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Function of Vascular Endothelial Growth Factor in inflammatory exacerbation

Research Project

Project/Area Number 18791599
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionKagoshima University

Principal Investigator

SHINO Kumiko  Kagoshima University, 医学部・歯学部附属病院, 助教 (50325792)

Project Period (FY) 2006 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥540,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2006: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords歯周病 / シグナル伝達 / 生体分子 / 歯学 / 細胞・組織 / 生理活性
Research Abstract

VEGF-A_<121> induced activations of pro-MMP-9, pro-MMP-2, active-MMP-2 dose dependently in Human gingival fibroblast. The other side, VEGF-A 165 has no activation of them. From these results, VEGF-A_<121> may relate to periodontal inflammatory exacerbation. But in this study, VEGF doesn't show uPA up-regulation. Therefore, it suggested that activations of pro-MMP-9, pro-MMP-2, active-MMP-2 by VEGF-A_<121> relate to periodontal inflammatory exacerbation.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (1 results)

All 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] ITの活用と導線の工夫などによる客観的臨床能力試験(OSCE)の新たな人的資源削減の試みとその効果2007

    • Author(s)
      宮脇正一、小椋幹記、瀬戸口尚志、小山徹、西原一秀、吉田礼子、坂口勝義、田畑純、五月女さき子、石神哲郎、川島清美、佐藤強志、重田浩樹、西恭宏、徳田雅行、志野久美子、鳥居光男、西川殷維
    • Journal Title

      日歯教誌 23

      Pages: 154-60

    • Related Report
      2009 Final Research Report
    • Peer Reviewed

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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