Site-specific mesenchymal-epithelial interactions elucidate pathogenesis of skindiseases and contribute to perfect tissue regeneration.

• Project/Area Number: 18689028
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Nagoya City University (2007-2008); Osaka University (2006)
• Principal Investigator: YAMAGUCHI Yuji Nagoya City University, 大学院・医学研究科, 准教授 (00335340)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2006: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
• Keywords: 皮膚腫瘍学 / 創傷治癒学 / 再生医学 / 色素細胞学 / 皮膚発生学 / 線維芽細胞 / 表皮細胞 / メラノサイト / 再生医療 / 創傷治癒 / 皮膚癌 / 紫外線 / 悪性黒色腫 / 部位特異性 / 上皮間葉系相互作用

Research Abstract

「ヒト成人においても、上皮間葉系相互作用(真皮線維芽細胞がその上にある上皮系細胞に与える作用)により部位特異性(皮膚のさまざまな部位で性質が異なること)を決定付けていること」を実証してきた。手のひら・足のうらの皮膚は、分厚い皮膚で外からの刺激に強い・毛が無い・色素が薄いという3つの特徴がある。手のひら・足のうらの真皮線維芽細胞で発現が高いDKK1が、メラノサイトの機能を抑えるだけでなく、表皮細胞のメラニン取り込み能を抑制すると同時に、重層化を促進している結果を得ることが出来た。

Research Products

• [Journal Article] Regulation of skin pigmentation and thickness by DKK1 (2009)
  • Author(s): Yamaguchi Y(4名・筆頭・責任著者) Morita A, et al.
  • Journal Title: J Investig DermatolSymp Proc (in press)
  • Peer Reviewed
• [Journal Article] Intractable wounds caused by pyoderma gangrenosum in a patient with critical limb ischemia treated with cyclosporine and adjuvant sympathectomy. (2009)
  • Author(s): Takahashi Y, Yamaguchi Y(6名・共筆頭・責任著者), et al.
  • Journal Title: Dermatol Surg (Epub)
  • Peer Reviewed
• [Journal Article] Short- and long-term effects of UV radiation on the skin. (2009)
  • Author(s): Coelho SG, 中略, Yamaguchi Y(15名・5番目), et al.
  • Journal Title: J Investig Dermatol Symp Proc (in press)
  • Peer Reviewed
• [Journal Article] Molecular basis of premature skin aging induced by tobacco smoking. (2009)
  • Author(s): Morita A, 中略, Yamaguchi Y(4名・最終著者)
  • Journal Title: J Investig Dermatol Symp Proc (in press)
  • Peer Reviewed
• [Journal Article] Stage III melanoma treated with chemotherapy after surgery during the second trimester of pregnancy. (2009)
  • Author(s): Ishida I, Yamaguchi Y(7名・共筆頭・責任著者), T et al.
  • Journal Title: ArchDermatol 145(3) Pages: 346-8
  • Peer Reviewed
• [Journal Article] The development of a filter to enhance the efficacy and safety of excimer light (308 nm) therapy. (2009)
  • Author(s): Kobayashi K, 中略, Yamaguchi Y(11名・10番目), et al.
  • Journal Title: Photodermatol Photoimmunol Photomed 25(1) Pages: 30-6
  • Peer Reviewed
• [Journal Article] Feasibility and a ccuracy of anewly developed hand-held device with a flat-type fluorescent lamp for measuring the minimal erythema dose for narrow-band UVB. (2009)
  • Author(s): Morita A, 中略, Yamaguchi Y(8名・7番目), et al.
  • Journal Title: Photodermatol Photoimmunol Photomed 25(1) Pages: 41-4
  • Peer Reviewed
• [Journal Article] Embryonic hair follicle fate change by augmented beta-catenin signaling through Shh and Bmp signaling. (2009)
  • Author(s): Suzuki K, Yamaguchi Y(13名・2番目), et al.
