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Synthesis & biological activity of Ru(II)-arene & Ir(III) complexes of multipodal aroylthioures

Research Project

Project/Area Number 18F18412
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Review Section Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Research InstitutionTokyo University of Science

Principal Investigator

青木 伸  東京理科大学, 薬学部生命創薬科学科, 教授 (00222472)

Co-Investigator(Kenkyū-buntansha) JEBITI HARIBABU  東京理科大学, 薬学部, 外国人特別研究員
Project Period (FY) 2018-11-09 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2020: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 2019: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 2018: ¥500,000 (Direct Cost: ¥500,000)
Keywordsイリジウム錯体-ペプチドハイブリッド / プログロム化細胞死 / パラトーシス / 発光 / 小胞体 / ミトコンドリア / カルシウム / 抗がん剤 / プログラム化細胞死 / 金属錯体 / イリジウム / ペプチド / ルテニウム / アロイルチオウレア
Outline of Annual Research Achievements

プログラムされた細胞死(Programmed Cell Death, PCD)は、固体の生命維持のために遺伝子によって制御された細胞死である。従来、細胞死は「PCDとしてのカスパーゼ依存性apoptosis」と「受動的な死=necrosis」に分類されていたが、最近necroptosis、autophagic cell death、paraptosisなど多様なPCD様式が明らかになり、それらを利用するがん治療の可能性が指摘されている。
申請者らは、イリジウム(IrIII))錯体と塩基性のKKKGGペプチドのハイブリッド化合物(IPH)ががん細胞のparatosisを誘導することを見出し、その作用機序の解明を目的として本研究を開始した。従来はC3対称性のIr錯体に3分子のKKKGGペプチドを導入していたため、本年度は、KKKGGペプチドの数が2つ、1つである誘導体を合成し、ペプチド数(それに伴う正電荷)と抗がん活性の間に良い相関があることを確認した。次に、paraptosisを誘導すると報告されているcelastrolとの作用機序を比較し、これらが異なる細胞内シグナル伝達経路を経由してがん細胞のparaptosisを誘導することが強く示唆された。そして、i) IPHはカルモジュリンまたはカルモジュリンのCa2+錯体に結合すること、ii) IPHは最初に細胞膜へ移行し、その後ミトコンドリアへ移行すること、iii) IPHはリソソームと小胞体の液胞化を誘導するが、celastrolはリソソームの液胞化を誘導すること、iv) IPHが小胞体からミトコンドリアへのCa2+輸送を促進し、ミトコンドリア膜電位を低下させること、それに対してcelastrolは細胞質内のCa2+濃度を上昇させるが、ミトコンドリア内のCa2+濃度とミトコンドリア膜電位には影響しないこと、などが明らかになった。

Research Progress Status

令和2年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和2年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (92 results)

All 2021 2020 2019 2018 Other

All Journal Article (24 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 24 results,  Open Access: 14 results) Presentation (62 results) (of which Int'l Joint Research: 14 results,  Invited: 16 results) Book (3 results) Remarks (3 results)

  • [Journal Article] N-Subsbtitution in Isatin Thiosemicarbazone Decides Nuclearity of Cu(II) Complexes -Spectroscopic, Molecular Docking and Cytotoxic Studies2021

    • Author(s)
      H. Jebiti, O. I. Alajrawy, K. Jeyelakshmi, C. Balachandran, D. A. Krishnan, N. Bhuvanesh, S. Aoki, and N. Karuppannan, R. Karvembu
    • Journal Title

      Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy

      Volume: 246 Pages: 118963-118963

    • DOI

      10.1016/j.saa.2020.118963

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and Synthesis of Supramolecular Phosphatases Formed from a Bis(Zn2+-Cyclen) Complex, Barbital-Crown-K+ Conjugate and Cu2+ for the Catalytic Hydrolysis of Phosphate Monoester2021

    • Author(s)
      A. B. Rahman, H. Okamoto, Y. Miyazawa, S. Aoki,
    • Journal Title

      European Journal of Inorganic Chemistry

      Volume: 2021 Issue: 13 Pages: 1213-1223

    • DOI

      10.1002/ejic.202001009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis and Anticancer Properties of Bis and Mono(cationic peptide) Hybrids of Cyclometalated Ir(III) Complexes: Effect of the Number of Peptide Units on Anticancer Activity2021

    • Author(s)
      H. Jebiti, Y. Tamura, K. Yokoi, C. Balachandran, M. Umezawa, K. Tsuchiya, Y. Yamada, and S. Aoki,
    • Journal Title

