Use of silica-surfactant nanochannels in a porous alumina membrane for separation of optical isomers

• Project/Area Number: 18750072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Analytical chemistry
• Research Institution: Toyama Institute of Health
• Principal Investigator: YAMASHITA Tomohisa Toyama Institute of Health, 化学部, 主任研究員 (10416092)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,070,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 陽極酸化アルミナ / チップ / クロマトグラフィー / 分離 / カラム / メソポーラスシリカ / 光学分割 / ナノカラム

Research Abstract

液体クロマトグラフィーシステムや分析チップ内に陽極酸化アルミナ薄膜を分離カラムとして設置,へプタン-エタノール混合溶離液,アセトニトリル-水混合溶離液および水溶離液を用いて溶質の分離を行なった。また,陽極酸化アルミナに対する溶質分子の吸着挙動を評価した。本研究の結果,陽極酸化アルミナの細孔は液体クロマトグラフィーや分析チップ等の分離カラムとしての機能することが示された。

Research Products

• [Journal Article] Separation of adenine, adenosine -5'- monophosphate and adenosine- 5'- triphosphate by fluidic chip with nanometre-order diameter columns inside porous anodic alumina using an aqueous mobile phase (2009)
  • Author(s): Tomohisa Yamashita, Shuji Kodama, Tomoko Kemmei, Mikiya Ohto, Eriko Nakayama, Tatsuya Muramoto, Akira Yamaguchi, Norio Teramae, Nobutaka Takayanagi
  • Journal Title: Lab on a Chip 9 Pages: 1337-1339
• [Journal Article] Separation of adenine, adenosine-5'-monophosphate and adenosine-5'-triphosphate by fluidic chip with nanometre-order diameter columns inside porous anodic alumina using an aqueous mobile phase (2009)
  • Author(s): Tomohisa Yamashita, et al.
  • Journal Title: Lab on a Chip 9 Pages: 1337-1339
  • Peer Reviewed
• [Journal Article] Enantioseparation of nicotine alkaloids in cigarettes by CE using sulfated β-CD as a chiral selector and a capillary coated with amino groups (2009)
  • Author(s): Shuji Kodama, et al.
  • Journal Title: Electrophresis 30 Pages: 349-356
  • Peer Reviewed
• [Journal Article] Utilization of nanometre-order diameter columns inside porous anodic alumina for chromatography chip system (2008)
  • Author(s): Tomohisa Yamashita, Shuji Kodama, Mikiya Ohto, Eriko Nakayama, Tomoko Kemmei, Tatsuya Muramoto, Akira Yamaguchi, Norio Teramae, and Nobutaka Takayanagi
  • Journal Title: Chemistry Letters 37 Pages: 18-19
  • NAID: 10020147464
  • Peer Reviewed
• [Journal Article] A fast and simple analysis of glyphosate in tea beverages by capillary electrophoresis with on-line copper(II)- glyphosate complex formation (2008)
  • Author(s): Shuji Kodama, Yuji Ito, Atsushi Taga, Yoko Nomura, Atsushi Yamamoto, Satoshi Chinaka, Kentaro Suzuki, Tomohisa Yamashita, Tomoko Kemmei, and Kazuichi Hayakawa
  • Journal Title: Journal of Health Science 54 Pages: 602-606
  • NAID: 110006935590
  • Peer Reviewed
• [Journal Article] Use of porous anodic alumina membranes as a nanometre-diameter columns for chromatography chip systems (2008)
  • Author(s): Tomohisa Yamashita, et. al.
  • Journal Title: Chemistry Letters Pages: 18-19
  • Peer Reviewed
• [Journal Article] Use of porous anodic alumina membranes as a nanometre-diameter column for high performance liquid chromatography (2007)
  • Author(s): Tomohisa Yamashita, Shuji Kodama, Mikiya Ohto, Eriko Nakayama, Nobutaka Takayanagi, Tomoko Kemmei, Akira Yamaguchi, Norio Teramae, and Yukio Saito