  • Journal Title: Development 136(3) Pages: 367-72
  • Peer Reviewed
• [Journal Article] Embryonic hair follicle fate change by augmented betacatenin signaling thro ugh Shh and Bmp signaling (2009)
  • Author(s): Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, Taketo MM, Nakagata N, Ts ukiyama T, Yamaguchi TP, Kato S, Birchmeier W, Yamada G
  • Journal Title: Development 136(3) Pages: 367-372
  • Peer Reviewed
• [Journal Article] The development of a filter to enhance the efficacy and safety of excimer ight (308 nm) therapy (2009)
  • Author(s): Kobayashi K, Yasuda Y, Shintani Y, Sumitomo T, Saga T, Kimura M, Yamamoto A, Mori T, Maeda A, Yamaguchi Y, Morita A
  • Journal Title: Photodermatol Photoimmunol Photomed 25(1) Pages: 30-36
  • Peer Reviewed
• [Journal Article] Feasibility and accuracy of a newly developed hand-held device with a flat-t ype fluorescent lamp for measuring the minimal erythema dose for narrow-b and UVB therapy (2009)
  • Author(s): Morita A, Shintani Y, Nishida E, Kato H, Yoshida H, Minamoto M, Yamaguchi Y, Maeda A
  • Journal Title: Photodermatol Photoimmunol Photomed 25(1) Pages: 41-44
  • Peer Reviewed
• [Journal Article] Stage III melanoma treated with chemotherapy after surgery during the seco nd trimester of pregnancy (2009)
  • Author(s): lshida I, Yamaguchi Y, Tanemura A, Hosokawa K, !tam' S, Morita A, Katayama I. (Co-first and Cor responding author)
  • Journal Title: Arch Dermatol (IN PRESS)
  • Peer Reviewed
• [Journal Article] al limb ischemia treated with cyclosporine and adjuvant sympathectomy (2009)
  • Author(s): K, Sano S, Morita Ad Katayama I. (Co-first and Corresponding aut hor)
  • Journal Title: Dermatol Surg (IN PRESS)
  • Peer Reviewed
• [Journal Article] Short and long-term effects of ultraviolet radiation on the pigmentation of human skin (2009)
  • Author(s): Coelho SG, Choi W, Brenner M, Miyamura Y, Yamaguchi Y, Wolber R, Smuda C, Batzer J, Kolbe L, Ito S, Wakamatsu K, Zmudzka B, Beer JZ, Miller SA, Hearing VJ
  • Journal Title: J Investig Dermatol Symp Proc (IN PRESS)
  • Peer Reviewed
• [Journal Article] Molecular basis of premature skin aging induced by tobacco smoking (2009)
  • Author(s): Morita A, Torii K, Maeda A, Yam aguchi Y
  • Journal Title: J Investig Dermatol Symp Proc (IN PRESS)
  • Peer Reviewed
• [Journal Article] Regulation of skin pigmentation and thickness by dickkopf 1 (DKK1) (2009)
  • Author(s): Yamaguchi Y, Morita A, Maeda A, Hearing VJ
  • Journal Title: J Investig Dermatol Symp Proc (IN PRESS)
  • Peer Reviewed
• [Journal Article] Establishment of suction blister roof grafting by injection of local anesthesia beneath the epidermis : less painful and more rapid formation of blisters. (2008)
  • Author(s): Hanafusa T, Yamaguchi Y(14名・共筆頭・責任著者), et al.
  • Journal Title: J Dermatol Sci 50(3) Pages: 243-7
  • NAID: 10024119244
  • Peer Reviewed
• [Journal Article] BeerJZ, Hearing VJ. Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation: factors influencing the incidence of skin cancer. (2008)
  • Author(s): Yamaguchi Y(3名・筆頭・責任著者)
  • Journal Title: Arch DermatolRes (300 Suppl 1)
  • Peer Reviewed
• [Journal Article] DKK1 regulates skin pigmentation and thickness by affecting Wnt/・-catenin signaling in keratinocytes. (2008)
  • Author(s): Yamaguchi Y(11名・筆頭・責任著者),Passeron T, et al.
  • Journal Title: FASEB J 22(4) Pages: 1009-20
  • Peer Reviewed
• [Journal Article] Involvement of dynein and spectrin with early melanosome transport and melanosomal protein trafficking. (2008)
  • Author(s): Watabe H, 中略, Yamaguchi Y(10名・4番目), et al.
  • Journal Title: J Invest Dermatol 128(1) Pages: 162-74
  • Peer Reviewed
• [Journal Article] Dynamics of pigmentation induction by repeated UV exposures: dose, dose interval and UV spectrum dependence. (2008)
  • Author(s): Miller SA, 中略, Yamaguchi Y(7名・5番目), et al.
  • Journal Title: Br J Dermatol 159 Pages: 921-30
  • Peer Reviewed
• [Journal Article] Congenital peristernal dermal sinuses: a new entity? (2008)
  • Author(s): Kubo T, 中略, Yamaguchi Y(5名・3番目),et al.
  • Journal Title: Br J Dermatol 159 Pages: 763-5
  • Peer Reviewed
• [Journal Article] Cyclobutane pyrimidine dimer formation and p53 production in human skin. (2008)
  • Author(s): Yamaguchi Y(7名・筆頭著者), Coelho SG, et al.
