Neural organization of the frontal eye field and the superior colliculus for the generation and suppression of eye movements

• Project/Area Number: 18700380
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: IZAWA Yoshiko Tokyo Medical and Dental University, 大学院医歯学総合研究科, 助教 (40372453)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,890,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 運動系神経生理学 / 前頭眼野 / 上丘 / サッケード / 固視 / オムニポーズニューロン

Research Abstract

動物は、視野内に興味ある物体が出現すると、速い眼球運動(サッケード)を行い視標を中心窩に捉える。本研究では微小電流刺激でサッケードの抑制を引き起こす大脳前頭眼野の部位と、サッケードの司令を出すと従来から考えられてきた古典的前頭眼野の部位がどの様に相互に働き、サッケードの発現と停止の制御を行っているかを解析した。さらに垂直眼球運動系において、これまで不明であった中脳上丘から外眼筋運動ニューロンに至る経路を明らかにした。

Research Products

• [Journal Article] Neural circuits for triggering saccades in the brainstem (2008)
  • Author(s): Shinoda Y, Sugiuchi Y, Izawa Y, and Takahashi M
  • Journal Title: Progress in Brain Research 17 Pages: 79-85
  • Peer Reviewed
• [Journal Article] Neural circuits for triggering saccades in the brainstem (2008)
  • Author(s): Shinoda Y, Sugiuchi Y, Izawa Y, Takahashi M
  • Journal Title: Progress in Brain Research 17 Pages: 79-85
  • Peer Reviewed
• [Journal Article] Neural organization of the pathways from the superior colliculus to trochlear motoneurons (2007)
  • Author(s): Izawa Y, Sugiuchi Y, and Shinoda Y
  • Journal Title: J.Neurophysiology 97 Pages: 3696-3712
  • Peer Reviewed
• [Journal Article] Neural pathways for vertical saccades: from the superior colliculus to trochlear motoneurons (2007)
  • Author(s): Izawa Y, Sugiuchi Y, and Shinoda Y
  • Journal Title: Neuro-Ophthalmology 31 Pages: 141-146
  • Peer Reviewed
• [Journal Article] Neural organization of the pathways from the superior colliculus to trochlear motoneurons. (2007)
  • Author(s): Izawa Y., Sugiuchi Y., and Shinoda Y.
  • Journal Title: J. Neurophysiology 97 Pages: 3696-3712
  • Peer Reviewed
• [Journal Article] Neural pathways for vertical saccades: from the superior colliculus to trochlear motoneurons. (2007)
  • Author(s): Izawa Y., Sugiuchi Y., and Shinoda Y.
  • Journal Title: Neuro-Ophthalmology 31 Pages: 141-146
  • Peer Reviewed
• [Journal Article] Controversy on "fixation zone" of the superior colliculus. (2007)
  • Author(s): Sugiuchi Y., Izawa Y., Takahashi M., Na J., and Shinoda Y.
  • Journal Title: Neuro-Ophthalmology 31 Pages: 147-155
  • Peer Reviewed
• [Journal Article] Neural organization of the pathways from the superior colliculus to trochlear motoneurons. (2007)
  • Author(s): Izawa, Y., Sugiuchi, Y., Shinoda, Y.
  • Journal Title: J. Neurophysiology 97(In press)
• [Journal Article] Neural pathways for vertical saccades : from the superior colliculus to trochlear motoneurons. (2007)
  • Author(s): Izawa, Y., Sugiuchi, Y., Shinoda, Y.
  • Journal Title: Neuro-Ophthalmology (In press)
• [Journal Article] Controversy on "fixation zone" of the superior colliculus. (2007)
  • Author(s): Sugiuchi, Y., Izawa, Y., Takahashi, M., Na, J., Shinoda, Y.
  • Journal Title: Neuro-Ophthalmology (In press)
• [Journal Article] Long descending motor tract axons and their control of neck and axial muscles (2006)
  • Author(s): Shinoda Y, Sugiuchi Y, Izawa Y, and Hata Y
  • Journal Title: Progress in Brain Research 151 Pages: 533-569
  • Peer Reviewed
• [Journal Article] Long descending motor tract axons and their control of neck and axial muscles. (2006)
  • Author(s): Shinoda, Y., Sugiuchi, Y., Izawa, Y., Hata, Y.
  • Journal Title: Progress in Brain Research 151 Pages: 533-569
• [Journal Article] Controversy on "fixation zone" of the superior colliculus
  • Author(s): Sugiuchi Y, Izawa Y, Takahashi M, NaJ, and Shinoda Y
  • Journal Title: Neuro-Ophthalmology 31 Pages: 147-155
  • Peer Reviewed
