• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Basic research of molecular therapy for oral squamous cell carcinomawith geldanamysin

Research Project

Project/Area Number 18791508
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionNagasaki University

Principal Investigator

SHINICHI Yamada  Nagasaki University, 大学院・医歯薬学総合研究科, 助教 (50380853)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,760,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2006: ¥900,000 (Direct Cost: ¥900,000)
Keywords分子シャペロン / actinin4 / EMS1 / siRNA / 浸潤能 / 増殖能 / RNAi / HSP90 / 熱ショックタンパク質
Research Abstract

口腔癌において予後を左右する因子とし癌細胞の転移・浸潤が大きな因子の一つとして挙げられる。この転移・浸潤に関して足場蛋白として種々の癌腫において発現し予後と相関すると報告されているα-actinin-4、EMS1について病理組織学的因子との関連、細胞生物学的特性について検討した。その結果、前者は浸潤型と、後者は腫瘍サイズ、所属リンパ節転移、浸潤型と相関し、また、各についてsiRNAにより浸潤能の低下がみられ、分子標的治療のターゲットに成りうることが示唆された。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (13 results)

All 2008 2007 2006

All Journal Article (9 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Overexpression of metastasis-associated MTA1 in oral squamous cell carcinomas : correlation with metastasis and invasion2008

    • Author(s)
      Kawasaki, G.
    • Journal Title

      International Journal of Oral and Maxillof acial Surgeruy 37

      Pages: 1039-1046

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronous double basal cell adenoma of the parotid gland : report of-a case2008

    • Author(s)
      Yamada, S.
    • Journal Title

      Oral Medicine & Pathology 13

      Pages: 21-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Giant Cell Fibroma of the Buccal Mucosa:A Case Report.2007

    • Author(s)
      Shin-ichi Yamada
    • Journal Title

      日本口腔診断学会雑誌 20(2)

      Pages: 444-447

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Articular Eminectomy for Chronic Bilateral Dislocation of the Temporomandibular Joint in Patients with Cerebral Infarction.2007

    • Author(s)
      Shin-ichi Yamada
    • Journal Title

      Asian Journal of Oral and Maxillofacial Sur gery 19(1)

      Pages: 48-53

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intraductal Papilloma of the Buccal Mucosa: A case report.2007

    • Author(s)
      Shin-ichi Yamada
    • Journal Title

      Asian Journal of Oral and Maxillofacial Sur gery 19(2)

      Pages: 113-117

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 顎矯正手術症例の臨床統計的検討2006

    • Author(s)
      山田慎一
    • Journal Title

      日本口腔診断学会雑誌 19(2)

      Pages: 213-219

    • NAID

      10025564343

    • Related Report
      2006 Annual Research Report
  • [Journal Article] High-grade Papillary Cystadenocarcinoma of the sublingual gland : A case report.2006

    • Author(s)
      Shin-ichi Yamada
    • Journal Title

      Journal of Oral and Maxillofacial Surgery. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Intraductal Papilloma of the Buccal Mucosa : A case report.2006

    • Author(s)
      Shin-ichi Yamada
    • Journal Title

      Asian Journai of Oral and Maxilloiacial Surgery. (in press)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] 下顎歯肉腺様扁平上皮癌と食道扁平上皮癌の同時性重複癌の一例2006

    • Author(s)
      山田慎一
    • Journal Title

      日本口腔外科学会雑誌 (in press)

    • NAID

      10018858419

    • Related Report
      2006 Annual Research Report
  • [Presentation] 口腔扁平上皮癌におけるactinin4の発現の意義2008

    • Author(s)
      山田慎一,柳本惣市,川崎五郎,吉冨泉,水野明夫
    • Organizer
      第62回日本口腔科学会学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] エナメル上皮種の臨床統計的ならびに病理組織学的検討2007

    • Author(s)
      山田慎一
    • Organizer
      第61回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      神戸市
    • Year and Date
      2007-03-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] Aminoacid substitutions observed in human Hsp90 isoforms that impede the dimeric interaction2007

    • Author(s)
      Nemoto, T. K., Kobayakawa, T., Ono, T., Yamada, S., Mizuno, A., Baba, T., Ohara-Nemoto, Y.
    • Organizer
      2nd World Conference of Stress, including 3rd Cell Stress Society International Congress on Stress Responses in Biology and Medicine
    • Place of Presentation
      Budapest, Hungry
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒトhsp90αSNP Glu488>His変異によるHsp90ダイマー形成能の低下2007

    • Author(s)
      小早川健,山田慎一,根本優子,水野野明夫,根本孝幸
    • Organizer
      第30回日本分子生物学会総会,第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜市
    • Related Report
      2008 Final Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi