Research and Development of Statistical Reasoning in Pharmacokinetics

• Project/Area Number: 18700272
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Statistical science
• Research Institution: Hyogo College of Medicine (2008); University of Shizuoka (2006-2007)
• Principal Investigator: DAIMON Takashi Hyogo College of Medicine, 医学部, 講師 (40372156)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,280,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 生物統計学 / 薬物動態学 / 医学統計 / 生物統計 / コンパートメント・モデル / 非線形 / 最適デザイン / 非線形性

Research Abstract

医薬品の評価過程では,生体内の薬物動態を解明する統計的方法論が大きな鍵を握り,そのための有用な道具の一つが「コンパートメント・モデル」である.本研究は,このコンパートメント・モデルに焦点をあて,薬物動態学(薬動学[Pharmacokinetics])における統計的推論方式を提示し,医薬品の適正な臨床評価過程の進展に寄与できた.

Research Products

• [Journal Article] Relative curvature measure for non-normal or heteroscedastic nonlinear regression (2008)
  • Author(s): Daimon, T., Yoshikawa, T., Kobayashi, T. and Goto, M
  • Journal Title: Communications in Statistics, Theory & Methods (in print)
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis (2008)
  • Author(s): Hayashi, H., Fujimaki, C., Daimon, T., Tsuboi, S., Matsuyama, T. and Itoh, K
  • Journal Title: Journal of Clinical Pharmacy and Therapeutics (in print)
  • Peer Reviewed
• [Journal Article] A note on parameterizations in pharmacokinetic compartment models (2008)
  • Author(s): Daimon, T. and Goto, M
  • Journal Title: Behaviormetrika 35 Pages: 1-14
  • NAID: 110006649323
  • Peer Reviewed
• [Journal Article] The mean squared error optimum design criterion for parameter estimation in nonlinear regression models. (2008)
  • Author(s): Daimon, T. and Goto, M
  • Journal Title: Communications in Statistics, Theory & Methods 37(4) Pages: 508-519
  • Peer Reviewed
• [Journal Article] Bayesian sample size calculations for a non-inferiority test of two proportions in clinical trials (2008)
  • Author(s): Daimon, T
  • Journal Title: Contemporary Clinical Trials 29 Pages: 507-516
  • Peer Reviewed
• [Journal Article] A note on parameterizations in pharmacokinetic compartment models (2008)
  • Author(s): Daimon, T. and Goto, M.
  • Journal Title: Behaviormetrika 35 Pages: 1-14
  • NAID: 110006649323
  • Peer Reviewed
• [Journal Article] The mean squared error optimum design criterion for parameter estimation in nonlinear regression models (2008)
  • Author(s): Daimon, T. and Goto, M.
  • Journal Title: Communications in Statistics, Theory & Methods 37 Pages: 508-519
  • Peer Reviewed
• [Journal Article] The mean squared error optimum design criterion for parameter estimation in nonlinear regression models (2008)
  • Author(s): Daimon T, Goto M.
  • Journal Title: Communications in Statistics, Theory and Methods 37 Pages: 508-519
  • Peer Reviewed
• [Journal Article] Intraarterial chemoradiotherapy for locally advanced oral cavity cancer:Analysis of therapeutic results in 134 cases (2008)
  • Author(s): Fuwa N, Kodaira T, Furutani K, Tachibana H, Nakamura T, Nakahara R, Tomoda T, Inokuchi H, Daimon T.
  • Journal Title: British Journal of Cancer 98 Pages: 1039-1045
  • Peer Reviewed
• [Journal Article] Relative curvature measure for non-normal or heteroscedastic nonlinear regression (2008)
  • Author(s): Daimon T, Yoshikawa T, Kobayashi T, Goto M.
  • Journal Title: Communications in Statistics, Theory and Methods (In press)
  • Peer Reviewed
• [Journal Article] A note on parameterizations in pharmacokinetic compartment models (2008)
