Prevention of hepatitis and Hepatocellular carcinoma by regulation of cytokine signaling
| Project/Area Number |
18790483
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
YOSHIDA Takafumi Kurume University, 医学部, 助教 (30368899)
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| Project Period (FY) |
2006 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,540,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | サイトカイン / シグナル伝達 / 肝炎 / 肝癌 / サイトカインシグナル伝達 / 終末糖化産物 / SOCS-1 / Spred |
|---|
| Research Abstract |
肝炎、肝癌の進行においてJAK-STATおよびRas-MAPKシグナルの活性化と、これらのシグナルの抑制因子SOCS、SpredがDNAメチル化などによる発現低下が関与していることを証明した。また、糖尿病や肥満や肝炎、肝癌の増悪に終末糖化産物(AGEs)が関与していることを証明し、さらに網膜色素上皮因子(PEDF)による抑制効果も証明した。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Serum C-reactive protein levels predict survival in hepatocellular carcinoma.2007
Author(s)
Nagaoka S, Yoshida T, Akiyoshi J, Akiba J, Torimura T, Adachi H, Kurogi J, Tajiri N, Inoue K, Niizeki T, Koga H, Imaizumi T, Kojiro M, Sata M.
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Journal Title
Liver Int. 27(8)
Pages: 1091-7
Related Report
Peer Reviewed
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[Journal Article] Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells.2007
Author(s)
Hanada S, Harada M, Kumemura H, Bishr Omary M, Koga H, Kawaguchi T, Taniguchi E, Yoshida T, Hisamoto T, Yanagimoto C, Maeyama M, Ueno T, Sata M.
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Journal Title
J Hepatol. 47(1)
Pages: 93-102
Related Report
Peer Reviewed
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[Journal Article] Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.2006
Author(s)
Yoshida T, Hisamoto T, Akiba J, Koga H, Nakamura K, Tokunaga Y, Hanada S, Kumemura H, Maeyama M, Harada M, Ogata H, Yano H, Kojiro M, Ueno T, Yoshimura A, Sata M.
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Journal Title
Oncogene. 5 ; 25(45)
Pages: 6056-66
Related Report
Peer Reviewed
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[Presentation] Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.2006
Author(s)
Yoshida Takafumi, Hisamoto Takao, Akiba Jun, Koga Hironori, Nakamura Kazuo, Yano Hirohisa, Kojiro Masamichi, Ueno Takato, Yoshimura Akihiko, Sata Michio.
Organizer
DDW-USA 2006
Place of Presentation
Los Angels, USA
Related Report
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