Analysis of immune escape mechanism in lung cancer : From a variant of abnormality of HLA expression on tumor cells
Project/Area Number |
18689035
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Thoracic surgery
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Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
ICHIKI Yoshinobu University of Occupational and Environmental Health, Japan, 医学部, 助教 (80419837)
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Project Period (FY) |
2006 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2006: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 免疫学 / 癌 / 肺癌 / HLA / 細胞障害性Tリンパ球 / 抗原 / 腫瘍免疫 / 細胞性免疫 / 免疫逃避機構 |
Research Abstract |
癌細胞はHLAクラスI分子上に腫瘍抗原を提示することで、CTLから認識され攻撃を受ける。この攻撃から逃避するため、癌細胞はHLAクラスI分子を欠失すると考えられる。 そこで、癌細胞に欠失したHLAクラスI分子を再移入したところ、CTLからより強力に攻撃された。すなわち、欠失したHLAクラスI分子に免疫原性の高い腫瘍抗原が提示されていたことが示唆された。この腫瘍抗原を用いたワクチン療法とともに癌細胞へのHLAクラスI分子移入療法の開発を行っていく。
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Clinical significance of HLA class I alleles on postoperative prognosis of lung cancer patients in Japan.2009
Author(s)
Nagata Y, Hanagiri T, Mizukami M, Kuroda K, Shigematsu Y, Baba T, Ichiki Y, Yasuda M, So T, Takenoyama M, Sugio K, Nagashima A, Yasumoto K
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Journal Title
Related Report
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[Journal Article] Lack and restoration of sensitivity of lung cancer cells to cellular attack with special reference to expression of human leukocyte antigen class I and/or major histocompatibility complex class I chain related molecules A/B.2007
Author(s)
Baba, T. ・Hanagiri, T.・Ichiki, Y.・Kuroda, K.・Shigematsu, Y.・Mizukami, M.・Sugaya, M.・Takenoyama, M.・Sugio, K.・Yasumoto, K.
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Journal Title
Cancer Sci 98(11)
Pages: 1795-1802
NAID
Related Report
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[Journal Article] Antitumor Effect of Antibody against a SEREX-Defined Antigen (UOEH-LC-1) on Lung Cancer Xenotransplanted into Severe Combined Immunodeficiency Mice2007
Author(s)
Mizukami, M. Hanagiri, T. Yasuda, M. Kuroda, K. Shigematsu, Y. Baba, T. Fukuyama, T. Nagata, Y. So, T. Ichiki, Y. Sugaya, M. So, T. Takenoyama, M. Sugio, K. Yasumoto, K.
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Journal Title
Cancer Res 67(17)
Pages: 8351-8357
Related Report
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[Journal Article] Cytokine production of lung cancer cell lines: Correlation between their production and the inflammatory/immunological responses both in vivo and in vitro.2007
Author(s)
Fukuyama, T. Ichiki, Y. Yamada, S. Shigematsu, Y. Baba, T. Nagata, Y. Mizukami, M. Sugaya, M. Takenoyama, M. Hanagiri, T. Sugio, K. Yasumoto, K.
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Journal Title
Cancer Sci 98(7)
Pages: 1048-1054
Related Report
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[Journal Article] Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung2007
Author(s)
Sugaya, M. Takenoyama, M. Shigematsu, Y. Baba, T. Fukuyama, T. Nagata, Y. Mizukami, M. So, T. Ichiki, Y. Yasuda, M. So, T. Hanagiri, T. Sugio, K. Yasumoto, K.
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Journal Title
Int J Cancer 120(5)
Pages: 1055-1062
Related Report
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[Journal Article] Antigens recognized by IgG derived from tumor-infiltrating B lymphocytes in human lung cancer2006
Author(s)
Yasuda, M. Mizukami, M. Hanagiri, T. Shigematsu, Y. Fukuyama, T. Nagata, Y. So, T. Ichiki, Y. Sugaya, M. Takenoyama, M. Sugio, K. Yasumoto, K.
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Journal Title
Anticancer Res 25(5)
Pages: 3607-3612
Related Report
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[Journal Article] Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma2006
Author(s)
Fukuyama, T. Hanagiri, T. Takenoyama, M. Ichiki, Y. Mizukami, M. So, T. Sugaya, M. So, T. Sugio, K. Yasumoto, K.
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Journal Title
Cancer Res 66(9)
Pages: 4922-4928
Related Report
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[Journal Article] Effect of IgG produced by tumor-infiltrating B lymphocytes on lung tumor growth.2006
Author(s)
Mizukami, M. Hanagiri, T. Shigematsu, Y. Baba, T. Fukuyama, T. Nagata, Y. So, T. Ichiki, Y. Sugaya, M. Yasuda, M. So, T. Takenoyama, M. Sugio, K.Yasumoto, K.
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Journal Title
Anticancer Res 26(3)
Pages: 1827-1832
Related Report
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[Presentation] Identification of human ribosomal protein L19 as a novel overexpressed tumour antigen recognized by autologous CTL in human lung adenocarcinoma2008
Author(s)
Kuroda, K. Takenoyama, M. Baba, T. Shiota, H. Shigematsu, Y. Mizukami, M. Ichiki, Y. Yasuda, M. Hanagiri, T. Sugio, K. Yasumoto, K.