  • Journal Title: Exp Dermatol 17(11) Pages: 916-24
  • Peer Reviewed
• [Journal Article] Apocrine adenocarcinoma originating from the Moll's gland of the eyelid: report of a case. (2008)
  • Author(s): Kanazawa S, 中略, Yamaguchi Y(7名・4番目), et al.
  • Journal Title: Eur J Plast Surg 31 Pages: 333-6
  • Peer Reviewed
• [Journal Article] Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting W nt/betacatenin signaling in keratinocytes (2008)
  • Author(s): Yamaguchi Y, Passeron T, Hoashi T, Watabe H, Rouzaud F, Yasum oto K, Hara T, Tohyama C, Katay ama I, Miki T, Hearing VJ. (Corr esponding author)
  • Journal Title: FASEB J 22(4) Pages: 1009-1020
  • Peer Reviewed
• [Journal Article] Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiati on : factors influencing the incidence of skin cancer (2008)
  • Author(s): Yamaguchi Y, Beer JZ, Hearing V J. (Corresponding author)
  • Journal Title: Arch Dermatol Res 300(Supplem ent 1) Pages: 43-50
  • Peer Reviewed
• [Journal Article] Establishment of suction blister roof grafting by injection of local anesthesia beneath the epidermis : less painful and more rapid formation of blisters (2008)
  • Author(s): Hanafusa T, Yamaguchi Y, Nakam ura M, Kojima R, Shima R, Furui Y, Watanabe S, Takeuchi A, Kan eko N, Shintani Y, Maeda A, Tani M, Morita A, Katayama I. (Co-fi rst and Corresponding author)
  • Journal Title: J Dermatol Sci 50(3) Pages: 243-247
  • NAID: 10024119244
  • Peer Reviewed
• [Journal Article] Cyclobutane pyrimidine dimer formation and p53 production in human skin a fter repeated UV exposure (2008)
  • Author(s): Yamaguchi Y, Coelho SG, Zmudz ka BZ, Takahashi K, Beer JZ, He aring VJ, Miller SA
  • Journal Title: Exp Dermatol 17(11) Pages: 916-924
  • Peer Reviewed
• [Journal Article] Dynamics of pigmentation induction by repeated UV exposures : dose, dose interval and UV spectrum dependence (2008)
  • Author(s): Miller SA, Coelho SG, Zmudzka B Z, Bushar HF, Yamaguchi Y, Hea ring VJ, Beer JZ
  • Journal Title: Br J Dermatol 159(4) Pages: 921-930
  • Peer Reviewed
• [Journal Article] Congenital peristernal dermal sinuses : a new entity? (2008)
  • Author(s): Kubo T, Takagi T, Yamaguchi Y, Yano K, Hosokawa K
  • Journal Title: Br J Dermatol 159(3) Pages: 763-765
  • Peer Reviewed
• [Journal Article] Apocrine adenocarcinoma originating from the Moll's gland of the eyelid : report of a case (2008)
  • Author(s): Kanazawa S, Kubo T, Tanag MA, Yamaguchi Y, Hoshida Y, Yano K, Hosokawa K
  • Journal Title: Eur J Plast Surg 31(6) Pages: 333-336
  • Peer Reviewed
• [Journal Article] Involvement of dynein and spectrin with early melanosome transport and melanosomal protein trafficking.[Selected as Journal Cover] (2008)
  • Author(s): Watabe H, Valencia J, Le Pape E, Yamaguchi Y, Nakamura M, Rouzaud F, Hoashi T, Kawa Y, Mizoguchi M, Hearing VJ.
  • Journal Title: J Invest Dermatol 128(1) Pages: 162-174
  • Peer Reviewed
• [Journal Article] The effects of dickkopf 1 on keratinocyte gene profiles and on Wnt/-catenin signaling pathways:the mechanisms by which dickkopf 1 reduces cell/cell contact and melanosome transfer (2008)
  • Author(s): Yamaguchi Y(Corresponding author), Passeron T, Watabe H, Hoashi T, Rouzaud F, Yasumoto K, Hara T, Mild T, Itami S, Katayama I, Hearing VJ.
  • Journal Title: FASEB J 22(4) Pages: 1009-1020
  • Peer Reviewed
• [Journal Article] Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation:factors influencing the incidence of skin cancer (2008)
  • Author(s): Yamaguchi Y(Corresponding author), Beer JZ, Hearing VJ.
