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Insulin signaling in organs and its integration in mice

Research Project

Project/Area Number 18GS0317
Research Category

Grant-in-Aid for Creative Scientific Research

Allocation TypeSingle-year Grants
Research Institution独立行政法人・国立国際医療研究センター(研究所) (2010)
Research Institute, International Medical Center of Japan (2008-2009)
Kobe University (2006-2007)

Principal Investigator

KASUGA Masato  独立行政法人・国立国際医療研究センター(研究所), 研究所, 所長 (50161047)

Co-Investigator(Kenkyū-buntansha) OGAWA Wataru  神戸大学, 大学院・医学研究科, 准教授 (40294219)
KIDO Yoshiaki  神戸大学, 大学院・保健学研究科, 准教授 (10335440)
TAMORI Yoshikazu  神戸大学, 大学院・医学研究科, 戦略的客員教授 (90379397)
NAKAE Jun  慶應義塾大学, 医学部, 特任教授 (00344573)
INOUE Hiroshi  金沢大学, フロンティアサイエンス機構, 特任准教授 (50397832)
MATSUMOTO Michihiro  国立国際医療研究センター, 分子代謝制御研究部, 部長 (90467663)
野口 哲也  神戸大学, 大学院・医学研究科, 助手 (10372640)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥564,200,000 (Direct Cost: ¥434,000,000、Indirect Cost: ¥130,200,000)
Fiscal Year 2010: ¥105,950,000 (Direct Cost: ¥81,500,000、Indirect Cost: ¥24,450,000)
Fiscal Year 2009: ¥105,950,000 (Direct Cost: ¥81,500,000、Indirect Cost: ¥24,450,000)
Fiscal Year 2008: ¥105,950,000 (Direct Cost: ¥81,500,000、Indirect Cost: ¥24,450,000)
Fiscal Year 2007: ¥111,150,000 (Direct Cost: ¥85,500,000、Indirect Cost: ¥25,650,000)
Fiscal Year 2006: ¥135,200,000 (Direct Cost: ¥104,000,000、Indirect Cost: ¥31,200,000)
Keywords糖尿病 / インスリン抵抗性 / 臓器間シグナル伝達 / インスリン / 糖新生 / 遺伝子発現 / 肥満 / 過食 / KLF15 / PDK1 / FSP27 / TSC2 / 膵β細胞 / インスリン分泌 / Dok1 / インスリンシグナル / MCP-1
Research Abstract

We revealed organ-specific insulin signaling by generating mice lacking a fundamental molecule for insulin signaling in an organ-specific manner. These mice also revealed signals used to communicate between organs. For example, we found insulin action in the brain inhibited hepatic glucose production via the nervous system. Thus, homeostasis in a whole body is regulated ingeniously by signals used to communicate within organs and between organs.

Report

(6 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (91 results)

All 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article (51 results) (of which Peer Reviewed: 22 results) Presentation (25 results) Book (2 results) Remarks (10 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] CITED2 links hormonal signaling to PGC-lαacetylation in regulation of gluconeogenesis2012

    • Author(s)
      Sakai M., Matsumoto M, Tsujimura T., Cao Y., Noguchi T., Inagaki K., Inoue H., Hosooka T., Takazawa K., Kido Y., Yasuda K., Hiramatsu R., Matsuki Y., Kasuga M
    • Journal Title

      Nature Med

      Volume: (in press)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Overexpression of KLF15 in adipocytes of mice results in down-regulation of SCD1 expression in adipocytes and consequent enhancement of glucose-induced insulin secretion2011

    • Author(s)
      Nagare T, Sakaue H, Matsumoto M, Cao Y, Inagaki K, Sakai M, Takashima Y, Nakamura K, Mori T, Okada Y, Matsuki Y, Watanabe E, Ikeda K, Taguchi R, Kamimura N, Ohta S, Hiramatsu R, Kasuga M
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 37458-37469

