Development of new adhesive methods to reduce hydrolysis of dentin collagen

• Project/Area Number: 18791401
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Okayama University
• Principal Investigator: NISHITANI Yoshihiro Okayama University, 大学院・医歯薬学総合研究科, 准教授 (60325123)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,740,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥600,000 (Direct Cost: ¥600,000); Fiscal Year 2006: ¥2,100,000 (Direct Cost: ¥2,100,000)
• Keywords: 保存修復学 / 接着歯学 / 象牙質 / 象牙質接着 / 象牙質コラーゲン / 加水分解

Research Abstract

保存修復治療が再治療となる原因の一つと考えられる象牙質コラーゲンの加水分解を最小にする接着システムは,コラーゲン分解酵素の活性値および接着耐久性の観点から判断して,疎水的なモノマーで構成されることである.しかしながら,疎水的な接着システムは初期の接着強さが低下することから,歯面処理にエタノールウェット法を応用することが求められる.

Research Products

• [Journal Article] Durability of resin-dentin bonds to water-vs. ethanol-saturated dentin (2009)
  • Author(s): Hosaka K, Nishitani Y, Tagami J, Yoshiyama M, Brackett WW, Agee KA, Tay FR, Pashley DH.
  • Journal Title: J Dent Res 88(2) Pages: 146-51
  • Peer Reviewed
• [Journal Article] Durability of resin-dentin bonds to water-vs. ethanol-saturated dentin (2009)
  • Author(s): Hosaka K
  • Journal Title: Journal of Dental Research 88(2) Pages: 146-151
  • Peer Reviewed
• [Journal Article] ワンボトルセルフエッチングシステムの脱灰および再石灰化象牙質に対する接着 (2009)
  • Author(s): 田中久美子
  • Journal Title: 日本歯科保存学会誌 52(1) Pages: 94-102
  • Peer Reviewed
• [Journal Article] 象牙質接着におけるレジンの親水性の影響 (2008)
  • Author(s): 西谷佳浩
  • Journal Title: 接着歯学 26(2) Pages: 92-98
  • NAID: 10020294795
  • Peer Reviewed
• [Journal Article] ワンボトルボンディング材"アブソリュート2"を用いた汚染歯質に対する接着 (2008)
  • Author(s): 高橋圭
  • Journal Title: 接着歯学 26(2) Pages: 99-105
  • Peer Reviewed
• [Journal Article] セルフアドヒーシブルーティングセメントの練和方法がセラミックスとの接着強さに及ぼす影響 (2008)
  • Author(s): 阿保備子
  • Journal Title: 接着歯学 26(2) Pages: 106-111
  • Peer Reviewed
• [Journal Article] Water sorption and solubility of methacrylate resin-based root canal sealers. (2007)
  • Author(s): sealers.,Donnelly A, Sword J, Nishitani Y, Yoshiyama M, Agee K, Tay FR, Pashley DH.
  • Journal Title: J Endod. 33(8) Pages: 990-4
  • Peer Reviewed
• [Journal Article] Use of Hoy's solubility parameters to predict water sorption/solubility of experimental primers and adhesives (2007)
  • Author(s): Nishitani Y, Yoshiyama M, Hosaka K, Tagami J, Donnelly A, Carrilho M, Tay FR, Pashley DH.
  • Journal Title: Eur J Oral Sci 115(1) Pages: 81-6
  • Peer Reviewed
• [Journal Article] Effects of resin hydrophilicity on dentin bond strength. (2007)
  • Author(s): Nishitani Y, Yoshiyama M, Donnelly AM, Agee KA, Sword J, Tay FR, Pashley DH.
  • Journal Title: Eur J Oral Sci 115(1) Pages: 81-6
  • Peer Reviewed
• [Journal Article] Effect of wet vs. dry testing on the mechanical properties of hydrophilic self-etching primer polymers (2007)
  • Author(s): Hosaka Keiichi, et. al.
  • Journal Title: European Journal of Oral Sciences 115 Pages: 239-245
  • Peer Reviewed
• [Journal Article] Water sorption and solubility of methacrylate resin-based root canal sealers (2007)
  • Author(s): Donnely Adam, et. al.
  • Journal Title: Journal of Endodontics 33 Pages: 990-994
  • Peer Reviewed
• [Journal Article] Dentine sealing provided by smear layer/smear plugs vs. adhesive resins/resin tags (2007)
  • Author(s): Carrilho Marcela, et. al.
  • Journal Title: European Journal of Oral Sciences 115 Pages: 321-329
  • Peer Reviewed
• [Journal Article] Use of Hoy's solubility parameters to predict water sorption/solubility of experimental primers and adhesives (2007)
