Functional analyses of neutrophil-like differentiated cell lines under a hyperglycemic condition.
| Project/Area Number |
18700606
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyoto Prefectural University of Medicine (2007-2008)
University of Shizuoka (2006) |
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Principal Investigator |
ITO Tomoko Kyoto Prefectural University of Medicine, 医学部, 准教授(寄附講座) (80329648)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,710,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 糖尿病 / 感染症 / 活性酸素 / 殺菌 / 好中球 / スーパーオキシド / 貪食 / 抗酸化物質 / 合併症 / 消化器疾患 / グリケーション / プロテオミクス / 酸化ストレス |
|---|
| Research Abstract |
ヒト急性骨髄性白血病細胞株由来の分化誘導後の好中球様細胞において高血糖状態によって活性酸素の過剰産生や貪食能の異常が認められた。糖尿病など高血糖によるストレス状態下での活性酸素産生能や殺菌作用の異常亢進は、傷害性因子が標的分子だけでなく周辺の組織へ傷害を生じ、重要臓器の機能障害や炎症性疾患を惹起する可能性が考えられた。また、各種茶粗抽出物や抗酸化物質が過剰に活性化された好中球様細胞に対して正常化効果を発揮し、炎症性疾患の防御に寄与するものと期待された。
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Effect of site-directed mutagenesis of methylglyoxal-modifiable arginine residues on the structure and chaperone function of human alphaA-crystallin.2006
Author(s)
Biswas, A., Miller, A., Oya-Ito, T., Santhoshkumar, P., Bhat, M., Nagaraj, R.H.
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Journal Title
Biochemistry 45
Pages: 4569-4577
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[Journal Article] Detection of dideoxyosone intermediates of glycation using a monoclonal antibody : Characterization of major epitope structures.2006
Author(s)
Puttaiah, S., Zhang, Y., Pilch, H.A., Pfahler, C., Oya-Ito, T., Sayre, L.M., Nagaraj, R.H.
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Journal Title
Arch Biochem Biophys 446
Pages: 186-196
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[Presentation] Modification of Heat Shock Protein 27 in Intestinal Epithelium2008
Author(s)
Oya-Ito, T., Naito, Y., Takagi, T., Handa, O., Fujiwake, H., Yamada, M., Shima, K., Yoshikawa, T. Methylglyoxal
Organizer
18th Japan Maillard Reaction Symposium
Place of Presentation
Kawasaki
Year and Date
2008-11-28
Related Report
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[Presentation] Analysis of Acrolein Modification of Acetic Acid-induced Gastric Ulcer in Diabetic Mice2008
Author(s)
Oya-Ito, T., Naito, Y., Takagi, T., Handa, O., Fujiwake, H., Yamada, M., Shima, K., Yoshikawa, T. Proteomic
Organizer
The International Symposium on Lipid Peroxidation 2008
Place of Presentation
Karuizawa
Year and Date
2008-10-17
Related Report
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[Presentation] Identification of Hsp 27 as Methylglyoxal Target in Colon Mucosa of Ulcerative Colitis2008
Author(s)
Oya-Ito, T., Naito, Y., Takagi, T., Handa, O., Matsui, H., Yoshikawa, T
Organizer
7th Annual World Congress Human Proteome Organisation (HUPO) 2008
Place of Presentation
Amsterdam
Year and Date
2008-08-17
Related Report
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[Presentation] Identification of heat shock protein 27 (hsp27) as methylglyoxal target in colon mucosa of ulcerative colitis2007
Author(s)
Oya-Ito, T., Naito, Y., Takagi, T., Handa, O., Matsui, H., Yoshikawa, T
Organizer
17th Japan Maillard Meeting
Place of Presentation
Kobe
Year and Date
2007-12-01
Related Report
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[Presentation] Identification of heat shock protein 27(Hsp27) as methylglyoxal target in colon mucosa of ulcerative colitis2007
Author(s)
Oya-Ito, T., Naito, Y., Takagi, T., Handa, O., Matsui, H., Yoshikawa, T.
Organizer
17th Japan Maillard Meeting
Place of Presentation
Kobe,JAPAN
Year and Date
2007-12-01
Related Report
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