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC12011

    • Author(s)
      Koyanagi M., Asahara S., Matsuda T., Hashimoto N., Shigeyama Y., Shibutani Y., Kannno A., Fuchita M., Mikami T., Hosooka T., Inoue H., Matsumoto M., Koike M., Uchiyama Y., Noda T., Seino S., Kasuga M., Kido Y
    • Journal Title

      PLoS ONE

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of S6K1 in regulation of SREBP1c expression in the liver2011

    • Author(s)
      Li S., Ogawa W., Emi A., Hayashi K., Senga Y., Nomura K., Hara K., Yu D., Kasuga M
    • Journal Title

      Biochem. Biophys. Res. Commun

    • Related Report
      2010 Final Research Report
  • [Journal Article] PDK1-Foxo1 in Agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure2011

    • Author(s)
      Cao Y, Nakata M, Okamoto S, Takano E, Yada T, Minokoshi Y, Hirata Y, Nakajima K, Iskandar K, Hayashi Y, Ogawa W, Barsh G S., Hosoda H, Kangawa K, Itoh H, Noda T, Kasuga M, J Nakae
    • Journal Title

      PLoS ONE

      Volume: 6

    • Related Report
      2010 Final Research Report
  • [Journal Article] PDK1/FoxO1 pathway in POMC neurons regulates pomc expression and food intake2010

    • Author(s)
      Iskandar K, Cao Y, Hayashi Y, Nakata M, Takano E, Yada T, Zhang C, Ogawa W, Oki M, Chua S Jr, Itoh H, Noda T, Kasuga M, Nakae J
    • Journal Title

      Am. J. Physiol. Endocrino. Metab

      Volume: 298

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action2010

    • Author(s)
      Takashima M, Ogawa W, Hayashi K, Inoue H, Kinoshita S, Okamoto Y, Sakaue H, Wataoka Y, Emi A, Senga Y, Matsuki Y, Watanabe E, Hiramatsu R, Kasuga M
    • Journal Title

      Diabetes

      Volume: 59 Pages: 1608-1615

    • Related Report
      2010 Final Research Report
  • [Journal Article] The t-SNAREs syntaxin4 and SNAP23 but not v-SNARE VAMP2 are indispensable to tether GLUT4 vesicles at the plasma membrane in adipocyte2010

    • Author(s)
      Kawaguchi T., Tamori Y., Kanda H., Yoshikawa M., Tateya S., Nishino N., Kasuga M
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 391 Pages: 1336-1341

    • NAID

      120003353237

    • Related Report
      2010 Final Research Report
  • [Journal Article] An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice2010

    • Author(s)
      Tateya S, Tamori Y, Kawaguchi T, Kanda H, Kasuga M
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 971-979

    • NAID

      120003238420

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ablation of C/EBPυalleviates ER stress and pancreaticυcell failure through induction of GRP782010

    • Author(s)
      Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M
    • Journal Title

      J. Clin. Invest

      Volume: 120 Pages: 115-126

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ablation of C/EBP alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice2010

    • Author(s)
      Matsuda, T., 他
    • Journal Title

      Journal of Clinical Investigation 120

      Pages: 115-126

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice2010

    • Author(s)
      Sanshiro Tateya, 他
    • Journal Title

      Endocrinology 151

      Pages: 971-979

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The t-SNAREs syntaxin4 and SNAP23 but not v-SNARE VAMP2 are in dispensable to tether GLUT4 vesicles at the plasma membrane in adipocyte2010

    • Author(s)
      Takayuki Kawaguchi, 他
    • Journal Title

      Biochem Biophys Res Commun 391

      Pages: 1336-1341

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake2010

    • Author(s)
      Iskandar K, 他
    • Journal Title

      Am J Physiol Endocrinol Metab 298

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1 coordinates survival pathways and beta-adrenergic response in the heart2009