      European Journal of Inorganic Chemistry

      Volume: 2021 Issue: 18 Pages: 1796-1814

    • DOI

      10.1002/ejic.202100154

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of Metallosupramolecular Phosphatases Based on Combinatorial Self-Assembly of Metal Complexes and Organic Building Blocks for Catalytic Hydrolysis of Phosphate Monoesters2021

    • Author(s)
      S. Aoki, A. B. Rahman, Y. Hisamatsu, Y. Miyazawa, M. Zulkefeli, Y. Saga, T. Tanaka
    • Journal Title

      Results in Chemistry (a joint special issue with Inorganica Chimica Acta)

      Volume: 3 Pages: 100133-100133

    • DOI

      10.1016/j.rechem.2021.100133

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis, Anticancer and Molecular Docking Studies of New Class of Benzoisoxazolyl-piperidinyl-1,2,3-triazoles2020

    • Author(s)
      G. Muniyappan, S. Kathavarayan, C. Balachandran, E. Kalliyappan, S. M. Mahalingam, A. Ajees A. Salam, S. Aoki, N.Arumugam, A. I. Almansour, R. S. Kumar
    • Journal Title

      The Journal of King Saud University-Science,

      Volume: 32 Issue: 8 Pages: 3286-3292

    • DOI

      10.1016/j.jksus.2020.09.012

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Amphiphilic Cationic Triscyclometalated Iridium(III) Complex-Peptide Hybrids Induce Paraptosis-like Cell Death of Cancer Cells via an Intracellular Ca2+-Dependent Pathway2020

    • Author(s)
      K. Yokoi, C. Balachandran, M. Umezawa, K. Tsuchiya, A. Mitric, S. Aoki
    • Journal Title

      ACS Omega

      Volume: 5 Issue: 12 Pages: 6983-7001

    • DOI

      10.1021/acsomega.0c00337

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis, Characterization, Theoretical, Molecular Docking and in Vitro Biological Activity Studies of Ru(II) (e6-p-Cymene) Complexes with Novel Aniline Substituted Aroyl Selenoureas2020

    • Author(s)
      M. Musthafa, R. Konakanchi, R. Ganguly, C. Balachandran, S. Aoki, A. Sreekanth
    • Journal Title

      Journal of Biomolecular Structure and Dynamics

      Volume: none Issue: 12 Pages: 1778531-1778531

    • DOI

      10.1080/07391102.2020.1778531

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and Synthesis of Cyclometalated Iridium(III) Complex-Chromophore Hybrids that Exhibit Long-Emission Lifetimes Based on a Reversible Electronic Energy Transfer Mechanism2020

    • Author(s)
      A. Kazama, Y. Imai, Y. Okayasu, Y. Yamada, J. Yuasa, S. Aoki
    • Journal Title

      Inorganic Chemistry

      Volume: 59 Issue: 10 Pages: 6905-6922

    • DOI

      10.1021/acs.inorgchem.0c00363

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective Effects of p53 Regulatory Agents against High-LET Radiation-Induced Injury in Mice2020

    • Author(s)
      A. Morita, B. Wang, K. Tanaka, T. Katsube, M. Murakami, T. Shimokawa, Y. Nishiyama, S. Ochi, H. Satoh, M. Nenoi and S. Aoki
    • Journal Title

      Frontiers in Public Health

      Volume: 8

    • DOI

      10.3389/fpubh.2020.601124

    • NAID

      120006937553

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] One-Pot Synthesis of Cyclic Oligosaccharides by the Polyglycosylation of Monothioglycosides2020

    • Author(s)
      Hidetoshi Someya, Takehito Seki, Gota Ishigami, Taiki Itoh, Yutaka Saga, Yasuyuki Yamada, Shin Aoki
    • Journal Title

      Carbohydrate Research

      Volume: 487 Pages: 107888-107888

    • DOI

      10.1016/j.carres.2019.107888

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unprecedented Formation of Palladium(II)-Pyrazole Based Thiourea from Chromone Thiosemicarbazone and [PdCl2(PPh3)2]: Interaction with Biomolecules and Apoptosis through Mitochondrial Signaling Pathway2020

    • Author(s)
      H. Jebiti, C. Balachandran, M. Muthu T. Y. Arun, N. S. P. Bhuvanesh, S. Aoki, and R. Karvembu
    • Journal Title

      J. Inorg. Biochem

      Volume: 205 Pages: 110988-110988

    • DOI

      10.1016/j.jinorgbio.2019.110988

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Iron Oxide Nanoparticle Core-Sell Magnetic Microspheres: Applications toward Targeted Drug Delivery2020

    • Author(s)
      S. Ayyanaar, M. P. Kesavan, C. Balachandran, S. Rasala, S. Aoki, J. Rajesh, T. Webster, G. Rajagopal,
    • Journal Title

      Nanomed. Nanotech. Biol. Med.

