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Diversity of energy transducing mechanism by organella from the parasites such as Plasmodium

Research Project

Project/Area Number 18GS0314
Research Category

Grant-in-Aid for Creative Scientific Research

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo

Principal Investigator

KITA Kiyoshi  東京大学, 大学院・医学系研究科, 教授 (90134444)

Co-Investigator(Kenkyū-buntansha) TANABE Kazuyuki  大阪大学, 微生物病研究所, 招へい教授 (40047410)
NOZAKI Tomoyoshi  国立感染症研究所, 寄生動物部, 部長(研究職) (60198588)
WATANABE Yoh-ichi  東京大学, 大学院・医学系研究科, 准教授 (90323568)
SASAKI Narie  名古屋大学, 大学院・理学研究科, 准教授 (20359699)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥526,370,000 (Direct Cost: ¥404,900,000、Indirect Cost: ¥121,470,000)
Fiscal Year 2010: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000)
Fiscal Year 2009: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000)
Fiscal Year 2008: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000)
Fiscal Year 2007: ¥108,680,000 (Direct Cost: ¥83,600,000、Indirect Cost: ¥25,080,000)
Fiscal Year 2006: ¥108,810,000 (Direct Cost: ¥83,700,000、Indirect Cost: ¥25,110,000)
Keywordsオルガネラ / 寄生虫 / 感染症 / エネルギー代謝 / 細胞・組織 / 進化 / 特殊環境 / 微生物
Research Abstract

Eukaryotic cells possess organella, which are essential for the maintenance of their biological function. By the extensive studies, many new findings on the origin, reaction mechanism and interaction of energy transducing mitochondria and plastid, which are indispensable for the survival of the cells, have been reported. Recent study revealed the unique mitochondria of parasites, which adapt to the anaerobic environment in the host as well as the parasites without mitochondria. However, information on the process of their establishment, details of their physiological functions, interaction between the organella is limited.
The aim of this research project is to answer these questions and establish a base of our understanding the diversity of energy transduction in the novel organella, dynamic interaction between the organella and their evolution. In this study, by focusing on parasitic protozoas such as malaria parasite, we have found novel properties of parasite organella, which bring a new insight organella biology.

Report

(7 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (88 results)

All 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article (72 results) (of which Peer Reviewed: 66 results) Presentation (12 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade2012

    • Author(s)
      Tachibana, S., Sullivan, S. A., Kawai, S., Nakamura, S., Kim, H. R., Goto, N., Arisue, N., Palacpac, N., Honma, H., Yagi, M., Tougan, T., 5, Katakai, Y., Kaneko, O., Mita, T., Kita, K., Yasutomi, Y., Sutton, P. L., Shakhbatyan, R., Horii, T., Yasunaga, T., Barnwell, J. W., Escalante, A. A., Carlton, J. M. and Tanabe, K
    • Journal Title

      Nature Genet

      Volume: (掲載確定)(印刷中)

    • NAID

      120006985529

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei2012

    • Author(s)
      A., Hirai, M., Tanaka, Q. T., Watanabe, Y., Matsuoka, H. and Kita, K.
    • Journal Title

      J. Biochem

      Volume: (掲載確定)(印刷中)

    • NAID

      10031166137

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Plasmodium apicoplast genome : conserved structure and close relationship of P.ovale to rodent malaria parasites2012

    • Author(s)
      Arisue, N., et al
    • Journal Title

      Mol.Biol.Evol.

      Volume: (掲載確定)(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system-a unique mitochondrial metabolism in tumor microenvironments2012

    • Author(s)
      Tomitsuka, E., et al
    • Journal Title

      J.Biochem.