  • Journal Title: Arch Dermatol Res 300(Supplement 1) Pages: 43-50
  • Peer Reviewed
• [Journal Article] Establishment of suction blister roof grafting by injection of local anesthesia beneath the epidermis:less painful and more rapid formation of blisters (2008)
  • Author(s): Hanafusa T, Yamaguchi Y(Co-first and Corresponding author), Nakamura M, Kojima R, Shima R, Furui Y, Watanabe S, Takeuchi A, Kaneko N, Shintani Y, Maeda A, Tani M, Morita A, Katayama I.
  • Journal Title: J Dermatol Sci 50(3) Pages: 243-247
  • Peer Reviewed
• [Journal Article] Cyclobutane pyrimidine dimer formation and p53 production in human skin after repeated UV exposure (2008)
  • Author(s): Yamaguchi Y, Coelho SG, Zmudzka BZ, Takahashi K, Beer JZ, Hearing VJ, Miller SA.
  • Journal Title: Exp Dermatol Pages: 23-23
  • Peer Reviewed
• [Journal Article] Dynamics of pigmentation induction by repeated UV exposures:dose,dose interval and UV spectrum dependence (2008)
  • Author(s): Miller SA, Coelho SG, Zmudzka BZ, Bushar HF, Yamaguchi Y, Hearing VJ, Beer JZ.
  • Journal Title: Br J Dermatol (In press)
  • Peer Reviewed
• [Journal Article] Congenital peristernal dermal sinuses:a new entity? (2008)
  • Author(s): Kubo T, Takagi T, Yamaguchi Y, Yano K, Hosokawa K.
  • Journal Title: Br J Dermatol (In press)
  • Peer Reviewed
• [Journal Article] Stage III melanoma treated with chemotherapy after surgery during the second trimester of pregnancy (2008)
  • Author(s): Ishida I, Yamaguchi Y(Co-first and Corresponding author), Tanemura A, Hosokawa K, Itami S, Morita A, Katayama I.
  • Journal Title: Arch Dermatol (In press)
  • Peer Reviewed
• [Journal Article] Wounds caused by pyoderma gangrenosum and vasculopathy secondary to diabetes mellitus treated with cyclosporine and sympathectomy (2008)
  • Author(s): Takahashi Y, Yamaguchi Y(Co-first and Corresponding author), Itoh K, Sano S, Morita A, Katayama I.
  • Journal Title: Dermatol Surg (In press)
  • Peer Reviewed
• [Journal Article] Epithelioid sarcoma on the foot masquerading as an intractable wound for 24 years (2008)
  • Author(s): Nishimura Y, Yamaguchi Y(Corresponding author), Hamada K, Tomita Y, Morita A, Katayama I.
  • Journal Title: Clin Exp Dermatol (In press)
  • Peer Reviewed
• [Journal Article] Embryonic hair follicle fate alteration by augmented beta-catenin signaling relayed by Bmp receptor(BmprIA) (2008)
  • Author(s): Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, Taketo MM, Nakagata N, Tsukiyama T, Yamaguchi TP, Kato S, Birchmeier W, Yamada G.
  • Journal Title: Development (In press)
  • Peer Reviewed
• [Journal Article] Katayama I. Intractable wounds caused by arteriosclerosis obliterans with end-stage renal disease treated by aggressive debridement and epidermal grafting. (2007)
  • Author(s): Hanafusa T, Yamaguchi Y(3名・責任著者),
  • Journal Title: J Am Acad Dermatol 57(2) Pages: 322-6
  • Peer Reviewed
• [Journal Article] Intractable wounds caused by calcific uremic arteriolopathy treated with bisphosphonates. (2007)
  • Author(s): Hanafusa T, Yamaguchi Y(6名・責任著者),et al.
  • Journal Title: J Am Acad Dermatol 57(6) Pages: 1021-5
  • Peer Reviewed
• [Journal Article] IRegulation of human skin pigmentation and responses to UV radiation. (2007)
  • Author(s): Miyamura Y, 中略, Yamaguchi Y(14名・12番目), et al.
  • Journal Title: Pigment Cell Res 20(1) Pages: 2-13
  • Peer Reviewed
• [Journal Article] The effects of dickkopf 1 on gene expression and Wnt signaling by melanocytes: mechanisms underlying its suppression of melanocyte function and proliferation. (2007)
  • Author(s): Yamaguchi Y(7名・筆頭・責任著者),Passeron T, et al.
  • Journal Title: J Invest Dermatol 127(5) Pages: 1217-25
  • Peer Reviewed
• [Journal Article] Intractable wounds from a herpe ssimplex infection in an immunosuppressed patient with rheumatoid arthritis. (2007)
  • Author(s): Hanafusa T, Yamaguchi Y(4名・責任著者), et al.
