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An analysis of age-related changes in the structure, cell dynamics and neuroepithelial regeneration of olfactory mucosa

Research Project

Project/Area Number 18799002
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

KONDO Kenji  The University of Tokyo, 医学部附属病院, 講師 (40334370)

Project Period (FY) 2006 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2006: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords嗅神経細胞 / 加齢変化 / 再生 / 老化 / 免疫組織化学
Research Abstract

マウス嗅上皮における変性部位の割合は加齢に伴って増加し、また高度変性部位の割合も増加した。また上皮下のBowman腺の形態異常も加齢に従って増加し、特に嗅上皮の変性部位の上皮下に高頻度で認められた。生理的加齢に伴って基底細胞の増殖と嗅上皮のアポトーシスの頻度はともに減少したが、前駆細胞から成熟嗅神経細胞に分化するまでの時間経過はほぼ一定であった。さらに嗅上皮傷害モデルマウスの解析では嗅上皮の再生能力が加齢変化とともに低下し、これは細胞の分化過程の遅延ではなく前駆細胞の増殖能の低下による可能性が高いと考えられた。

Report

(4 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (24 results)

All 2009 2008 2007 2006

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (10 results) Book (1 results)

  • [Journal Article] Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa : age-related progression2009

    • Author(s)
      Kondo K, Watanabe K, Sakamoto T, Suzukawa K, Nibu K, Kaga K, Yamasoba T
    • Journal Title

      Cell Tissue Res 335

      Pages: 489-503

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and severity of spontaneous lesions in the neuroepithelium and Bowman's glands in mouse olfactory mucosa : age-related progression2009

    • Author(s)
      Kondo K, Watanabe K, S akamoto T, et.al.
    • Journal Title

      Cell Tissue Res 355

      Pages: 489-503

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified nasal specula and flexible holder for endoscopic nasal surgery2008

    • Author(s)
      Ushio M, Nakaya M, Kondo K, Suzuki M, Yamasoba T.
    • Journal Title

      Laryngoscope 118

      Pages: 1293-4

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical study of m1-m5 muscarinic receptors and nNOS in human inferior turbinate mucosa2007

    • Author(s)
      Nakaya M. Kondo K, Kaga K
    • Journal Title

      Acta Otolaryngol Suppl 559

      Pages: 103-7

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related change of the axonal diameter of the olfactory nerve in mouse lamina propria2007

    • Author(s)
      Watanabe K, Kondo K, Yamasoba T, Kaga K
    • Journal Title

      Acta Otolaryngol Suppl 559

      Pages: 108-112

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Musashi-1 expression in the postnatal mouse olfactory epithelium2007

    • Author(s)
      Watanabe K, Kondo K, Takeuchi N, Okano H, Yamasoba T
    • Journal Title

      Neuroreport 18

      Pages: 641-644

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methimazole-induced cell death in rat olfactory receptor neurons occurs via apoptosis triggered through mitochondrial cytochrome c-mediated caspase-3 activation pathway2007

    • Author(s)
      Sakamoto T, Kondo K, Kashio A, Suzukawa K, Yamasoba K
    • Journal Title

      J Neurosci Res 85

      Pages: 548-557

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical study of m1-m5 muscarinic receptors and nNos in human inferior turbinate mucosa2007

    • Author(s)
      Nakaya M, Kondo K, Kaga K
    • Journal Title

      Acta Otolaryngol supplemet559

      Pages: 103-107

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related change of the axonal diameter of the olfactory nerve in mouse lamina propria2007

    • Author(s)
      Watanabe K, Kondo K, Yamasoba T, Kaga K
    • Journal Title

      Acta Otolaryngol supplemet559

      Pages: 108-112

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methimazole-induced cell death in rat olfactory receptor neurons occurs via apoptosis triggered through mitochondrial cytochrome c-mediated caspase-3 activation pathway2007

    • Author(s)
      Sakamoto T, Kondo K, Kashio A, Suzukawa K, Yamasoba T
    • Journal Title