      Volume: (掲載確定)(印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial fumarate reductase as a target of chemotherapy : from parasites to cancer cells2012

    • Author(s)
      Sakai, C., et al
    • Journal Title

      Biochim.Biophys.Acta

      Volume: 1820 Pages: 643-651

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila2012

    • Author(s)
      Oda, Y., et al
    • Journal Title

      Mitochondrion

      Volume: 12 Pages: 345-351

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi2012

    • Author(s)
      Nara, T., et al
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 418 Pages: 140-143

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm2012

    • Author(s)
      Hashimoto, M., et al
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 417 Pages: 1002-1006

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel transmembrane receptor involved in phagosome transport of lysozymes and ss-hexosaminidase in the enteric protozoan Entamoeba histolytica2012

    • Author(s)
      Furukawa, A., et al
    • Journal Title

      PLoS Pathogens

      Volume: 8(2)(電子版)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concatenated mitochondrial DNA of the coccidian parasite Eimeria tenella2011

    • Author(s)
      Hikosaka, K., Nakai, Y., Watanabe, Y., Tachibana, S., Arisue, N., Palacpac, N. M., Toyama, T., Honma, H., Horii, T., Kita, K. and Tanabe, K
    • Journal Title

      Mitochondrion

      Volume: 11 Pages: 273-278

    • Related Report
      2010 Annual Research Report 2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Global Analysis of gene expression in response to L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica2011

    • Author(s)
      Husain, A., et al
    • Journal Title

      BMC Genomics

      Volume: 12(電子版) Pages: 275-275

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sulfate activation in mitosomes plays a crucial role in the proliferation of Entamoeba histolytica2011

    • Author(s)
      Mi-ichi, F., et al
    • Journal Title

      PLoS Negl.Trop.Dis.

      Volume: 5(電子版)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly conserved gene arrangement of the mitochondrial genomes of 23 Plasmodium species2011

    • Author(s)
      Hikosaka, K., et al
    • Journal Title

      Parasitol.Int.

      Volume: 60 Pages: 175-180

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp.FKI-33892011

    • Author(s)
      Mori, M., et al
    • Journal Title

      Tetrahedron

      Volume: 67 Pages: 6582-6586

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive frameshift at all AGG and CCC codons in the mitochondrial cytochrome c oxidase subunit 1 gene of Perkinsus marinus(Alveolata ; Dinoflagellata)2010

    • Author(s)
      Masuda, I., Matsuzaki, M. and Kita, K
    • Journal Title

      Nucleic Acids Research

      Volume: 38 Pages: 6186-6194

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies2010

    • Author(s)
      Nakamura, K., et al
    • Journal Title

      Parasitol.Int.

      Volume: 59 Pages: 560-564

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extensive frameshift at all AGG and CCC codons in the mitochondrial cytochrome c oxidase subunit 1 gene of Perkinsus marinus (Alveolata ; Dinoflagellata)2010

    • Author(s)
      Masuda, I, et al
    • Journal Title

      Nucleic Acids Research

      Volume: 38 Pages: 6186-6194

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Purification and kinetic characterization of recombinant alternative oxidase from Trypanosoma brucei brucei2010

    • Author(s)
      Kido, Y., et al.
    • Journal Title

      Biochim Biophys.Acta(Bioenergetics) 1797

      Pages: 443-450

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase2010

    • Author(s)
      Balogun, O.E., et al.
    • Journal Title

      Acta Crystallographica F66

      Pages: 304-308

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Divergence of mitochondrial genome structure in the apicomplexan parasites, Babesia and Theileria2010

    • Author(s)
      Hikosaka, K., et al.
    • Journal Title

      Mol.Biol.Evolution 27

      Pages: 1107-1116

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A broad distribution of mitochondrial alternative oxidase in microsporidian parasites2010

    • Author(s)
      Williams, B.A.P., et al.
    • Journal Title

      PLoS Pathogens 6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei2010

    • Author(s)
      Kido, Y., et al.
    • Journal Title

      Acta Crystallographica F66

      Pages: 275-278

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of the FAD and quinone binding sites to the production of reactive oxygen species(ROS)from Ascaris suum mitochondrial complex II2010

    • Author(s)
      Paranagama, M.P., et al.
    • Journal Title

      Mitochondrion 10

      Pages: 158-165

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitosomes in Entamoeba histolytica contain a sulfate activation pathway2009

