Preventive effect of antioxidant compounds with antiangiogenic activity on metabolic syndrome
Project/Area Number |
18700608
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Eating habits, studies on eating habits
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Research Institution | Hiroshima University (2007-2008) Okayama Prefectural University (2006) |
Principal Investigator |
MATSUBARA Kiminori Hiroshima University, 大学院・教育学研究科, 准教授 (90254565)
|
Project Period (FY) |
2006 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥3,730,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
Keywords | 抗酸化成分 / 血管新生 / メタボリックシンドローム / ビタミン / 血管内皮細胞 / 脂肪細胞 / 幹細胞 / 肥満 / 抗酸化作用 / カテキン / 食品 / 胚性幹細胞(ES細胞) |
Research Abstract |
本研究では、抗酸化作用を有する食品成分であるカロテノイド・ポリフェノール類から血管新生抑制作用を示すものを新たに見出し、その作用機序について血管内皮細胞を用いて明らかにした。更に、それらの成分が、血管内皮細胞に対して保護的に作用することや肥満に繋がる幹細胞からの脂肪細胞分化を抑制することを見出した。これらの成果から、抗酸化作用と血管新生抑制作用を有する食品成分は、メタボリックシンドローム発症予防に有効であることが示唆された。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] 1, 4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis.2009
Author(s)
Kayashima, T., Mori, M., Yoshida, H.,Mizushina, Y., Matsubara, K.
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Journal Title
Cancer Lett., 278
Pages: 34-40
Related Report
Peer Reviewed
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[Journal Article] Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis.2007
Author(s)
Matsubara, K., Saito, A., Tanaka, A., Nakajima, N., Akagi, R., Mori, M., Mizushina, Y.
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Journal Title
Life Sci. 80
Pages: 1578-1585
Related Report
Peer Reviewed
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[Journal Article] Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.2006
Author(s)
Sugawara, T., Matsubara, K., Akagi, R., Mori, M., Hirata, T.
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Journal Title
J. Agric. Food Chem. 54
Pages: 9805-9810
Related Report
Peer Reviewed
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[Journal Article] Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.2006
Author(s)
Sugawara, T., Matsubara, K., Akagi, R., Mori, M., Hirata, T.
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Journal Title
Journal of Agricultural and Food Chemistry 54
Pages: 9805-9810
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[Presentation] Coezymes, and Biofactors, Dietary vitamin B6 suppresses colon heat shock proteins, targets for cancer therapy, in 1,2-dimethylhydrazine-treated rats.2008
Author(s)
Kayashima, T., Tanaka, K., Matsubara, K., Yanaka, N., Kato, N.
Organizer
The 2nd International Interdisciplinary Conference on Vitamins
Place of Presentation
Athens, Georgia, USA.
Year and Date
2008-10-30
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