Evolution of the Rh superfamily genes

• Project/Area Number: 18770002
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Genetics/Genome dynamics
• Research Institution: Ibaraki University (2007-2008); Yamagata University (2006)
• Principal Investigator: KITANO Takashi Ibaraki University, 工学部, 准教授 (90400564)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,930,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: 系統樹 / 多型 / ゲノム / 進化 / 遺伝子

Research Abstract

スナヤツメから3種類のRhスーパーファミリー遺伝子の塩基配列を決定した。そのうちの1つは、他の脊椎動物のRHBGと、また、残りの2つは他の脊椎動物のRHCGとそれぞれクラスターを形成した。一方、ナメクジウオからは2種類の遺伝子の存在が示され、これらは3'UTRに大きな構造的差異があった。系統解析から、これらはナメクジウオの系統で独自に重複したと考えられた。さらに、Rh遺伝子スーパーファミリー全体の進化解析も行った。

Research Products

• [Journal Article] Distinct carboxy-terminus of the B subunit for factor XIII in a population-associated major phenotype: the first case of complete allele-specific alternative splicing products in the coagulation and fibrinolytic systems. (2009)
  • Author(s): Iwata H, Kitano T, Umetsu K, Yuasa I, Yamazaki K, Kemkes-Matthes B, and Ichinose A.
  • Journal Title: Journal of thrombosis and haemostasis. (In press)
  • Peer Reviewed
• [Journal Article] Relic of ancient recombinations in gibbon ABO blood group genes deciphered through phylogenetic network analysis. (2009)
  • Author(s): Kitano T, Noda R, Takenaka O, and Saitou N.
  • Journal Title: Molecular Phylogenetics and Evolution 51 Pages: 465-471
  • Peer Reviewed
• [Journal Article] Relic of ancient recombinations in gibbon ABO blood group genes decip hered through phylogenetic network analysis (2009)
  • Author(s): Kitano T, Noda R, Takenaka O, Saitou N
  • Journal Title: Molecular Phylogenetics and Evolution (In press)
  • Peer Reviewed
• [Journal Article] Distinct carboxy-terminus of the B subunit for factor XIII in a population-specific major phenotype : The first case of complete allele-specific alternative splicing products in the coagulation and fibrinolytic systems (2009)
  • Author(s): Iwata H, Kitano T, Umetsu K, Yuasa I, Yamazaki K, Kemkes-Matthes, B, Ichinose A
  • Journal Title: Journal of Thrombosis and Haemostasis (In press)
  • Peer Reviewed
• [Journal Article] Tempo and mode of evolution of the Rh blood group genes before and after gene duplication. (2007)
  • Author(s): Kitano T, Umetsu K, Tian W, Yamazaki K, and Saitou N.
  • Journal Title: Immunogenetics. 59 Pages: 427-431
  • Peer Reviewed
• [Journal Article] Tempo and mode of evolution of the Rh blood group genes before and after gene duplication (2007)
  • Author(s): Kitano T
  • Journal Title: Immunogenetics 59(5) Pages: 427-431
• [Journal Article] Origin and evolution of gene for prolactin-induced protein. (2006)
  • Author(s): Kitano T, Tian W, Umetsu K, Yuasa I, Yamazaki K, Saitou N and Osawa M.
  • Journal Title: Gene 383 Pages: 64-70
  • Peer Reviewed
• [Journal Article] Origin and evolution of gene for prolactin-induced protein (2006)
  • Author(s): Kitano T
  • Journal Title: Gene 383 Pages: 64-70
• [Presentation] Rh式血液型遺伝子スーパーファミリーの進化 (2008)
  • Author(s): 北野 誉
  • Organizer: 日本進化学会
  • Place of Presentation: 東京
  • Year and Date: 2008-08-22
• [Presentation] Rh式血液型遺伝子スーパーファミリーの進化 (2008)
  • Author(s): 北野誉
  • Organizer: 日本進化学会
  • Place of Presentation: 東京大学駒場キャンパス
  • Year and Date: 2008-08-22
• [Presentation] 脊椎動物におけるRh遺伝子族の進化 (2006)
  • Author(s): 北野 誉
  • Organizer: 日本進化学会
  • Place of Presentation: 東京
  • Year and Date: 2006-08-30
• [Remarks]
  • URL: http://info.ibaraki.ac.jp/scripts/websearch/index.htm
• [Remarks] 茨城大学研究者情報総覧
  • URL: http://info.ibaraki.ac.jp/scripts/websearch/index.htm