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自己免疫性末梢神経疾患における新たな抗糖脂質抗体の同定

Research Project

Project/Area Number 18790599
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionYamaguchi University

Principal Investigator

古賀 道明  Yamaguchi University, 医学部・附属病院, 助教 (60383014)

Project Period (FY) 2006 – 2007
Project Status Completed (Fiscal Year 2007)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2006: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywordsギラン・パレー症候群 / 抗ガングリオシド抗体 / Campylobacter jejuni / リポオリゴ糖 / ギラン・バレー症候群 / Campylobacer jejuni
Research Abstract

Fisher症候群(FS)患者の9割で、急性期血中にIgG抗GQ1b抗体が検出される。一方、近年FSやGuillain-Barre症候群(GBS)で、複数のガングリオシドからなる「ガングリオシド複合体」に対するIgG抗体が検出されることが明らかにされてきた。さらに、FS患者より分離培養されたCampylobater jejuniのリポオリゴ糖(LOS)上にGD1c様構造とGalNAc-GM1b様構造が存在することが示されている。これらの知見から本研究では、IgG抗GQ1b抗体陰性のFS症例(GQ1b-seronegative FS)において、抗ガングリオシド複合体抗体、およびGDlc様LOSとGa1NAc-GM1b様LOSに対するIgG抗体が検出されるか検討した。抗GQlb抗体陰性FS 24例を対象に、ガングリオシド複合体、およびカンピロバクター・リポオリゴ糖(LOS)に対するIgG抗体を測定した。
その結果、24例中4例(17%)でGM1/GT1a複合体抗体が、6例(25%)でGD1c様LOSないしGa1NAc-GM1b様LOSに対するIgG抗体が陽性であった(健常者37例では全例陰性)。これらの抗体が陽性の症例は、抗GQ1b抗体陽性例と臨床像が類似していた。つまり、先行感染症状や神経所見からこれらの抗体の有無の推測は困難と考えられる。FSでIgG抗GQ1b抗体に加え、ガングリオシド複合体(特にGM1/GT1a)に対する抗体を測定することで検査感度を上げることができることが示された。またGD1cとGa1NAc-GM1bがFSの標的分子である可能性が示唆され、今後は、GD1cとGa1NAc-GM1bとを用いて抗体測定を行う必要がある。

Report

(2 results)
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (28 results)

All 2008 2007 2006

All Journal Article (24 results) (of which Peer Reviewed: 12 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Bickerstaff's brainstem encephalitis and Fisher syndrome form a continuous snectrum: clinical analysis of 581 cases.2008

    • Author(s)
      Ito M, et. al.
    • Journal Title

      J Neurol (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subclass IgG to motor gangliosides related to infection and clinical course in Guillaiti-Barre syndrome.2008

    • Author(s)
      Jacobs BC, et. al.
    • Journal Title

      J Neuroimmunol (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bickerstaff's brainstem encephalitis after an outbreak of Campylobacter jejuni enteritis.2008

    • Author(s)
      Mori M, et. al.
    • Journal Title

      J Neuroimmunol (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rulminant case of Guillain-Barre syndrome with poor recovery and depression following Haemophilus influenzae infection.2008

    • Author(s)
      Tagami S, et. al.
    • Journal Title

      Psychiat Clin Neurosci (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 髄膜炎の臨床:高齢発症の一例を通して2008

    • Author(s)
      古賀道明、他
    • Journal Title

      臨床と研究 85

      Pages: 293-297

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 嚥下障害,拘束性換気障害を呈したdiffuse idiopathic skeletal hyperostosis2008

    • Author(s)
      安部真影、他
    • Journal Title

      脳神経 60

      Pages: 171-174

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多発性硬化症治療の診断と治療:アザチオプリン2008

    • Author(s)
      古賀道明、他
    • Journal Title

      Modern Physician (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Campylobacter jejuni cst-ll polymorphisms and association with develonment of Guillain-Barre syndrome.2007

    • Author(s)
      Koga M, et. al.
    • Journal Title

      Neurology 69

      Pages: 1727-1727

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous spectrum of pharvneeal-cervical-brachial variant of Guillain-Barre syndrome.2007

    • Author(s)
      Nagashima T, et. al.
    • Journal Title

      Arch Neurol 64

      Pages: 1519-1523

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Haemophilus iniluenzae strain associated with Fisher syndrome expressesa novel disialylated ganglioside mimic.2007

