Diversity of energy transducing mechanism by organella from the parasites such as Plasmodium

• Project/Area Number: 18GS0314
• Research Category: Grant-in-Aid for Creative Scientific Research
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo
• Principal Investigator: KITA Kiyoshi 東京大学, 大学院・医学系研究科, 教授 (90134444)
• Co-Investigator(Kenkyū-buntansha): TANABE Kazuyuki 大阪大学, 微生物病研究所, 招へい教授 (40047410) ; NOZAKI Tomoyoshi 国立感染症研究所, 寄生動物部, 部長(研究職) (60198588) ; WATANABE Yoh-ichi 東京大学, 大学院・医学系研究科, 准教授 (90323568) ; SASAKI Narie 名古屋大学, 大学院・理学研究科, 准教授 (20359699)
• Project Period (FY): 2006 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥526,370,000 (Direct Cost: ¥404,900,000、Indirect Cost: ¥121,470,000); Fiscal Year 2010: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000); Fiscal Year 2009: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000); Fiscal Year 2008: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000); Fiscal Year 2007: ¥108,680,000 (Direct Cost: ¥83,600,000、Indirect Cost: ¥25,080,000); Fiscal Year 2006: ¥108,810,000 (Direct Cost: ¥83,700,000、Indirect Cost: ¥25,110,000)
• Keywords: オルガネラ / 寄生虫 / 感染症 / エネルギー代謝 / 細胞・組織 / 進化 / 特殊環境 / 微生物

Research Abstract

Eukaryotic cells possess organella, which are essential for the maintenance of their biological function. By the extensive studies, many new findings on the origin, reaction mechanism and interaction of energy transducing mitochondria and plastid, which are indispensable for the survival of the cells, have been reported. Recent study revealed the unique mitochondria of parasites, which adapt to the anaerobic environment in the host as well as the parasites without mitochondria. However, information on the process of their establishment, details of their physiological functions, interaction between the organella is limited.
The aim of this research project is to answer these questions and establish a base of our understanding the diversity of energy transduction in the novel organella, dynamic interaction between the organella and their evolution. In this study, by focusing on parasitic protozoas such as malaria parasite, we have found novel properties of parasite organella, which bring a new insight organella biology.

Research Products

• [Journal Article] Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade (2012)
  • Author(s): Tachibana, S., Sullivan, S. A., Kawai, S., Nakamura, S., Kim, H. R., Goto, N., Arisue, N., Palacpac, N., Honma, H., Yagi, M., Tougan, T., 5, Katakai, Y., Kaneko, O., Mita, T., Kita, K., Yasutomi, Y., Sutton, P. L., Shakhbatyan, R., Horii, T., Yasunaga, T., Barnwell, J. W., Escalante, A. A., Carlton, J. M. and Tanabe, K
  • Journal Title: Nature Genet Volume: (掲載確定)(印刷中)
  • NAID: 120006985529
  • Peer Reviewed
• [Journal Article] Critical roles of the mitochondrial complex II in oocyst formation of rodent malaria parasite Plasmodium berghei (2012)
  • Author(s): A., Hirai, M., Tanaka, Q. T., Watanabe, Y., Matsuoka, H. and Kita, K.