      Volume: 24

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simple and Convenient Method for the Isolation, Culture, and Re-collection of Cancer Cells from Blood by Using Glass-Bead Filters2019

    • Author(s)
      B. Shashni, H. Matsuura, R. Saito, T. Hirata, S. Ariyasu, K. Nomura, H. Takemura, K. Akimoto, N.Aikawa, A. Yasumori and S. Aoki,
    • Journal Title

      ACS Biomater. Sci. Eng.

      Volume: 5 Issue: 2 Pages: 438-452

    • DOI

      10.1021/acsbiomaterials.8b01335

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stereoselective aldol reactions of dihydroxyacetone derivatives catalyzed by chiral Zn2+ complexes2019

    • Author(s)
      Yasuda Masato、Saga Yutaka、Tokunaga Takuya、Itoh Susumu、Aoki Shin
    • Journal Title

      Tetrahedron

      Volume: 75 Issue: 6 Pages: 757-777

    • DOI

      10.1016/j.tet.2018.12.060

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catalytic Hydrolysis of Phosphate Monoester by Supramolecular Phosphatases Formed from a Monoalkylated Dizinc(II) Complex, Cyclic Diimide Units, and Copper(II) in Two-Phase Solvent System2019

    • Author(s)
      Rahman Akib Bin、Imafuku Hiroki、Miyazawa Yuya、Kafle Ananda、Sakai Hideki、Saga Yutaka、Aoki Shin
    • Journal Title

      Inorganic Chemistry

      Volume: 58 Issue: 9 Pages: 5603-5616

    • DOI

      10.1021/acs.inorgchem.8b03586

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly Active Copper(I) Complexes of Aroylthiourea Ligands Against Cancer Cells; Synthetic and Biological Studies2019

    • Author(s)
      Kumaramangalam Jeyalakshmi, Jebiti Haribabu, Chandrasekar Balachandran, Eswaramoorthi Narmatha, Nattamai S. P. Bhuvanesh, Shin Aoki, and Ramasamy Karvembu
    • Journal Title

      New Journal of Chemistry

      Volume: none Issue: 7 Pages: 3188-3198

    • DOI

      10.1039/c8nj04246b

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Design, Synthesis, DNA/HSA Binding and Cytotoxic Activity of Half-Sandwich Ru(II)-Arene Complexes Containing Tiarylamines-Thiosemicarbazone Hybrids2019

    • Author(s)
      M. Muralisankar, R. Dheepika, J. Haribabu, C. Balachandran, S. Aoki, N. Bhuvanesh, S. Nagarajan,
    • Journal Title

      ACS Omega

      Volume: 4 Issue: 7 Pages: 11712-11723

    • DOI

      10.1021/acsomega.9b01022

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Catalytic Hydrolysis of Phosphate Monoester by Supramolecular Complexes Formed by the Self-Assembly of a Hydrophobic Bis(Zn2+-cyclen) Complex, Copper, and Barbital Units That Are Functionalized with Amino Acids in a Two-Phase Solvent System2019

    • Author(s)
      Yuya Miyazawa, Akib Bin Rahaman, Yutaka Saga, Hiroki Imafuku, Yosuke Hisamatsu, Shin Aoki
    • Journal Title

      Micromachines

      Volume: 10 Issue: 7 Pages: 452-452

    • DOI

      10.3390/mi10070452

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Design, synthesis, and anticancer activity of iridium(III) complex-peptide hybrids that contain hydrophobic acyl groups at the N-terminus of the peptide units2019

    • Author(s)
      Naito Kana、Yokoi Kenta、Balachandran Chandrasekar、Hisamatsu Yosuke、Aoki Shin
    • Journal Title

      Journal of Inorganic Biochemistry

      Volume: 199 Pages: 110785-110785

    • DOI

      10.1016/j.jinorgbio.2019.110785

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Zn2+ Coordination Structures in Chiral Zn2+ Complexes Based on Shape Measurement Factors: Relationships between Catalytic Activity and the Coordination Structure2019

    • Author(s)
      Shin Aoki, Chiharu Kikuchi, Yuichi Kitagawa, Yasuchika Hasegawa, Syotaro Sonoike, Yutaka Saga, Miho Hatanaka
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 44 Issue: 44 Pages: 4740-4751

    • DOI

      10.1002/ejic.201900934

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NHC Catalyzed Green Synthesis of Functionalized Chromones: DFT Mechanistic Insights and in vitro Activities in Cancer Cells2019

    • Author(s)
      N. Murugesh, J. Haribabu, K. Arumugam, C. Balachandran, R.Swaathy, S. Aoki, A. Sreekanth, R. Karvembu, and S. Vedachalam
    • Journal Title

      New J. Chem.

