Investigation of the mechanism underlying the selective vulnerability of motoneurons

• Project/Area Number: 18790604
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: KONO Yu Jikei University School of Medicine, 医学部, 助教 (00349581)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,600,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 筋萎縮性側索硬化症 / 運動神経細胞 / パッチクランプ / グリシン / ALS / patch-clamp / anoxla / motor neuron / glycine / anoxia

Research Abstract

運動神経細胞において,代謝ストレスによりグリシン放出が促進され,本来は抑制性作用を示すこの神経伝達物質がシナプス間隙においてspilloverし,NMDA受容体に対しては共作動物質として機能し,最終的には興奮性作用のあるNMDA受容体活性が増強され,選択的に細胞死が誘導されることを,世界で初めて電気生理学的に証明した.

Research Products

• [Journal Article] 神経難病の進行の鍵を握るグリア細胞 (2008)
  • Author(s): 河野優,加藤総夫
  • Journal Title: 実験医学 26 Pages: 1730-1731
• [Journal Article] 神経難病の進行の鍵を握るグリア細胞 (2008)
  • Author(s): 河野優・加藤総夫
  • Journal Title: 実験医学 26 Pages: 1730-1731
• [Journal Article] Facilitation of spontaneous glycine release by anoxia potentiates NMDA receptor current in the hypoglossal motor neurons of the rat (2007)
  • Author(s): Kono Y, Shigetomi E, Inoue K, Kato F
  • Journal Title: Eur J Neurosci 25 Pages: 1748-56
  • Peer Reviewed
• [Journal Article] Facilitation of spontaneous glycine release by anoxia potentiates NMDA receptor current in the hypoglossal motor neurons of the rat (2007)
  • Author(s): Yu Kono, Eiji Shigetomi, Kiyoharu Inoue, Fusao Kato
  • Journal Title: European Journal of Neuroscience 25 Pages: 1748-1757
• [Presentation] 代謝障害誘発グリシン放出による舌下運動神経NMDA受容体電流の増大 (2006)
  • Author(s): 河野優、繁富英治、井上聖啓、加藤総夫
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 京都
• [Presentation] Potentiation of NMDA receptor-mediated current by anoxia through glycine release facilitation in the hypoglossal motor neurons of the rat (2006)
  • Author(s): Kono Y, Shigetomi E, Kato F
  • Organizer: 36^<th> Society for Neuroscience Annual Meeting
  • Place of Presentation: Atlanta