  • Journal Title: J. Biochem Volume: (掲載確定)(印刷中)
  • NAID: 10031166137
  • Peer Reviewed
• [Journal Article] The Plasmodium apicoplast genome : conserved structure and close relationship of P.ovale to rodent malaria parasites (2012)
  • Author(s): Arisue, N., et al
  • Journal Title: Mol.Biol.Evol. Volume: (掲載確定)(印刷中)
  • Peer Reviewed
• [Journal Article] An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system-a unique mitochondrial metabolism in tumor microenvironments (2012)
  • Author(s): Tomitsuka, E., et al
  • Journal Title: J.Biochem. Volume: (掲載確定)(印刷中)
  • Peer Reviewed
• [Journal Article] Mitochondrial fumarate reductase as a target of chemotherapy : from parasites to cancer cells (2012)
  • Author(s): Sakai, C., et al
  • Journal Title: Biochim.Biophys.Acta Volume: 1820 Pages: 643-651
  • Peer Reviewed
• [Journal Article] Age-related changes in the activities of respiratory chain complexes and mitochondrial morphology in Drosophila (2012)
  • Author(s): Oda, Y., et al
  • Journal Title: Mitochondrion Volume: 12 Pages: 345-351
  • Peer Reviewed
• [Journal Article] Molecular interaction of the first 3 enzymes of the de novo pyrimidine biosynthetic pathway of Trypanosoma cruzi (2012)
  • Author(s): Nara, T., et al
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 418 Pages: 140-143
  • Peer Reviewed
• [Journal Article] Critical importance of the de novo pyrimidine biosynthesis pathway for Trypanosoma cruzi growth in the mammalian host cell cytoplasm (2012)
  • Author(s): Hashimoto, M., et al
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 417 Pages: 1002-1006
  • Peer Reviewed
• [Journal Article] Novel transmembrane receptor involved in phagosome transport of lysozymes and ss-hexosaminidase in the enteric protozoan Entamoeba histolytica (2012)
  • Author(s): Furukawa, A., et al
  • Journal Title: PLoS Pathogens Volume: 8(2)(電子版)
  • Peer Reviewed
• [Journal Article] Concatenated mitochondrial DNA of the coccidian parasite Eimeria tenella (2011)
  • Author(s): Hikosaka, K., Nakai, Y., Watanabe, Y., Tachibana, S., Arisue, N., Palacpac, N. M., Toyama, T., Honma, H., Horii, T., Kita, K. and Tanabe, K
  • Journal Title: Mitochondrion Volume: 11 Pages: 273-278
  • Peer Reviewed
• [Journal Article] Global Analysis of gene expression in response to L-cysteine deprivation in the anaerobic protozoan parasite Entamoeba histolytica (2011)
  • Author(s): Husain, A., et al
  • Journal Title: BMC Genomics Volume: 12(電子版) Pages: 275-275
  • Peer Reviewed
• [Journal Article] Sulfate activation in mitosomes plays a crucial role in the proliferation of Entamoeba histolytica (2011)
  • Author(s): Mi-ichi, F., et al
  • Journal Title: PLoS Negl.Trop.Dis. Volume: 5(電子版)
  • Peer Reviewed
• [Journal Article] Highly conserved gene arrangement of the mitochondrial genomes of 23 Plasmodium species (2011)
  • Author(s): Hikosaka, K., et al
  • Journal Title: Parasitol.Int. Volume: 60 Pages: 175-180
  • Peer Reviewed
• [Journal Article] Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp.FKI-3389 (2011)
  • Author(s): Mori, M., et al
  • Journal Title: Tetrahedron Volume: 67 Pages: 6582-6586
  • Peer Reviewed
• [Journal Article] Extensive frameshift at all AGG and CCC codons in the mitochondrial cytochrome c oxidase subunit 1 gene of Perkinsus marinus(Alveolata ; Dinoflagellata) (2010)
  • Author(s): Masuda, I., Matsuzaki, M. and Kita, K
  • Journal Title: Nucleic Acids Research Volume: 38 Pages: 6186-6194
  • Peer Reviewed
• [Journal Article] Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies (2010)
  • Author(s): Nakamura, K., et al
  • Journal Title: Parasitol.Int. Volume: 59 Pages: 560-564
  • Peer Reviewed
• [Journal Article] Extensive frameshift at all AGG and CCC codons in the mitochondrial cytochrome c oxidase subunit 1 gene of Perkinsus marinus (Alveolata ; Dinoflagellata) (2010)
  • Author(s): Masuda, I, et al
  • Journal Title: Nucleic Acids Research Volume: 38 Pages: 6186-6194
  • Peer Reviewed
• [Journal Article] Purification and kinetic characterization of recombinant alternative oxidase from Trypanosoma brucei brucei (2010)
  • Author(s): Kido, Y., et al.
