Studies on analysis of oxidative stress in the temporomandibular joint with TMDs

• Project/Area Number: 18791527
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: KAWAI Yoshiaki Kanagawa Dental College, 顎顔面外科学講座, 助教 (00333154)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,670,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000); Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 顎関節症 / 滑液 / 活性酸素 / ESR / Bioredox / NO / hydroxylradical / SOD / X-band ESR / desferrioxamine / L-band ESR / hydroxyl radical / bio-redox / パンピングマニピュレーション / NO^・

Research Abstract

顎関節症発症における病態メカニズムの一つとしての活性酸素(フリーラジカル)は,健常者においても常に存在し,生理学的に重要な分子としてその恒常性を維持している.しかし炎症に起因した結果に出現する活性酸素種が多く出現することにより生理機能として維持していた活性酸素を組織障害性の強い活性酸素に変化させ,その症状を増強すると考えられた.そして,これまで仮説として示されているメカニカルストレスに起因する虚血再灌流障害は活性酸素の誘発を助長する結果とはならないことが示唆された.

Research Products

• [Journal Article] Reactive oxygen species (ROS) and reactive nitrogen species (RNS) in synovial fluid of Temporomandibular disease patient (2008)
  • Author(s): Kawai, Y., Tajima, D., Yoshino, F., Takahashi, S., Lee, MC. and Kubota, E
  • Journal Title: Bull Kanagawa Dent Col 36 Pages: 93-96
• [Journal Article] Oxidative Stress and Temporomandibular Joint Disorders (2008)
  • Author(s): Kawai, Y., Lee, MC. and Kubota, E
  • Journal Title: JDSR 44 Pages: 145-150
  • NAID: 10023923265
  • Peer Reviewed
• [Journal Article] Noninvasive measurement of oxidative stress in experimentally induced arthritis of the temporomandibular joint in vivo ESR system (2008)
  • Author(s): Tajima, D., Kawai, Y., Shoji, H., Lee, MC. and Kubota, E
  • Journal Title: Bull Kanagawa Dent Col 36 Pages: 47-53
  • Peer Reviewed
• [Journal Article] Reactive oxygen species (ROS) and reactive nitrogen species (RNS) in synovial fluid of Temporomandibular disease patient (2008)
  • Author(s): Kawai, Y
  • Journal Title: Bull Kanagawa Dent Col 36 Pages: 93-96
  • Peer Reviewed
• [Journal Article] Oxidative Stress and Temporomandibular Joint Disorders (2008)
  • Author(s): Kawai, Y
  • Journal Title: JDSR 44 Pages: 145-150
  • NAID: 10023923265
  • Peer Reviewed
• [Journal Article] Noninvasive measurement of oxidative stress in experimentally induced arthritis of the temporomandibular joint in vivo ESR system (2008)
  • Author(s): Tajima, D
  • Journal Title: Bull Kanagawa Dent Col 36 Pages: 457-461
  • Peer Reviewed
• [Presentation] 顎関節症患者滑液中のRedox反応の解析 (2007)
  • Author(s): 田島大太郎,河合良明,吉野文彦,高橋俊介,李昌一,久保田英朗
  • Organizer: 神奈川歯大学学会総会
  • Year and Date: 2007-12-08
• [Presentation] 顎関節症患者滑液中のRedox反応の解析 (2007)
  • Author(s): 田島大太郎, 河合良明, 吉野文彦, 高橋俊介, 李 昌一, 久保田英朗
  • Organizer: 神奈川歯科大学総会
  • Place of Presentation: 神奈川歯科大学
  • Year and Date: 2007-12-08