Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer

• Project/Area Number: 18791141
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Tohoku University
• Principal Investigator: YOSHINAGA Kousuke Tohoku University, 病院, 助教授 (40343058)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,550,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000); Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: vasohibin / VEGF / VEGFR-2 / 子宮内膜癌 / 血管新生 / 血管密度 / リンパ管密度 / Vasohibin / angiogenesis / VEGF receptor II / Podoplanin / microvessel density / lymphovessel density / endometrial cancer

Research Abstract

結果として正常内膜・分化度との比較において類内膜腺癌では低分化になるほど血管新生増殖に向かっていることが客観的に明らかになり、類内膜腺癌においてVasohibinを用いた血管新生阻害治療が有効である可能性を示した。このことは論文発表しており今後は血漿中のVasohibinのELISA測定を行い、類内膜癌の腫瘍マーカーとしての可能性を検討し、将来的にはvasohibinを用いて本邦オリジナルの血管新生阻害薬の開発につなげていきたい。

Research Products

• [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer (2008)
  • Author(s): Kousuke Yoshinaga, et al
  • Journal Title: Cancer Sci. 99 Pages: 914-919
  • NAID: 10024005878
  • Peer Reviewed
• [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor in endometrial cancer (2008)
  • Author(s): Kousuke Yoshinaga
  • Journal Title: Cancer Science 99 Pages: 914-9
  • NAID: 10024005878
  • Peer Reviewed
• [Journal Article] Expression of vasohibin as a novel endothelium-derived angiogenesis inhibitor, in endometrial cancer
  • Author(s): Kousuke Yoshinaga
  • Journal Title: Cancer Science (In press)
  • NAID: 10024005878
  • Peer Reviewed
• [Presentation] a novel endothelium-derived angiogenesis inhibitor: its expression on endometrial carcinoma in relation to tumor vascularity (2008)
  • Author(s): Kousuke Yoshinaga. Vasohibin
  • Organizer: 98th Association of American Cancer Research
  • Place of Presentation: Washington D,C
  • Year and Date: 2008-04-05
• [Presentation] Vasohibin, a novel endothelium-derived angiogenesis inhibitor : its expression on endometrial carcinoma in relation to tumor vascularity (2008)
  • Author(s): Kousuke Yoshinaga
  • Organizer: 98th Association of American Cancer Research
  • Place of Presentation: ワシントンD.C, USA
  • Year and Date: 2008-04-05