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Development of field-effect based glucose sensors using a ZnMgO alloy

Research Project

Project/Area Number 18760310
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Measurement engineering
Research InstitutionOsaka Institute of Technology

Principal Investigator

KOIKE Kazuto  Osaka Institute of Technology, 工学部, 准教授 (40351457)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,620,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2007: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2006: ¥2,700,000 (Direct Cost: ¥2,700,000)
Keywords酸化マグネシウム亜鉛 / 酸化亜鉛 / グルコースセンサ / バイオセンサ / 電界効果トランジスタ / グルコース酸化酵素 / エッチング耐性 / シランカップリング / ナノロッド / バイオFET / 分子線エピタキシー / グルコースオキシダーゼ / 分子線エピタキシ / イオンセンサ / 酵素
Research Abstract

65歳以上の人口が国内総人口の1/5を占める今日,生活習慣病を煩う患者数が年々増加の一途をたどっている.特に糖尿病患者の割合が大きく深刻な社会問題となっている.この問題を解決するため本研究では,微量の血液で血糖値を手軽に検出できる電界効果型グルコースセンサ(血糖値センサ)の開発を行った.センサの母体材料には生体適合性の高い酸化マグネシウム亜鉛を用い,グルコースの検出にはグルコース酸化酵素を用いた.最終的に,グルコースに対する検出速度が20秒以下,検出可能範囲が0〜5mg/cm3のセンサを開発することに成功した.

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (41 results)

All 2009 2008 2007 2006 Other

All Journal Article (15 results) (of which Peer Reviewed: 11 results) Presentation (21 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Characteristics of an enzyme-based ZnO/Zn0.7Mg0.3O heterojunction field-effect transistor as glucose sensor2009

    • Author(s)
      Kazuto Koike, Daisuke Takagi, Mitsuhiro Hashimoto, Takahito Hashimoto, Tomoyuki Inoue, Ken-ichi Ogata, Shigehiko Sasa, Masataka Inoue, Mitsuaki Yano
    • Journal Title

      Japanese Journal of Applied Physics 48

    • NAID

      210000066592

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of enzyme-based ZnO/Zn_<0.7>Mg_<0.3>O heterojunction field-effect transistor as glucose sensor2009

    • Author(s)
      Kazuto Koike
    • Journal Title

      Japanese Journal of Applied Physics 48(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高移動度ZnO/ZnMgO電界効果トランジスタとバイオセンサ応用2008

    • Author(s)
      小池一歩
    • Journal Title

      応用物理 77

      Pages: 296-300

    • NAID

      10021108868

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Performance and stability of ZnO/ZnMgO hetero-metal-insulator-semicon ductor field-effect transistors2008

    • Author(s)
      Shigehiko Sasa
    • Journal Title

      Japanese Journal of Applied Physics 47

      Pages: 2845-2847

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 酸化亜鉛薄膜を用いた透明トランジスタ開発とバイオメディカルセンサへの応用2008

    • Author(s)
      矢野満明
    • Journal Title

      工業材料 56

      Pages: 72-75

    • Related Report
      2008 Annual Research Report
  • [Journal Article] X-ray analysis of ZnO nanorods grown by microwave irradiation heating on ZnO films2008

    • Author(s)
      Ken-ichi Ogata
    • Journal Title

      Applied Surface Science 254

      Pages: 7708-7711

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of ZnO nanorods on O-polar ZnO layers grown by molecular beam epitaxy and electrical characterization using conductive atomic force microscopy2008

    • Author(s)
      Ken-ichi Ogata
    • Journal Title

      Semiconductor Science and Technology 24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 第一原理計算によるウルツ鉱構造Zn_<1-x>Mg_xOの自発分極解析2008

    • Author(s)
      上辻靖智
    • Journal Title

      材料 58

      Pages: 243-250

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高移動度ZnO/ZnMgO電界効果トランジスタとバイオセンサー応用2008

    • Author(s)
      小池 一歩
    • Journal Title

      応用物理 77

      Pages: 296-300

    • NAID

      10021108868

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ion-sensitive characteristics of an electrolyte-solution-gate ZnO/ZnMgO heterojunction field-effect transistor as a biosensing transducer2007

    • Author(s)
      Kazuto Koike, Daisuke Takagi, Motoki Kawasaki, Takahito Hashimoto, Tomoyuki Inoue, Ken-ichi Ogata, Shigehiko Sasa, Masataka Inoue, Mitsuaki Yano
    • Journal Title