• [Presentation] Neural Network that Subserves Vertical Saccadic Eye Movements (2008)
  • Author(s): Izawa Y, Sugiuchi Y, and Shinoda Y
  • Organizer: The XXV Barany Society Meeting
  • Place of Presentation: 京都国際会館(京都市)
  • Year and Date: 2008-04-03
• [Presentation] The Interstitial Nucleus of Cajal and Its Functional Roles in Generation of Vertical Saccades and the Vestibulo-ocular Reflex (2008)
  • Author(s): Sugiuchi Y, Izawa Y, Takahashi M, and Shinoda Y
  • Organizer: The XXV Barany Society Meeting
  • Place of Presentation: 京都国際会館(京都市)
  • Year and Date: 2008-04-03
• [Presentation] Output pathways from the superior colliculus that subserves vertical saccades (2008)
  • Author(s): Izawa Y, Sugiuchi Y, and Shinoda Y
  • Organizer: Satellite symposium to XXV Barany society meeting "Neural mechanism in control of eye, head and limb movements"
  • Place of Presentation: Royal Oak Hotel, Ohtsu
  • Year and Date: 2008-03-30
• [Presentation] Output pathways from the superior colliculus that subserves vertical saccades. (2008)
  • Author(s): Izawa Y., Sugiuchi Y., and Shinods Y.
  • Organizer: Satellite symposium to XXV Barany society meeting "Neural mechanism in control of eye, head and l imb movements"
  • Place of Presentation: Royal Oak Hotel, Ohtsu
  • Year and Date: 2008-03-30
• [Presentation] 上丘から上斜筋運動ニューロンへの相反入力パターンの解析 (2008)
  • Author(s): 伊澤佳子、杉内友理子、篠田義一
  • Organizer: 第67回日本めまい平衡医学会総会
  • Place of Presentation: 秋田ビューホテル
• [Presentation] カハル間質核細胞の垂直性サッケード生成における役割 (2008)
  • Author(s): 杉内友理子、伊澤佳子、高橋真有、篠田義一
  • Organizer: 第67回日本めまい平衡医学会総会
  • Place of Presentation: 秋田ビューホテル
• [Presentation] Excitatory and inhibitory pathways from the superior colliculus to vertical ocular motoneurons (2008)
  • Author(s): Izawa Y, Sugiuchi Y, and Shinoda Y
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] 上丘から上斜筋運動ニューロンへの目反入力パターンの解析 (2008)
  • Author(s): 伊澤佳子、杉内友理子、篠田義一
  • Organizer: 第67回日本めまい平衡医学会総会
  • Place of Presentation: 秋田ビューホテル
• [Presentation] カハル問質核細胞め垂直性サッケード生成における役割 (2008)
  • Author(s): 杉内友理子、伊澤佳子、高橋真有、篠田義一
  • Organizer: 第67回日本めまい平衡医学会総会
  • Place of Presentation: 秋田ピコーホテル
• [Presentation] 水平性サッケードと垂直性サッケードの出力神経機構 (2007)
  • Author(s): 伊澤佳子、杉内友理子、篠田義一
  • Organizer: 第66回めまい平衡医学会総会
  • Place of Presentation: 大阪国際交流センター
  • Year and Date: 2007-11-15
• [Presentation] Neural pathways mediating excitation and inhibition from the superior colliculus to vertical ocular motoneurons (2007)
  • Author(s): Izawa Y, Sugiuchi Y, and Shinoda Y
  • Organizer: Gordon Research Conference "Oculomotor system biology"
  • Place of Presentation: Bates college, Lewiston
  • Year and Date: 2007-07-11
• [Presentation] Neural pathways mediating excitation and inhibition from the superior colliculus to vertical ocular motoneurons. (2007)
  • Author(s): Izawa Y., Sugiuchi Y., and Shinoda Y.
  • Organizer: Gordon Research Conference "Oculomotor system biology"
  • Place of Presentation: Bates college, Lewiston
  • Year and Date: 2007-07-11
• [Presentation] 水平性・垂直性サッケードの出力系中枢神経回路の解析 (2007)
  • Author(s): 伊澤佳子、杉内友理子、篠田義一
  • Organizer: 生理学研究所Motor Control研究会、生理学研究所
  • Place of Presentation: 岡崎コンファレンスセンター
  • Year and Date: 2007-06-28
• [Presentation] 水平性・垂直性サッケードの出力系中枢神経回路の解析 (2007)
  • Author(s): 伊澤佳子、杉内友理子、篠田義一
  • Organizer: 生理学研究所MotorControl研究会
  • Place of Presentation: 生理学研究所 岡崎コンファレンスセンター
  • Year and Date: 2007-06-28
• [Presentation] 上丘から水平性および垂直性眼球運動ニューロンに至る経路 (2007)
  • Author(s): 伊澤佳子
  • Organizer: 平成18年度生理学研究所研究会第3回「高次脳機能研究の新展開」
  • Place of Presentation: 岡崎
  • Year and Date: 2007-01-17
• [Presentation] 空間識と運動制御に関与する大脳前庭野の同定とその入出力 (2007)
  • Author(s): 篠田義一、杉内友理子、伊澤佳子
  • Organizer: 宇宙利用シンポジウム(第23回)
  • Place of Presentation: 東京
  • Year and Date: 2007-01-15
• [Presentation] Neural circuit for triggering saccades in the brainstem (2007)
