Article] Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and MATE family). (2006)
  • Author(s): Yonezawa A et al.
  • Journal Title: Pharmacol Exp Ther 319・2 Pages: 879-886
• [Journal Article] Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1. (2006)
  • Author(s): Terada T et al.
  • Journal Title: Pharm Res 23・8 Pages: 1696-1701
• [Journal Article] INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+leukemia cells in the central nervous system and cyclosporine A augments its in vivo activity (2006)
  • Author(s): Yokota A et al.
  • Journal Title: Blood 109・1 Pages: 306-314
• [Presentation] 白金系抗癌剤の毒性発現における有機カチオントランスポータの役割;シンポジウムS17トランスポーター研究のパラダイムシフト:薬物輸送体から薬物標的へ (2009)
  • Author(s): 増田智先、乾賢一
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 移植医療における免疫抑制剤の血中濃度管理と薬剤師の役割 (2008)
  • Author(s): 増田智先
  • Organizer: 第8回千葉県東部TDM情報研究会
  • Place of Presentation: 成田赤十字病院、千葉県成田市
  • Year and Date: 2008-11-14
• [Presentation] 移植医療における免疫抑制剤の血中濃度管理と薬剤師の役割 (2008)
  • Author(s): 増田智先
  • Organizer: 第8回千葉県東部TDM情報研究会
  • Place of Presentation: 成田市
  • Year and Date: 2008-11-14
• [Presentation] Association between CYP3A5 genotypes and biotransformation of tacrolimus in living-donor liver transplant patients (2008)
  • Author(s): Masuda S
  • Organizer: Clinical Pharmacology and Therapeutics(CPT2008)・第9回国際臨床薬理学会
  • Place of Presentation: ケベック市、カナダ
  • Year and Date: 2008-07-29
• [Presentation] Association between intestinal CYP2C19 genotypes and tacrolimus trough levels with proton pump inhibitors in adult living-donor liver transplant patients (2008)
  • Author(s): Hosohata K
  • Organizer: Clinical Pharmacology and Therapeutics(CPT2008)・第9回国際臨床薬理学会
  • Place of Presentation: ケベック市、カナダ
  • Year and Date: 2008-07-29
• [Presentation] 免疫抑制剤のゲノム薬理学;パネルディスカッション1「ゲノム薬理学の臨床応用へ向けての現状と問題」 (2008)
  • Author(s): 増田智先、乾賢一
  • Organizer: 第29回日本臨床薬理学会年会に参加した
  • Place of Presentation: 京王プラザホテル、東京都新宿区
• [Presentation] Transcriptome analysis using purified proximal tubules in progressive renal failure rats (2008)
  • Author(s): Kumiko Nishihara, Satohiro Masuda, Atsushi Yonezawa, Shunsaku Nakagawa, Toshiya Katsura, Ken-ichi Inui
  • Organizer: 2008 AAPS Annual Meeting and Exposition(米国薬学会
  • Place of Presentation: Atlanta、U.S.A.
• [Presentation] Characterization of KIM- 1 as a novel target receptor for renal clear cellcarcinoma (2008)
  • Author(s): Satohiro Masuda, Takaharu Ichimura, Joseph Vincent Bonventre
  • Organizer: Renal Week 2008に出席し、以下の発表を行った(第40回米国腎臓病学会
  • Place of Presentation: Philadelphia、U.S.A.