    • Author(s)
      Houliston RS, et. al.
    • Journal Title

      Biochemistry 46

      Pages: 8164-8171

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genomic analysis of Campylobacter jeiuni associated with Guillain-Barre and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of senomic similarity.2007

    • Author(s)
      Taboada EN, et. al.
    • Journal Title

      BMC Genomics 8

      Pages: 359-359

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sjogren症候群を合併し抗神経抗体を伴う進行性の下位運動ニューロン徴候を呈した45歳女性例2007

    • Author(s)
      清水文崇、他
    • Journal Title

      臨床神経 47

      Pages: 502-506

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haemophilis infuenzaeとCampylobacter jejuniの混合感染が疑われ、経過甲に強皮症を発症したlgG抗GMI抗体陽性Guillain-Barre症候群の1例2007

    • Author(s)
      永井勅久、他
    • Journal Title

      神経内科 66

      Pages: 303-305

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective study on anti-ganglioside antibodies in childhood Guillain-Barre syndrome.2007

    • Author(s)
      Schessl et al.
    • Journal Title

      Arch Dis Child 92

      Pages: 48-52

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ganglioside-specific IgG and IgA recruit leukocyte effector functions in Guillain-Barre syndrome.2007

    • Author(s)
      van Sorge et al.
    • Journal Title

      J Neuroimmunol 182

      Pages: 177-184

    • Related Report
      2006 Annual Research Report
  • [Journal Article] An adolescent with pharyngeal-cervical-brachial variant of Guillain-Barre syndrome after cytomegalovirus infection.2006

    • Author(s)
      Murakami et al.
    • Journal Title

      Brain Dev 28

      Pages: 269-271

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Campylobacter coli enteritis and Guillain-Barre syndrome : no evidence of molecular mimicry and serological relationship.2006

    • Author(s)
      Funakoshi et al.
    • Journal Title

      J Neurol Sci 246

      Pages: 163-168

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Spectrum of neurological diseases associated with antibodies to minor gangliosides GM1b and Ga1NAc-GD1a.2006

    • Author(s)
      Tatsumoto et al.
    • Journal Title

      J Neuroimmunol 177

      Pages: 201-208

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Relationship of bacterial strains to clinical syndromes of Campylobacter-associated neuropathies.2006

    • Author(s)
      Kimoto et al.
    • Journal Title

      Neurology 67

      Pages: 1837-1843

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Identification of a sialate-O-acetyltransferase from Campylobacter jejuni : demonstration of direct transfer to the C9 position of terminal 〓-2, 8-linked sialic acid.2006

    • Author(s)
      Houliston et al.
    • Journal Title

      J Biol Chem 281

      Pages: 11480-11486

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Bacterial infections in Guillain-Barre and Fisher syndromes.2006

    • Author(s)
      Yuki et al.
    • Journal Title

      Curr Opin Neurol 19

      Pages: 451-457

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Campylobacter jejuni感染とギラン・バレー症候群2006

    • Author(s)
      古賀道明
    • Journal Title

      臨床免疫 45

      Pages: 477-482

    • NAID

      40007282725

    • Related Report
      2006 Annual Research Report
  • [Journal Article] ギラン・バレー症候群とカンピロバクター2006

    • Author(s)
      古賀道明
    • Journal Title

      Neuroimmunology 14

      Pages: 163-168

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 抗ガングリオシド抗体検出キットの開発 : Guillain-Barre症候群、 Fisher症候群における臨床的有用性の検討2006

    • Author(s)
      秋山真弓, 他
    • Journal Title

      脳神経 58

      Pages: 477-481

    • Related Report
      2006 Annual Research Report
  • [Presentation] ギラン・バレー症候群の研究・治療の最前線2007

    • Author(s)
      古賀道明
    • Organizer
      第16回 日本神経学会中国・四国地区生涯教育講演会
    • Place of Presentation
      宇部
    • Year and Date
      2007-06-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] カンピロバクターのガングリオシドエピトープの多様性2007

    • Author(s)
      古賀道明、他
    • Organizer
      第48回 日本神経学会 総会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] Campylobacter jejuni リポオリゴ糖におけるガングリオシドエピトープの多様性2007

    • Author(s)
      古賀道明、他
    • Organizer
      第19回 日本神経免疫学会学術集会
    • Place of Presentation
      金沢
    • Related Report
      2007 Annual Research Report
  • [Book] 神経疾患最新の治療2009-20112008

    • Author(s)
      古賀道明、他
    • Publisher
      南江堂(印刷中)
    • Related Report
      2007 Annual Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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