      Journal of Neuroscience Research 85

      Pages: 548-557

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Age-related changes in cell density and the proliferation rate of olfactory ensheathing cells in the lamina propria of postnatal mouse olfactory mucosa2006

    • Author(s)
      Watanabe K, Kondo K, Takeuchi N, Nibu K, Kaga K.
    • Journal Title

      Brain Res 1116

      Pages: 82-92

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo2006

    • Author(s)
      Yamasoba T, Kondo K
    • Journal Title

      Cell Tissue Res 325

      Pages: 23-31

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-related changes in cell density and the proliferation rate of olfactory ensheathing cells in the lamina propria of postnatal mouse olfactory mucosa2006

    • Author(s)
      Watanabe K, Kondo K, Takeuchi N, Nibu K, Kaga K
    • Journal Title

      Brain Research 1116

      Pages: 82-92

    • Related Report
      2006 Annual Research Report
  • [Presentation] 加齢による嗅覚障害の特徴2008

    • Author(s)
      近藤健二
    • Organizer
      感覚器シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-03-07
    • Related Report
      2008 Final Research Report
  • [Presentation] 加齢マウスの嗅上皮変性部位の上皮下にみられるBowman腺の変化2008

    • Author(s)
      近藤健二、渡辺健太、坂本幸士、鈴川圭吾、山岨達也
    • Organizer
      第109回日本耳鼻咽喉科学会
    • Place of Presentation
      大阪
    • Related Report
      2008 Final Research Report
  • [Presentation] 加齢マウスの嗅上皮変性部位の上皮下にみられるBowman腺の変化2008

    • Author(s)
      近藤健二、渡辺健太、坂本幸士、鈴川佳吾、丹生健一、山岨達也
    • Organizer
      日本味と匂い学会
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report
  • [Presentation] 嗅粘膜における性ホルモン受容体の発現と分布に関する免疫組織学的検討2008

    • Author(s)
      近藤健二、鈴川佳吾、金谷佳織、坂本幸士、渡辺健太、山岨達也
    • Organizer
      第47回日本鼻科学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 加齢マウスの嗅上皮変性部位の上皮下にみられるBowman腺の変化2008

    • Author(s)
      近藤健二・渡辺健太・坂本幸士・鈴川佳吾・山岨達也
    • Organizer
      日本耳鼻咽喉科学会学術講演会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 加齢マウスの嗅上皮変性部位の上皮下にみられるBowman腺の変化2008

    • Author(s)
      近藤健二・渡辺健太・坂本幸士・鈴川佳吾・丹生健一・山岨達也
    • Organizer
      日本味と匂学会
    • Place of Presentation
      富山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 嗅粘膜における性ホルモン受容体の発現と分布に関する免疫組織学的検討2008

    • Author(s)
      近藤健二・鈴川佳吾・金谷佳織・坂本幸士・渡辺健太・山岨達也
    • Organizer
      日本鼻科学会
    • Place of Presentation
      名古屋
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生理的加齢変化により進行するマウス嗅上皮の変性2007

    • Author(s)
      近藤健二、渡辺健太、丹生健一、山岨達也
    • Organizer
      第108回日本耳鼻咽喉科学会
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] 加齢マウスの嗅上皮変性部位の上皮下に見られるBowman腺の変化2007

    • Author(s)
      近藤健二、渡辺健太、鈴川佳吾、山岨達也
    • Organizer
      第46回日本鼻科学会
    • Place of Presentation
      宇都宮
    • Related Report
      2008 Final Research Report
  • [Presentation] マウス嗅上皮の基底細胞から成熟嗅神経細胞への分化過程及び分化速度の解析:生理的加齢変化における検討2006

    • Author(s)
      近藤健二、丹生健一、竹内直信
    • Organizer
      第45回日本鼻科学会
    • Place of Presentation
      三重
    • Related Report
      2008 Final Research Report
  • [Book] 嗅覚とアンチエイジング.アンチエイジング医学の基礎と臨床2008

    • Author(s)
      近藤健二
    • Publisher
      MEDICALVIEW
    • Related Report
      2008 Final Research Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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