  • Journal Title: Biochim Biophys.Acta(Bioenergetics) 1797 Pages: 443-450
  • Peer Reviewed
• [Journal Article] Overproduction, purification, crystallization and preliminary X-ray diffraction analysis of Trypanosoma brucei gambiense glycerol kinase (2010)
  • Author(s): Balogun, O.E., et al.
  • Journal Title: Acta Crystallographica F66 Pages: 304-308
  • Peer Reviewed
• [Journal Article] Divergence of mitochondrial genome structure in the apicomplexan parasites, Babesia and Theileria (2010)
  • Author(s): Hikosaka, K., et al.
  • Journal Title: Mol.Biol.Evolution 27 Pages: 1107-1116
  • Peer Reviewed
• [Journal Article] A broad distribution of mitochondrial alternative oxidase in microsporidian parasites (2010)
  • Author(s): Williams, B.A.P., et al.
  • Journal Title: PLoS Pathogens 6
  • Peer Reviewed
• [Journal Article] Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei (2010)
  • Author(s): Kido, Y., et al.
  • Journal Title: Acta Crystallographica F66 Pages: 275-278
  • Peer Reviewed
• [Journal Article] Contribution of the FAD and quinone binding sites to the production of reactive oxygen species(ROS)from Ascaris suum mitochondrial complex II (2010)
  • Author(s): Paranagama, M.P., et al.
  • Journal Title: Mitochondrion 10 Pages: 158-165
  • Peer Reviewed
• [Journal Article] Mitosomes in Entamoeba histolytica contain a sulfate activation pathway (2009)
  • Author(s): Mi-ichi, F., Yousuf, M. A., Nakada-Tsukui, K. and Nozaki T
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 106 Pages: 21731-21736
  • Peer Reviewed
• [Journal Article] The Plasmodium HU homolog, which binds the plastid DNA sequence-independent manner, is essential for the parasite's survival (2009)
  • Author(s): Sasaki N., Hirai, M., Maeda, K., Yui, R., Itoh, K., Namiki, S., Morita, T., Hata, M., Murakami-Murofushi, K., Matsuoka, H., Kita, K., Sato, S
  • Journal Title: FEBS Lett Volume: 583 Pages: 1446-1450
  • Peer Reviewed
• [Journal Article] Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi is Composed of Twelve Peptides Including a Heterodimeric Ip Subunit (2009)
  • Author(s): Morales, J., Mogi, T., Mineki, S., Takashima, E., Mineki, R., Hirawake, H., Sakamoto, K., . mura, S. and Kita, K
  • Journal Title: J. Biol. Chem Volume: 284 Pages: 7255-7263
  • Peer Reviewed
• [Journal Article] Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii (2009)
  • Author(s): Kawahara, K., Mogi, T., Tanaka, Q. T., Hata, M., Miyoshi, H. and Kita K
  • Journal Title: J. Biochem Volume: 145 Pages: 229-237
  • NAID: 10026301704
  • Peer Reviewed
• [Journal Article] Visualization of mitochondrial and apicoplast nucleoids in the human malaria parasite Plasmodium falciparum by SYBR Green I and PicoGreen staining (2009)
  • Author(s): Sano-Maeda, K., et al.
  • Journal Title: Cytologia 74 Pages: 449-455
  • Peer Reviewed
• [Journal Article] Three redox states of Trypanosoma brucei alternative oxidase identified by infrared spectroscopy and electrochemistry (2009)
  • Author(s): Marechal, A., et al.
  • Journal Title: J.Biol.Chem. 284 Pages: 31827-31833
  • Peer Reviewed
• [Journal Article] Crystallization and preliminary X-ray analysis of aspartate transcarbamoylase from theparasitic protist Trypanosoma cruzi (2009)
  • Author(s): Matoba, K., et al.
  • Journal Title: Acta Crystallographica F65 Pages: 933-936
  • Peer Reviewed
• [Journal Article] Identification of mitochondrial Complex II subunits SDH3 and SDH4 and ATP synthase subunits a and b in Plasmodium spp (2009)
  • Author(s): Mogi, T., et al.