  • Author(s): Nishitani Yoshihiro
  • Journal Title: European Journal of Oral Sciences 115 Pages: 81-86
• [Journal Article] Effects of resin hydrophilicity on dentin bond strength. (2006)
  • Author(s): Nishitani Y, Yoshiyama M, Donnelly AM, Agee KA, Sword J, Tay FR, Pashley DH.
  • Journal Title: J Dent Res. 85(11) Pages: 1016-21
  • Peer Reviewed
• [Journal Article] Activation of gelatinolytic/collagenolytic activity in dentin by self-etching adhesives (2006)
  • Author(s): Nishitani Yoshihiro
  • Journal Title: European Journal of Oral Sciences 114 Pages: 160-166
• [Journal Article] Effects of resin hydrophilicity on dentin bond strength (2006)
  • Author(s): Nishitani Yoshihiro
  • Journal Title: Journal of Dental Research 85(11) Pages: 1016-1021
• [Journal Article] セルフエッチングプライマーによる象牙質中のゼラチン分解酵素の活性化 (2006)
  • Author(s): 西谷佳浩
  • Journal Title: 歯科材料・器械 25(5) Pages: 381-381
  • NAID: 130006963244
• [Journal Article] 象牙質接着におけるレジンの親水性の影響 (2006)
  • Author(s): 西谷佳浩
  • Journal Title: 日夲歯科保存学会雑誌 49秋季特別号 Pages: 14-14
  • NAID: 10020294795
• [Presentation] 新規PMMA系レジンセメントのサーマルサイクル負荷後の象牙質接着強さ (2009)
  • Author(s): 中田貴
  • Organizer: 日本接着歯学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-02-22
• [Presentation] 再石灰化象牙質に対するワンステップ接着システムの接着性 (2009)
  • Author(s): 田中久美子
  • Organizer: 日本接着歯学会
  • Place of Presentation: 仙台
  • Year and Date: 2009-02-21
• [Presentation] Effects of eccentric vs concentric specimen attachment on micro-tensile bond strengths using 1 step self-etching adhesive (2008)
  • Author(s): Nishitani Y
  • Organizer: The 3rd International Congress on Adhesive Dentistry
  • Place of Presentation: Xian, China
  • Year and Date: 2008-09-26
• [Presentation] Effects of incorporating chlorhexidine into all-in-one adhesives (2008)
  • Author(s): Nishitani Y
  • Organizer: 86th International Association for Dental Research
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2008-07-03
• [Presentation] Er : YAGレーザー照射象牙質の元素解析に関する研究 (2008)
  • Author(s): 大前正範
  • Organizer: 日本歯科保存学会
  • Place of Presentation: 新潟
  • Year and Date: 2008-06-06
• [Presentation] 各種処理剤を塗布した歯面への接着 (2008)
  • Author(s): 坂本朝美
  • Organizer: 日本歯科保存学会
  • Place of Presentation: 新潟
  • Year and Date: 2008-06-06
• [Presentation] 新規PMMA系レジンセメントのサーマルサイクル後の象牙質接着強さ (2008)
  • Author(s): 林真千子
  • Organizer: 日本歯科保存学会
  • Place of Presentation: 新潟
  • Year and Date: 2008-06-05
• [Presentation] Durability of Resins Bonded to Water Vs. Ethanol-Saturated Acid-Etched Dentin (2008)
  • Author(s): Pashley D
  • Organizer: 37th American Association for Dental Research
  • Place of Presentation: Dallas, USA
  • Year and Date: 2008-04-03
• [Presentation] Effects of Incorporating into Chlorhexidine Self-etching Primers (2007)
  • Author(s): Nishitani Y
  • Organizer: Proceedings of the International Dental Materials Congress 2007
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2007-11-23
• [Presentation] Effects of Incorporating into Chlorhexidine Self-etching Primers (2007)
  • Author(s): Nishitani Yishihiro, et. al.
  • Organizer: Proceedings of the International Dental Materials Congress 2007
  • Place of Presentation: バンコク
  • Year and Date: 2007-11-23
• [Presentation] 象牙質接着におけるレジンの親水性の影響 (2006)
  • Author(s): 西谷佳浩
  • Organizer: 第125回日本歯科保存学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2006-11-09
• [Presentation] セルフエッチングプライマーによる象牙質中のゼラチン分解酵素の活性化 (2006)
  • Author(s): 西谷佳浩
  • Organizer: 第48回日本歯科理工学会
  • Place of Presentation: 名古屋
  • Year and Date: 2006-10-28