Genetic studies comprehensively viewing circadian disorders and mood disorders

• Project/Area Number: 18790855
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Fujita Health University
• Principal Investigator: KITAJIMA Tsuyoshi Fujita Health University, 医学部, 講師 (40360234)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: 精神生理学 / ゲノム医科学的研究 / 気分障害 / 概日リズム / 時計遺伝子 / 関連解析 / 薬物反応 / 選択的セロトニン再取り込み阻害薬

Research Abstract

生体リズムの病態への関与が指摘されている気分障害の疾患脆弱性あるいは薬物反応性に関して、時計関連遺伝子との関連解析を行った。時計遺伝子機構の主要因子であるCLOCK遺伝子の多型と大うつ病性障害における抗うつ薬Fluvoxamineへの反応性との間に関連を見出した。また概日リズム機構の出力因子であるprokineticin 2の受容体遺伝子PKR2の多型と、大うつ病性障害および双極性障害の双方との間に関連を見出した。

Research Products

• [Journal Article] Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population (2009)
  • Author(s): Kishi T, Kitajima T, Ikeda M, Yamanouchi Y et. al.
  • Journal Title: Eur Arch Psychiatry Clin Neurosci (in press)
  • Peer Reviewed
• [Journal Article] CLOCK may Predict the Response to Fluvoxamine Treatment in Japanese Major Depressive Disorder Patients (2009)
  • Author(s): Kishi T, Kitajima T, Ikeda M, Yamanouchi Y et. al.
  • Journal Title: Neuromolecular Med (in press)
  • Peer Reviewed
• [Journal Article] The orphan nuclear receptor Rev-erb alpha gene (NR1D1) and fluvoxamine response in major depressive disorder in the Japanese population (2009)
  • Author(s): Kishi T, Kitajima T, Ikeda M, Yamanouchi Y et. al.
  • Journal Title: Neuropsychobiology (in press)
  • Peer Reviewed
• [Journal Article] Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population (2009)
  • Author(s): Kishi T, Kitajima T, Tsunoka T, Ikeda M et. al.
  • Journal Title: NeuroMolecular medicine (in press)
  • Peer Reviewed
• [Journal Article] Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population (2009)
  • Author(s): Kishi T, Kitajima T, et.al.
  • Journal Title: Eur Arch Psychiatry Clin Neurosci (In press)
  • Peer Reviewed
• [Journal Article] Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population (2008)
  • Author(s): Kishi T, Kitajima T, Ikeda M, Yamanouchi Y, et. al.
  • Journal Title: Neurosci Res 62(4) Pages: 211-215
  • Peer Reviewed
• [Journal Article] Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population (2008)
  • Author(s): Kishi T, Kitajima T, et.al.
  • Journal Title: Neurosci Res 62(4) Pages: 211-5
  • Peer Reviewed
• [Journal Article] Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia (2007)
  • Author(s): Ikeda M, Ozaki N, Suzuki T, Kitajima T et.al.
  • Journal Title: Genes Brain Behav 6(1) Pages: 107-112
  • Peer Reviewed
• [Journal Article] No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population (2007)
  • Author(s): Ikeda M, Ozaki N, Yamanouchi Y, Suzuki T, Kitajima T et.al.
  • Journal Title: Schizophr Res 91(1-3) Pages: 22-26
  • Peer Reviewed
• [Journal Article] Association of SOX10 with schizophrenia in the Japanese population (2007)
  • Author(s): Maeno N, Kitajima T, Yamanouchi Y et. al.
  • Journal Title: Psychiatr Genet 17(4) Pages: 227-231
  • Peer Reviewed
• [Journal Article] 睡眠覚醒リズム障害評価尺度作成の試み (2007)
  • Author(s): 北島剛司、目片隆宏、服部美穂、奥田明子 他
  • Journal Title: 不眠研究2007 Pages: 17-24
• [Journal Article] Association of SOX10 with schizophrenia in the Japanese population (2007)
  • Author(s): Maeno N, Kitajima T, et. al.
  • Journal Title: Psychiatr Genet. 17(4) Pages: 227-31
  • Peer Reviewed
• [Journal Article] 睡眠覚醒リズム障害評価尺度作成の試み (2007)
  • Author(s): 北島剛司、目片隆宏, 他
  • Journal Title: 不眠研究2007 Pages: 17-24
• [Journal Article] No association between the glutamate decarboxylase 67 gene (GADI) and schizophrenia in the Japanese population. (2007)
  • Author(s): Ikeda M, Ozaki N, Kitajima T et al.
  • Journal Title: Schizophr Res. 91(1-3) Pages: 22-26
• [Journal Article] Possible association of beta-arrestin 2 gene with methamphetamine use disorder, but not schizophrenia. (2007)
  • Author(s): Ikeda M, Ozaki N, Kitajima T et al.
  • Journal Title: Genes Brain Behav. 6(1) Pages: 107-112
• [Journal Article] Association Study between Vesicle-Associated Membrane Protein 2 Gene Polymorphisms and Fluvoxamine Response in Japanese Major Depressive Patients (2007)
  • Author(s): Saito S, Takahashi N, Kitajima T et al.
  • Journal Title: Neuropsychobiology. 54(4) Pages: 226-230
• [Journal Article] The 2', 3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population (2006)
