The effects of reactive oxygen species on proliferation and vascular endothelial growth factor of epidermal keratinocytes

• Project/Area Number: 18790791
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kagawa University
• Principal Investigator: NAKAI Kozo Kagawa University, 医学部・附属病院, 助教 (40363204)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,000,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥800,000 (Direct Cost: ¥800,000); Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
• Keywords: 表皮角化細胞 / 活性酸素 / 細胞増殖 / 血管内皮細胞増殖因子 / 表皮増殖因子受容体 / アンギオテンシンII

Research Abstract

昇圧作用を持つアンギオテンシンIIが表皮角化細胞のスーパーオキサイドという活性酸素産生と細胞増殖を促進した。表皮増殖因子のひとつ、HB-EGFが表皮角化細胞の一酸化窒素という活性酸素産生と血管内皮細胞増殖因子(VEGF)産生を促進し、細胞増殖も促進した。

Research Products

• [Journal Article] Angiotensin II enhances EGF receptor expression levels via ROS formation in HaCaT cells (2008)
  • Author(s): Kozo Nakai
  • Journal Title: Journal of Dermatological Science 51 Pages: 181-189
  • NAID: 10024298430
  • Peer Reviewed
• [Journal Article] Angiotensin II. enhances EGF receptor expression levels via ROS formation in HaCaT cells (2008)
  • Author(s): Kozo Nakai
  • Journal Title: Journal of Dermatological Science 51 Pages: 181-189
  • NAID: 10024298430
  • Peer Reviewed
• [Journal Article] Angiotensin II enhances EGF receptor expression levels via ROS formation in HaCaT cells (2008)
  • Author(s): Kozo Nakai
  • Journal Title: Journal of Dermatological Science (In press掲載確定済)
  • NAID: 10024298430
  • Peer Reviewed
• [Presentation] アンギオテンシンIIはHaCaT細胞の活性酸素産生を増やしてEGF受容体の発現を増加させる (2008)
  • Author(s): 中井浩三
  • Organizer: 第15回四国四大学皮膚科研究会
  • Place of Presentation: 高知日本
  • Year and Date: 2008-06-21
• [Presentation] Angiotensin II enhances EGF receptor expression in HaCaT cells (2008)
  • Author(s): Kozo Nakai
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2008-05-16
• [Presentation] Angiotensin II enhances EGF receptor expression in. HaCaT cells (2008)
  • Author(s): Kozo Nakai
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: 京都
  • Year and Date: 2008-05-16
• [Presentation] Angiotensin II enhances EGF receptor expression in HaCaT cells. (2008)
  • Author(s): Kozo Nakai
  • Organizer: International Investigative Dermatology 2008
  • Place of Presentation: 京都
  • Year and Date: 2008-05-16
• [Presentation] Angiotensin II enhances EGF receptor expression in HaCaT cells (2007)
  • Author(s): Kozo Nakai
  • Organizer: SFRBM 14th annual meeting
  • Place of Presentation: Washington DC USA
  • Year and Date: 2007-11-16
• [Presentation] Angiotensin II enhanced EGF receptor expression in HaCaT cells. (2007)
  • Author(s): Kozo Nakai
  • Organizer: SFRBM 14^th annual meeting 2007年
  • Place of Presentation: ワシントンDC USA
  • Year and Date: 2007-11-16