      Volume: none Issue: 34 Pages: 13509-13525

    • DOI

      10.1039/c9nj02650a

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A New Class of beta-Pyrrolidino-1,2,3-triazole Derivatives as β-Adrenergic Receptor Inhibitors: Synthesis, Pharmacological and Docking Studies2019

    • Author(s)
      K. Easwaramoorthi, J. A. Rajendran, K. C. Rao, C. Balachandran, Y. Arun, S. M. Mahalingam, N. Arumugam, A. I. Almansour, R. S. Kumar, D. M. Al-thamili, S. Aoki,
    • Journal Title

      Molecules

      Volume: 24 Issue: 19 Pages: 3501-3501

    • DOI

      10.3390/molecules24193501

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Design and Green Synthesis of Novel Benzotriazoloquinolinyl Spirooxindolopyrrolizidines: Antimycobacterial and Antiproliferative Studies2019

    • Author(s)
      V. Pogaku, V. S. Krishna, C. Balachandran, K. Rangan, D. Sriram, S. Aoki, S. Basavoju
    • Journal Title

      New J. Chem.

      Volume: 43 Issue: 44 Pages: 17511-17520

    • DOI

      10.1039/c9nj03802g

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and Synthesis of Boron Containing Monosaccharides by the Hydroboration of D-Glucal for Use in Boron Neutron Capture Therapy (BNCT)2018

    • Author(s)
      Taiki Itoh, Kei Tamura, Hiroki Ueda, Tomohiro Tanaka, Kyouhei Satoh, Reiko Kuroda, and Shin Aoki
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 26 Issue: 22 Pages: 5922-5933

    • DOI

      10.1016/j.bmc.2018.10.041

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] ホウ素中性子捕捉療法を指向したBSH含有ナノ粒子の開発2021

    • Author(s)
      田中 智博、上田 大貴、鈴木 実、櫻井 良憲、青木 伸
    • Organizer
      第55回京都大学複合原子力科学研究所学術講演会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ホウ素中性子捕捉療法のためのポリアミン誘導体の創製2021

    • Author(s)
      上田 大貴、田中 智博、鈴木 実、櫻井 良憲、青木 伸
    • Organizer
      第55回京都大学複合原子力科学研究所学術講演会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Expression Analysis of Genes Associated with the Radioprotective Effect of p53 Modulator 5CHQ on Acute Intestinal Radiation Injury2021

    • Author(s)
      Takuma Sakai, Akinori Morita, Akinori Kanai, Bing Wang, Atsushi Enomoto, Shohei Ujita, Shin Aoki, Hidetoshi Sato, Masahiro Sakaue, Yuichi Nishiyama1 Toshiya Inaba
    • Organizer
      The 5th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster and Medical Science-Nucelar Disaster Management, Community Engagement and Resilience
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design and Synthesis of Metallosupramolecular Catalysts Formed by the Self-Assembly of Functionalized Building Blocks to Mimic Natural Enzymes2021

    • Author(s)
      Shin Aoki, Akib Bin Rahman, Hirokazu Okamoto, Yuya Miyazawa, and Yutaka Saga
    • Organizer
      5th International Conference on Catalysis and Chemical Engineering (CCE-2021) (online)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Facile Synthesis of Cyclic Oligosaccharides by One-Pot Glycosylation of Glycosyl Donor/Acceptor Molecules2021

    • Author(s)
      Shin Aoki, Hidehisa Someya, Takehito Seki, Gota Ishigami, nd Tomohiro Tanaka
    • Organizer
      7th International Conference on Biochemistry and Glyco Science
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多視点画像とCNNを用いたバーチャルスクリーニング2021

    • Author(s)
      釘本 晃佑、古田 諒祐、入江 豪、青木 伸、谷口 行信
    • Organizer
      2021年電子情報通信学会総合大会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3次元点群を用いたタンパク質阻害剤の高速探索2021

    • Author(s)
      苅谷 健、古田 諒祐、入江 豪、青木 伸、谷口 行信
    • Organizer
      2021年電子情報通信学会総合大会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design and Synthesis of Supramolecular Phosphatases Functionalized with Lewis Acid Moieties for Catalytic Hydrolysis of Phosphate Monoester in Two-Phase Solvent System2021