  • Journal Title: Arch Dermatol 143(10) Pages: 1340-2
  • Peer Reviewed
• [Journal Article] Brenner M, Hearing VJ. The regulation of skin pigmentation. (2007)
  • Author(s): Yamaguchi Y(3名・筆頭著者),
  • Journal Title: J Biol Chem 282(38) Pages: 27557-61
  • Peer Reviewed
• [Journal Article] Sialylated core 1 O-glycans influence the sorting of Pmel17/gp100 and determine its capacity to form fibrils. (2007)
  • Author(s): Valencia JC, Yamaguchi Y(14名・6番目), et al.
  • Journal Title: J Biol Chem 282(15) Pages: 11266-80
  • Peer Reviewed
• [Journal Article] Regulation of human skin pigmentation and responses to ultraviolet rad iation (2007)
  • Author(s): Miyamura Y, Coelho SG, Wolber R, Miller SA, Wakamatsu K, Z mudzka BZ, Ito S, Smuda C, Passeron T, Choi W, Batzer J, Yamaguchi Y, Beer JZ, Hearing VJ.
  • Journal Title: Pigment Cell Res 20(1) Pages: 2-13
  • Peer Reviewed
• [Journal Article] Sialylated core 1 O-glycans influence the sorting of Pme117/gp100 and determine its capacity to form fibrils (2007)
  • Author(s): Valencia JC, Rouzaud F, Julien S, Chen KG, Passeron T, Yamaguchi Y, Abu-Asab M, Tsokos M, Costin GE, Yamaguchi H, Miller Jenkins LM, Nagashima K, Appella E, Hearing VJ.
  • Journal Title: J Biol Chem 282(15) Pages: 11266-11280
  • Peer Reviewed
• [Journal Article] The effects of dickkopf 1(DKK1)on gene expression and Wnt signaling by melanocytes:mechanisms underlying its suppression of melanocyte function and proliferation (2007)
  • Author(s): Yamaguchi Y(Corresponding author), Passeron T, Watabe H, Yasumoto K, Rouzaud F, Hoashi T, Hearing VJ.
  • Journal Title: J Invest Dermatol 127(5) Pages: 1217-1225
  • Peer Reviewed
• [Journal Article] Intractable wounds caused by arteriosclerosis obliterans with end-stage renal disease treated by aggressive debridement and epidermal grafting (2007)
  • Author(s): Hanafusa T, Yamaguchi Y, Katayama I.
  • Journal Title: J Am Acad Dermatol 57(2) Pages: 322-326
  • Peer Reviewed
• [Journal Article] The regulation of skin pigmentation.[Selected as Journal Cover] (2007)
  • Author(s): Yamaguchi Y, Brenner M, Hearing VJ.
  • Journal Title: J Biol Chem 282(38) Pages: 27557-27561
  • Peer Reviewed
• [Journal Article] Intractable wounds from a herpes simplex infection in an immunosuppressed patient with rheumatoid arthritis (2007)
  • Author(s): Hanafusa T, Yamaguchi Y(Corresponding author), Kitaba S, Katayama I.
  • Journal Title: Arch Dermatol 143(10) Pages: 1340-1342
  • Peer Reviewed
• [Journal Article] Intractable wounds caused by calcific uremic arteriolopathy treated with bisphosphonates (2007)
  • Author(s): Hanafusa T, Yamaguchi Y(Corresponding author), Tani M, Umegaki N, Nishimura Y, Katayama I.
