Establishment of consomic mice to clarify host susceptibility to caries

• Project/Area Number: 18791567
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Nihon University
• Principal Investigator: SHIMIZU Kunihiko Nihon University, 松戸歯学部, 講師 (30328760)
• Project Period (FY): 2006 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,470,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000); Fiscal Year 2006: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: 実験動物 / マウス / コンソミックマウス / 第2番染色体 / う蝕 / C57BL / 6 / C3H / 齲蝕

Research Abstract

C57BL/6系統(齲蝕高感受性マウス)由来の全染色体のうち第2番染色体をC3H/He系統(齲蝕低感受性マウス)に置き換えたコンソミックマウスB6-Chr.2C3Hの作成を行った。マウスの兄妹交配と第2番染色体の組み換え状態の確認を12世代まで行い,この世代の兄妹交配によりコンソミックマウスB6-Chr.2C3Hを得たことにより,マウス第2番染色体に存在する齲蝕発症に関わる原因遺伝子の解明が可能となった。

Research Products

• [Journal Article] Establishment of consomic mice to clarify host susceptibility to caries (2009)
  • Author(s): Makoto Nomi, Kunihiko Shimizu
  • Journal Title: Pediatric Dental Journal 19
  • NAID: 10027484721
  • Peer Reviewed
• [Presentation] Establishment of comsomic mice to clarify host susceptibility to caries (2008)
  • Author(s): Makoto Nomi, Kunihiko Shimizu, Daisuke Orino, Atsuko Nagata, Nana Ikematsu, Wataru Morita, Takahide Maeda
  • Organizer: Internal association for dental research
  • Place of Presentation: Toronto Canada.
• [Presentation] Establishment of comsomic mice to clarify host susceptibility to caries (2008)
  • Author(s): Makoto Nomi
  • Organizer: Internal association for dental research
  • Place of Presentation: Tront Canada