Function of Vascular Endothelial Growth Factor in inflammatory exacerbation

Research Project

Project/Area Number	18791599
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Periodontal dentistry
Research Institution	Kagoshima University
Principal Investigator	SHINO Kumiko Kagoshima University, 医学部・歯学部附属病院, 助教 (50325792)
Project Period (FY)	2006 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥540,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000) Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords	歯周病 / シグナル伝達 / 生体分子 / 歯学 / 細胞・組織 / 生理活性
Research Abstract	VEGF-A_<121> induced activations of pro-MMP-9, pro-MMP-2, active-MMP-2 dose dependently in Human gingival fibroblast. The other side, VEGF-A 165 has no activation of them. From these results, VEGF-A_<121> may relate to periodontal inflammatory exacerbation. But in this study, VEGF doesn't show uPA up-regulation. Therefore, it suggested that activations of pro-MMP-9, pro-MMP-2, active-MMP-2 by VEGF-A_<121> relate to periodontal inflammatory exacerbation.

Report

(4 results)