    • Author(s)
      Mi-ichi, F., Yousuf, M. A., Nakada-Tsukui, K. and Nozaki T
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 106 Pages: 21731-21736

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Plasmodium HU homolog, which binds the plastid DNA sequence-independent manner, is essential for the parasite's survival2009

    • Author(s)
      Sasaki N., Hirai, M., Maeda, K., Yui, R., Itoh, K., Namiki, S., Morita, T., Hata, M., Murakami-Murofushi, K., Matsuoka, H., Kita, K., Sato, S
    • Journal Title

      FEBS Lett

      Volume: 583 Pages: 1446-1450

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi is Composed of Twelve Peptides Including a Heterodimeric Ip Subunit2009

    • Author(s)
      Morales, J., Mogi, T., Mineki, S., Takashima, E., Mineki, R., Hirawake, H., Sakamoto, K., . mura, S. and Kita, K
    • Journal Title

      J. Biol. Chem

      Volume: 284 Pages: 7255-7263

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii2009

    • Author(s)
      Kawahara, K., Mogi, T., Tanaka, Q. T., Hata, M., Miyoshi, H. and Kita K
    • Journal Title

      J. Biochem

      Volume: 145 Pages: 229-237

    • NAID

      10026301704

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of mitochondrial and apicoplast nucleoids in the human malaria parasite Plasmodium falciparum by SYBR Green I and PicoGreen staining2009

    • Author(s)
      Sano-Maeda, K., et al.
    • Journal Title

      Cytologia 74

      Pages: 449-455

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three redox states of Trypanosoma brucei alternative oxidase identified by infrared spectroscopy and electrochemistry2009

    • Author(s)
      Marechal, A., et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 31827-31833

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crystallization and preliminary X-ray analysis of aspartate transcarbamoylase from theparasitic protist Trypanosoma cruzi2009

    • Author(s)
      Matoba, K., et al.
    • Journal Title

      Acta Crystallographica F65

      Pages: 933-936

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of mitochondrial Complex II subunits SDH3 and SDH4 and ATP synthase subunits a and b in Plasmodium spp2009

    • Author(s)
      Mogi, T., et al.
    • Journal Title

      Mitochondrion 9

      Pages: 443-453

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Plasmodium HU homolog, which binds the plastid DNA sequence-independent manner, is essential for the parasite's survival2009

    • Author(s)
      Sasaki, N., et al.
    • Journal Title

      〓EBS Lett. 583

      Pages: 1446-1450

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi is Composed of Twelve Peptides Including a Heterodimeric Ip Subunit2009

    • Author(s)
      Morales, J., et al.
    • Journal Title

      J.Biol.Chem. 284

      Pages: 7255-7263

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases2009

    • Author(s)
      Mogi, T., et al.
    • Journal Title

      Biochim Biophys.Acta(Bioenergetics) 1787

      Pages: 129-133

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii2009

    • Author(s)
      Kawahara, K., et al.
    • Journal Title

      J.Biochem. 145

      Pages: 229-237

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of New Inhibitors for Alternative NADH Dehydrogenase(NDH-II)2009

    • Author(s)
      Mogi, T., et al.
    • Journal Title

      FEMS Miclobiol.Lett. 291

      Pages: 157-161

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Plasmodium HU homolog, which binds the plastid DNA sequence-independent manner,is essential for the parasite's survival2009

    • Author(s)
      Sasaki, N., Hirai, M., Maeda, K., Yui, R., Itoh, K., Namiki, S., Morita, T., Hata, M., Murakami-Murofushi, K., Matsuoka, H., Kita, K., Sato, S.
    • Journal Title

      FEBS Lett. 583

      Pages: 1446-1450

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi is Composed of Twelve Peptides Including a Heterodimeric Ip Subunit2009

    • Author(s)
      Morales, J., Mogi, T., Mineki, S., Takashima, E., Mineki, R., Hirawake, H., Sakamoto, K., mura, S.and Kita, K.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 7255-7263

