The essential fatty acid ratio affect the development of overt diabetes.
| Project/Area Number |
18790742
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | The University of Shimane (2009)
The University of Shimane Junior College (2007-2008)
Shimane Prefectual Shimane Women's College (2006) |
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Principal Investigator |
KAGOHASHI Yukiko The University of Shimane, 短期大学部・健康栄養学科, 助教 (30369756)
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| Project Period (FY) |
2006 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2006: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 小児代謝 / 栄養学 / 1型糖尿病 / 必須脂肪酸 / 食餌環境 / 顕性糖尿病 / 治療 / ハネムーン期 / 一次予防 / 二次予防 / 胎児期 / 乳幼児期 |
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| Research Abstract |
In this study, to investigate the effect of maternal nutrition, in particular the essential fatty acid (EFA) ratio, on the development of overt diabetes in the offspring, we prepared chows with n-6/n-3 EFA ratios of 3.0 and 14.5, and provided them to pregnant female NOD mice, a type 1 diabetes model. The present study suggests that the maternal dietary n-6/n-3 EFA ratio modifies the expression of IAA and immune response in the offspring, which might further affect the development of overt diabetes, and a diet with a low n-6/n-3 EFA ratio can prolong the honeymoon period after the onset of type 1 diabetes.
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Report
(4 results)
Research Products
(32 results)