Organizer
2008 World Cancer Congress
Place of Presentation
Geneva, Switzerland.
Related Report
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[Presentation] Antitumor effect of antibody againset a novel(UOEH-LC-1)on lung cancer xenotransplanted into SCID mice.2007
Author(s)
Mizukami, M. Hanagiri, T.Yasuda, M.Baba, T.Nagata, Y.Ichiki, Y.Sugaya, M.So, T.Takenoyama, M.Sugio, K.Yasumoto, K.
Organizer
12th World Conference on Lung Cancer.
Place of Presentation
Seoul, Korea
Related Report
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[Presentation] Analysis of the correlation between HLA phenotype and prognosis of non-small cell lung cancer patients in Japan2007
Author(s)
Nagata, Y. ・Kuroda, K.・Shigematsu, Y.・Baba, T.・Fukuyama, T.・Mizukami, M.・So, T.・Ichiki, Y.・Sugaya, M.・Yasuda, M.・So, T.・Takenoyama, M.・Hanagiri, T.・Sugio, K.・Nagashima, A.・Yasumoto, K.:
Organizer
12th World Conference on Lung Cancer
Place of Presentation
Seoul, Korea
Related Report
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[Presentation] Restoration of HLA-class I expression on lung cancer cells and successful induction of CTL against tumor cells2007
Author(s)
Hanagiri, T. ・Baba, T.・Kuroda, K.・Shigematsu, Y.・Nagata, Y.・Mizukami, M.・So, T.・Ichiki, Y.・Sugaya, M.・Yasuda, M.・Nozoe, T.・Takenoyama, M.・Sugio, K.・Yasumoto, K:
Organizer
98th AACR.
Place of Presentation
Los Angeles, USA.
Related Report
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[Presentation] Analysis of humonal immunity of tumor infiltrating B lymphocyte in parients with malignant mesothelioma2007
Author(s)
Shigematsu, Y. ・Hanagiri, T.・Baba, T.・Kuroda, K.・Nagata, Y.・Mizukami, M.・Ichiki, Y.・Sugaya, M.・Yasuda, M.・Nozoe, T.・Takenoyama, M.・Sugio, K.・Yasumoto, K.
Organizer
98th AACR
Place of Presentation
Los Angeles, USA
Related Report
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[Presentation] Evasion of lung cancer cells with HLA-class I abnormality from host defense and exploration of the immunotherapy-strategy againest such cancer cells.2007
Author(s)
Takenoyama, M. ・Baba, T.・Ichiki, Y.・Mizukami, M.・Sugaya, M.・Yasuda, M.・Hanagiri, T.・Sugio, K.・Yasumoto, K:
Organizer
Keystone Symposia
Place of Presentation
Banff, Canada
Related Report
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[Presentation] Identifiation of the gene encoding a tumor associated antigen using immortalized T cells transduced with T cell reseptor from the specific CTL clone in a lung cancer patient2007
Author(s)
Baba, T. ・Ichiki, Y.・Mizukami, M.・Sugaya, M.・Yasuda, M.・Takenoyama, M.・Hanagiri, T.・Sugio, K.・Yasumoto, K.
Organizer
Keystone Symposia
Place of Presentation
Banff, Canada
Related Report
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[Presentation] Identification of a new cancer/testis antigen and the expression in non-small cell lung cancer2007
Author(s)
Hanagiri, T. ・Fukuyama, T.・Baba, T.・Kuroda, K.・Shigematsu, Y.・Nagata, Y.・Mizukami, M.・Ichiki, Y.・Sugaya, M.・Yasuda, M.・Nozoe, T.・Takenoyama, M.・Sugio, K.・Yasumoto, K.
Organizer
First JCA-AACR Special Joint Conference
Place of Presentation
Nagoya, Japan
Related Report
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[Presentation] Identification of a new tumor antigen by using an immortalized T cell receptor gene2006
Author(s)
Ichiki, Y. ・Baba, T.・Hanagiri, T.・Takenoyama, M.・Shigematsu, Y.・Fukuyama, T.・Nagata, Y.・Mizukami, M.・So, T.・Sugaya, M.・So, T.・Sugio, K.・Yasumoto, K.
Organizer
97th Annual Meeting AACR.
Place of Presentation
Washington,DC, USA
Year and Date
2006-04-01
Related Report
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[Presentation] Identification of a new cancer/testis antigen recognized by autologous CTL induced in a patient with lung adenocarcinoma2006
Author(s)
Fukuyama, T. ・Shigematsu, Y.・Baba, T.・Nagata, Y.・Mizukami, M.・So, T.・Ichiki, Y.・Sugaya, M.・So, T.・Takenoyama, M.・Oyama, T.・Hanagiri, T.・Sugio, K.・Yasumoto, K.
Organizer
97th Annual Meeting AACR.
Place of Presentation
Washington,DC, USA.
Year and Date
2006-04-01
Related Report
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