  • Journal Title: Chemical Communications Pages: 1160-1162
  • Peer Reviewed
• [Journal Article] Usefulness of catechins and caffeine profiles to determine growing areas of green tea leaves of a single variety, in Japan (2007)
  • Author(s): Shuji Kodama, Yuji Ito, Hirofumi Nagase, Tomohisa Yamashita, Tomoko Kemmei, Astushi Yamamoto, and Kazuichi Hayakawa
  • Journal Title: Journal of Health Science 53 Pages: 491-495
  • Peer Reviewed
• [Journal Article] Simultaneous chiral resolution of monosaccharides as 8-aminonaphthalene -1,3,6-trisulfonate derivatives by ligand-exchange CE using borate as a central ion of the chiral selector (2007)
  • Author(s): Shuji Kodama, Sen-ichi Aizawa, Atsushi Taga, Tomohisa Yamashita, Tomoko Kemmei, Atsushi Yamamoto, Kazuichi Hayakawa
  • Journal Title: Electrophoresis 28 Pages: 3933-3939
  • Peer Reviewed
• [Journal Article] Enantioseparation of isoxanthohumol in beer by hydroxypropyl-γ-cyclodextrin modified micellar electrokinetic chromatography (2007)
  • Author(s): Shuji Kodama, Atsushi Yamamoto, Atsushi Sato, Kentaro Suzuki, Tomohisa Yamashita, Tomoko Kemmei, Atsushi Taga, Kazuichi Hayakawa
  • Journal Title: Journal of Agricultural and Food Chemistry 55 Pages: 6547-6552
  • Peer Reviewed
• [Journal Article] Simultancous chiral resolution of monosaccharides as 8-aminonaphthalene-1,3,6-trisulfnate derivatives by ligand-exchange CE using borate as a central ion of the chiral selector (2007)
  • Author(s): Shuji Kodama, et. al.
  • Journal Title: Electrophresis 28 Pages: 3939-3933
  • Peer Reviewed
• [Journal Article] Enantioseparation of isoxanthohumol in beer by hydroxypropylry-cyclodexhin-modifled micellar electrokinetic chromatography (2007)
  • Author(s): Shuji Kodama, et. al.
  • Journal Title: Journal of Agricultiural and Food Chemistry 55 Pages: 6547-6552
  • Peer Reviewed
• [Journal Article] Usefulness of catechins and caffeine profiles to detemlime growing areas of green tea leaves of a single variety,Yabukita,in Japan (2007)
  • Author(s): Shuji Kodama, et. al.
  • Journal Title: Journal of Health Science 53 Pages: 491-495
  • Peer Reviewed
• [Journal Article] Use of porous anodic alumina membranes as a nanometre-diameter column for high performance liquid chromatography (2007)
  • Author(s): Tomohisa Yamashita, et al.
  • Journal Title: Chemical Communications Pages: 1160-1162
• [Journal Article] Chiral resolution of monosaccharides as 1-phenyl-3-methyl-5-pyrazolone derivatives by ligand-exchange CE using borate anion as a central ion of the chiral selector (2006)
  • Author(s): Shuji Kodama, Sen-ichi Aizawa, Atsushi Taga, Tomohisa Yamashita, Atsushi Yamamoto
  • Journal Title: Electrophoresis 27 Pages: 4730-4734
  • Peer Reviewed
• [Journal Article] Extraction mechanisms of charged organic dye molecules into silica -surfactant nanochannels in a porous alumina membrane (2006)
  • Author(s): Akira Yamaguchi, Jun Watanabe, Mekawy M Mahmoud, Rise Fujiwara, Kotaro Morita, Tomohisa Yamashita, Yosuke Amino, Yong Chen, Logudurai Radhakrishnan, and Norio Teramae
  • Journal Title: Analytica Chimica Acta 556 Pages: 157-163
  • Peer Reviewed
• [Journal Article] Permeation flux of organic molecules through silica-surfactant nanochannels in a porous alumina membrane (2006)