  • Journal Title: J Am Acad Dermatol 57(6) Pages: 1021-1025
  • Peer Reviewed
• [Journal Article] The effects of dickkopf 1 (DKK1) on gene expression and Wnt signaling by melanocytes : mechanisms underlying its suppression of melanocyte function and proliferation. (2007)
  • Author(s): Yamaguchi Y, Passeron T, Watabe H, Yasumoto K, Rouzaud F, Hoashi T, Hearing VJ
  • Journal Title: Journal of Investigative Dermatology (J Invest Dermatol) 127(In press)
• [Journal Article] Sialylated core 10-glycans influence the sorting of Pmel 17/gplOO and determine its capacity to form fibrils. (2007)
  • Author(s): Valencia JC, Rouzaud F, Julien S, Chen KG, Passeron T, Yamaguchi Y, Abu-Asab M, Tsokos M, Costin GE, Yamaguchi H, Miller Jenkins LM, Nagashima K, Appella E, Hearing VJ
  • Journal Title: J Biol Chem (In Press)
• [Journal Article] Melanin mediated apoptosis of epidermal cells damaged by ultraviolet radiation : factors influencing the incidence of skin cancer. (2007)
  • Author(s): Yamaguchi Y, Beer JZ, Hearing VJ
  • Journal Title: J Deramtol Sci (In Press)
• [Journal Article] Intractable wounds from a herpes simplex infection in an immunosuppressed patient with rheumatoid arthritis. (2007)
  • Author(s): Hanafusa T, Yamaguchi Y (Corresponding author), Kitaba S, Katayama I
  • Journal Title: Arch Deramtol (In press)
• [Journal Article] 難治性趾端・指端潰瘍の治療法の展望 (2007)
  • Author(s): 山口裕史
  • Journal Title: 皮膚病診療 (In press)
• [Journal Article] Regulation of human skin pigmentation and responses to ultraviolet radiation. (2007)
  • Author(s): Miyamura Y, Coelho SG, Wolber R, Miller SA, Wakamatsu K, Zmudzka BZ, Ito S, Smuda C, Passeron T, Choi W, Batzer J, Yamaguchi Y, Beer JZ, Hearing VJ
  • Journal Title: Pigment Cell Research 20(1) Pages: 2-13
• [Journal Article] UV increases the nuclear localization of APE/Ref-1 in human skin. (2006)
  • Author(s): Takahashi K, 中略, Yamaguchi Y(7名・3番目), et al.
  • Journal Title: J Invest Dermatol 126(12) Pages: 2723-6
  • Peer Reviewed
• [Journal Article] Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. (2006)
  • Author(s): Yamaguchi Y(9名・筆頭著者), TakahashiK, et al.
  • Journal Title: FASEB J 20(9) Pages: 1486-8
  • Peer Reviewed
• [Journal Article] Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2 : evidence for the polarized nature of melanocytes. (2006)
  • Author(s): Valencia JC, 中略, Yamaguchi Y(14名・8番目), et al.
  • Journal Title: J Cell Sci 119(Pt 6) Pages: 1080-91
  • Peer Reviewed
• [Journal Article] Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG. (2006)
  • Author(s): Watari A, 中略, Yamaguchi Y(14名・8番目), et al.
  • Journal Title: Oncogene 25(56) Pages: 7373-80
  • Peer Reviewed
• [Journal Article] Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms. (2006)
  • Author(s): Rouzaud F, 中略, Yamaguchi Y(10名・3番目), et al.
  • Journal Title: FASEB J 20(11) Pages: 1927-9
  • Peer Reviewed
• [Journal Article] Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1-receptor isoforms. (2006)
  • Author(s): Rounzaud F, Costin EG, Yamaguchi Y, Valencia JC, Berens WF, Chen K, Hoashi T, Bohm M, Abdel-Malek Z, Hearing VJ
  • Journal Title: FASEB Journal 20(11) Pages: 1927-1929
• [Journal Article] Suppression of tumorigenicity, but not anchorage-independence, of human cancer cells by new candidate tumor suppressor gene CapG. (2006)
  • Author(s): Watari A, Takaki K, Higashiyama S, Li Y, Satomi Y, Takao T, Tanemura A, Yamaguchi Y, Katayama I, Shimakage M, Miyashiro I, Takami K, Kodama K, Yutsudo M
  • Journal Title: Oncogene 25(56) Pages: 7373-7380
• [Journal Article] UV increases the nuclear localization of apurinic/apyrimidinic endonuclease (APE1/Ref-1) in human skin. (2006)
  • Author(s): Takahashi K, Hoashi T, Yamaguchi Y, Mutsuga N, Suzuki I, Vieira WD, Hearing VJ
  • Journal Title: J Invest Dermatol 126(12) Pages: 2723-2726
• [Journal Article] Human skin responses to UV radiation : pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. (2006)
  • Author(s): Yamaguchi Y, Takahashi K, Zmudzka BZ, Kornhauser A, Miller SA, Tadokoro T, Berens W, Beer JZ, Hearing VJ
  • Journal Title: FASEB Journal 20(9) Pages: 1486-1488
