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Development of on-site analyzer for human metabolites using catalysis/micro-flow analysis system

Research Project

Project/Area Number 18750067
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Analytical chemistry
Research InstitutionAichi Institute of Technology

Principal Investigator

TESHIMA Norio  Aichi Institute of Technology, 工学部, 准教授 (30292501)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,940,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2006: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywords化学センサー / バナジウム / 呼気分析 / 呼気ホルムアルデヒド / 糖尿病 / 流れ分析 / バイオマーカー / 呼気アセトン / 脂肪酸代謝 / 標準ガス発生 / フローインジェクション分析 / 吸光光度分析 / アンモニア定量 / 自動分析 / ガス拡散セル / 陽イオン交換樹脂カラム / インドフエノール青法 / 吸光光度法 / 海水 / バナジウム定量 / 接触分析 / p-アニシジン / 臭素酸塩 / タイロン / ストップフロー
Research Abstract

ヒト代謝物質の濃度は,健康状態を反映して増減する.従ってこれら物質の精確な計測技術の確立は,迅速簡便な健康診断や病態診断に役立つ.本研究では,呼気から排出される揮発性有機化合物,尿中の微量金属をターゲットにした分析法の確立を目指した.その結果,呼気中ホルムアルデヒドの計測技術を確立し,また,尿分析への適用には至らなかったが,糖尿病に効果があるといわれる環境水中のバナジウムの計測技術を開発した.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (42 results)

All 2009 2008 2007 2006

All Journal Article (25 results) (of which Peer Reviewed: 19 results) Presentation (14 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Automated stopped-in-dual-loop flow analysis system for catalytic determination of vanadium in drinking water, Talanta, accepted.2009

    • Author(s)
      N. Teshima, M. Kuno, M. Ueda, H. Ueda, S. Ohno, T. Sakai
    • Journal Title

      talantaTalanta Doi:10.1016/j.talanta

      Pages: 8-8

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advancement of Flow-Based Analysis with Alternative Chemical Reactions and New Devices for Environmental and Biological Samples2008

    • Author(s)
      T. Sakai, N. Teshima
    • Journal Title

      Anal. Sci. 24

      Pages: 855-864

    • NAID

      10025204850

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 重力滴下-蒸発法によるホルムアルデヒド標準ガス発生法の開発と呼気ホルムアルデヒド分析への応用2008

    • Author(s)
      上田実,手嶋紀雄,酒井忠雄
    • Journal Title

      分析化学 57

      Pages: 605-611

    • NAID

      110006863814

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 反応速度差を用いるアスコルビン酸とグルタチオンのフローインジェクション吸光光度同時定量2008

    • Author(s)
      手嶋紀雄,信田拓哉,酒井忠雄
    • Journal Title

      分析化学 57

      Pages: 327-333

    • NAID

      110006664668

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 反応速度差を用いるアスコルビン酸とグルタチオンのフローインジェクション吸光光度同時定量2008

    • Author(s)
      手嶋紀雄, 信田拓哉, 酒井忠雄
    • Journal Title

      分析化学 57

      Pages: 327-333

    • NAID

      110006664668

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 重力滴下-蒸発法によるホルムアルデヒド標準ガス発生法の開発と呼気ホルムアルデヒド分析への応用2008

    • Author(s)
      上田実, 手嶋紀雄, 酒井忠雄
    • Journal Title

      分析化学 57

      Pages: 605-611

    • NAID

      110006863814

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advancement of Flow-Based Analysis with Alternative Chemical Reactions and New Devices for Environmental and Biological Samples2008

    • Author(s)
      Tadao Sakai, Norio Teshima
    • Journal Title

      Analytical Sciences 24

      Pages: 855-864

    • NAID

      10025204850

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successive determination of urinary protein and glucose using spectrophotometric sequential injection method2007

    • Author(s)
      K. Watla-iad, T. Sakai, N. Teshima, S. Katoh, K. Grudpan
    • Journal Title

      Anal. Chim. Acta 604

      Pages: 139-146

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] オンラインガス拡散/イオン交換濃縮法を用いる海水中微量アンモニウムイオンのフローインジェクション吸光光度定量2007

    • Author(s)
      福井啓典,大野慎介,樋口慶郎,手嶋紀雄,酒井忠雄
    • Journal Title

      分析化学 56

      Pages: 757-763

    • NAID

      110006388493

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An Alternative Interface for Flow Injection-Capillary Electrophoresis System with Electrokinetic Injection2007

    • Author(s)
      N. Teshima, T. Hino, T. Sakai
    • Journal Title

      Anal. Sci. 23

      Pages: 751-753

    • NAID

      130004441478

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stopped-in-loop flow analysis of trace vanadium in water2007