  • Author(s): Tomohisa Yamashita, Shuji Kodama, Mikiya Ohto, Eriko Nakayama, Sumiyo Hasegawa, Nobutaka Takayanagi, Tomoko Kemmei, Akira Yamaguchi, Norio Teramae, and Yukio Saito
  • Journal Title: Analytical Science 22 Pages: 1945-1500
  • NAID: 10020139962
  • Peer Reviewed
• [Journal Article] Local environments of coumarin dyes within mesostructured silica-surfactant nanocomposites (2006)
  • Author(s): Akira Yamaguchi, Yosuke Amino, Kentaro Shima, Shintaro Suzuki, Tomohisa Yamashita, and Norio Teramae
  • Journal Title: Journal of Physical Chemistry B 110 Pages: 3910-3916
  • Peer Reviewed
• [Journal Article] Longitudinal diffusion behavior of hemicyanine dyes across phospholipid vesicle membranes as studied by second -harminic generation and fluorescence spectroscopies (2006)
  • Author(s): Akira Yamaguchi, Masaki Nakano, Kimihisa Nochi, Tomohisa Yamashita, Kotaro Morita, and Norio Teramae
  • Journal Title: Analytical and Bioanalytical Chemistry 386 Pages: 627-632
  • Peer Reviewed
• [Journal Article] Permeation flux of organic molecules through silica-surfactant nanochannels in a porous alumina membrane (2006)
  • Author(s): Tomohisa Yamashita, et al.
  • Journal Title: Analytical Sciences 22 Pages: 1495-1500
  • NAID: 10020139962
• [Journal Article] Chiral resolution of monosaccharides as 1-phenyl-3-methyl-5-pyrazolone derivatives by ligand exchange capillary electrophoresis using borate anion as a central ion of the chiral selector (2006)
  • Author(s): Shuji Kodama, et al.
  • Journal Title: Electrophoresis 27 Pages: 4730-4734
• [Journal Article] Extraction mechanisms of charged organic dye molecules into silica-surfactant nanochannels in a porous alumina membrane (2006)
  • Author(s): Akira Yamaguchi, et al.
  • Journal Title: Analytica Chimica Acta 556 Pages: 157-163
• [Journal Article] Local environments of coumarin dyes within mesostructured silica-surfactant nanocomposites (2006)
  • Author(s): Akira Yamaguchi, et al.
  • Journal Title: The Journal of Physical Chemistry B 110 Pages: 3910-3916
• [Journal Article] Longitudinal diffusion behavior of hemicyanine dyes across phospholipid vesicle membranes as studied by second-harmonic generation and fluorescence spectroscopies (2006)
  • Author(s): Akira Yamaguchi, et al.
  • Journal Title: Analytical and Bioanalytical Chemistry 386 Pages: 627-632
• [Presentation] ナノカラムを分離媒体とした液体クロマトグラフィーチップによるアデニン,AMP, ATPの水溶液移動相による分離 (2009)
  • Author(s): 山下智富
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学
  • Year and Date: 2009-03-27
• [Presentation] 陽極酸化アルミナ薄膜の液体クロマトグラフィーチップ用ナノカラムとしての利用 (2008)
  • Author(s): 山下 智富
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京都立教大学
  • Year and Date: 2008-03-27
• [Presentation] 陽極酸化アルミナ薄膜の液体クロマトグラフィーチップ用ナノカラムとしての利用 (2008)
  • Author(s): 山下智富
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
• [Presentation] ナノカラムを分離媒体とした液体クロマトグラフィーチップによるアデニン,AMP,ATPの水溶液移動相による分離 (2008)
  • Author(s): 山下智富
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 東京
• [Presentation] 陽極酸化アルミナ薄膜の液体クロマトグラフィー用ナノカラムとしての利用 (2007)
  • Author(s): 山下智富
  • Organizer: 日本化学会第87春季年会
  • Place of Presentation: 大阪