COX-2 expression and involvement of PGE2-synthesizing pathway in carcinogenesis of head and neck cancer

• Project/Area Number: 18791211
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Kagawa University
• Principal Investigator: GOTO Rieko Kagawa University, 医学部, 助教 (20304602)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,700,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000); Fiscal Year 2006: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: COX2 / PGE2 receptor / carcinogenesis / COX-2 / Head and Neck / carcinoma

Research Abstract

頭頸部癌ではCOX-2の過剰発現を認め、異形成でも6割に過剰発現を認めた。PGE2レセプターに関してはEP3、EP4レセプターが癌細胞において高頻度に発現を認め、COX-2ならびにPGE2産生能の異なる2種類の頭頸部癌培養細胞を用いてEP3阻害剤とEP4阻害剤の効果を検討したところ、EP3阻害剤による細胞増殖抑制効果を認めた。COX-2阻害剤と同様にEP3阻害剤は癌細胞の増殖を抑制する可能性が示唆されたが、その機序はPGE2合成経路以外の関与も考えられ、今後のさらなる検討を要する。

Research Products

• [Journal Article] Expression of prostaglandin E2 reseptors in oral squamous cell carcinomas and growth inhibitory effects of an EP3 selective antagonist, ONO-AE3-240. (2009)
  • Author(s): Hoshikawa H, Goto R, et al
  • Journal Title: International Journal of Oncology 34 Pages: 847-852
  • Peer Reviewed
• [Journal Article] Eipression of prostaglandin E2 receptors in oral squamous cell carcinomas and growth inhibitory effects of an EP3 selective antagonist, ONO-AE3-240 (2009)
  • Author(s): Hoshikawa H, Goto R, Mori T, et.al.
  • Journal Title: International Journal of Oncology 34 Pages: 847-852
  • Peer Reviewed
• [Journal Article] Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma (2008)
  • Author(s): Goto R, Hoshikawa H, Fujii T et.al
  • Journal Title: Oncology Reports 19 Pages: 645-650
  • Peer Reviewed
• [Journal Article] Clinicopathological significance of cyclooxygenase-2 expression in hypopharyngeal squamous cell carcinoma (2008)
  • Author(s): Rieko Goto
  • Journal Title: Oncology Reports 19 Pages: 645-650
  • Peer Reviewed
• [Presentation] 頭頸部扁平上皮癌に対するPG受容体の発現と選択的拮抗薬の効果 (2006)
  • Author(s): 星川広史
  • Organizer: 日本癌治療学会
  • Place of Presentation: 東京都
  • Year and Date: 2006-10-20