Interaction among human chromosomes and its relationship to spatial organization of chromosomes in a nucleus

• Project/Area Number: 18710159
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: 基礎ゲノム科学
• Research Institution: Hokkaido University
• Principal Investigator: KOYANAGI Kanako Hokkaido University, 大学院情報科学研究科, 准教授 (20362840)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,657,675 (Direct Cost: ¥4,447,675、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥1,747,675 (Direct Cost: ¥1,747,675); Fiscal Year 2006: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 遺伝子 / ゲノム / 進化 / 染色体 / 核内配置

Research Abstract

本研究の目的は、ヒトゲノム情報解析から染色体間の相互作用を示す情報を抽出し、核内における染色体の核内配置との関連性を検証することである。本研究では、染色体間の相互作用を示す情報として、ヒトゲノム中にみられるプロセス型偽遺伝子とゲノム内重複領域の染色体分布を解析し、染色体間の偏りを検出した。またこの研究の過程において、種特異的な重複領域を高精度に同定する目的で、分子進化解析に基づくゲノム直系領域の同定方法を開発した。

Research Products

• [Journal Article] Highly diversified molecular evolution of downstream transcription start sites in rice and Arabidopsis (2009)
  • Author(s): Tanaka T, Koyanagi KO, Itoh T.
  • Journal Title: Plant Physiol 149(3) Pages: 1316-24
  • Peer Reviewed
• [Journal Article] Evola : Ortholog database of all human genes in H-InvDB with manual curation of phylogenetic trees (2008)
  • Author(s): Matsuya A, Sakate R, Kawahara Y, Koyanagi KO, Sato Y, Fujii Y, Yamasaki C, Habara T, Nakaoka H, Todokoro F, Yamaguchi K, Endo T, Oota S, Makalowski W, Ikeo K, Suzuki Y, Hanada K, Hashimoto K, Hirai M, Iwama H, Saitou N, Hiraki AT, Jin L, Kaneko Y, Kanno M, Murakami K, Noda AO, Saichi N, Sanbonmatsu R, Suzuki M, Takeda J, Tanaka M, Gojobori T, Imanishi T, Itoh T
  • Journal Title: Nucleic Acids Research 36
  • Peer Reviewed
• [Journal Article] The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts (2008)
  • Author(s): Yamasaki C et al. (12番目、他137名)
  • Journal Title: Nucleic Acids Research 36
  • Peer Reviewed
• [Journal Article] Frequent emergence and functional resurrection of processed pseudogenes in the human and mouse genomes (2007)
  • Author(s): Sakai H, Koyanagi KO, Imanishi T, Itoh T, Gojobori T
  • Journal Title: Gene 389(2) Pages: 196-203
  • Peer Reviewed