  • Journal Title: Mitochondrion 9 Pages: 443-453
  • Peer Reviewed
• [Journal Article] The Plasmodium HU homolog, which binds the plastid DNA sequence-independent manner, is essential for the parasite's survival (2009)
  • Author(s): Sasaki, N., et al.
  • Journal Title: 〓EBS Lett. 583 Pages: 1446-1450
  • Peer Reviewed
• [Journal Article] Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi is Composed of Twelve Peptides Including a Heterodimeric Ip Subunit (2009)
  • Author(s): Morales, J., et al.
  • Journal Title: J.Biol.Chem. 284 Pages: 7255-7263
  • Peer Reviewed
• [Journal Article] Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases (2009)
  • Author(s): Mogi, T., et al.
  • Journal Title: Biochim Biophys.Acta(Bioenergetics) 1787 Pages: 129-133
  • Peer Reviewed
• [Journal Article] Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii (2009)
  • Author(s): Kawahara, K., et al.
  • Journal Title: J.Biochem. 145 Pages: 229-237
  • Peer Reviewed
• [Journal Article] Identification of New Inhibitors for Alternative NADH Dehydrogenase(NDH-II) (2009)
  • Author(s): Mogi, T., et al.
  • Journal Title: FEMS Miclobiol.Lett. 291 Pages: 157-161
  • Peer Reviewed
• [Journal Article] The Plasmodium HU homolog, which binds the plastid DNA sequence-independent manner,is essential for the parasite's survival (2009)
  • Author(s): Sasaki, N., Hirai, M., Maeda, K., Yui, R., Itoh, K., Namiki, S., Morita, T., Hata, M., Murakami-Murofushi, K., Matsuoka, H., Kita, K., Sato, S.
  • Journal Title: FEBS Lett. 583 Pages: 1446-1450
  • Peer Reviewed
• [Journal Article] Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi is Composed of Twelve Peptides Including a Heterodimeric Ip Subunit (2009)
  • Author(s): Morales, J., Mogi, T., Mineki, S., Takashima, E., Mineki, R., Hirawake, H., Sakamoto, K., mura, S.and Kita, K.
  • Journal Title: J. Biol. Chem. 284 Pages: 7255-7263
  • Peer Reviewed
• [Journal Article] Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii (2009)
  • Author(s): Kawahara,K., Mogi, T., Tanaka, Q. T., Hata, M., Miyoshi, H.and Kita K.
  • Journal Title: J. Biochem 145 Pages: 229-237
  • NAID: 10026301704
  • Peer Reviewed
• [Journal Article] Biochemical and spectroscopic properties of cyanide-insensitive insensitive quinol oxidase from Gluconobacter oxydans (2009)
  • Author(s): Mogi, T., et al.
  • Journal Title: J. Biochem. ((印刷中)掲載確定)
  • Peer Reviewed
• [Journal Article] The Plasmodium HU homolog, which binds the plastid DNA sequence-independent manner, is essential for the parasite's survival (2009)
  • Author(s): Sasaki, N., et al.
  • Journal Title: FEBS Lett. ((印刷中)掲載確定)
  • Peer Reviewed
• [Journal Article] Novel Mitochondrial Complex II Isolated from Trypanoaoma cruzi is Composed of Twelve Peptides Including a Heterodimeric Ip Subunit (2009)
  • Author(s): Morales, J., et al.
  • Journal Title: J. Biol. Chem. 284 Pages: 7255-7263
  • Peer Reviewed
• [Journal Article] Fasting induced hypothermia and reduced energy production in mice lacking Acetyl-CoA Synthetase 2. (2009)
  • Author(s): Sakakibara, I., et al.
  • Journal Title: Cell Metabolism 9 Pages: 191-202
  • Peer Reviewed
• [Journal Article] Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases. (2009)
  • Author(s): Mogi, T., et al.