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii2009

    • Author(s)
      Kawahara,K., Mogi, T., Tanaka, Q. T., Hata, M., Miyoshi, H.and Kita K.
    • Journal Title

      J. Biochem 145

      Pages: 229-237

    • NAID

      10026301704

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Biochemical and spectroscopic properties of cyanide-insensitive insensitive quinol oxidase from Gluconobacter oxydans2009

    • Author(s)
      Mogi, T., et al.
    • Journal Title

      J. Biochem. ((印刷中)掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Plasmodium HU homolog, which binds the plastid DNA sequence-independent manner, is essential for the parasite's survival2009

    • Author(s)
      Sasaki, N., et al.
    • Journal Title

      FEBS Lett. ((印刷中)掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Mitochondrial Complex II Isolated from Trypanoaoma cruzi is Composed of Twelve Peptides Including a Heterodimeric Ip Subunit2009

    • Author(s)
      Morales, J., et al.
    • Journal Title

      J. Biol. Chem. 284

      Pages: 7255-7263

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fasting induced hypothermia and reduced energy production in mice lacking Acetyl-CoA Synthetase 2.2009

    • Author(s)
      Sakakibara, I., et al.
    • Journal Title

      Cell Metabolism 9

      Pages: 191-202

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases.2009

    • Author(s)
      Mogi, T., et al.
    • Journal Title

      Biochim Biophys. Acta (Bioenergetics) 1787

      Pages: 129-133

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii2009

    • Author(s)
      Kawahara, K., et al.
    • Journal Title

      J. Biochem. 145

      Pages: 229-237

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of New Inhibitors for Alternative NADH Dehydrogenase (NDH-II)2009

    • Author(s)
      Mogi, T., et al.
    • Journal Title

      FEMS Miclobiol. Lett. 291

      Pages: 157-161

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Big bang in the evolution of extant malaria parasites2008

    • Author(s)
      T. Hayakawa, R. Culleton, H. Otani, T. Horii, and K. Tanabe
    • Journal Title

      Mol. Biol. Evol

      Volume: 25 Pages: 2233-2239

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A cryptic algal group unveiled : a plastid biosynthesis pathway in the oyster parasite Perkinsus marinus2008

    • Author(s)
      Matsuzaki M., Kuroiwa H., Kuroiwa T., Kita K. and Nozaki H
    • Journal Title

      Mol. Biol. Evolution

      Volume: 25 Pages: 1167-1179

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo_2) of the cytochrome b gene.2008

    • Author(s)
      Siregar J. E., Syafruddin D., Matsuoka H, Kita K., and Marzuki S.
    • Journal Title

      Parasitol. Int. 57

      Pages: 229-232

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A cryptic algal group unveiled: a plastid biosynthesis pathway in the oyster parasite Perkinsus marinus2008

    • Author(s)
      Matsuzaki M., Kuroiwa H., Kuroiwa T., Kita K., and Nozaki H.
    • Journal Title

      Mol. Biol. Evolution 25

      Pages: 1167-1179

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Screening of detergents for solubilization, purification and crystallization of membrane proteins: a case study on succinate: ubiquinone oxidore ductase from Escherichia coli2008

    • Author(s)
      Shimizu, H., et al.
    • Journal Title

      Acta Crystallographica F64

      Pages: 858-862

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: Atomic resolution insiehts into mechanisms of dihvdroorotate oxidation and fumarate reduction.2008

    • Author(s)
      Inaoka, D. K., et al.
    • Journal Title

      Biochemistry 47

      Pages: 10881-10891

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gramicidin S identified as a potent inhibitor for cytochrome bd-type quinol oxides2008

    • Author(s)
      Mogi, T., et al.
    • Journal Title

      FEBS Lett. 582

      Pages: 2299-2302

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malaria parasites reproduce with the same manner as flowering plants2008

    • Author(s)
      Hirai, M., et al.
    • Journal Title

      Current Biol. 18

      Pages: 607-613

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cryptic algal group unveiled: a plastid biosynthesis pathway in the oyster parasite Perkinsus marinua2008