      Japanese Journal of Applied Physics 46

    • NAID

      40015670998

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] ZnOトランジスタのバイオセンサ応用2007

    • Author(s)
      小池 一歩
    • Journal Title

      独立行政法人日本学術振興会「光電相互変換第125委員会」第197回研究会資料

      Pages: 20-25

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Polarization-induced two-dimensional electron gas at Zn_<1-x>Mg_xO/ZnO heterointerface2007

    • Author(s)
      Mitsuaki Yano
    • Journal Title

      Journal of Crystal Growth 301-302

      Pages: 353-357

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ion-sensitive characteristics of an electrolyte-solution gate ZnO/ZnMgO heterojunction field-effect transistor as a biosensing transducer2007

    • Author(s)
      Kazuto Koike
    • Journal Title

      Japanese Journal of Applied Physics 46

    • NAID

      40015670998

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarization-Induced Two-Dimentional Electron Gas at Zn_<1-x>Mg_xO/ZnO Heterointerface2007

    • Author(s)
      M.Yano, K.Hashimoto, K.Fujimoto, K.Koike, S.Sasa, M.Inoue, Y.Uetsuji, T.Ohnishi, K.Inaba
    • Journal Title

      Journal of Crystal Growth 301-302

      Pages: 353-357

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High-Performance ZnO/ZnMgO Field-Effect Transistors using a Hetero-Metal-Insulator-Semiconductor Structure2006

    • Author(s)
      S.Sasa, M.Ozaki, K.Koike, M.Yano, M.Inoue
    • Journal Title

      Applied Physics Letter 89

      Pages: 53502-53504

    • Related Report
      2006 Annual Research Report
  • [Presentation] スパッタ法を用いたガラス基板上へのIZO/ZnMgOヘテロ構造の作製とpHセンサー応用2009

    • Author(s)
      生和泰明
    • Organizer
      第56回応用物理学関係連合講演会
    • Place of Presentation
      筑波大学
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 第一原理計算によるウルツ鉱構造Zn_<1-x>Mg_xO混晶の自発分極解析2009

    • Author(s)
      奥野嘉大
    • Organizer
      日本材料学会半導体エレクトロニクス部門研究会
    • Place of Presentation
      大阪大学
    • Year and Date
      2009-03-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 第一原理計算によるウルツ鉱構造ZnMgOの自発分極解析2009

    • Author(s)
      橋本貴史
    • Organizer
      材料・構造の複合化と機能化に関するシンポジウム
    • Place of Presentation
      同志社大学
    • Year and Date
      2009-03-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fabrication of ZnO nanorod arrays on Si(111) and A-plane sapphire substrates using aqueous solution with microwave-assisted heating2008

    • Author(s)
      Ken-ichi Ogata
    • Organizer
      IEEE Nanotechnology Materials and Devices Conference
    • Place of Presentation
      京都大学
    • Year and Date
      2008-10-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characteristics of an enzyme-based ZnO/Zn0.7Mg0.3O heterojunction fieldeffect transistor as a glucose sensor2008

    • Author(s)
      Kazuto Koike, Daisuke Takagi, Mitsuhiro Hashimoto, Takahito Hashimoto, Tomoyuki Inoue, Ken-ichi Ogata, Shigehiko Sasa, Masataka Inoue, Mitsuaki Yano
    • Organizer
      2008 International Conference on Solid State Devices and Materials
    • Place of Presentation
      Ibaraki, Japan
    • Year and Date
      2008-09-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Characteristics of an enzyme-based ZnO/Zn_<0.7>Mg_<0.3>O heterojunction field-effect transistor as a glucose sensor2008

    • Author(s)
      Kazuto Koike
    • Organizer
      2008 International Conference on Solid State Devices and Materials
    • Place of Presentation
      筑波国際会議場, 茨城県
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] ZnO nanorods arrays on n-type Si(111) substrates for pH measurements2008

    • Author(s)
      Ken-ichi Ogata
    • Organizer
      5th International Workshop on ZnO and Related Materials
    • Place of Presentation
      Ann Arbor-Ypsilanti, Michigan, USA
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] XPS characterization of ZnO nanorod arrays grown by an aqueous solution method with microwaveOassisted heating2008

    • Author(s)
      Ken-ichi Ogata
    • Organizer
      5th International Workshop on ZnO and Related Materials
    • Place of Presentation
      Ann Arbor-Ypsilanti, Michigan, USA
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characteristics of an enzyme-immobilized ZnO/Zn_<0.7>Mg_<0.3>O heterojunction field-effect transistor for glucose sensing2008

    • Author(s)
      Daisuke Takagi
    • Organizer
      27th Electronic Materials Symposium
    • Place of Presentation
      ラフォーレ修善寺(静岡県伊豆市)
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Glucose sensing by an enzyme-immobilized ZnO/Zn_<0.7>Mg_<0.3>O heterojunction field-effect transistor2008

