The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation

• Project/Area Number: 18791031
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Cerebral neurosurgery
• Research Institution: Tazuke Kofukai Medical Research Institute
• Principal Investigator: TODA Hiroki Tazuke Kofukai Medical Research Institute, 医学研究所第5研究部, 研究員 (80414118)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,680,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000); Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: 成体神経新生(adult neurogenesis) / 海馬(hippocampus) / 視床前核(anterior thalamic nucleus) / 脳深部刺激療法(deep brain stimulation) / 成体神経新生 / 脳深部刺激療法 / 視床前核 / 海馬 / 神経新生 / 深部脳刺激療法

Research Abstract

本研究は成体神経新生の制御機構における神経活動の重要性に着目し、また深部脳刺激の可変性を利用して、成体ラットを対象に定位的に視床前核を高頻度電気刺激すると海馬神経新生が増加することを示した.また海馬神経新生抑制モデルに応用すると、コルチコステロン投与により正常の約30%程度に抑制された神経新生が視床前核の高頻度電気刺激により正常の約80%まで回復することを示した.成長因子や栄養因子に頼らない神経新生を増加させる方法を開発した.

Research Products

• [Journal Article] The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation (2008)
  • Author(s): H. Toda, et. Al
  • Journal Title: Journal of Neurosurgery 108(1) Pages: 132-138
  • Peer Reviewed
• [Journal Article] The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation (2008)
  • Author(s): H.Toda,et.al
  • Journal Title: Journal of Neurosurgery 108(1) Pages: 132-138
  • Peer Reviewed
• [Journal Article] The regulation of adult rodent hippocampal neurogenesis by deep brain stimulation. (2008)
  • Author(s): Toda H, et a1.
  • Journal Title: Journal of Neurosurgery 108(1) Pages: 132-138
  • Peer Reviewed
• [Presentation] 視床前核高頻度刺激による成体ラット海馬神経新生の亢進 (2008)
  • Author(s): 戸田弘紀
  • Organizer: 第47回日本定位・機能神経外科学会
  • Place of Presentation: 浜松
  • Year and Date: 2008-01-25
• [Presentation] High frequency stimulation of the anterior thalamic nucleus increases adult hippocampal neurogenesis in rats (2007)
  • Author(s): H. Toda
  • Organizer: 2007 Society for Neuroscience Annual Meeting
  • Place of Presentation: San Diego, U. S. A
  • Year and Date: 2007-11-05
• [Presentation] High frequency stimulation of the anterior thalamic nucleus increases adult hippocampal neurogenesis in rats (2007)
  • Author(s): Toda H, et. al.
  • Organizer: 2007 Society for Neuroscience annual meeting第47回 日本定位脳/機能神経外科学会
  • Place of Presentation: San Diego, CA, USA浜松
• [Presentation] Neuromodulation restores suppressed adult hippocampal neurogenesis (2006)
  • Author(s): H. Toda
  • Organizer: 2006 American Association of Neurological Surgeons, Annual Meeting
  • Place of Presentation: San Francisco, U. S. A
  • Year and Date: 2006-04-25