    • Author(s)
      Matsuzaki, M., et al.
    • Journal Title

      Mol. Biol. Evolution 25

      Pages: 1167-1179

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compelling EPR evidence that the alternative oxidase is a diiron carboxylate protein2008

    • Author(s)
      Moore, A. L., et al.
    • Journal Title

      Biochim Biophys. Acta (Bioenergetics) 1777

      Pages: 327-330

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coinfection with nonlethal murine malaria parasites suppresses pathogenesis caused by Plasmodium bershei NK652008

    • Author(s)
      ura, M., et al.
    • Journal Title

      J. Immunol. 180

      Pages: 6877-6884

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo2)of the cvtochrome b gene2008

    • Author(s)
      Siregar, J. E., et al.
    • Journal Title

      Parasitol. Int. 57

      Pages: 229-232

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change of subunit composition of mitochondrial complex II (Succinate-ubiquinone reductase/Quinol-fumarate reductase) in Ascaris suum during the migration in the experimental host2008

    • Author(s)
      Iwata, F., et al.
    • Journal Title

      Parasitol. Int. 57

      Pages: 54-61

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A cryptic algal group unveiled: a plastid biosynthesis pathway in the oyster parasite Perkinsus marinus.2008

    • Author(s)
      Matsuzaki M., et. al.
    • Journal Title

      Mol. Biol. Evolution (印刷中)(掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compelling EPR evidence that the alternative oxidase is a diiron carboxylate protein.2008

    • Author(s)
      Moore A.L., et. al.
    • Journal Title

      Biochim. Biophys. Acta (Bioenergetics) (印刷中)(掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malaria parasites reproduce with the same manner as flowering plants.2008

    • Author(s)
      Hirai M., et. al.
    • Journal Title

      Current Biol. 18

      Pages: 1-7

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo_2) of the cytochrome b gene.2008

    • Author(s)
      Siregar J.E., et. al.
    • Journal Title

      Parasitol. Int. 57

      Pages: 229-232

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anaerobic NADH-Fumarate Reductase System Is Predominant in the Respiratory Chain of Echinococcus multilocularis, Providing a Novel Target for the Chemotherapy of Alveolar Echinococcosis.2008

    • Author(s)
      Matsumoto J., et. al.
    • Journal Title

      Antimicrob. Agents. Chemother. 52

      Pages: 164-170

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change of subunit composition of mitochondrial complex II (Succinate-ubiquinone reductase/Quinol-fumarate reductase) in Ascaris suum during the migration in the experimental host.2008

    • Author(s)
      Iwata F., et. al.
    • Journal Title

      Parasitol. Int. 57

      Pages: 54-61

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decursin and decursinol angelate selectively inhibits NADH-fumarate reductase of Ascaris suum.2007

    • Author(s)
      Shiomi K., et. al.
    • Journal Title

      Planta Medica 73

      Pages: 1478-1481

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between reactive oxygen species and heme metabolism during the differentiation of Neuro2a cells.2007

    • Author(s)
      新庄 記子 et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Parasitology in Japan : Advances in drug discovery and biochemical studies.2007

    • Author(s)
      北 潔 et al.
    • Journal Title

      Trends in Parasitol. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Cloning and characterization of ferredoxin and ferredoxin-NADP+ reductase from human malaria parasite.2007

    • Author(s)
      木又・有賀 洋子 et al.
    • Journal Title

      J. Biochem. (印刷中)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Independent evolution of pyrimethamine resistance in Plasmodium falciparum in Melanesia.2007

    • Author(s)
      三田 俊秀 et al.
    • Journal Title

      Antimicrob. Agents. Chemother. 51

      Pages: 1071-1077

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Mitochondria and apicoplast of Plasmodium falciparum : behaviour on subcellular fractionation and the implication.2007

    • Author(s)
      小林 環 et al.
    • Journal Title

      Mitochondrion 7

      Pages: 125-132

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083.2006

    • Author(s)
      宇井 英明 et al.
    • Journal Title

      J. Antibiot. 59

      Pages: 785-790

    • Related Report
      2006 Annual Research Report
  • [Presentation] The different roles of mitochondrial complex II in the intraerythrocytic stages and insect stage of Plasmodium studied by gene targeting of the Fp subunit2012