    • Author(s)
      N. Teshima, S. Ohno, T. Sakai
    • Journal Title

      Anal. Sci. 23

      Pages: 1-2

    • NAID

      10018463835

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] アナターゼ型酸化チタンの光触媒反応によるクリスタルバイオレットの脱色機構及び分解生成物の解析2007

    • Author(s)
      手嶋紀雄,山本真吾,Qinghe Zhang,山田善市,酒井忠雄
    • Journal Title

      分析化学 56

      Pages: 99-106

    • NAID

      110006202058

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] An Alternative Interface for Flow Injection-Capillary Electrophoresis System with Electrokinetic Injection2007

    • Author(s)
      Norio Teshima, et al.
    • Journal Title

      Analytical Sciences 23

      Pages: 751-753

    • NAID

      130004441478

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オンラインガス拡散/イオン交換濃縮法を用いる海水中微量アンモニウムイオンのフローインジェクション吸光光度定量2007

    • Author(s)
      福井啓典 ら
    • Journal Title

      分析化学 56

      Pages: 757-763

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successive determination of urinary protein and glucose using spectrophotometric sequential injection method2007

    • Author(s)
      Kanchana. Watla-iad, et al.
    • Journal Title

      Analytica Chimica Acta 604

      Pages: 139-146

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アナターセ型酸化チタンの光触媒反応によるクリスタルバイオレットの脱色機構及び分解生成物の解析2007

    • Author(s)
      手嶋紀雄, 山本真吾, Qinghe Zhang, 山田善市, 酒井忠雄
    • Journal Title

      分析化学 56

      Pages: 99-106

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Stopped-in-loop flow analysis of trace vanadium in water2007

    • Author(s)
      Norio Teshima, Shinsuke Ohno, Tadao Sakai
    • Journal Title

      Anal.Sci. 23

      Pages: 1-2

    • NAID

      10018463835

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 反応速度を用いる分析法2006

    • Author(s)
      手嶋紀雄,酒井忠雄
    • Journal Title

      ぶんせき

      Pages: 215-220

    • NAID

      10017496316

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] On-Line Preconcentration and Determination of Phenols at Sub-ppb Levels Using Three Switching Valves2006

    • Author(s)
      T. Sakai, S. Fujimoto, K. Higuchi, N. Teshima
    • Journal Title

      American Laboratory News 38(15)

      Pages: 40-41

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-shot flow injection spectrophotometric simultaneous determination of copper, iron and zinc in patients'sera with newly developed multi-compartment flow cell2006

    • Author(s)
      N. Teshima, S. Gotoh, K. Ida, T. Sakai
    • Journal Title

      Anal. Chim. Acta 557

      Pages: 387-392

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequential injection lab-on-valve simultaneous spectrophotometric determination of trace amounts of copper and iron2006

    • Author(s)
      S. Ohno, N. Teshima, T. Sakai, K. Grudpan, M. Polasek
    • Journal Title

      Talanta 68

      Pages: 527-534

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequential injection lab-on-valve simultaneous spectrophotometric determination of trace amounts of copper and iron2006

    • Author(s)
      S.Ohno, N.Teshima, T.Sakai, K.Grudpan, M.Polasek
    • Journal Title

      Talanta 68

      Pages: 527-534

    • Related Report
      2006 Annual Research Report
  • [Journal Article] One-shot flow injection spectrophotometric simultaneous determination of copper, iron and zinc in patients' sera with newly developed multi-compartment flow cell2006

    • Author(s)
      N.Teshima, S.Gotoh, K.Ida, T.Sakai
    • Journal Title

      Anal.Chim.Acta 557

      Pages: 387-392

    • Related Report
      2006 Annual Research Report
  • [Journal Article] On-Line Preconcentration and Determination of Phenols at Sub-ppb Levels Using Three Switching Valves2006

    • Author(s)
      Tadao Sakai, Shun-ichi Fujimoto, Keiro Higuchi, Norio Teshima
    • Journal Title

      American Laboratory News 38(15)

      Pages: 40-41

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 反応速度を用いる分析法2006

    • Author(s)
      手嶋紀雄, 酒井忠雄
    • Journal Title

      ぶんせき 2006

      Pages: 215-220

    • NAID

      10017496316

    • Related Report
      2006 Annual Research Report
  • [Presentation] ストップト-イン・ループフロー分析法による金属イオンの接触分析における加温効果2008

