Preventive effect of antioxidant compounds with antiangiogenic activity on metabolic syndrome

• Project/Area Number: 18700608
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Hiroshima University (2007-2008); Okayama Prefectural University (2006)
• Principal Investigator: MATSUBARA Kiminori Hiroshima University, 大学院・教育学研究科, 准教授 (90254565)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,730,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2006: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 抗酸化成分 / 血管新生 / メタボリックシンドローム / ビタミン / 血管内皮細胞 / 脂肪細胞 / 幹細胞 / 肥満 / 抗酸化作用 / カテキン / 食品 / 胚性幹細胞(ES細胞)

Research Abstract

本研究では、抗酸化作用を有する食品成分であるカロテノイド・ポリフェノール類から血管新生抑制作用を示すものを新たに見出し、その作用機序について血管内皮細胞を用いて明らかにした。更に、それらの成分が、血管内皮細胞に対して保護的に作用することや肥満に繋がる幹細胞からの脂肪細胞分化を抑制することを見出した。これらの成果から、抗酸化作用と血管新生抑制作用を有する食品成分は、メタボリックシンドローム発症予防に有効であることが示唆された。

Research Products

• [Journal Article] 1, 4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis. (2009)
  • Author(s): Kayashima, T., Mori, M., Yoshida, H.,Mizushina, Y., Matsubara, K.
  • Journal Title: Cancer Lett., 278 Pages: 34-40
  • Peer Reviewed
• [Journal Article] 1, 4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis (2009)
  • Author(s): Tomoko Kayashima
  • Journal Title: Cancer Lett. (In press)
  • Peer Reviewed
• [Journal Article] Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis. (2008)
  • Author(s): Matsubara, K., Kayashima, T., Mori, M., Mizushina, Y.
  • Journal Title: Int. J. Mol. Med. 22 Pages: 381-387
  • NAID: 120006726184
  • Peer Reviewed
• [Journal Article] Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis (2008)
  • Author(s): Kiminori Matsubara
  • Journal Title: Int. J. Mol. Med. 22 Pages: 381-387
  • NAID: 120006726184
  • Peer Reviewed
• [Journal Article] Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis. (2007)
  • Author(s): Matsubara, K., Saito, A., Tanaka, A., Nakajima, N., Akagi, R., Mori, M., Mizushina, Y.
  • Journal Title: Life Sci. 80 Pages: 1578-1585
  • Peer Reviewed
• [Journal Article] Epicatechin conjugated with fatty acid is a potent inhibitor of DNA polymerase and angiogenesis. (2007)
  • Author(s): Kiminori Matsubara, et. al.
  • Journal Title: Life Sciences 80 Pages: 1578-1585
  • Peer Reviewed
• [Journal Article] Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. (2006)
  • Author(s): Sugawara, T., Matsubara, K., Akagi, R., Mori, M., Hirata, T.
  • Journal Title: J. Agric. Food Chem. 54 Pages: 9805-9810
  • Peer Reviewed
• [Journal Article] Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. (2006)
  • Author(s): Sugawara, T., Matsubara, K., Akagi, R., Mori, M., Hirata, T.
  • Journal Title: Journal of Agricultural and Food Chemistry 54 Pages: 9805-9810
• [Presentation] カルノシン酸の血管新生抑制作用 (2009)
  • Author(s): 萱島知子・水品善之・松原主典
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-29
• [Presentation] カルノシン酸の血管新生抑制作用 (2009)
  • Author(s): 萱島知子
  • Organizer: 日本農芸化学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-29
• [Presentation] Coezymes, and Biofactors, Dietary vitamin B6 suppresses colon heat shock proteins, targets for cancer therapy, in 1,2-dimethylhydrazine-treated rats. (2008)
  • Author(s): Kayashima, T., Tanaka, K., Matsubara, K., Yanaka, N., Kato, N.
  • Organizer: The 2nd International Interdisciplinary Conference on Vitamins
  • Place of Presentation: Athens, Georgia, USA.
  • Year and Date: 2008-10-30
• [Presentation] Vitamin K3 is a potent inhibitor of angiogenesis and DNA polymerase. (2008)
  • Author(s): Matsubara, K., Kayashima, T., Mizushina, Y.,
  • Organizer: 2nd World Congress on Magic Bullets
  • Place of Presentation: Nurnberg, Germany.
  • Year and Date: 2008-10-04
• [Presentation] Vitamin K3 is a potent inhibitor of angiogenesis and DNA polymerase (2008)
  • Author(s): Kiminori Matsubara
  • Organizer: 2^<nd> World Conference on Magic Bullets
  • Place of Presentation: Nurnberg, Germany
  • Year and Date: 2008-10-03
• [Presentation] キノン系化合物の血管新生抑制作用 (2008)
  • Author(s): 萱島知子・松原主典・水品善之
  • Organizer: 日本食品科学工学会
  • Place of Presentation: 京都
  • Year and Date: 2008-09-06
• [Presentation] ビタミンK3 の血管新生抑制作用に関する検討 (2008)
  • Author(s): 萱島知子・松原主典・水品善之
  • Organizer: 日本農芸化学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-03-28
• [Presentation] 血管新生抑制作用を有する機能成分の新展開 (2007)
  • Author(s): 松原主典
  • Organizer: 日本栄養・食糧学会中四国・近畿支部合同大会
  • Place of Presentation: 広島
  • Year and Date: 2007-11-17
• [Presentation] ビタミンB6 が血管新生関連遺伝子発現に与える影響についての検討 (2007)
  • Author(s): 萱島知子・中澤昇映・松原主典・加藤範久
  • Organizer: 日本家政学会中国・四国支部大会
  • Place of Presentation: 広島
  • Year and Date: 2007-10-14
• [Presentation] カロテノイドと血管新生 (2006)
  • Author(s): 松原主典
  • Organizer: 日本水産学会春季大会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2006-03-31
• [Book] Handbook of Green Tea and Health Research (2009)
  • Author(s): Kiminori Matsubara
  • Publisher: Nova Science Publishers, Inc(In press)
• [Book] カロテノイドと血管新生抑制 (2008)
  • Author(s): 松原主典
  • Publisher: 恒星社厚生閣
• [Book] Green tea catechin as angiogenesis inhibitors. In Handbook of Green Tea and Health Research
  • Author(s): Matsubara, K.
  • Publisher: Nova Science Publishers, Inc.,New Yorik, USA,(in press)
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2008)
  • Inventor(s): 松原主典, 萱島知子
  • Industrial Property Rights Holder: 国立大学法人広島大学
  • Filing Date: 2008-10-03
• [Patent(Industrial Property Rights)] 血管新生抑制剤 (2008)
  • Inventor(s): 松原主典
  • Industrial Property Rights Holder: 国立大学法人広島大学
  • Filing Date: 2008-10-03