• [Presentation] 腎尿細管薬物トランスポータの病態生理学的役割;シンポジウム1「腎におけるトランスポータ・チャネル研究の基礎と臨床」 (2008)
  • Author(s): 増田智先、乾賢一
  • Organizer: 第23回日本薬物動態学会年会
  • Place of Presentation: 熊本市民会館ほか、熊本県
• [Presentation] Association between CYP3A5 genotypes and biotransformation of tacrolimus in living-donor liver transplant patients (2008)
  • Author(s): Satohiro Masuda, Masahiro Shimomura, Toshiya Katsura, Yasuhiro Ogura, Fumitaka Oike, Yasutsugu Takada, Shinji Uemoto, Ken-ichi Inui
  • Organizer: The IXth World Conference on Clinical Pharmacology and Therapeutics(世界臨床薬理学会議)
  • Place of Presentation: Que bec City Convention Centre、Que bec、Canada
• [Presentation] Structural characterisitcs and substrate specificity of hMATE2-K (2007)
  • Author(s): Yuko Tanihara, Satohiro Masuda, Atsushi Yonezawa, Toshiya Katsura, Ken-ichi Inui
  • Organizer: BioMedical Transporters 2007
  • Place of Presentation: Kursaal Congress Center, Bern, Switzerland
• [Presentation] Expressional and functional changes in rat H+/organic cation antiporter MATE1 in chronic renal failure (2007)
  • Author(s): Kumiko Nishihara, Satohiro Masuda, Toshiya Katsura, Ken-ichi Inui
  • Organizer: BioMedical Transporters 2007
  • Place of Presentation: Kursaal Congress Center, Bern, Switzerland
• [Presentation] Intestinal CYP3A5 genotype and MDR1 expression influence apparent clearacne of tacrolimus in adult living-donor liver transplant recipient (2007)
  • Author(s): Fukudo, M., Yoshimura, A., Yano, I., Masuda, S., Uesugi, M., Hosohata, K., Katsura, T., Takada, Y., Uemoto, S., Inui, K.
  • Organizer: 第10回国際TDM学会に出席し、以下の研究発表を行った
  • Place of Presentation: ニース、フランス
• [Presentation] Procainamide and N-acetylprocainamide are superior substrates for hepatic organic cation transporter OCT1 rather than renal OCT2 (2007)
  • Author(s): Masahiro, Shimomura, Satohiro Masuda, Tomohiro Terada, Atsushi Yonezawa, Yuko Tanihara, Toshiya Katsura, Ken-ichi Inui
  • Organizer: 2007 AAPS Annual Meeting and Exposition (米国薬学会)
  • Place of Presentation: San Diego Convention Center, San Diego, CA, USA
• [Presentation] cDNA cloning and functional chracterization of a novel H+/organic cation antiporter MATE2-K specifically expressed in the kidney (2006)
  • Author(s): Satohiro Masuda, Tomohiro Terada, Atsushi Yonezawa, Yuko Tanihara, Toshiya Katsura, Ken-ichi Inui
  • Organizer: 2006 AAPS Annual Meeting and Exposition米国薬学会
  • Place of Presentation: Henry B. Gonzalez Convention Center, San Antonio, TX, USA
• [Presentation] OCT2/SLC22A2 mediates renal accumulation of cisplatin, which causes nephrotoxicity (2006)
  • Author(s): Atsushi Yonezawa, Kumiko Nishihara, Sachiko Yokoo, Satohiro Masuda, Toshiya Katsura, Ken-ichi Inui
  • Organizer: 2006 AAPS Annual Meeting and Exposition米国薬学会
  • Place of Presentation: Henry B. Gonzalez Convention Center, San Antonio, TX, USA
• [Presentation] A novel human kidney-specific H+/organic cation antiporter MATE2-K: cDNA cloning, tissue distribution and functional chracterization (2006)
  • Author(s): Satohiro Masuda, Tomohiro Terada, Atsushi Yonezawa, Yuko Tanihara, Toshiya Katsura, Ken-ichi Inui
  • Organizer: Renal Week 2006 第39回米国腎臓病学会
  • Place of Presentation: San Diego Convention Center, San Diego, CA, USA
• [Presentation] Role of human organic cation transporters (hOCT and hMATE) in the cellular accumulation and toxicity of cisplatin and oxaliplatin, but not carboplatin and nedaplatin (2006)
  • Author(s): Atsushi Yonezawa, Sachiko Yokoo, Satohiro Masuda, Toshiya Katsura, Ken-ichi Inui
  • Organizer: Renal Week 2006第39回米国腎臓病学会
  • Place of Presentation: San Diego Convention Center, San Diego, CA, USA