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Subcortical processing of visual fear stimuli in the common marmoset

Research Project

Project/Area Number 18F18105
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Research Field Neurophysiology / General neuroscience
Research InstitutionKyoto University

Principal Investigator

伊佐 正  京都大学, 医学研究科, 教授 (20212805)

Co-Investigator(Kenkyū-buntansha) CHEN CHIH-YANG  京都大学, 医学(系)研究科(研究院), 外国人特別研究員
Project Period (FY) 2018-04-25 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2019: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2018: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsmarmoset / innate fear / amygdala / superior colliculus / pupillometry / eye movement
Outline of Annual Research Achievements

I have finished my JSPS fellow and am grateful that JSPS gave me such a good opportunity with funding to support my research. I have achieved several important milestones regarding my research. First, I have recorded eye movements from head-restrained marmosets while they were viewing fearful and non-fearful pictures. It was clear that they spent more time looking at the fearful pictures. I have also successfully tested several different 3D printed implants on the marmosets. Furthermore, I have trained the marmosets with saccade tasks and I am currently writing a manuscript on the results. As a side product, I have also successfully performed microstimulation in marmoset cortex and identified an important brain area related to saccade. I have finished the data acquisition and will start to write the manuscript soon. I also successfully established method for brain microinjection on marmosets and successfully traced the superior colliculus. This is very important result. As what stated last year, I have also performed double injection, one anterograde in the superior colliculus and one retrograde in the amygdala in the same marmoset to exploring the connection between the two brain areas. I am currently testing several types of AAV virus to have good expression for future optogenetic experiments. With the grant provided by JSPS, I have also participated several local and international conferences to present my work and got feedbacks from other researchers. Overall, I believe I have reached several goals I set before and I would like to continue my research about innate fear.

Research Progress Status

令和元年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和元年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (13 results)

All 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] チューブンゲン大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] The Foveal Visual Representation of the Primate Superior Colliculus,2019

    • Author(s)
      Chih-Yang Chen, Klaus-Peter Hoffmann, Claudia Distler, Ziad M. Hafed
    • Journal Title

      Current Biology

      Volume: 29 Issue: 13 Pages: 2109-2119

    • DOI

      10.1016/j.cub.2019.05.040

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spatial frequency sensitivity in macaque midbrain.2018

    • Author(s)
      Chen CY, Sonnenberg L, Weller S, Witschel T, Hafed ZM
    • Journal Title

      Nature Communications

      Volume: 9(1) Issue: 1 Pages: 2852-2852

    • DOI

      10.1038/s41467-018-05302-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Orientation and Contrast Tuning Properties and Temporal Flicker Fusion Characteristics of Primate Superior Colliculus Neurons.2018

    • Author(s)
      Chen CY, Hafed ZM
    • Journal Title

      Front Neural Circuits

      Volume: 12 Pages: 58-58

    • DOI

      10.3389/fncir.2018.00058

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Topographic representation of saccade vector in frontal eye field of common marmoset2019

    • Author(s)
      Chih-Yang Chen, Denis Matrov, Wajd Amly, Kuan-Ting Ho, Tadashi Isa
    • Organizer
      29th NCM Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Topographic representation of saccade vector in frontal eye field of common marmoset2019

    • Author(s)
      Chih-Yang Chen, Denis Matrov, Wajd Amly, Kuan-Ting Ho, Hirotaka Onoe, Tadashi Isa
    • Organizer
      Annual Meeting of Japan Neuroscience Society
    • Related Report
      2019 Annual Research Report
  • [Presentation] Mapping saccade representation in the frontal cortex of common marmoset2019

    • Author(s)
      Chih-Yang Chen, Denis Matrov, Wajd Amly, Kuan-Ting Ho, Hirotaka Onoe, Tadashi Isa
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Eye movement tracking in head-fixed common marmosets2019

    • Author(s)
      Chih-Yang Chen, Denis Matrov, Richard Veale, Kuan-Ting Ho, Wajd Amly, Hirotaka Onoe, Kenichi Miura, Tadashi Isa
    • Organizer
      第9回日本マーモセット研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Mapping saccadic representation in the frontal cortex of common marmoset2019

    • Author(s)
      Chih-Yang Chen, Denis Matrov, ,Kuan-Ting Ho, Wajd Amly, Hirotaka Onoe, Tadashi Isa
    • Organizer
      第9回日本マーモセット研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Topographic representation of saccade vector in frontal eye field of common marmoset2019

    • Author(s)
      Chih-Yang Chen, Denis Matrov, Kuan-Ting Ho, Tadashi Isa
    • Organizer
      FAOPS Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of saccadic behavior between common marmosets, macaque monkeys, and humans2018

    • Author(s)
      Chih-Yang Chen, Denis Matrov, Richard Veale, Masatoshi Yoshida, Kenichiro Miura, Tadashi Isa
    • Organizer
      Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2018 Annual Research Report
  • [Presentation] Comparison of saccadic behavior between common marmosets, rhesus macaques, and humans2018

    • Author(s)
      Chih-Yang Chen, Denis Matrov, Richard Veale, Masatoshi Yoshida, Kenichiro Miura, Tadashi Isa
    • Organizer
      Society for Neuroscience 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 京都大学大学院医学研究科高次脳科学講座神経生物学分野

    • URL

      https://nscinbiol.med.kyoto-u.ac.jp/

    • Related Report
      2019 Annual Research Report

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Published: 2018-05-01   Modified: 2024-03-26  

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