| Co-Investigator(Kenkyū-buntansha) |
KAZUNARI Yoshizawa 九州大学, 先導物質化学研究所, 教授 (30273486)
HIGUCHI Yoshiki 兵庫県立大学, 大学院・生命理学研究科, 教授 (90183574)
KAWAGUCHI Hiroyuki 東京工業大学, 大学院・理工学研究科, 教授 (20262850)
MATSUMOTO Tsuyoshi 名古屋大学, 大学院・理学研究科, 助教 (50311717)
OHKI Yasuhiro 名古屋大学, 大学院・理学研究科, 准教授 (10324394)
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| Budget Amount *help |
¥579,150,000 (Direct Cost: ¥445,500,000、Indirect Cost: ¥133,650,000)
Fiscal Year 2010: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000)
Fiscal Year 2009: ¥114,400,000 (Direct Cost: ¥88,000,000、Indirect Cost: ¥26,400,000)
Fiscal Year 2008: ¥114,400,000 (Direct Cost: ¥88,000,000、Indirect Cost: ¥26,400,000)
Fiscal Year 2007: ¥114,400,000 (Direct Cost: ¥88,000,000、Indirect Cost: ¥26,400,000)
Fiscal Year 2006: ¥132,990,000 (Direct Cost: ¥102,300,000、Indirect Cost: ¥30,690,000)
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| Research Abstract |
Through the integration of coordination/organometallic chemistry, structural biology, and theoretical chemistry, we have undertaken the chemical study of reductases, the importance of which has been noticed recently in connection with social needs for energy and food. Our accomplishments in this program have exceeded our expectations, and we have achieved significant results that provide clues in understanding the enzymatic function of reductases at the cluster active sites. We have succeeded in synthesizing favourable models of the active-sites of nitrogenase and hydrogenase, and their physicochemical properties have been clarified, enabling us to study the chemistry of these enzymes. From the theoretical analysis of the newly synthesized dinuclear complex that activates dinitrogen, we revealed its reaction mechanism, which also provides us with important information concerning the reaction mechanisms of nitrogenase and hydrogenases. We have also discovered the novel[4Fe-3S] cluster in the structure of an oxygen-tolerant[NiFe] hydrogenase.
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