  • Journal Title: Biochim Biophys. Acta (Bioenergetics) 1787 Pages: 129-133
  • Peer Reviewed
• [Journal Article] Mitochondrial Dehydrogenases in the Aerobic Respiratory Chain of the Rodent Malaria Parasite Plasmodium yoelii yoelii (2009)
  • Author(s): Kawahara, K., et al.
  • Journal Title: J. Biochem. 145 Pages: 229-237
  • Peer Reviewed
• [Journal Article] Identification of New Inhibitors for Alternative NADH Dehydrogenase (NDH-II) (2009)
  • Author(s): Mogi, T., et al.
  • Journal Title: FEMS Miclobiol. Lett. 291 Pages: 157-161
  • Peer Reviewed
• [Journal Article] Big bang in the evolution of extant malaria parasites (2008)
  • Author(s): T. Hayakawa, R. Culleton, H. Otani, T. Horii, and K. Tanabe
  • Journal Title: Mol. Biol. Evol Volume: 25 Pages: 2233-2239
  • Peer Reviewed
• [Journal Article] A cryptic algal group unveiled : a plastid biosynthesis pathway in the oyster parasite Perkinsus marinus (2008)
  • Author(s): Matsuzaki M., Kuroiwa H., Kuroiwa T., Kita K. and Nozaki H
  • Journal Title: Mol. Biol. Evolution Volume: 25 Pages: 1167-1179
  • Peer Reviewed
• [Journal Article] Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo_2) of the cytochrome b gene. (2008)
  • Author(s): Siregar J. E., Syafruddin D., Matsuoka H, Kita K., and Marzuki S.
  • Journal Title: Parasitol. Int. 57 Pages: 229-232
  • Peer Reviewed
• [Journal Article] A cryptic algal group unveiled: a plastid biosynthesis pathway in the oyster parasite Perkinsus marinus (2008)
  • Author(s): Matsuzaki M., Kuroiwa H., Kuroiwa T., Kita K., and Nozaki H.
  • Journal Title: Mol. Biol. Evolution 25 Pages: 1167-1179
  • Peer Reviewed
• [Journal Article] Screening of detergents for solubilization, purification and crystallization of membrane proteins: a case study on succinate: ubiquinone oxidore ductase from Escherichia coli (2008)
  • Author(s): Shimizu, H., et al.
  • Journal Title: Acta Crystallographica F64 Pages: 858-862
  • Peer Reviewed
• [Journal Article] Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: Atomic resolution insiehts into mechanisms of dihvdroorotate oxidation and fumarate reduction. (2008)
  • Author(s): Inaoka, D. K., et al.
  • Journal Title: Biochemistry 47 Pages: 10881-10891
  • Peer Reviewed
• [Journal Article] Gramicidin S identified as a potent inhibitor for cytochrome bd-type quinol oxides (2008)
  • Author(s): Mogi, T., et al.
  • Journal Title: FEBS Lett. 582 Pages: 2299-2302
  • Peer Reviewed
• [Journal Article] Malaria parasites reproduce with the same manner as flowering plants (2008)
  • Author(s): Hirai, M., et al.
  • Journal Title: Current Biol. 18 Pages: 607-613
  • Peer Reviewed
• [Journal Article] A cryptic algal group unveiled: a plastid biosynthesis pathway in the oyster parasite Perkinsus marinua (2008)
  • Author(s): Matsuzaki, M., et al.
  • Journal Title: Mol. Biol. Evolution 25 Pages: 1167-1179
  • Peer Reviewed
• [Journal Article] Compelling EPR evidence that the alternative oxidase is a diiron carboxylate protein (2008)
  • Author(s): Moore, A. L., et al.
  • Journal Title: Biochim Biophys. Acta (Bioenergetics) 1777 Pages: 327-330
  • Peer Reviewed
• [Journal Article] Coinfection with nonlethal murine malaria parasites suppresses pathogenesis caused by Plasmodium bershei NK65 (2008)
  • Author(s): ura, M., et al.
  • Journal Title: J. Immunol. 180 Pages: 6877-6884
  • Peer Reviewed
• [Journal Article] Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo2)of the cvtochrome b gene (2008)
  • Author(s): Siregar, J. E., et al.
