The effects of reactive oxygen species on proliferation and vascular endothelial growth factor of epidermal keratinocytes
Project/Area Number |
18790791
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Dermatology
|
Research Institution | Kagawa University |
Principal Investigator |
NAKAI Kozo Kagawa University, 医学部・附属病院, 助教 (40363204)
|
Project Period (FY) |
2006 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥3,000,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
|
Keywords | 表皮角化細胞 / 活性酸素 / 細胞増殖 / 血管内皮細胞増殖因子 / 表皮増殖因子受容体 / アンギオテンシンII |
Research Abstract |
昇圧作用を持つアンギオテンシンIIが表皮角化細胞のスーパーオキサイドという活性酸素産生と細胞増殖を促進した。表皮増殖因子のひとつ、HB-EGFが表皮角化細胞の一酸化窒素という活性酸素産生と血管内皮細胞増殖因子(VEGF)産生を促進し、細胞増殖も促進した。
|
Report
(4 results)
Research Products
(9 results)