    • Author(s)
      久野真紗美, 上田実, 手嶋紀雄, 酒井忠雄
    • Organizer
      第39回中部化学連合学協会支部連合秋季大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2008-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Standard gas generator based on gravitational dispensing-vaporization for breath formaldehyde analysis system2008

    • Author(s)
      Norio Teshima, Miroru Ueda, Tadao Sakai
    • Organizer
      The 15^<th> International Conference on Flow Injection Analysis (ICFIA 2008) & The 25^<th> Anniversary Meeting of Japanese Association for Flow Injection Analysis
    • Place of Presentation
      名古屋ガーデンパレス
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Stopped-in-Dual-Loop Flow Analysis of Trace Vanadium in Drinking Water2008

    • Author(s)
      Norio Teshima, Masami Kuno, Minoru Ueda, Tadao Sakai
    • Organizer
      Tokyo Conference 2008, Asia Young Analytical Chemist Session 2008
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2008-09-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] ストップト-イン-ループフロー分析法による金属イオンの接触分析における加温効果2008

    • Author(s)
      久野真紗美,上田実,手嶋紀雄,酒井忠雄
    • Organizer
      第39回中部化学連合学協会支部連合秋季大会
    • Related Report
      2008 Final Research Report
  • [Presentation] Standard gas generator based on gravitational dispensing- vaporization for breath formaldehyde analysis system2008

    • Author(s)
      N. Teshima, M. Ueda, T. Sakai
    • Place of Presentation
      Nagoya
    • Related Report
      2008 Final Research Report
  • [Presentation] サリチルアルデヒド吸光光度法による呼気アセトン分析2008

    • Author(s)
      手嶋紀雄,上田実,飯田憲治,久木田惇,酒井忠雄
    • Organizer
      日本分析化学会第57年会
    • Place of Presentation
      福岡大学
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Stopped-in-Dual-Loop Flow Analysis of Trace Vanadium in Drinking Water2008

    • Author(s)
      N. Teshima, M. Kuno, M. Ueda, T. Sakai
    • Organizer
      Tokyo Conference 2008, Asia Young Analytical Chemist Session 2008
    • Place of Presentation
      Chiba
    • Related Report
      2008 Final Research Report
  • [Presentation] 流れ分析技術の臨床化学への応用2008

    • Author(s)
      手嶋紀雄,酒井忠雄
    • Organizer
      第69回分析化学討論会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 呼気ホルムアルデヒドの自動分析2008

    • Author(s)
      上田実,手嶋紀雄,酒井忠雄
    • Organizer
      第69回分析化学討論会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] タッチパネル可変式自動フローインジェクション装置の開発2008

    • Author(s)
      久野真紗美,上田実,手嶋紀雄,酒井忠雄
    • Organizer
      第69回分析化学討論会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Automated stopped-in-loop flow analysis for trace metal ion determination using catalytic reaction2007

    • Author(s)
      Norio Teshima ら
    • Organizer
      The 15th International Conference on Flow Injection Analysis
    • Place of Presentation
      ベルリン(ドイツ)
    • Year and Date
      2007-09-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規ストップトフロー法によるバナジウムの自動分析2007

    • Author(s)
      久野真紗美,上田実,手嶋紀雄,酒井忠雄
    • Organizer
      日本分析化学会第56年会
    • Place of Presentation
      徳島大学
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 微量ガスホルムアルデヒド分析のための自動システムの開発2007

    • Author(s)
      上田実,手嶋紀雄,酒井忠雄
    • Organizer
      日本分析化学会第56年会
    • Place of Presentation
      徳島大学
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Automated stopped-in-loop flow analysis for trace metal ion determination using catalytic reaction2007

    • Author(s)
      N. Teshima, M. Kuno, M. Ueda, S. Ohno, T. Sakai
    • Organizer
      The 15th International Conference on Flow Injection Analysis
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2008 Final Research Report
  • [Book] 新しい地平をひらく分析手法の最前線,酒井忠雄,手嶋紀雄分担執筆:24章固相抽出を利用する水試料中のフェノールの高感度吸光光度法2009

    • Author(s)
      北森武彦編
    • Publisher
      化学同人
    • Related Report
      2008 Final Research Report
  • [Book] 北森武彦編 : 新しい地平をひらく分析手法の最前線, 24章固相抽出を利用する水試料中のフェノールの高感度吸光光度法2009

    • Author(s)
      酒井忠雄, 手嶋紀雄
    • Total Pages
      8
    • Publisher
      化学同人
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] フローインジェクション分析装置用加熱装置2008

    • Inventor(s)
      手嶋紀雄, 村瀬武生
    • Industrial Property Rights Holder
      手嶋紀雄, 村瀬武生
    • Filing Date
      2008-11-04
    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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