    • Author(s)
      青木 伸、Akib Bin Rahman、岡本 紘知、宮澤 有哉
    • Organizer
      日本化学会第101春季年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 次の時代の迅速診断・迅速治療に向けた東京理科大学の異分野連携研究2021

    • Author(s)
      青木 伸
    • Organizer
      理化学研究所―東京理科大学合同シンポジウム(オンライン)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Identification and Development of Novel Compounds Inhibitory to SARS-CoV-2 Replication (新型コロナウイルスの複製を阻害する新規化合物の同定と開発)2021

    • Author(s)
      Masanori Baba, Mika Okamoto, Shin Aoki, Yoshiki Yagi, Masaaki Toyama, Tomohiro Tanaka, Takuro Niwa
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] カチオン性ポリマーを用いたホウ素中性子捕捉療法のためのBSH含有ナノ粒子の開発2021

    • Author(s)
      田中智博、上田大貴、鈴木実、櫻井良憲、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] ホウ素中性子捕捉療法のための新規ポリアミン誘導体の開発2021

    • Author(s)
      上田大貴、鈴木実、櫻井良憲、田中智博、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] シクロメタレート型イリジウム錯体―ペプチドハイブリッドのがん細胞死誘導活性評価およびカルシウム依存的な誘導メカニズムの解析2021

    • Author(s)
      横井 健汰、Chandrasekar Balachandran、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 放射線防護活性を有する2-pyrrolone類の設計、合成、活性評価及びターゲット探索2021

    • Author(s)
      佐藤 秀哉、越智 進太郎、氏田 将平、多田 佳寿美、西山 祐一、松下 洋輔、出口 雄一、鈴木 啓司、田中 義正、植田 弘師、稲葉 俊哉、細井 義夫、森田 明典、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] テンプレート上糖鎖合成法を目的とするプロリン型チオグリコシドの設計と合成2021

    • Author(s)
      直井 竜大、田中 智博、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] チオガラクトシド供与体を用いるone-pot大環状オリゴ糖合成法の開発2021

    • Author(s)
      石上 剛大 、関 健仁、染谷 英寿、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] シス型に固定されたアゾベンゼン骨格を有するキラル環状化合物の設計と合成2021

    • Author(s)
      芝内涼太、田中智博、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] がん細胞のプログラム細胞誘導死を目的としたトリプチセン-ペプチドハイブリッドの合成・設計及び生物活性評価2021

    • Author(s)
      山口 晃平、横井 健汰、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] シクロメタレート型イリジウム錯体―カチオン性ペプチドハイブリッドによるがん細胞のパラトーシス誘導と作用機序2020

    • Author(s)
      青木伸、横井健汰、Chandrasekar Balachandran、Haribabu Jebit、小山田有紗、梅澤雅和、土屋好司
    • Organizer
      第14回バイオ関連化学シンポジウム(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design, Synthesis, and Photophysical and Biological Property of Hybrid Compounds of Cyclometalated Iridium(III) Complexes with Peptides and Chromophores2020

    • Author(s)
      Shin Aoki, Kenta Yokoi, Chandrasekar Balachandran, Haribabu Jebiti, Abdullah-Al Masum, Ayami Kazama and Kana Naito
    • Organizer
      International Webinar on Chemistry and Biology: Sustainable Progress of Human Civilization
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ホウ素中性子線捕捉療法のためのBSH含有ナノ粒子の創製2020

    • Author(s)
      田中智博、上田大貴、鈴木実、櫻井良憲、青木伸
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design, Synthesis and Anticancer Properties of Bis-, and Mono(Cationic Peptide) Hybrids of Ir(III) Complexes: Effect of the Number of Peptide Units on Anticancer Activity2020

    • Author(s)
      Haribabu Jebiti, Yuichi Tamura, Kenta Yokoi, Chandrasekar Balachandran, and Shin Aoki
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design and Synthesis of Supramolecular Phosphatase Mimics Formed by the Self-Assembly of Monoalkylated Bis(Zn2+-cyclen) Complex, Copper and Functionalized Diimide Units2020

    • Author(s)
      Akib Bin Rahman, Yuya Miyazawa, Shin Aoki
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] カルシウム依存的ながん細胞死を誘導するシクロメタレート型イリジウム錯体―ペプチドハイブリッドの設計、合成および生物学的評価2020

    • Author(s)
      横井健汰、Balachandran Chandrasekar、青木伸
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] BNCT用ポリアミン誘導体の設計・合成および生物学的評価2020