    • Author(s)
      Kita, Kiyoshi
    • Organizer
      The Mantra Erskine Beach Resort
    • Place of Presentation
      Lorne(Australia)
    • Year and Date
      2012-02-22
    • Related Report
      2010 Final Research Report
  • [Presentation] The different roles of mitochondrial complex II in the intraerythrocytic stages and insect stage of Plasmodium studied by gene targeting of the Fp subunit2012

    • Author(s)
      北潔
    • Organizer
      MAM2012 Molecular Approaches to Malaria
    • Place of Presentation
      ローンMantra Erskine Resort(オーストラリア)
    • Year and Date
      2012-02-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] The roles of mitochondrial complex II(succinate-ubiquinone reductase/quinol-fumarate reductase) of Plasmodium studied by gene targeting of the Fp subunit2011

    • Author(s)
      Kita, Kiyoshi
    • Organizer
      Hotel Borobudur
    • Place of Presentation
      Jakarta(Indonesia)
    • Year and Date
      2011-11-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 寄生虫ミトコンドリアの多様性:薬剤標的として2011

    • Author(s)
      北潔
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館、京都府
    • Year and Date
      2011-09-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 寄生性渦鞭毛藻類Perkinsusのミトコンドリアにおけるribosomal frameshiftを伴う遺伝子発現系2009

    • Author(s)
      増田功、松崎素道、北潔
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド、兵庫県
    • Year and Date
      2009-10-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 低酸素適応におけるミトコンドリアの役割2009

    • Author(s)
      北潔
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミトコンドリアを持たない寄生原虫・クリプトスポリジウムにおける呼吸鎖の生化学的解析2009

    • Author(s)
      原田倫世
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Year and Date
      2009-10-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] マラリア原虫コハク酸-ユビキノン還元(複合体II)の遺伝子破壊による表現型解析2009

    • Author(s)
      日野明紀菜、平井誠、田中健、松岡裕之、北潔
    • Organizer
      第78回日本寄生虫学会大会
    • Place of Presentation
      法政大学市ヶ谷キャンパス外濠校舎、東京都
    • Year and Date
      2009-03-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Purification and crystallization of drug target trypanosome alternative oxidase (TAO) from Trypanosoma brucei2008

    • Author(s)
      Kido, Y.
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria 2008
    • Place of Presentation
      Cheju, Korea
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Novel subunit organization of the respiratory Complex II (succinate-ubiquinone oxidoreductase) in Trypanoaoma cruzi2008

    • Author(s)
      Morales, J.
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria 2008
    • Place of Presentation
      Cheju, Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] Toward anti-cryptosporidial chemotherapy by ascofuranone, specific and potent inhibitoragainst alternative oxidase (AOX)2008

    • Author(s)
      Harada, M.
    • Organizer
      XVIIth International Congress for Tropical Medicine and Malaria 2008
    • Place of Presentation
      Cheju, Korea
    • Related Report
      2008 Annual Research Report
  • [Presentation] Parasite mitochondria as a target of chemotherapy2007

    • Author(s)
      Kita K.
    • Organizer
      10th IUBMB Conference
    • Place of Presentation
      Salvador, Bahia, Brazil
    • Year and Date
      2007-05-25
    • Related Report
      2007 Annual Research Report
  • [Book] 「クリプトスポリジウム」感染症事典2012

    • Author(s)
      原田倫世、北潔
    • Publisher
      オーム社
    • Related Report
      2010 Final Research Report
  • [Book] 「眠り病は眠らない」岩波科学ライブラリー2008

    • Author(s)
      山内一也、北潔
    • Publisher
      岩波書店
    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.sih.m.u-tokyo.ac.jp/chem_top-J.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.sih.m.u-tokyo.ac.jp/chem_top-J.html

    • Related Report
      2008 Self-evaluation Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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