  • Author(s): Daimon T, Goto M.
  • Journal Title: Behaviormetrika (In press)
  • NAID: 110006649323
  • Peer Reviewed
• [Journal Article] Determination of methotrexate-polyglutamates using fluorescence polarization immunoassay and clinical application in rheumatoid arthritis patients (2008)
  • Author(s): Hayashi H, Fujimaki C, Tsuboi S, Matsuyama T, Daimon T, Itoh K.
  • Journal Title: Tohoku Journal of Experimental Medicine (In press)
  • Peer Reviewed
• [Journal Article] Arterial chemoradiothgrapy for locally advanced tongue cancer:Analysis of a retrospective study of therapeutic results in 88 cases (2008)
  • Author(s): Fuwa N, Kodaira T, Furutani K, Tachibana H, Nakamura T, Nakahara R, Tomoda T, Inokuti H, Daimon T.
  • Journal Title: International Journal of Radiation Oncology Biology Physics (In press)
  • Peer Reviewed
• [Journal Article] Exclusion of actin-binding protein p57/coronin-1 from bacteria-containing phagosomes in macrophages infected with Legionella (2008)
  • Author(s): Hayashi I, Miyake M, Fukui I, Sugaya N, Daimon T, Itoh S, Oku T, Tsuji T, Toyoshima S, Imai, Y.
  • Journal Title: Biological & Pharmaceutical Bulletin (In press)
  • NAID: 110006663942
  • Peer Reviewed
• [Journal Article] Curvature-adjusted optimal design of sampling times for the inference of pharmacokinetic compartment models (2007)
  • Author(s): Daimon, T. and Goto, M
  • Journal Title: Statistics in Medicine 26(14) Pages: 2799-2812
  • Peer Reviewed
• [Journal Article] Assessing nonlinearity in compartment models via the relative curvature measure (2007)
  • Author(s): Daimon, T., Yamada, H., and Goto, M
  • Journal Title: Journal of Pharmacokinetics and Pharmacodynamics 34(2) Pages: 207-227
  • Peer Reviewed
• [Journal Article] Curvature-adjusted optimal design of sampling times for the inference in pharmacokinetic compartment models (2007)
  • Author(s): Daimon T, Goto M.
  • Journal Title: Statistics in Medicine 26 Pages: 2799-2812
  • Peer Reviewed
• [Journal Article] Assessing nonlinearity in compartment models via the relative curvature measure (2007)
  • Author(s): Daimon T, Yamada H, Goto M.
  • Journal Title: Journal of Pharmacokinetics and Pharmacodynamics 34 Pages: 207-227
  • Peer Reviewed
• [Journal Article] Screening of biochemical modulator by tumor cell permeability of doxorubicin (2007)
  • Author(s): Sadzuka Y, Hatakeyama H, Daimon T, Sonobe T.
  • Journal Title: International Journal of Pharmaceutics 354 Pages: 63-69
  • Peer Reviewed
• [Journal Article] Factors involved in lymph node metastasis in clinical stage I non-small cell lung cancer-From studies of 604 surgical cases (2007)
  • Author(s): Fuwa N, Mitsudomi T, Daimon T, Yatabe Y, Shinoda M, Haotooka S, Mori S, Fukui T, Inaba Y.
  • Journal Title: Lung Cancer 57 Pages: 311-316
  • Peer Reviewed
• [Journal Article] Treatment results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil-A phase II study (2007)
  • Author(s): Fuwa N, Shikama N, Hayashi N, Matsuzuka T, Toita T, Yuta A, Oonishi H, Kodaira T, Tachibana H, Nakamura T, Daimon T.
  • Journal Title: Oral Oncology 43 Pages: 948-955
  • Peer Reviewed
• [Journal Article] Chemoradiation therapy using radiotherapy,systemic chemotherapy with 5-fluorouracil and nedaplatin,and intra-arterial infusion using carboplatin for locally advanced head and neck cancer-Phase II study (2007)
  • Author(s): Fuwa N, Kodaira T, Furutani K, Tachibana H, Nakamura T, Daimon T.