    • Author(s)
      Mitsuaki Yano
    • Organizer
      27th Electronic Materials Symposium
    • Place of Presentation
      ラフォーレ修善寺(静岡県伊豆市)
    • Year and Date
      2008-07-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characteristics of an enzyme-modified ZnO/ZnMgO heterojunction field-effect transistor as a biosensor2008

    • Author(s)
      Daisuke Takagi
    • Organizer
      2008 International Meeting for Future of Electron Devices, Kansai
    • Place of Presentation
      大阪大学
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] ZnO thin-film transistors fabricated by sol-gel method2008

    • Author(s)
      Hiroyasu Tanaka
    • Organizer
      2008 International Meeting for Future of Electron Devices, Kansai
    • Place of Presentation
      大阪大学
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 原子間力顕微鏡によるZnOナノロッド観察2008

    • Author(s)
      尾形 健一
    • Organizer
      第54回応用物理学関係連合講演会
    • Place of Presentation
      日本大学,千葉
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 第一原理計算によるウルツ鉱構造Zn_<1-x>Mg_xOの自発分極解析と実験値との比較2008

    • Author(s)
      橋本 貴史
    • Organizer
      第54回応用物理学関係連合講演会
    • Place of Presentation
      日本大学,千葉
    • Year and Date
      2008-03-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] ZnO/ZnMgOヘテロ接合電界効果トランジスターを用いたグルコースセンサーの作製2008

    • Author(s)
      高木 大輔
    • Organizer
      第54回応用物理学関係連合講演会
    • Place of Presentation
      日本大学,千葉
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Electrolyte gate ZnO/ZnMgOfield effect transistors as pH sensors2007

    • Author(s)
      Kazuto Koike, Daisuke Takagi, Motoki Kawasaki, Yoshinobu Nakamura, Yoshiaki Hirano, Shigehiko Sasa, Masataka Inoue, Mitsuaki Yano
    • Organizer
      The 13th International Conference onII-VI Compounds
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2007-09-11
    • Related Report
      2008 Final Research Report
  • [Presentation] Electrolyte gate ZnO/ZnMgO field effect transistors as pH sensors2007

    • Author(s)
      Kazuto Koike
    • Organizer
      13th international conference on II-VI compounds
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] ZnOトランジスタのバイオセンサ応用2007

    • Author(s)
      小池 一歩
    • Organizer
      独立行政法人日本学術振興会「光電相互変換第125委員会」第197回研究会
    • Place of Presentation
      早稲田大学,東京
    • Year and Date
      2007-07-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] pH response of a surface-modified ZnO/ZnMgOfield-effect transistor in an electrolyte solution2007

    • Author(s)
      Kazuto Koike, Daisuke Takagi, Shigehiko Sasa, Yoshiaki Hirano, Yoshinobu Nakamura, Masataka Inoue, Mitsuaki Yano
    • Organizer
      2007 International Meeting for Future of Electron Devices
    • Place of Presentation
      Kansai, Osaka
    • Year and Date
      2007-04-24
    • Related Report
      2008 Final Research Report
  • [Presentation] pH Response of a Surface-Modified ZnO/ZnMgO Field-Effect Transistor in an Electrolyte Solution2007

    • Author(s)
      Kazuto Koike
    • Organizer
      2007 International Meeting for Future of Electron Devices, Kansai
    • Place of Presentation
      大阪大学,大阪
    • Year and Date
      2007-04-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Microwave-assisted synthesis of c-axis oriented ZnO Nanorods on a glass substrate coated with ZnO film2007

    • Author(s)
      Ken-ichi Ogata
    • Organizer
      Materials Research Society, fall meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2007 Annual Research Report
  • [Book] 「酸化亜鉛系トランジスタとその応用」,八百編:ZnO系の最新技術と応用2007

    • Author(s)
      佐々誠彦,小池一歩,前元利彦,矢野満明,井上正崇
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.oit.ac.jp/japanese/nanotech/

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.oit.ac.jp/japanese/nanotech/

    • Related Report
      2008 Annual Research Report
  • [Remarks] 「日刊工業新聞」1月8日の記事に掲載

    • URL

      http://www.oit.ac.jp/cgi-bin/event/topics.cgi?busho=nano&=2008&m=01&d=08

    • Related Report
      2007 Annual Research Report
  • [Remarks] 「日経エレクトロニクス(日経BP社発行)」の2007年8月27日号の「透明回路」特集号に掲載

    • URL

      http://www.oit.ac.jp/cgi-bin/event/topics.cgi?busho=nano&y=2008&m=1&d=08

    • Related Report
      2007 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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