Creation of bio-nanomachine utilizing polysaccharide/polymer complexes

• Project/Area Number: 18750153
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Chemistry related to living body
• Research Institution: Kyoto Prefectural University (2008); Ritsumeikan University (2007); Kyushu University (2006)
• Principal Investigator: NUMATA Munenori Kyoto Prefectural University, 生命環境科学研究科, 准教授 (70423564)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,020,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 多糖 / 超分子化学 / らせん高分子 / ポリスチレン / ブロックポリマー / 巨大ミセル / 超分子 / ブロックコポリマー / ミセル / ドラッグデリバリーシステム

Research Abstract

有機溶媒/水の界面にてシゾフィランをRenatureさせ、疎水性ポリマーへのラッピングを行った。このような界面でのラッピング過程を利用することにより超分子ポリマーの形成が可能となると期待される。得られた水溶液のDLS測定の結果、直径100-200nmの構造体の形成が示唆された。さらに、TEMによる観察の結果では内部に疎水性ドメインを持つ水溶性巨大ミセルの形成が明らかとなった。

Research Products

• [Journal Article] Creation of Hierarchical Carbon Nanotube Assemblies through Alternative Packing of Complementary Semi-Artificial β-1,3-Glucan/Carbon Nanotube Composites (2008)
  • Author(s): M. Numata, K. Sugikawa, K. Kaneko, and S. Shinkai
  • Journal Title: Chemistry A Europian Journal 14 Pages: 2398-2404
  • Peer Reviewed
• [Journal Article] Immobilization of Polythiophene Chirality Induced by a Helix-Forming β-1, 3-Glucan Polysaccharide (SchizophyIlan) through Sol-Gel Reaction (2008)
  • Author(s): S. Haraguchi, M. Numata, K. Kaneko, and S. Shinkai
  • Journal Title: Bulletin of the Chemical Society of Japan 8 Pages: 1002-1006
  • Peer Reviewed
• [Journal Article] Creation of Hierarchical Carbon Nanotube Assemblies through Alternative Packing of Complementary Semi-Artificial 3-1,3-Glucan/Carbon Nanotube Composites (2008)
  • Author(s): M. Numata, K. Sugikawa, K. Kanek o, and S. Shinkai
  • Journal Title: Chemistry A European Journal 14 Pages: 2398-2404
  • Peer Reviewed
• [Journal Article] Instantaneous Inclusion of a Polynucleotide and Hydrophobic Guest Molecules into a Helical Core of Cationic β-1,3-Glucan Polysaccharide (2007)
  • Author(s): M. Ikeda, T. Hasegawa, M. Numata, K. Sugikawa, K. Sakurai, M. Fujiki, and S. Shinkai
  • Journal Title: Journal of American Chemical Society 129 Pages: 3979-3886
  • Peer Reviewed
• [Journal Article] Controlled Stability of the Triple-Stranded Helical Structure of a・-1,3-Glucan with a Chromophoric Aromatic Moiety at a Peripheral Position (2007)
  • Author(s): Masato Ikeda, Shuichi Haraguchi, Munenori Numata and Seiji Shinkai
  • Journal Title: Chem. Asian J. 2 Pages: 1290-1298
  • Peer Reviewed
• [Journal Article] Complex formation between cationic ・-1,3-glucan and hetero-sequence oligodeoxynucleotide and its delivery into macrophage-like cells to in duce cytokine secretion (2007)
  • Author(s): Masato Ikeda, Jusaku Minari, Naohiko Shimada, Munenori Numata, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: Org. Bioorg. Chem. 5 Pages: 2219-2224
  • Peer Reviewed
• [Journal Article] ・-1,3-Glucan (Schyzophyllan) Can Act as a One-Dimensional Host for Creating Chirally Twisted Poly (p-phenylene Ethynylene) (2007)
  • Author(s): Munenori Numata, Tomohisa Fujisawa, Chun Li, Shunichi Haraguchi, Masato Ikeda, Kazuo Sakurai and Seiji Shinkai
  • Journal Title: Supramolecular Chem 19 Pages: 107-113
  • Peer Reviewed
• [Journal Article] Instantaneous Inclusion of a Polynucleotide and Hydrophobic Guest Molecules into a Helical Core of Cationic-1,3-Glucan Polysaccharide (2007)
  • Author(s): Masato Lkeda, Teruaki Hasegawa, Munenori Numata, Kouta Sugikawa, Kazuo Sakurai, Michiya Fujiki, Seiji Shinkai
  • Journal Title: Journal of American Chemical Society 129 Pages: 3979-3886
• [Journal Article] β-1,3-Glucan Polysaccharide (Schizophyllan) Acts as a One-Dimensional Host for Creating Supramolecular Dye Assemblies (2006)
  • Author(s): M. Numata, S. Tamesue, T. Fujisawa, S. Haraguchi, T. Hasegawa, A.-H. Bae, C. Li, K. Sakurai, and S. Shinkai
  • Journal Title: Organic Letters. 8 Pages: 5533-5533
  • Peer Reviewed
• [Journal Article] β-1,3-Glucan Polysaccharide (Schizophyllan) Acting as a One-Dimensional Host for Creating Supramolecular Dye Assemblies (2006)
  • Author(s): Munenori Numata, Shingo Tamesue, Tomohisa Fujisawa, Shuichi Haraguchi, Teruaki Hasegawa, Ah-Hyun Bae, Chun Li, Kazuo Sakurai, Seiji Shinkai
  • Journal Title: Organic Letters 8 Pages: 5533-3336
• [Presentation] 天然らせん高分子によるラッピングを利用した人工クロロソームの創製 (2009)
  • Author(s): 叶野徹、沼田宗典、民秋均、新海征治
  • Organizer: 日本化学会第89回春季年会
  • Place of Presentation: 日大船橋キャンパス
  • Year and Date: 2009-03-28
• [Presentation] 多糖のラッピング機能を活用した機能性ナノ材料の開発 (2008)
  • Author(s): 沼田宗典
  • Organizer: 第57回高分子討論会
  • Place of Presentation: 大阪市立大学
  • Year and Date: 2008-09-25
• [Presentation] 半人工β1、3グルカンの1次元ホスト機能を活用した機能性高分子の階層構造制御 (2007)
  • Author(s): 沼田 宗典
  • Organizer: 第2回ホスト・ゲスト化学シンポジウム
  • Place of Presentation: 大阪市立大学学術情報総合センター
  • Year and Date: 2007-05-25
• [Book] 「有機・無機・金属ナノチューブ」-非カーボンナノチューブ系の最新技術と応用展開-清水敏美、木島剛編集、第4章高分子系ナノチューブ "β-1,3-グルカン系多糖高分子を用いた一次元シリンダーホスト" (2008)
  • Author(s): 沼田宗典、新海征治
  • Publisher: フロンティア出版