  • Author(s): Shinoda Y, Sugiuchi Y, Izawa Y, and Takahashi M
  • Organizer: The 17th Meeting of The Neural Control of Movement Society
  • Place of Presentation: Seville, Spain
• [Presentation] Neural organization of the pathways from the superior colliculus to vertical ocular motoneurons (2007)
  • Author(s): Izawa Y, Sugiuchi Y, and Shinoda Y
  • Organizer: Asatellite symposium on "Neural basis of motor learning and performance: from cell to function" to the 17th Annual Meeting of Neural Control of Movements
  • Place of Presentation: Carmona (Seville), Spain
• [Presentation] Brainstem mechanisms of initiation and suppression of saccades (2007)
  • Author(s): Shinoda Y, Sugiuchi Y, Izawa Y, and Takahashi M
  • Organizer: A satellite symposium on "Neural basis of motor learning and performance: from cell to function" to the 17th Annual Meeting of Neural Control of Movements
  • Place of Presentation: Carmona (Seville), Spain
• [Presentation] Neural connections of the superior colliculus with the brainstem saccade generator (2007)
  • Author(s): Sugiuchi Y, Izawa Y, Takahashi M, and Shinoda Y
  • Organizer: A satellite symposium on "Neural basis of motor learning and performance: from cell to function" to the 17th Annual Meeting of Neural Control of Movements
  • Place of Presentation: Carmona (Seville), Spain
• [Presentation] Fixation and initiation of saccades by the frontal eye field and the superior colliculus (2006)
  • Author(s): Shinoda Y, Sugiuchi Y, Izawa Y, and Takahashi M
  • Organizer: XVI International Neuro-Ophthalmology Society Meeting
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2006-12-01
• [Presentation] 固視の神経機構 (2006)
  • Author(s): 伊澤佳子、鈴木寿夫、篠田義一
  • Organizer: 日本めまい平衡医学会・夏期セミナー
  • Place of Presentation: 東京
  • Year and Date: 2006-07-01
• [Presentation] Neural pathways for vertical saccades: from the superior colliculus to trochlear movements (2006)
  • Author(s): Izawa Y, Sugiuchi Y,and Shinoda Y
  • Organizer: XVI International Neuro-Ophthalmology Society Meeting
  • Place of Presentation: Tokyo, Japan
• [Presentation] Neural organization from the rostral and caudal zones of the superior colliculus to inhibitory burst and omnipause neurons (2006)
  • Author(s): Sugiuchi Y, Izawa Y, Takahashi M, and Shinoda Y
  • Organizer: XVI International Neuro-Ophthalmology Society Meeting
  • Place of Presentation: Tokyo, Japan
• [Presentation] Functional roles of commissural excitation and inhibition in the superior colliculus for vertical and horizontal saccades (2006)
  • Author(s): Takahashi M, Sugiuchi Y, Izawa Y, and Shinoda Y
  • Organizer: XVI International Neuro-Ophthalmology Society Meeting
  • Place of Presentation: Tokyo, Japan
• [Presentation] 垂直性サッケード発現の神経回路:上丘から上斜筋運動ニューロンへ (2006)
  • Author(s): 伊澤佳子
  • Organizer: 第65回日本めまい平衡医学会総会
  • Place of Presentation: 東京
• [Presentation] Suppression of saccades and fixation neurons in the monkey frontal eye field (2006)
  • Author(s): Izawa Y, Suzuki H, and Shinoda Y
  • Organizer: The 16th Annual Meeting of Neural Control of Movement
  • Place of Presentation: Key Biscayne, Florida, USA
• [Presentation] Neural organization from the rostral and caudal areas of the superior colliculus to inhibitory burst and omnipause neurons (2006)
  • Author(s): Sugiuchi Y, Izawa Y, Takahashi M, and Shinoda Y
  • Organizer: The 16th Annual Meeting of Neural Control of Movement
  • Place of Presentation: Key Biscayne, Florida, USA
• [Presentation] Functional roles of commissural excitation and inhibition of tectoreticular neurons in the superior colliculus (2006)
  • Author(s): Takahashi M, Sugiuchi Y, Izawa Y, and Shinoda Y
  • Organizer: The 16th Annual Meeting of Neural Control of Movement
  • Place of Presentation: Key Biscayne, Florida, USA