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The neuroprotective effects of diazoxide for the glaucoma model by NMDA and ischemia

Research Project

Project/Area Number 18791307
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionOsaka Medical College

Principal Investigator

OKUNO Takashi  Osaka Medical College, 医学部, 非常勤講師 (20411366)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,760,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2006: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywords神経保護 / 緑内障 / 網膜神経節細胞 / 視覚誘発電位 / 網膜電図 / 視神経萎縮 / ウサギ / サル / 神経節細胞 / OGD誘発細胞死 / fluorescence activated cell sorting / mitchondria KATP channel / 5-hydroxydecanoic acid / in vivo
Research Abstract

まず、in vitro研究により、ジアゾキサイド(diazoxide)はラット網膜神経節細胞由来細胞株に対し細胞死の抑制効果があり、この効果はミトコンドリア内膜に存在する ATP 感受性リウムチャンネルを介していることが確認できた。
また、経時的に測定した視覚誘発電位や眼組織標本などを用いたin vitro研究においても、NMDAによる緑内障モデルの神経障害の回復を促進させ、神経保護作用を持つことがウサギおよびサルの両者において示された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (32 results)

All 2009 2008 2007 2006 Other

All Journal Article (20 results) (of which Peer Reviewed: 17 results) Presentation (12 results)

  • [Journal Article] Shift of temporal responsivity curve of pattern reversal visually evoked potentials to lower frequencies in patients after recovery from optic neuritis2009

    • Author(s)
      Okuno T, Oku H, Sugasawa J, Utsumi T, Iked T.
    • Journal Title

      Acta Ophthalmol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral cone dystrophy in an elderly man2009

    • Author(s)
      Okuno T, Oku H, Kurimoto T, Oono S, Ikeda T.
    • Journal Title

      Clin Experiment Ophthalmol 36

      Pages: 897-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling2008

    • Author(s)
      Shimazawa M, Inokuchi Y, Okuno T, Nakajima Y, Sakaguchi G, Kato A, Oku H, Sugiyama T, Kudo T, Ikeda T, Takeda M, Hara H.
    • Journal Title

      J Neurochem 107

      Pages: 279-90

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve2008

    • Author(s)
      Oku H, Fukuhara M, Kurimoto T, Okuno T, Sugiyama T, Ikeda T.
    • Journal Title

      Curr Eye Res 33

      Pages: 611-20

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electroretinographic study of spontaneously diabetic Torii rats2008

    • Author(s)
      Okuno T, Oku H, Sugiyama T, Ikeda T.
    • Journal Title

      Doc Ophthalmol 117

      Pages: 191-6

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin-1 (ET-1) causes death of retinal neurons through activation of nitric oxide synthase (NOS) and production of superoxide anion2008

    • Author(s)
      Oku H, Fukuhara M, Komori A, Okuno T, Sugiyama T, Ikeda T.
    • Journal Title

      Exp Eye Res 86

      Pages: 118-30

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electroretinographic study of spontaneously diabetic Torii rats2008

    • Author(s)
      Takashi Okuno
    • Journal Title

      Doc Ophthalmol 117

      Pages: 191-196

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin-1 (ET-1) is increased in rat retina after crushing optic nerve2008

    • Author(s)
      Hidehiro Oku
    • Journal Title

      Curr Eye Res 33

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling2008

    • Author(s)
      Masamitsu Simazawa
    • Journal Title

      J Neurochem 107

      Pages: 279-290

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin-l (ET-1) causes death of retinal neurons through activation of nitric oxide synthase (NOS) and production of superoxide anion2008

    • Author(s)
      Hidehiro Oku
    • Journal Title

      Exp Eye Res 86

      Pages: 118-130

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes2007

    • Author(s)
      Sugiyama T, Okuno T, Fukuhara M, Oku H, Ikeda T, Obayashi H, Ohta M, Fukui M, Hasegawa G, Nakamura N.
    • Journal Title

      Exp Eye Res 85

      Pages: 406-12

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] High infusion pressure in conjunction with vitreous surgery alters the morphology and function of the retina of rabbits2007

    • Author(s)
      Minami M, Oku H, Okuno T, Fukuhara M, Ikeda T.
    • Journal Title

      Acta Ophthalmol Scand 85

      Pages: 633-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type2 diabetes2007

    • Author(s)
      Tetsuya Sugiyama
    • Journal Title

      Exp Eye Res. 85

      Pages: 406-412

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormalities of visual-evoked potentials and pupillary light reflexes in a family with autosomal dominant occult macular dystrophy.2007

    • Author(s)
      Takashi Okuno
    • Journal Title

      Clin Experiment Ophthalmol 35

      Pages: 781-783

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutamate level in optic nerve head is increased by artificial elevation of intraocular pressure in rabbits2006

    • Author(s)
      Okuno T, Oku H, Sugiyama T, Ikeda T.
    • Journal Title

      Exp Eye Res 82

      Pages: 465-70

    • NAID

      10018257119

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormalities of visual-evoked potentials and pupillary light reflexes in a family with autosomal dominant occult macular dystrophy2006

