Studies on chick-specific feeding regulatory mechanism by prolactin-releasing peptide in the brain

• Project/Area Number: 18780203
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Zootechnical science/Grassland science
• Research Institution: Ehime University
• Principal Investigator: TACHIBANA Tetsuya Ehime University, 農学部, 准教授 (80346832)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,670,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 畜産学 / 行動学 / 脳・神経 / 生体分子 / 薬理学 / 摂食行動 / プロラクチン放出ペプチド

Research Abstract

プロラクチン放出ペプチド(PrRP)は哺乳類の摂食行動を抑制する脳内神経ペプチドである。本研究では、PrRPがニワトリヒナの摂食行動を促進することを見出し、PrRPの作用が哺乳類とは異なることを明らかにした。さらにその作用機序を調べたところ、PrRPはニワトリヒナの他の脳内摂食促進神経ペプチドとは明らかに異なる機構で摂食行動を促進することを見出し、PrRPによるヒナ独自の脳内摂食促進機構の存在を明らかにした。

Research Products

• [Journal Article] Cline MA. Role of adrenergic alpha-2-receptors on feeding behavior in layer-type chicks. (2009)
  • Author(s): Tachibana T, Sugahara K, Ueda H
  • Journal Title: General and Comparative Endocrinology 161 Pages: 407-411
  • Peer Reviewed
• [Journal Article] Central administration of somatostatin stimulates feeding behavior in chicks (2009)
  • Author(s): Tachibana T, Cline MA, Sugahara K, Ueda H, Hiramatsu K
  • Journal Title: General and Comparative Endocrinology 161 Pages: 354-359
  • Peer Reviewed
• [Journal Article] Role of adrenergic alpha-2-receptors on feeding behavior in layer-type chicks (2009)
  • Author(s): Tachibana T, et.al.
  • Journal Title: General and Comparative Endocrinology 161 Pages: 407-411
  • Peer Reviewed
• [Journal Article] Central administration of somatostatin stimulates feeding behavior in chicks (2009)
  • Author(s): Tachibana T, et.al.
  • Journal Title: General and Comparative Endocrinology 161 Pages: 354-359
  • Peer Reviewed
• [Journal Article] Nitric oxide synthase inhibitor attenuates the anorexigenic effect of corticotropin-releasing hormone in neonatal chicks. Comparative Biochemistry and Physiology A (2008)
  • Author(s): Khan MS, Nakano Y, Tachibana T, Ueda H
  • Journal Title: Molecular and Integrative Physiology 149 Pages: 325-329
  • Peer Reviewed
• [Journal Article] Central administration of galanin stimulates feeding behavior in chicks. Comparative Biochemistry and Physiology A (2008)
  • Author(s): Tachibana T, Mori M, Khan MS, Ueda H, Sugahara K, Hiramatsu K
  • Journal Title: Molecular and Integrative Physiology 151 Pages: 637-640
  • Peer Reviewed
• [Journal Article] Central administration of galanin stimulates feeding behavior in chicks (2008)
  • Author(s): Tachibana T, et.al.
  • Journal Title: Comparative Biochemistry & Physiology Part A Molecular and Integrative Physiology 151 Pages: 637-640
  • Peer Reviewed
• [Journal Article] Nitric oxide synthase inhibitor attenuates the anorexigenic effect of corticotropin-releasing hormone in neonatal chicks. (2008)
  • Author(s): Khan MS, et. al.
  • Journal Title: Comparative Biochemistry & Physiology Part A M olecular and Integrative Physiology. 149 Pages: 325-329
  • Peer Reviewed
• [Journal Article] Peripheral or central administration of nitric oxide synthase inhibitor affects feeding behavior in chicks. Comparative Biochemistry and Physiology A (2007)
  • Author(s): Khan MS, Tachibana T, Hasebe Y, Masuda N, Ueda H
  • Journal Title: Molecular and Integrative Physiology 148 Pages: 458-462
  • Peer Reviewed
• [Journal Article] Central administration of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide differentially regulates energy metabolism in chicks. Comparative Biochemistry and Physiology A (2007)
  • Author(s): Tachibana T, Oikawa D, Adachi N, Boswell T, Furuse M
  • Journal Title: Molecular and Integrative Physiology 147 Pages: 156-164
  • Peer Reviewed
• [Journal Article] Peripheral or central administration of nitric oxide synthase inhibitor affects feeding behavior in chicks. (2007)
  • Author(s): Khan MS, et. al.
  • Journal Title: Comparative Biochemistry & Physiology Part A M olecular and Integrative Physiology. 148 Pages: 458-462
  • Peer Reviewed
• [Journal Article] Central administration of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide differentially regulates energy metabolism in chicks. (2007)
  • Author(s): Tachibana T. et al.
  • Journal Title: Comparative Biochemistry ＆ Physiology Part A Molecular and Integrative Physiology. 147・1 Pages: 156-164
• [Presentation] ソマトスタチンの脳内投与はニワトリヒナの摂食行動を刺激する. (2009)
  • Author(s): 橘哲也・Mark A. Cline・菅原邦生・上田博史・平松浩二
  • Organizer: 日本家禽学会大会
  • Place of Presentation: 日本大学
  • Year and Date: 2009-03-28
• [Presentation] ソマトスタチンの脳内投与はニワトリヒナの摂食行動を刺激する (2009)
  • Author(s): 橘哲也
  • Organizer: 日本家禽学会
  • Place of Presentation: 日本大学
  • Year and Date: 2009-03-28
• [Presentation] ガラニンはニワトリヒナの摂食行動を刺激する (2008)
  • Author(s): 橘哲也
  • Organizer: 日本家禽学会
  • Place of Presentation: 北里大学
  • Year and Date: 2008-08-29
• [Presentation] ガラニンはニワトリヒナの摂食行動を刺激する (2008)
  • Author(s): 橘哲也・森みやび・上田博史・菅原邦生・平松浩二
  • Organizer: 日本家禽学会大会
  • Place of Presentation: 北里大学
  • Year and Date: 2008-08-28
• [Presentation] 性腺刺激ホルモン放出抑制ホルモンはオピオイド神経系を介してニワトリヒナの摂食行動を刺激する (2007)
  • Author(s): 橘 哲也
  • Organizer: 日本家禽学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2007-09-29
• [Presentation] 性腺刺激ホルモン放出抑制ホルモンはオピオイド神経系を介してニワトリヒナの摂食行動を刺激する (2007)
  • Author(s): 橘哲也・益田直人・浮穴和義・筒井和義・上田博史
  • Organizer: 日本家禽学会大会
  • Place of Presentation: 岡山大学
  • Year and Date: 2007-09-28