  • Author(s): Usui H, Takahashi N, Saito S, Ishihara R, Aoyama N, Ikeda M, Suzuki T, Kitajima et. al.
  • Journal Title: Schizophr Res 88(1-3) Pages: 245-250
  • Peer Reviewed
• [Journal Article] Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population (2006)
  • Author(s): Aoyama N, Takahashi N, Saito S, Maeno N, Ishihara R, Ji X, Miura H, Ikeda M, Suzuki T, Kitajima T, et. al.
  • Journal Title: Genes Brain Behav 5(4) Pages: 364-368
  • Peer Reviewed
• [Journal Article] Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population (2006)
  • Author(s): Takahashi N, Ishihara R, Saito S, Maemo N, Aoyama N, Ji X, Miura H, Ikeda M, Iwata N, Suzuki T, Kitajima T, et. al.
  • Journal Title: Schizophr Res 83(2-3) Pages: 179-183
  • Peer Reviewed
• [Journal Article] Association study between vesicle-associated membrane protein 2 gene polymorphisms and fluvoxamine response in Japanese major depressive patients (2006)
  • Author(s): Saito S, Takahashi N, Ishihara R, Ikeda M, Suzuki T, Kitajima T et. al.
  • Journal Title: Neuropsychobiology 54(4) Pages: 226-230
  • Peer Reviewed
• [Journal Article] The 2',3'-cyclic nucleotide 3'-phosphodiesterase and oligodendrocyte lineage transcription factor 2 genes do not appear to be associated with schizophrenia in the Japanese population. (2006)
  • Author(s): Usui H, Takahashi N, Kitajima T et al.
  • Journal Title: Schizophr Res 88(1-3) Pages: 245-250
• [Journal Article] Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. (2006)
  • Author(s): Aoyama N, Takahashi N, Kitajima T et al.
  • Journal Title: Genes Brain Behav 5(4) Pages: 364-368
• [Journal Article] Association between chromogranin A gene polymorphism and schizophrenia in the Japanese population. (2006)
  • Author(s): Takahashi N, Ishihara R, Kitajima T et al.
  • Journal Title: Schizophr Res. 83(2-3) Pages: 179-183
• [Presentation] Association study of clock gene (CLOCK) and schizophrenia in the Japanese population (2008)
  • Author(s): Kishi T, Kitajima T et.al.
  • Organizer: XVIth World Congress for Psychiatric Genetics
  • Place of Presentation: 大阪
• [Presentation] SNPs of CLOCK gene may predict the response of fluvoxamine treatment in Japanese major depressive disorder patients (2008)
  • Author(s): Kishi T, Kitajima T et.al.
  • Organizer: 第18回日本臨床精神神経薬理学会
  • Place of Presentation: 東京
• [Presentation] Association analysis of Rev-erb alpha gene (NR1D1) with the fluvoxamine therapeutic response in major depressive disorder in the Japanese population (2008)
  • Author(s): Kishi T, Kitajima T et. al.
  • Organizer: 第18回日本臨床精神神経薬理学会
  • Place of Presentation: 東京
• [Presentation] Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population (2008)
  • Author(s): Kishi T, Kitajima T et.al.
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山
• [Presentation] Association study of clock gene (CLOCK) and schizophrenia and mood disorders in the Japanese population (2008)
  • Author(s): Kishi T, Kitajima T, et.al.
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山国際会議場(富山市)
• [Presentation] SNPs of CLOCK gene may predict the response of fluvoxamine treatment in Japanese major depressive disorder patients. (2008)
  • Author(s): Kishi T, Kitajima T, et.al.
  • Organizer: 第18回日本臨床精神神経薬理学会
  • Place of Presentation: 品川プリンスホテル(東京)
• [Presentation] Association analysis of Rev-erb alpha gene (NR1D1) with the fluvoxamine therapeutic response in major depressive disorder in the Japanese population (2008)
  • Author(s): Kishi T, Kitajima T, et.al.
  • Organizer: 第18回日本臨床精神神経薬理学会
  • Place of Presentation: 品川プリンスホテル(東京)
• [Presentation] Association study of clock gene (CLOCK) and schizophrenia in the Japanese population (2008)
  • Author(s): Kishi T, Kitajima T, et.al.
  • Organizer: XVIth World Congress for Psychiatric Genetics
  • Place of Presentation: 大阪国際コンベンションセンター(大阪)
• [Presentation] No association between Nuclear Receptor Rev- erb α gene (NR1D1) and Bipolar disorder in the Japanese population (2007)
  • Author(s): 岸太郎、北島剛司 他
  • Organizer: 日本睡眠学会第32回定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-08
• [Presentation] No association between Nuclear Receptor Rev-erb α gene (NR1D1) and Bipolar disorder in the Japanese population (2007)
  • Author(s): 岸太郎、北島剛司 他
  • Organizer: 日本睡眠学会第32回定期学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-08