Research for Nano-switch delivery system of siRNA
| Project/Area Number |
18710173
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied genomics
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| Research Institution | Fukuoka University (2007-2008)
Gifu University (2006) |
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Principal Investigator |
KODAMA Kota Fukuoka University, 薬学部, 助教 (90419424)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,700,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | siRNA / DDS / 感染症 / Peptide / molecular design / peptide |
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| Research Abstract |
siRNAに同じ標的mRNAに結合能を持つような特殊なペプチドをリンカーでつなぐことによって、標的であるmRNAの近くにおいてsiRNAが放出されるようなDelivery Systemの開発を行い、システムの構築を目指した。この結果、ナノスイッチ型siRNAと名付けたペプチドーsiRNAの合成法の確立に成功し、siRNA単独とほぼ同程度の遺伝子抑制活性を得ることができた。
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice,2009
Author(s)
Nishioku T., Dohgu S., Takata F., Eto T., Ishikawa N., Kodama KB., Nakagawa S., Yamauchi A., Kataoka Y,
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Journal Title
Cell Mol Neurobiology,Cell Mol Neurobiol 29
Pages: 309-316
Related Report
Peer Reviewed
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[Journal Article] Hot spots in prion protein for pathogenic conversion,2007
Author(s)
Kuwata K., Nishida N., Matsumoto T.,Kamatari YO., Hosokawa-Muto J., Kodama K., Nakamura HK., Kimura K., Kawasaki M., Takakura Y., Shirabe S., Takata J., Kataoka Y, Katamine S.,
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Journal Title
PNAS vol.104
Pages: 11921-11926
Related Report
Peer Reviewed
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[Presentation] "A Hot Spot in Prion Protein for PathogenicConversion."2007
Author(s)
K. Kuwata, N. Nishida, T. Matsumoto, Y Kamatari, K. Kodama, J-H. Muto, H. Nakamura、K. Kimura, M. Kawasaki, Y Takakura, S. Shirabe, J. Takata, Y. Kataoka and S.Katamine
Organizer
The 21st Annual Symposium of The Protein Society
Place of Presentation
the Boston Marriott Copley Place, USA
Year and Date
2007-07-24
Related Report
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