    • Author(s)
      Ito K, Akazawa H, Tamagawa M, Furukawa K, Ogawa W, Yasuda N, Kudo Y, Liao CH, Yamamoto R, Sato T, Molkentin JD, Kasuga M, Noda T, Nakaya H, Komuro I
    • Journal Title

      Proc Natl. Acad. Sci. U. S. A

      Volume: 106 Pages: 8689-8694

    • Related Report
      2010 Final Research Report
  • [Journal Article] Muscle-specific overexpression of heparin-binding EGF-like growth factor increases peripheral glucose disposal and insulin sensitivity2009

    • Author(s)
      Fukatsu Y., Noguchi T., Hosooka T., Ogura T., Kotani K., Abe T., Shibakusa T., Inoue K., Sakai M., Tobimatsu K., Inagaki K., Yoshioka T., Matsuo M., Nakae J., Matsuki Y., Hiramatsu R., Kaku K., Okamura H., Fushiki T., and Kasuga M
    • Journal Title

      Endocrinology

      Volume: 150 Pages: 2683-2691

    • Related Report
      2010 Final Research Report
  • [Journal Article] The Kruppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes2009

    • Author(s)
      Nagare T., Sakaue H., Takashima M., Takahashi K., Gomi H., Matsuki Y., Watanabe E., Hiramatsu R., Ogawa W., Kasuga M
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 379 Pages: 98-103

    • Related Report
      2010 Final Research Report
  • [Journal Article] Overexpression of the transcriptional coregulator Cited2 protects against glucocorticoid-induced atrophy of C2C12 myotubes2009

    • Author(s)
      Tobimatsu K., Noguchi T., Hosooka T., Sakai M., Inagaki K., Matsuki Y., Hiramatsu R. and Kasuga M
    • Journal Title

      Biochem. Biophys. Res. Commum

      Volume: 378 Pages: 399-403

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification and characterization of an alternative promoter of the human PGC-1alpha gene2009

    • Author(s)
      Yoshioka T, 他
    • Journal Title

      Biochem Biophys Res Commun 381

      Pages: 537-543

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1 coordinates survival pathways and beta-adrenergic response in the heart2009

    • Author(s)
      Ito K, 他
    • Journal Title

      Proc Natl Acad Sci USA. 106

      Pages: 8689-8694

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of intrauterine undernutrition during late gestation on pancreatic β cell mass2009

    • Author(s)
      Inoue, T., 他
    • Journal Title

      Biomedical Research 30

      Pages: 325-330

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      Ogawa W
    • Journal Title

      Role of Kruppel-like factor 15 in Adipocytes. In "The biology of Kruppel-like factors"(Springer)

      Pages: 151-157

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Skp2 promotes adipocyte differentiation via a p27Kip1-independent mechanism in primary mouse embryonic fibroblasts2009

    • Author(s)
      Okada Y, 他
    • Journal Title

      Biochem Biophys Res Commun 379

      Pages: 249-254

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the E3 ubiquitin ligase gene related to anergy in lymphocytes in glucose and lipid metabolism in the liver2009

    • Author(s)
      Nakamichi S, 他
    • Journal Title

      J Mol Endocrinol 42

      Pages: 161-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Kruppel-like factor KLF15 inhibits transcription of the adrenomedullin gene in adipocytes2009

    • Author(s)
      Nagare T, 他
    • Journal Title

      Biochem Biophys Res Commun 379

      Pages: 98-103

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of the transcriptional coregulator Cited2 protects against glucocorticoid-induced atrophy of C2C12 myotubes2009

    • Author(s)
      Tobimatus T, 他
    • Journal Title

      Biochem Biophys Res Commun 378

      Pages: 399-403

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets2009

    • Author(s)
      Nishino N, 他
    • Journal Title

      J Clin Invest 283

      Pages: 17702-17711

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression2009

    • Author(s)
      Nakamura K, 他
    • Journal Title

      J Biol Chem 118

      Pages: 2808-2821

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice2009

    • Author(s)
      Shigeyama Y, 他
    • Journal Title

      Mol Cell Biol 28

      Pages: 2971-2979

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fat stress and liver resistance2008