• [Journal Article] Sorting of Pmel 17 to melanosomes through the plasma membrane by API and AP2 : evidence for the polarized nature of melanocytes. (2006)
  • Author(s): Valencia JC, Watabe H, Chi A, Rouzaud F, Chen KG, Vieira WD, Takahashi K, Yamaguchi Y, Berens W, Nagashima K, Shabanowitz J, Hunt DF, Appella E, Hearing VJ
  • Journal Title: J Cell Sci 119 (6)
• [Journal Article] 「最近のトピックス 2006 Clinical Dermatology 2006」皮膚疾患の病態 皮膚潰瘍の治癒機転における表皮真皮相互作用 (2006)
  • Author(s): 山口裕史
  • Journal Title: 臨床皮膚科 60(5) Pages: 37-43
• [Journal Article] 海外研究施設・ラボ紹介「Laboratory of Cell Biology, National Cancer Institute,National Institutes of Health, Bethesda, Maryland, USAJ (2006)
  • Author(s): 山口裕史
  • Journal Title: 皮膚アレルギーフロンテイア 4(1) Pages: 44-45
• [Journal Article] 「病態よりみた難治性下腿潰瘍の診断と治療」糖尿病性潰瘍の診断と治療 (2006)
  • Author(s): 辻隆治, 山口裕史, 片山一朗, 矢野健二, 細川亙
  • Journal Title: 形成外科 49(2) Pages: 159-169
• [Journal Article] Epithelioid sarcoma on the foot masquerading as an intractable wound
  • Author(s): Nishimura Y, Yamaguchi Y, Hama da K, Tomita Y, Maeda A, Morita A, Katayama I
  • Journal Title: Clin Exp Dermatol (IN PRESS)
  • Peer Reviewed
• [Presentation] Adult dermal fibroblasts determine the fate of the overlying epidermis. (2009)
  • Author(s): Yamaguchi Y.
  • Organizer: The Global COE Liaison Laboratory regular seminar
  • Place of Presentation: [Invited lecturer] Kumamoto, Japan.
  • Year and Date: 2009-05-04
• [Presentation] Adult dermal fibroblasts determine the fate of the overlying epide rmis (2009)
  • Author(s): Yamaquchi Y
  • Organizer: The Global COE Liaison Laboratory regular seminar
  • Place of Presentation: Kumamoto, Japan
  • Year and Date: 2009-03-04
• [Presentation] The effect of UV on human skin pigmentation. (2009)
  • Author(s): Yamaguchi Y.
  • Organizer: The 3rd Annual Symposium in Institute of Dermatological Science
  • Place of Presentation: [Invited lecturer] Seoul, Korea.
  • Year and Date: 2009-02-06
• [Presentation] The effect of UV on human skin pigmentation (2009)
  • Author(s): Yamaquchi Y
  • Organizer: 3^<rd> Annual Symposium in Institute of Dermatological Science
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-02-06
• [Presentation] Melanocyte Biology (2009)
  • Author(s): Yamaguchi Y .
  • Organizer: Pre-seminar for the 3rd Annual Symposium in Institute of Dermatological Science
  • Place of Presentation: [Invited lecturer] Seoul, Korea.
  • Year and Date: 2009-02-05
• [Presentation] Melanocyte biology (2009)
  • Author(s): Yamaquchi Y
  • Organizer: Preseminar for the 3^<rd> Annual Symposium in Institute of Dermatological Science
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-02-05
• [Presentation] The efficacy of epidermal grafting (2008)
  • Author(s): Yamaguchi Y
  • Organizer: World Congress of Dermatology
  • Place of Presentation: Buenos Aires,Argentine
  • Year and Date: 2008-10-03
• [Presentation] The effects of dickkopf 1 on skin pigmentation. (2008)
  • Author(s): Yamaguchi Y
  • Organizer: Avon invited lecture series
  • Place of Presentation: New York,USA
  • Year and Date: 2008-05-16
• [Presentation] Regulation of skin pigmentation and thickness by dickkopf 1(DKK1). (2008)
  • Author(s): Yamaguchi Y.
  • Organizer: IID 2008 Satellite Symposium Photoaging Research Symposium
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-05-13
• [Presentation] Regulation of skin pigmentation and thickness by dickkopf 1 (DKK 1) (2008)
  • Author(s): Yamaguchi Y
  • Organizer: IID 2008 Satellite Symposium Photoaging Research Symposium
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-05-13
• [Presentation] The effects of dickkopf 1 on gene expression and Wnt signaling by kera tirtocvtes. (2008)
  • Author(s): Yamaguchi Y
  • Organizer: Society for Investigative dermatology
  • Place of Presentation: Los Angeles,USA
  • Year and Date: 2008-05-11
• [Presentation] Workshop : CS-14 Molecular and surgical pathology. (2008)
  • Author(s): Yamaguchi Y.
  • Organizer: The 20th International Pigment Cell Conference and 5th International Melanoma Research Conference.
