| Co-Investigator(Kenkyū-buntansha) |
MURAYAMA Akiko 筑波大学, 生命環境科学研究科, 講師 (50431656)
TATE Shinーichi 広島大学, 理学研究科, 教授 (20216998)
KIMURA Keiji 筑波大学, 生命環境科学研究科, 准教授 (50332268)
OYAMA Takuji 大阪大学, 蛋白質研究所, 特任研究員 (60423133)
SHIRAKI Takuma 東北大学, 医学系研究科, 助教 (10311747)
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| Budget Amount *help |
¥578,500,000 (Direct Cost: ¥445,000,000、Indirect Cost: ¥133,500,000)
Fiscal Year 2010: ¥114,400,000 (Direct Cost: ¥88,000,000、Indirect Cost: ¥26,400,000)
Fiscal Year 2009: ¥114,400,000 (Direct Cost: ¥88,000,000、Indirect Cost: ¥26,400,000)
Fiscal Year 2008: ¥114,400,000 (Direct Cost: ¥88,000,000、Indirect Cost: ¥26,400,000)
Fiscal Year 2007: ¥114,400,000 (Direct Cost: ¥88,000,000、Indirect Cost: ¥26,400,000)
Fiscal Year 2006: ¥120,900,000 (Direct Cost: ¥93,000,000、Indirect Cost: ¥27,900,000)
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| Research Abstract |
Various "-ome" researches are currently ongoing. Although we acknowledge that these data are enormous collections for elementary pieces of biological phenomena, it remains unclear how biological system connects these pieces each other at the molecular level. In our research project, we focused on the apparently classical theme, "functional coupling between transcription and cellular metabolism". From this point of view, we have focused on nuclear receptors, and revealed the structural basis for how transcription factors monitors cellular metabolites and regulates homeostasis.
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