    • Author(s)
      Okuno T, Oku H, Kondo M, Miyake Y, Sugasawa J, Utsumi T, Ikeda T.
    • Journal Title

      Clin ExperimentOphthalmol 35

      Pages: 781-3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ocular blood flow changes after dynamic exercise in humans2006

    • Author(s)
      Okuno T, Sugiyama T, Kohyama M, Kojima S, Oku H, Ikeda T.
    • Journal Title

      Eye 20

      Pages: 796-800

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glutamate level in optic nerve head is increased by artificial elevation of intraocular pressure in rabbits.2006

    • Author(s)
      Takashi Okuno
    • Journal Title

      Exp Eye Res. 82(3)

      Pages: 465-470

    • NAID

      10018257119

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Ocular blood flow changes after dynamic exercise in humans2006

    • Author(s)
      Takashi Okuno
    • Journal Title

      Eye 20(7)

      Pages: 796-800

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High infusion pressure in conjunction with vitreous surgery alters the morphology and function of the retina of rabbits

    • Author(s)
      Masahiro Minami
    • Journal Title

      Acta Ophthalmol Scand. (in press)

    • Related Report
      2006 Annual Research Report
  • [Presentation] 低酸素状態における一酸化窒素の神経毒性2009

    • Author(s)
      奥英弘、福原雅之、奥野高司、勝村浩三、松尾純子、小嶌祥太、杉山哲也、池田恒彦
    • Organizer
      第112回日本眼科学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 視神経乳頭循環自動調節能に対するグリア細胞の関与2009

    • Author(s)
      柴田真帆,杉山哲也,奥英弘,奥野高司,小林正人,平尾真美,池田恒彦
    • Organizer
      第112回日本眼科学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 最終糖化産物(AGE)による網膜周皮細胞死に対するスタチンの抑制効果2009

    • Author(s)
      松尾純子、奥英弘、勝村ちひろ、杉山哲也、神原裕子、小林崇俊、福原雅之、奥野高司、池田恒彦
    • Organizer
      第112回日本眼科学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 網膜神経節細胞株(RGC-5)に対するスタチンの神経保護作用の検討2008

    • Author(s)
      奥英弘,勝村浩三,松尾純子,奥野高司,小林崇俊,小嶌祥太,福原雅之,杉山哲也,池田恒彦
    • Organizer
      第112回日本眼科学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] アミロイドβ蛋白質の網膜機能および細胞死に対する影響2008

    • Author(s)
      嶋澤雅光,井口勇太,奥野高司,坂口岳,加藤晃,奥英弘,杉山哲也,工藤喬,池田恒彦,武田雅俊,原英彰
    • Organizer
      第112回日本眼科学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] SDTラットの網膜電図に対するアンジオテンシンII受容体拮抗薬の効果2007

    • Author(s)
      奥野高司,奥英弘,杉山哲也,小森麻子,池田恒彦
    • Organizer
      第55回日本臨床視覚電気生理学会
    • Place of Presentation
      名古屋
    • Year and Date
      2007-11-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Involvement of Amyloid-β in Retinal Function2007

    • Author(s)
      Shimazawa M, Inokuchi Y, Okuno T, Sakaguchi G, Kato A, Sugiyama T, Kudo T, Ikeda T, Takeda M, Hara H.
    • Organizer
      79th Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Florida, USA.
    • Related Report
      2008 Final Research Report
  • [Presentation] Endothelin-1 (ET-1) Causes Death of Retinal Neurons Through Activation of Nitric Oxide Synthase (NOS) and Production of Superoxide Anion2007

    • Author(s)
      Oku H, Fukuhara M, Komori A, Okuno T, Sugiyama T, Ikeda T.
    • Organizer
      79th Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Florida, USA.
    • Related Report
      2008 Final Research Report
  • [Presentation] ラット視神経挫滅モデルにおける網膜内エンドセリン-1の変化2007

    • Author(s)
      奥野高司,奥英弘,福原雅之,杉山哲也,池田恒彦
    • Organizer
      第111回日本眼科学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] NMDA 誘発網膜内層障害に対するミトコンドリア内膜カリウムチャネル開口薬の効果2007

    • Author(s)
      奥野高司,奥英弘,杉山哲也,小森麻子,池田恒彦
    • Organizer
      第110回日本眼科学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] SDTラット眼内・蛋白糖化最終産物に対するアンジオテンシンII受容体拮薬の作用2007

    • Author(s)
      杉山哲也,奥野高司,福原雅之,小森麻子,奥英弘,池田恒彦,太田光煕,尾林博
    • Organizer
      第110回日本眼科学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] Temporal frequency changes in the pattern reversal visual evoked potential (PVEP) amplitude in optic neuritis2006

    • Author(s)
      Okuno T, Oku H, Sugasawa J, Utsumi T, Ikeda T.
    • Organizer
      16th International Neuron-Ophthalmology Society (INOS) Congress
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2008 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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