  • Journal Title: Parasitol. Int. 57 Pages: 229-232
  • Peer Reviewed
• [Journal Article] Change of subunit composition of mitochondrial complex II (Succinate-ubiquinone reductase/Quinol-fumarate reductase) in Ascaris suum during the migration in the experimental host (2008)
  • Author(s): Iwata, F., et al.
  • Journal Title: Parasitol. Int. 57 Pages: 54-61
  • Peer Reviewed
• [Journal Article] A cryptic algal group unveiled: a plastid biosynthesis pathway in the oyster parasite Perkinsus marinus. (2008)
  • Author(s): Matsuzaki M., et. al.
  • Journal Title: Mol. Biol. Evolution (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Compelling EPR evidence that the alternative oxidase is a diiron carboxylate protein. (2008)
  • Author(s): Moore A.L., et. al.
  • Journal Title: Biochim. Biophys. Acta (Bioenergetics) (印刷中)(掲載確定)
  • Peer Reviewed
• [Journal Article] Malaria parasites reproduce with the same manner as flowering plants. (2008)
  • Author(s): Hirai M., et. al.
  • Journal Title: Current Biol. 18 Pages: 1-7
  • Peer Reviewed
• [Journal Article] Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo_2) of the cytochrome b gene. (2008)
  • Author(s): Siregar J.E., et. al.
  • Journal Title: Parasitol. Int. 57 Pages: 229-232
  • Peer Reviewed
• [Journal Article] Anaerobic NADH-Fumarate Reductase System Is Predominant in the Respiratory Chain of Echinococcus multilocularis, Providing a Novel Target for the Chemotherapy of Alveolar Echinococcosis. (2008)
  • Author(s): Matsumoto J., et. al.
  • Journal Title: Antimicrob. Agents. Chemother. 52 Pages: 164-170
  • Peer Reviewed
• [Journal Article] Change of subunit composition of mitochondrial complex II (Succinate-ubiquinone reductase/Quinol-fumarate reductase) in Ascaris suum during the migration in the experimental host. (2008)
  • Author(s): Iwata F., et. al.
  • Journal Title: Parasitol. Int. 57 Pages: 54-61
  • Peer Reviewed
• [Journal Article] Decursin and decursinol angelate selectively inhibits NADH-fumarate reductase of Ascaris suum. (2007)
  • Author(s): Shiomi K., et. al.
  • Journal Title: Planta Medica 73 Pages: 1478-1481
  • Peer Reviewed
• [Journal Article] Relationship between reactive oxygen species and heme metabolism during the differentiation of Neuro2a cells. (2007)
  • Author(s): 新庄 記子 et al.
  • Journal Title: Biochem. Biophys. Res. Commun. (印刷中)
• [Journal Article] Parasitology in Japan : Advances in drug discovery and biochemical studies. (2007)
  • Author(s): 北 潔 et al.
  • Journal Title: Trends in Parasitol. (印刷中)
• [Journal Article] Cloning and characterization of ferredoxin and ferredoxin-NADP+ reductase from human malaria parasite. (2007)
  • Author(s): 木又・有賀 洋子 et al.
  • Journal Title: J. Biochem. (印刷中)
• [Journal Article] Independent evolution of pyrimethamine resistance in Plasmodium falciparum in Melanesia. (2007)
  • Author(s): 三田 俊秀 et al.
  • Journal Title: Antimicrob. Agents. Chemother. 51 Pages: 1071-1077
• [Journal Article] Mitochondria and apicoplast of Plasmodium falciparum : behaviour on subcellular fractionation and the implication. (2007)
  • Author(s): 小林 環 et al.
  • Journal Title: Mitochondrion 7 Pages: 125-132
• [Journal Article] Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083. (2006)
  • Author(s): 宇井 英明 et al.
