Role of the newly identified cytokine IFN-lambda(IL-28/29) in skin cancer

• Project/Area Number: 18790803
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Jichi Medical University
• Principal Investigator: SATO Atsuko Jichi Medical University, 医学部, 研究員 (50382916)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: 腫瘍免疫 / インターフェロン / NK細胞

Research Abstract

近年、腫瘍免疫活性化を目的としたサイトカイン治療は、効果が短期間なことや過剰な副作用が問題となっており、より効果的で安全な新規サイトカインが必要とされている。本研究では、新規サイトカインIFN-lambdaの抗腫瘍効果に着目し、固形癌に対する治療戦略を目指した総合的研究を実施した。IFN-lambdaは細胞周期G1/S停止とアポトーシスを誘導し、腫瘍局所部位で過剰発現させると腫瘍形成と転移を抑制し、その抗腫瘍効果にはNK細胞が必要であることを証明した。

Research Products

• [Journal Article] Transcriptional modulation using HDACi depsipeptide promotes immune cell-mediated tumor destruction of murine B16 melanoma. (2008)
  • Author(s): Murakami T, Sato A, Chun NA, Hara M, Naito Y, Kobayashi Y, Kano Y, Ohtsuki M, Furukawa Y, Kobayashi E.
  • Journal Title: J Invest Dermatol. 128 Pages: 1506-1516
  • Peer Reviewed
• [Journal Article] Transcriptional Modulation Using HDACi Depsipeptide Promotes Immune Cell-Mediated Tumor Destruction of Murine B16 Melanoma. (2008)
  • Author(s): Murakami T, Sato A, Chun NA, Hara M, Naito Y, Kobayashi Y, Kano Y, Ohtsuki M, Furukawa Y, Kobayashi E.
  • Journal Title: J Invest Dermatol.
  • Peer Reviewed
• [Journal Article] Antitumor activity of IFN-lambda in murine tumor models. (2006)
  • Author(s): Sato A, Ohtsuki M, Hata M, Kobayashi E, Murakami T.
  • Journal Title: J Immunol. 176 Pages: 7686-7694
  • Peer Reviewed
• [Journal Article] Antitumor Activity of IFN-λ in Murine Tumor Models (2006)
  • Author(s): Sato A, et al.
  • Journal Title: J Immunol 176 Pages: 7686-7694
• [Presentation] Differential NK cell-mediated antitumor activity between IFN-lambda (IL-28/IL-29) and IL-21. (2007)
  • Author(s): Sato, A., et, al
  • Organizer: The 66TH Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
• [Presentation] Differential antitumor activity between IFN-lambda and IL-21. (2007)
  • Author(s): Sato, A., et, al.
  • Organizer: The 94TH AAI Annual Meeting Immunology.
  • Place of Presentation: Miami
• [Presentation] Differential antitumor activity between IFN-lambda and IL-21. (2007)
  • Author(s): Sato, A., et, al.
  • Organizer: The 94TH AAI Annual Meeting Immunology.
  • Place of Presentation: Miami.
• [Presentation] Differential NK cell-mediated antitumor activity between IFN-lambda (IL-28/IL-29) and IL-21. (2007)
  • Author(s): Sato, A., et, al.
  • Organizer: The 66TH Annual Meeting of the Japanese Cancer Association.
  • Place of Presentation: Yokohama.
• [Presentation] IFN-λ(IL-28/29)はNK細胞を介して抗腫瘍効果を発揮する. (2006)
  • Author(s): 佐藤篤子,村上孝,小林英司
  • Organizer: 第65回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] The antitumor activity of interferon-λ against murine tumors (2006)
  • Author(s): A Sato., et, al.
  • Organizer: Society for Investigative Dermatology
  • Place of Presentation: Philadelphia, USA