    • Author(s)
      上田大貴、田中 智博、鈴木 実、櫻井 良憲、青木伸
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 放射線防護活性を有する2-pyrrolone類縁体の設計、合成、活性評価及び標的分子の探索2020

    • Author(s)
      佐藤秀哉、越智進太郎、水野皓介、氏田将平、多田佳寿美、松下洋輔2、出口雄一、鈴木啓司、田中義正、植田弘師、稲葉俊哉、細井義夫、森田明典、青木伸
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design and Synthesis of Cyclometalated Iridium (III) Complex-Peptide Hybrids that Induce Paraptosis of Cancer Cells,2020

    • Author(s)
      Shin Aoki
    • Organizer
      Webinar on Dementia Congress, Biotechnology Congress, Chemistry and Toxicology Congress 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complex-Chromophore Hybrids that Have Long Emission Lifetimes Based on a Reversible Electronic Energy Transfer (REET) Mechanism2020

    • Author(s)
      Shin Aoki, Ayami Kazama, Kenta Yokoi, Yasuyuki Yamada, and Junpei Yuasa
    • Organizer
      錯体化学会第70回討論会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design, Synthesis and Anticancer Activity of Bis-, and Mono(Cationic Peptide) Hybrids of Cyclometalated Iridium(III) Complexes: Effect of the Number of Peptide Units on Anticancer Property2020

    • Author(s)
      Haribabu Jebiti, Kenta Yokoi,Yuichi Tamura, Chandrasekar Balachandran, and Shin Aoki
    • Organizer
      錯体化学会第70回討論会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Amphiphilic Cationic Triscyclometalated Iridium(III) Complex-Peptide Hybrids Induce Paraptosis of Cancer Cells via Ca2+ Transfer from ER to Mitochondria2020

    • Author(s)
      Kenta Yokoi, Chandrasekar Balachandran, and Shin Aoki
    • Organizer
      錯体化学会第70回討論会(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design, Synthesis, and Biological Evaluation of Luminescent Cyclometalated Iridium(III) Complex-Peptide Hybrids for the Detection and Programmed Cell Death Induction of Cancer Cells2020

    • Author(s)
      Shin Aoki, Kenta Yokoi, Heribabu Jebiti, Chandrasekar Balachandran
    • Organizer
      6th International Electronic Conference on Medicinal Chemistry (Online)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ホウ素中性子捕捉療法のための環状ポリアミン誘導体の開発2020

    • Author(s)
      上田 大貴、田中 智博、鈴木 実、櫻井 良憲、青木 伸
    • Organizer
      東京理科大学・日本医科大学第7回合同シンポジウム(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 放射線防護活性を有する2-Pyrrolone類の設計、合成、活性評価及び標的探索2020

    • Author(s)
      佐藤 秀哉、越智 進太郎、森田 明典、青木 伸
    • Organizer
      東京理科大学・日本医科大学第7回合同シンポジウム(オンライン)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complex-Peptide Hybrids for the Induction of Cancer Cell Death2019

    • Author(s)
      Shin Aoki
    • Organizer
      The 9th World Congress on Chemistry and Medicinal Chemistry (WCC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] モノアルキル化された二核亜鉛錯体と有機分子ブロックの自己集積による超分子ホスファターゼの設計・合成とリン酸モノエステル加水分解活性2019

    • Author(s)
      青木 伸、Akib Bin Rahman、宮澤 有哉、嵯峨 裕
    • Organizer
      第17回ホストゲスト・超分子化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] シクロメタレート型イリジウム (Ir(III)) 錯体塩基性ペプチドハイブリッドの 設計・合成・がん細胞死誘導活性とメカニズム解明2019

    • Author(s)
      横井健汰、Chanderalar Balachandran、内藤 佳奈、清水舜、青木伸
    • Organizer
      第17回次世代を担う有機化学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complex-Peptide Hybrids that Induce Paraptosis of Cancer Cells and Detect Dead Cells2019

    • Author(s)
      Shin Aoki, Kenta Yokoii, Chandrasekar Balachandran, Kana Naito
    • Organizer
      第29回金属の関与する生体関連反応シンポジウム(SRM2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complex-Peptide Hybrids for the Induction of Cancer Cell Death2019

    • Author(s)
      Shin Aoki, Kenta Yokoi, Kana Naito, Chandrasekar Balachandran, Shun Shimizu
    • Organizer
      15th International Symposium of Applied Biological Chemistry (ISABC15)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of New Methods for the Detection, Isolation, Growth, and Re-collection of Cancer Cells in Blood Based on Size-discrimination of Cancer Cells and Mormal Cells2019