  • Journal Title: J. Antibiot. 59 Pages: 785-790
• [Presentation] The different roles of mitochondrial complex II in the intraerythrocytic stages and insect stage of Plasmodium studied by gene targeting of the Fp subunit (2012)
  • Author(s): Kita, Kiyoshi
  • Organizer: The Mantra Erskine Beach Resort
  • Place of Presentation: Lorne(Australia)
  • Year and Date: 2012-02-22
• [Presentation] The different roles of mitochondrial complex II in the intraerythrocytic stages and insect stage of Plasmodium studied by gene targeting of the Fp subunit (2012)
  • Author(s): 北潔
  • Organizer: MAM2012 Molecular Approaches to Malaria
  • Place of Presentation: ローンMantra Erskine Resort(オーストラリア)
  • Year and Date: 2012-02-22
• [Presentation] The roles of mitochondrial complex II(succinate-ubiquinone reductase/quinol-fumarate reductase) of Plasmodium studied by gene targeting of the Fp subunit (2011)
  • Author(s): Kita, Kiyoshi
  • Organizer: Hotel Borobudur
  • Place of Presentation: Jakarta(Indonesia)
  • Year and Date: 2011-11-08
• [Presentation] 寄生虫ミトコンドリアの多様性:薬剤標的として (2011)
  • Author(s): 北潔
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館、京都府
  • Year and Date: 2011-09-21
• [Presentation] 寄生性渦鞭毛藻類Perkinsusのミトコンドリアにおけるribosomal frameshiftを伴う遺伝子発現系 (2009)
  • Author(s): 増田功、松崎素道、北潔
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド、兵庫県
  • Year and Date: 2009-10-23
• [Presentation] 低酸素適応におけるミトコンドリアの役割 (2009)
  • Author(s): 北潔
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2009-10-23
• [Presentation] ミトコンドリアを持たない寄生原虫・クリプトスポリジウムにおける呼吸鎖の生化学的解析 (2009)
  • Author(s): 原田倫世
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2009-10-22
• [Presentation] マラリア原虫コハク酸-ユビキノン還元(複合体II)の遺伝子破壊による表現型解析 (2009)
  • Author(s): 日野明紀菜、平井誠、田中健、松岡裕之、北潔
  • Organizer: 第78回日本寄生虫学会大会
  • Place of Presentation: 法政大学市ヶ谷キャンパス外濠校舎、東京都
  • Year and Date: 2009-03-27
• [Presentation] Purification and crystallization of drug target trypanosome alternative oxidase (TAO) from Trypanosoma brucei (2008)
  • Author(s): Kido, Y.
  • Organizer: XVIIth International Congress for Tropical Medicine and Malaria 2008
  • Place of Presentation: Cheju, Korea
  • Year and Date: 2008-09-30
• [Presentation] Novel subunit organization of the respiratory Complex II (succinate-ubiquinone oxidoreductase) in Trypanoaoma cruzi (2008)
  • Author(s): Morales, J.
  • Organizer: XVIIth International Congress for Tropical Medicine and Malaria 2008
  • Place of Presentation: Cheju, Korea
• [Presentation] Toward anti-cryptosporidial chemotherapy by ascofuranone, specific and potent inhibitoragainst alternative oxidase (AOX) (2008)
  • Author(s): Harada, M.
  • Organizer: XVIIth International Congress for Tropical Medicine and Malaria 2008
  • Place of Presentation: Cheju, Korea
• [Presentation] Parasite mitochondria as a target of chemotherapy (2007)
  • Author(s): Kita K.
  • Organizer: 10th IUBMB Conference
  • Place of Presentation: Salvador, Bahia, Brazil
  • Year and Date: 2007-05-25
• [Book] 「クリプトスポリジウム」感染症事典 (2012)
  • Author(s): 原田倫世、北潔
  • Publisher: オーム社
• [Book] 「眠り病は眠らない」岩波科学ライブラリー (2008)
  • Author(s): 山内一也、北潔
  • Publisher: 岩波書店
• [Remarks]
  • URL: http://www.sih.m.u-tokyo.ac.jp/chem_top-J.html
• [Remarks]
  • URL: http://www.sih.m.u-tokyo.ac.jp/chem_top-J.html