  • Journal Title: Oral Oncology 43 Pages: 1014-1020
  • Peer Reviewed
• [Journal Article] Treatment results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil -A phase II study- (2007)
  • Author(s): Fuwa N., Shikama N, Matsuzuka T, Toita T, Yuta A, Oonishi H, Kodaira T, Tachibana H, Nakamura T, Daimon T
  • Journal Title: Oral Oncology (In press)
• [Journal Article] Curvature-adjusted optimal design of sampling times for the inference in pharmacokinetic compartment models (2007)
  • Author(s): Daimon T, Goto M
  • Journal Title: Statistics in Medicine (In press)
• [Journal Article] Assessing nonlinearity in compartment models via the relative curvature measure (2007)
  • Author(s): Daimon T, Yamada H, Goto M
  • Journal Title: Journal of Pharmacokinetics and Pharmacodynamics (In press)
• [Journal Article] Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents : a prospective clinical study (2006)
  • Author(s): Yamada H, Takuma N, Daimon T, Hara Y
  • Journal Title: Journal of Alternative and Complement Medicine 12・7 Pages: 669-672
• [Journal Article] Application of a newly designed electronic monitoring device for press through packaging sheets in a clinical trial (2006)
  • Author(s): Yamada H, Sesoko S, Daimon T, Nakashima M
  • Journal Title: British Journal of Clinical Pharmacology 61・2 Pages: 238-239
• [Journal Article] Relationship between the growth pattern of nasopharyngeal cancer and the cervical lymph nodes based on MRI findings : can the cervical radiation field be reduced in patients with nasopharyngeal cancer? (2006)
  • Author(s): Fuwa N., Ariji, Y., Daimon T., Wakisaka M., Matsumoto A., Kodaira I., Tachibana H., Nakamura T., Satou Y.
  • Journal Title: British Journal of Radiology 79・945 Pages: 725-729
• [Presentation] Model-switching Bayesian approaches to dose-finding cancer clinical trials (2008)
  • Author(s): Daimon, T.
  • Organizer: International Association for Statistical Computing
  • Place of Presentation: Yokohama
  • Year and Date: 2008-12-05
• [Presentation] Model-switching Bayesian approaches to dose-finding cancer clinical trials. Joint Meeting of the 4th World Conference of the International(368-376) (2008)
  • Author(s): Daimon, T
  • Organizer: Association for Statistical Computing and 6th Conference of the Asian Regional Section of the International Association for Statistical Computing on Computational Statistics & Data Analysis (IASC2008)
  • Place of Presentation: Yokohama
• [Presentation] 高脂血症患者の生活習慣と服薬コンプライアンスの関連について:パーソナル・コンピュータを使用した服薬記録器による解析 (2007)
  • Author(s): 岸佳伸,佐久間陽子,高屋和彦,田口吉孝,井上達秀,鈴木崇代,曽我俊幸,松田捷彦,中島光好,大門貴志,山田浩
  • Organizer: 日本臨床薬理学会第29回年会
  • Place of Presentation: 宇都宮
• [Presentation] ジェネリック医薬品に対する意識に関する医師へのアンケート調査 (2007)
  • Author(s): 後藤貴裕,進士三明,濱口浩太,山田英毅,遠藤美登利,竹之内敏弘,松田捷彦,鈴木千恵子,浅野正宏,吉田雅行,大門貴志,山田浩
  • Organizer: 日本臨床薬理学会第29回年会
  • Place of Presentation: 宇都宮
• [Presentation] 関節リウマチにおけるメトトレキサートの赤血球中濃度測定の有用性 (2007)
  • Author(s): 林秀樹,藤巻千裕,坪井声示,大門貴志,松山耐至,原田直人,伊藤邦彦
  • Organizer: 日本臨床薬理学会第29回年会
  • Place of Presentation: 宇都宮
• [Book] 薬物動態の統計数理 (2008)
  • Author(s): 後藤昌司・大門貴志
  • Publisher: (株)MPC社
• [Book] 薬物動態の統計数理 (2008)
  • Author(s): 後藤昌司, 大門貴志
  • Total Pages: 196
  • Publisher: 株式会社MPC
• [Book] 薬物動態の統計数理 (2008)
  • Author(s): 後藤 昌司・大門 貴志
  • Total Pages: 182
  • Publisher: 株式会社MPC
• [Book] 臨床試験における統計的考え方,7章. CRCスキルアップ・マニュアル(山田浩, 中野眞汎, 鈴木千恵子監修) (2006)
  • Author(s): 大門貴志
  • Publisher: メディカル・パブリケーションズ(東京)