  • Place of Presentation: Sapporo, Japan
• [Presentation] CS-14 Molecular and surgical pathology (2008)
  • Author(s): Yamaguchi Y
  • Organizer: The 20th International Pigment Cell Conference and 5th International Melanoma Research Conference
  • Place of Presentation: Sapporo, Japan
• [Presentation] Suction blister formation time reduction by subepidermal injection (2008)
  • Author(s): Yamaquchi Y, Hanafusa T, Nakamura M, Morita A
  • Organizer: IID 2008 (International Investigative Dermatology 200 81
  • Place of Presentation: Kyoto, Japan
• [Presentation] The effect of DKK1 on human skin (2007)
  • Author(s): Yamaguchi Y
  • Organizer: Korean Society for Investigative Dermatology
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2007-10-17
• [Presentation] Regulation of skin pigmentation. (2007)
  • Author(s): Yamaguchi Y .
  • Organizer: Avon Lecture Series for Pigment Cell Research.
  • Place of Presentation: New York, NY, USA
  • Year and Date: 2007-05-15
• [Presentation] The effect of DKK1 on keratinocytes (2007)
  • Author(s): Yamaguchi Y
  • Organizer: Japanese Society for Investigative Dermatology
  • Place of Presentation: Yokohama,Japan
  • Year and Date: 2007-04-20
• [Presentation] Epidermal sheet grafting for chronic wound.Workshop : Modern wound management. (2007)
  • Author(s): Yamaguchi Y.
  • Organizer: The 21st World Congress of Dermatology.
  • Place of Presentation: Buenos Aires, Argentina
• [Presentation] The effects of dickkopf 1 on gene expression and Wnt signaling by keratinocytes: mechanisms regulating skin pigmentation and thickness. (2007)
  • Author(s): Yamaguchi Y, Passeron T, Katayama I, Hearing VJ.
  • Organizer: The 68th Annual Meeting of the Society for Investigative Dermatology.
  • Place of Presentation: LosAngeles, CA, USA
• [Book] 看護学テキストNiCE疾患論第17章皮膚疾患色素異常症 (2009)
  • Author(s): 山口裕史
  • Total Pages: 500
  • Publisher: 南光堂(Inpress)
• [Book] 1冊でわかる光皮膚科-皮膚科医に必須のPhotodermatology紫外線とメラノサイト (2009)
  • Author(s): 山口裕史
  • Total Pages: 232
  • Publisher: 文光堂
• [Book] 1冊でわかる光皮膚科 (2008)
  • Author(s): 山口 裕史
  • Total Pages: 232
  • Publisher: 分光堂
• [Book] すぐに役立つ日常皮膚診療における私の工夫 G.ありふれた皮膚疾患のベスト治療と私の工夫 13.尋常性白斑 (2007)
  • Author(s): 山口 裕史、片山 一朗
  • Total Pages: 309
  • Publisher: 全日本病院出版会
• [Book] 皮膚科診療プラクティス 20巻 1.光皮膚科学 1)急性皮膚障害 (2007)
  • Author(s): 山口 裕史、森田 明理
  • Total Pages: 365
  • Publisher: メディカルリビュー社
• [Book] 皮膚科診療プラクティス 20巻 1.光皮膚科学 1) 急性皮膚障害. (2007)
  • Author(s): 山口裕史, 森田明理
  • Publisher: メディカルリビュー社(In press)
• [Book] すぐに役立つ日常皮膚診療における私の工夫 G. ありふれた皮膚疾患のベスト治療と私の工夫 13.尋常性白斑 (2007)
  • Author(s): 山口裕史, 片山一朗
  • Total Pages: 6
  • Publisher: 全日本病院出版会
• [Book] Melanocyte distribution and function in human skin (2006)
  • Author(s): Yamaguchi Y(2名・筆頭著者)
  • Publisher: Humana Press
• [Book] Chapter 6 : Melanocyte distribution and function in human skin. From Melanocytes to Malignant Melanoma (2006)
  • Author(s): Yamaguchi Y, Hearing VJ
  • Total Pages: 15
  • Publisher: Humana Press
• [Book] 細胞増殖因子と再生医療 HGF 皮膚潰瘍 (2006)
  • Author(s): 山口裕史, 板見智
  • Total Pages: 5
  • Publisher: メディカルリビュー社
• [Book] 皮膚のガン 予防とっきあい方シリーズ 老年病・認知症 (2006)
  • Author(s): 山口裕史
  • Total Pages: 164
  • Publisher: メディカルリビュー社
• [Remarks]
  • URL: http://read.jst.go.jp/