Role of HZF in adipocyte differentiation

• Project/Area Number: 18689021
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: National Institute for Longevity Sciences,NCGG
• Principal Investigator: SUGIMOTO Masataka National Institute for Longevity Sciences,NCGG, 老化機構研究部・代謝研究室, 室長 (50426491)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2006: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
• Keywords: 代謝異常学 / 脂肪細胞 / mRNA翻訳 / 転写因子 / インスリン抵抗性

Research Abstract

脂肪細胞の分化・成熟には、複数の転写因子から構成される複雑なネットワークの活性化が必要である。我々はHZFと呼ばれるRNA結合タンパク質が脂肪細胞分化に不可欠であるC/EBPαの発現を翻訳レベルで制御していることを見出した。HZF非存在下では脂肪細胞の分化に異常が見られること、またHZFノックアウトマウスは著しいインスリン抵抗性を示すことを発見した。

Research Products

• [Journal Article] Hzf regulates adipogenesis through translational control of C/EBPα (2008)
  • Author(s): Hiroyuki Kawagishi, Takeshi Wakoh, Hatsume Uno, Mitsuo Maruyama, Ayako Moriya, Satoru Morikawa, Hideyuki Okano, Charles J. Sherr, Masatoshi Takagi, Masataka Sugimoto
  • Journal Title: The EMBO Journal 27(10) Pages: 1481-1490
  • Peer Reviewed
• [Journal Article] Hzf regulates adipogenesis through translational control of C/EBPα (2008)
  • Author(s): 川岸 裕幸
  • Journal Title: The EMBO Journal 27 Pages: 1481-1490
  • Peer Reviewed
• [Journal Article] Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage. (2006)
  • Author(s): Masataka Sugimoto
  • Journal Title: Molecular and Cellular Biology 26・2 Pages: 502-502
• [Presentation] Hzf collaborates with HuR to regulate adipogenesis (2008)
  • Author(s): Masataka Sugimoto
  • Organizer: BMB2008
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-14
• [Presentation] Physical and functional interactions of RNA- binding proteins Hzf and HuR (2008)
  • Author(s): Hideaki Nakamura
  • Organizer: BMB2008
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] Physical and functional interactions of RNA-binding proteins, Hzf and HuR (2008)
  • Author(s): 中村 英亮
  • Organizer: BMB2008
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-12
• [Presentation] Hzf collaborates with HuR to regulate adipogenesis (2008)
  • Author(s): 杉本 昌隆
  • Organizer: BMB2008
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-12
• [Presentation] Role of Hzf in adipocyte differentiation (2008)
  • Author(s): 杉本昌隆
  • Organizer: 第一回FANTASY
  • Place of Presentation: 東京
  • Year and Date: 2008-02-02
• [Presentation] Role of Hzf in adipocyte differentiation (2008)
  • Author(s): 杉本 昌隆
  • Organizer: 第一回FANTASY
  • Place of Presentation: グランドパレス(東京)
  • Year and Date: 2008-02-02
• [Presentation] Hzf regulates the translation of C/EBPalpha mRNA during adipocyte differentiation (2007)
  • Author(s): Masataka Sugimoto
  • Organizer: BMB2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] Hzf regulates the translation of C/EBPalpha during adipocyte differentiation (2007)
  • Author(s): 杉本 昌隆
  • Organizer: BMB2007
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2007-12-12
• [Presentation] Hzf regulates the translation of CEBPalpha mRNA during adipocyte differentiation (2007)
  • Author(s): Masataka Sugimoto
  • Organizer: The 7th MBSJ Spring Symposium
  • Place of Presentation: 兵庫
  • Year and Date: 2007-04-23
• [Presentation] Hzf regulates the translation of C/EBPalpha during adipocyte differentiation (2007)
  • Author(s): 杉本 昌隆
  • Organizer: The 7th MBSJ Spring Symposium
  • Place of Presentation: 淡路舞台国際会議場
  • Year and Date: 2007-04-23
• [Presentation] Role of Hzf in adipocyte differentiation (2006)
  • Author(s): Masataka Sugimoto
  • Organizer: The 11th Adiposcience Symposium
  • Place of Presentation: 大阪
  • Year and Date: 2006-08-19
• [Presentation] Role of HZF in adipocyte differentiation (2006)
  • Author(s): Takeshi Wakoh
  • Organizer: 20th IUBMB International Congress of Biochemistry and Molecular Biology
  • Place of Presentation: 京都
  • Year and Date: 2006-06-22
• [Remarks]
  • URL: http://www.nils.go.jp/department/dma/ee.html