Roles of metabotropic glutamate receptors incross-modal plasticity in the mammalian cerebral cortex

• Project/Area Number: 18700317
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Kyoto University
• Principal Investigator: TAGAWA Yoshiaki Kyoto University, 大学院・理学研究科, 助教 (50303813)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,810,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000); Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 大脳皮質 / グルタミン酸受容体 / 発達 / 可塑性 / 神経活動 / 神経ネットワーク / 脳神経 / 視覚 / 神経活動依存的 / GFP / 遺伝子導入 / 遺伝子欠損マウス

Research Abstract

脳発達期の正確な神経回路網形成には、遺伝的プログラムと神経活動の両者の働きが必須である。本研究では、神経活動に依存した脳の回路発達・可塑性メカニズムの解明をめざした。実験動物(マウス)の大脳皮質内神経回路の解剖学的・機能的なつながり(神経連絡パターン)とその発達過程を詳細に可視化する新たな実験系を確立した。さらに、その発達過程にシナプス前・後細胞の神経活動が重要な役割を担うことを明らかにした。

Research Products

• [Journal Article] Activity-dependent development of interhemispheric connections in the visual cortex. (2008)
  • Author(s): Tarawa Y. Mizuno H, Hirano T.
  • Journal Title: Reviews in the Neurosciences 19 Pages: 19-28
• [Journal Article] Activity-dependent development of interhemispheric connections in the visual cortex (2008)
  • Author(s): Tagawa Y, Mizuno H, Hirano T
  • Journal Title: Reviews in the Neurosciences 19 Pages: 19-28
  • Peer Reviewed
• [Journal Article] Evidence for activity-dependent cortical wiring : Formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity (2007)
  • Author(s): Mizuno H, Hirano T, & Tarawa Y.
  • Journal Title: The Journal of Neuroscience 27(25) Pages: 6760-6770
• [Journal Article] Evidence for activity-dependent cortical wiring: formation of interhemispheric connections in neonetal mouse visual cortex requires projection neuron activity. (2007)
  • Author(s): Mizuno H, Hirano T and Tagawa Y.
  • Journal Title: The Journal of Neuroscience 27 Pages: 6760-6770
  • Peer Reviewed
• [Presentation] Differential effects of presynaptic and postsynaptic activity-blockade on interhemispheric connection development in mouse cerebral cortex. (2008)
  • Author(s): Mizuno H, Hirano T, & Tagawa Y.
  • Organizer: 38^<th> Annual Meeting, Society for Neuroscience
  • Place of Presentation: Washington D.C.
  • Year and Date: 2008-11-16
• [Presentation] Activity-dependent cortical wiring in vivo : Formation of interhemispheric connections requires presynaptic and postsynaptic neuron activity (2008)
  • Author(s): Tagawa Y, Mizuno H, Hirano T
  • Organizer: 第31回日本神経科学大会ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Activity-dependent development of interhemispheric connections in mouse visual cortex. (2008)
  • Author(s): Mizuno H, Hirano T, & Tagawa Y.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Activity-dependent cortical wiring in vivo : Formation of interhemispheric connections requires presynaptic and postsynaptic neuron activity (2008)
  • Author(s): Tagawa Y, Mizuno H, Hirano T
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-10
• [Presentation] Formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity. (2007)
  • Author(s): Mizuno H, Hirano T, & Tagawa Y.
  • Organizer: 37^<th> Annual Meeting, Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-04
• [Presentation] Formation of interhemispheric connections in neonatal mouse visual cortex requires projection neuron activity. (2007)
  • Author(s): Mizuno H, Hirano T and Tagawa Y.
  • Organizer: 37rd Annual Meeting, Society for Neuroscience
  • Place of Presentation: アメリカ、サンディエゴ
  • Year and Date: 2007-11-04
• [Presentation] Roles of pre- and postsynaptic neuron activity in interhemispheric connection development in the mouse visual cortex. (2007)
  • Author(s): Mizuno H, Hirano T, & Tagawa Y.
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] Activity-dependent development of interhemispheric connections in mouse visual cortex. (2006)
  • Author(s): Mizuno H, Hirano T, & Tagawa Y.
  • Organizer: 第35回生理研・統合脳国際シンポジウム
  • Place of Presentation: 岡崎
  • Year and Date: 2006-07-25
• [Presentation] Activity-dependent development of interhemispheric connections in mouse visual cortex. (2006)
  • Author(s): Mizuno H, Hirano T, & Tagawa Y.
  • Organizer: 第29回日本神経科学大会
  • Place of Presentation: 京都
  • Year and Date: 2006-07-20
• [Remarks]
  • URL: http://www.biophys.kyoto-u.ac.jp/hirano.php