Elucidation of roles of gasotransmitters in the pathogenesis of atopic dermatitis
| Project/Area Number |
18F18410
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Juntendo University |
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Principal Investigator |
高森 建二 順天堂大学, 医学部, 特任教授 (40053144)
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| Co-Investigator(Kenkyū-buntansha) |
MONIAGA CATHARINA 順天堂大学, 医学部, 外国人特別研究員
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| Project Period (FY) |
2018-10-12 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 2020: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2019: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2018: ¥500,000 (Direct Cost: ¥500,000)
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| Keywords | Hydrogen sulfide / Atopic dermatitis / axon-guidance molecules / human keratinocytes / Axon-guidance molecule / Keratinocytes / Itch |
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| Outline of Annual Research Achievements |
Despite the numerous reports that H2S is involved in various pathological diseases and/or itch, however, there have been no reports of its involvement in the expression of axon-guidance molecules in human keratinocytes (KCs).I found that H2S-producing enzymes were expressed in human skin (mainly KCs), and were increased in human atopic dermatitis (AD) skin lesion. Notably, the H2S donor stimulation upregulated NGF and ARTN, and downregulated Sema3A levels in the cultured normal human epidermal keratinocytes, which is considered to be a cause of peripheral itch sensitization in AD skin lesion. I suggest that the involvement of H2S under the experimental conditions used in the present work in relation with AD. Our data raise the possibility that H2S, at least in part, modulates the epidermal hyperinnervation of the human skin through alteration of axon-guidance molecules in KCs. These findings add insight of the possible role of gasotransmitter in epidermal hyperinnervation of human skin, especially in itchy skin inflammatory condition such as AD. The result of the project has been published in international journal (Journal of Dermatological Science).
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| Research Progress Status |
令和2年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和2年度が最終年度であるため、記入しない。
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Calcium-inducible MAPK/AP-1 signaling drives semaphorin 3A expression in normal human epidermal keratinocytes.2020
Author(s)
Kamata Y, Tominaga M, Umehara Y, Honda K, Kamo A, Moniaga CS, Komiya E, Toyama S, Suga Y, Ogawa H, Takamori K
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Journal Title
J Invest Dermatol.
Volume: ー
Issue: 7
Pages: 1346-1354
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Calcium-Inducible MAPK/AP-1 Signaling Drives Semaphorin 3A Expression in Normal Human Epidermal Keratinocytes2020
Author(s)
Kamata Y, Tominaga M, Umehara Y, Honda K, Kamo A, Moniaga CS, Komiya E, Toyama S, Suga Y, Ogawa H, Takamori K
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Journal Title
Journal of Investigative Dermatology
Volume: N.A.
Related Report
Peer Reviewed / Int'l Joint Research
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