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Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer

Research Project

Project/Area Number 18791141
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

YOSHINAGA Kousuke  Tohoku University, 病院, 助教授 (40343058)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,550,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsvasohibin / VEGF / VEGFR-2 / 子宮内膜癌 / 血管新生 / 血管密度 / リンパ管密度 / Vasohibin / angiogenesis / VEGF receptor II / Podoplanin / microvessel density / lymphovessel density / endometrial cancer
Research Abstract

結果として正常内膜・分化度との比較において類内膜腺癌では低分化になるほど血管新生増殖に向かっていることが客観的に明らかになり、類内膜腺癌においてVasohibinを用いた血管新生阻害治療が有効である可能性を示した。このことは論文発表しており今後は血漿中のVasohibinのELISA測定を行い、類内膜癌の腫瘍マーカーとしての可能性を検討し、将来的にはvasohibinを用いて本邦オリジナルの血管新生阻害薬の開発につなげていきたい。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (5 results)

All 2008 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer2008

    • Author(s)
      Kousuke Yoshinaga, et al
    • Journal Title

      Cancer Sci. 99

      Pages: 914-919

    • NAID

      10024005878

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer2008

    • Author(s)
      Kousuke Yoshinaga
    • Journal Title

      Cancer Science 99

      Pages: 914-9

    • NAID

      10024005878

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor, in endometrial cancer

    • Author(s)
      Kousuke Yoshinaga
    • Journal Title

      Cancer Science (In press)

    • NAID

      10024005878

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] a novel endothelium-derived angiogenesis inhibitor: its expression on endometrial carcinoma in relation to tumor vascularity2008

    • Author(s)
      Kousuke Yoshinaga. Vasohibin
    • Organizer
      98th Association of American Cancer Research
    • Place of Presentation
      Washington D,C
    • Year and Date
      2008-04-05
    • Related Report
      2008 Final Research Report
  • [Presentation] Vasohibin, a novel endothelium-derived angiogenesis inhibitor : its expression on endometrial carcinoma in relation to tumor vascularity2008

    • Author(s)
      Kousuke Yoshinaga
    • Organizer
      98th Association of American Cancer Research
    • Place of Presentation
      ワシントンD.C, USA
    • Year and Date
      2008-04-05
    • Related Report
      2008 Annual Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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