    • Author(s)
      Shin Aoki, Babita Shashni, Shinya Ariyasu, Hiroshi Takemura, Kazunori Akimoto, Naoyuki Aikawa, Ken-ichiro Iwasaki, Takayuki Nakanishi, Atsuo Yasumori, Tomohiro Osaki, Norihiko Itoh,
    • Organizer
      International Conference on Cancer Research (e-ICCR2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シクロメタレート型Ir(III)錯体-ペプチドハイブリッドによるがん細胞のプログラム細胞死誘導とそのメカニズム解析2019

    • Author(s)
      青木 伸、横井 健汰、Chandrasekar Balachandran、内藤 佳奈
    • Organizer
      日本ケミカルバイオロジー学会第13回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Recent Progress in the Design and Synthesis of Cyclometalated Iridium(III) Complexes Based on Post-Complexation Functionalization2019

    • Author(s)
      Shin Aoki, Yuichi Tamura, Hiroki Ohwada, Ayami Kazama, Kyouhei Sato, Reiko Kuroda, and Junpei Yuasa
    • Organizer
      23th International Symposium on Photochemistry and Photophysics of Coordination Compounds (ISPPCC2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Selective Substitution and Decomposition Reactions of Cyclometalated Iridium Complexes and Their Applications to Biomedical and Material Sciences2019

    • Author(s)
      Shin Aoki, Kenta Yokoi, Yuichi Tamura, Kana Naito, Ayami Kazama, Chandrasekar Balachandran, Haribabu Jebiti, Junpei Yuasa, and Reiko Kuroda
    • Organizer
      27th International Society of Heterocyclic Chemical Congress (ISHC2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ルイス酸を用いたシクロメタレート型イリジウム錯体の立体化学変換反応2019

    • Author(s)
      大和田 紘喜、田村 祐一、風間 彩水、青木 伸
    • Organizer
      第63回日本薬学会関東支部大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complexes Functionalized with Peptides and Chromophores in Biomedical and Material Sciences2019

    • Author(s)
      Shin Aoki, Kenta Yokoi, Kana Naito, Chandrasekar Balachandran, Ayami Kazama, Junpei Yuasal Reiko Kuroda
    • Organizer
      錯体化学会第69回討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Design and Synthesis of Metallosupramoelcular Catalysts in Two-Phase Solvent Systems that Mimic Natural Enzymes2019

    • Author(s)
      Shin Aoki
    • Organizer
      7th Asian Congress on Coordination Chemistry (ACCC7)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Amphiphilic Cationic Triscyclometalated Iridium(III) Complex-Peptide Hybrids Induce Paraptosis-like Cell Death of Cancer Cells via Intracellular Ca2+-Dependent Pathway2019

    • Author(s)
      Kenta Yokoi, Chandrasekar Balachandran, and Shin Aoki
    • Organizer
      7th Asian Congress on Coordination Chemistry (ACCC7)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complexes as Luminescent Weapon for the Detection and Cell Death Induction of Cancer Cells2019

    • Author(s)
      Shin Aoki, Kenta Yokoi, Chandrasekar Balachandran, Haribabu Jebiti, Abdullah-Al Masum, and Kana Naito
    • Organizer
      3rd Asian Conference on Chemosensors and Imaging Probes (Asian ChIP-2019)、11/6-9, 2019, Amritsar, India
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Post-Complexation Functionalization of Cyclometalated Iridium Complexes and Its Applications to Biomedical and Material Sciences2019

    • Author(s)
      Shin Aoki, Kenta Yokoi, Ayami Kazama, Chandrasekar Balachandran, Haribabu Jebiti, Yuki Imai, and Junpei Yuasa
    • Organizer
      18th Asian Chemical Congress (18ACC) and 20th General Assembly of the Federation of Asian Chemical Societies
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] イリジウム錯体ーペプチドハイブリッドの発光機能を利用するがん細胞のプログラム細胞死の誘導と機構解析2019

    • Author(s)
      横井健汰, Chandrasekar Balachandran, Aleksandra Mitric, 青木伸
    • Organizer
      東京理科大学総合研究院イメージングフロンティアセンターシンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cyclometalated Iridium(III)-Peptide Hybrids (IPHs) Induce a Paraptosis Mediated Cell Death in Cancer Cell2019

    • Author(s)
      Chandrasekar Balachandran, Kenta Yokoi, Kana Naito, Shin Aoki(
    • Organizer
      東京理科大学・日本医科大学第6回合同シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of New Boron Compounds for Biomedical Sciences by Means of Traditional rRactions of Sugar Derivatives2019

    • Author(s)
      Shin Aoki, Taiki Itoh, Hidehisa Someya, Hiroki Ueda, Kosuke Mizuno
    • Organizer
      2019 International Biomedical Interface Symposium (2019IBMI)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complexes Based on Post-Complexation Functionalization for Photochemistry and Chemical Biology2019

    • Author(s)
      Shin Aoki
    • Organizer
      Invited Seminar at National Tsing Hua University
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Cell Death Induction of Cancer Cells by Cyclometalated Iridium(III) Complex-Peptide Hybrids and Mechanism2019

    • Author(s)
      Shin Aoki, Kenta Yokoi, Kana Naito, Chandrasekar Balachandran
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Mechanistic Study of Cell Death of Cancer Cells Induced by Cyclometalated Iridium(III)-Peptide Hybrids (IPHs)2019

    • Author(s)
      Chandrasekar Balachandran, Kenta Yokoi, Kana Naito, Shin Aoki
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ルイス酸によるシクロメタレート型イリジウム錯体の立体化学変換反応2019

    • Author(s)
      大和田紘喜、田村裕一、風間彩水、佐藤享平、黒田玲子、青木伸
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] カルシウム依存的な細胞死誘導経路を有するシクロメタレート型イリジウム錯体―カチオン性ペプチドハイブリッドの設計および合成とがん細胞死誘導2019

    • Author(s)
      横井 健汰、内藤 佳奈、Chanderalar Balachandran、青木 伸
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] REET(Reversible Electronic Energy Transfer)機構によるシクロメタレート型イリジウム(Ⅲ)錯体の発光長寿命化2019

    • Author(s)
      風間 彩水、今井 祐輝、湯浅 順平、青木 伸
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ボロン酸エステルをヌクレオシド水酸基の一時的保護として利用した位置選択的O-グリコシル化反応による二糖ヌクレオシドの合成2018

    • Author(s)
      染谷英寿、伊藤太基、加藤萌、青木伸
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] p53制御剤による重粒子放射線防護効果2018

    • Author(s)
      森田 明典、王 冰、田中 薫、勝部 孝則、村上 正弘、西山 祐一、越智 進太郎、寺岡 達朗、ラマダニー・ドゥウィー、下川 卓志、根井 充、青木 伸
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化合物ライブラリーから選抜されたp53依存性細胞死抑制剤の作用機構解析2018

    • Author(s)
      越智 進太郎、佐藤 秀哉、氏田 将平、多田 佳寿美、松下 洋輔、水野 皓介、出口 雄一、鈴木 啓司、田中 義正、植田 弘師、稲葉 俊哉、細井 義夫、青木 伸、森田 明典
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糖骨格をもつBNCTホウ素キャリアーの設計、合成とがん細胞への移行性2018

    • Author(s)
      青木伸、伊藤太基、上田大貴、水野皓輔、鈴木実、櫻井良憲
    • Organizer
      東京理科大学・日本医科大学第5回合同シンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Photophysical and Biological Activity of Cyclometalated Iridium(III) Complex-Peptide Conjugates Synthesized by Post-Complexation Functionalization2018

    • Author(s)
      Shin Aoki, Kenta Yokoi, Kana Naito, Abdullah-Al Masum, Ayami Kazama, Yuki Imai, Junpei Yuasa
    • Organizer
      9th Asian Biological Inoganic Chemistry Conference (AsBIC9)
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Book] 知っておきたい有機反応100 第2版2019

    • Author(s)
      日本薬学会編,
    • Total Pages
      290
    • Publisher
      東京化学同人
    • Related Report
      2019 Annual Research Report
  • [Book] 錯体化合物事典2019

    • Author(s)
      錯体化学会編
    • Publisher
      朝倉出版,
    • ISBN
      9784254141054
    • Related Report
      2019 Annual Research Report
  • [Book] 知っておきたい有機反応100 第2版2019

    • Author(s)
      日本薬学会編
    • Total Pages
      290
    • Publisher
      東京化学同人
    • Related Report
      2018 Annual Research Report
  • [Remarks] Lighting Up Iridium Complexes

    • URL

      https://researchoutreach.org/articles/lighting-up-iridium-complexes/

    • Related Report
      2020 Annual Research Report
  • [Remarks] Lighting Up Iridium Complexes (video abstract)

    • URL

      https://www.youtube.com/watch?v=CTbNlQSMtA4

    • Related Report
      2020 Annual Research Report
  • [Remarks] 東京理科大学薬学部青木研究室

    • URL

      http://www.rs.noda.tus.ac.jp/aokilab/index.html

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-11-12   Modified: 2024-03-26  

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