    • Author(s)
      Ogawa W., Kasuga M
    • Journal Title

      Science

      Volume: 322 Pages: 1483-1484

    • Related Report
      2010 Final Research Report
  • [Journal Article] FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets2008

    • Author(s)
      Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., Hiramatsu, R., Masubuchi, S., Omachi, A., Kimura, K., Saito, M., Amo, T., Ohta, S., Yamaguchi, T., Osumi, T., Cheng, J., Fujimoto, T., Nakao, H., Nakao, K., Aiba, A., Okamura, H., Fushiki, T., and Kasuga, M
    • Journal Title

      J. Clin. Invest

      Volume: 118 Pages: 2808-2821

    • Related Report
      2010 Final Research Report
  • [Journal Article] PDK1 regulates cell proliferation and cell cycle progression through control of cylin D1 and p27Kip1 expression2008

    • Author(s)
      Nakamura K., Sakaue H., Nishizawa A., Matsuki Y., Gomi H., Watanabe E., Hiramatsu R., Tamori-Adachi M., Kitajima S., Noda T., Ogawa W., Kasuga M
    • Journal Title

      J. Biol. Chem

      Volume: 283 Pages: 17702-17711

    • Related Report
      2010 Final Research Report
  • [Journal Article] Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice2008

    • Author(s)
      Shigeyama Y., Kobayashi T., Kido Y., Hashimoto N., Asahara S., Matsuda T., Takeda A., Inoue T., Shibutani Y., Koyanagi M., Uchida T., Inoue M., Hino O., Kasuga M., Noda T
    • Journal Title

      Mol. Cell Biol

      Volume: 28 Pages: 2971-2979

    • Related Report
      2010 Final Research Report
  • [Journal Article] Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-γphosphorylation2008

    • Author(s)
      Hosooka, T., Noguchi, T., Kotani, K., Nakamura, T., Sakaue, H., Inoue, H., Ogawa, W., Tobimatsu, K., Takazawa, K., Sakai, M., Matsuki, Y., Hiramatsu, R., Yasuda, T., Lazar, MA., Yamanashi, Y., and Kasuga, M
    • Journal Title

      Nature Med

      Volume: 14 Pages: 188-193

    • Related Report
      2010 Final Research Report
  • [Journal Article] FSP27 Contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets2008

    • Author(s)
      Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., Hiramatsu, R., Masubuchi, S., Omachi, A., Kimura, K., Saito, M., Amo, T., Ohta, S., Yamaguchi, T., Osumi, T., Cheng, J., Fujimoto, T., Nakao, H., Nakao, K., Aiba, A., Okamura, H., Fushiki, T., and Kasuga, M
    • Journal Title

      J. Clin. Invest 118

      Pages: 2808-2821

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation2008

    • Author(s)
      Hosooka, T., Noguchi, T.,Kotani, K., Nakamura, T., Sakaue, H., Inoue, H., Ogawa, W., Tobimatsu, K., Takazawa, K., Sakai, M., Matsuki, Y., Hiramatsu, R., Yasuda, T., Lazar, MA., Yamanashi, Y., and Kasuga, M
    • Journal Title

      Nature Med 14

      Pages: 188-193

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Biphasic response of pancreatic βcell mass to ablation of TSC2 in mice.2008

    • Author(s)
      Shigeyama Y, 他
    • Journal Title

      Mol. Cell. Biol. (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.2008

    • Author(s)
      Hosooka T, 他
    • Journal Title

      Nat. Med. 14

      Pages: 188-193

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skp2 controls adipocyte proliferation during the development of obesity2007

    • Author(s)
      Sakai T., Sakaue, H., Nakamura T., Okada M., Matsuki Y., Watanabe E., Hiramatsu R., Nakayama K., Nakayama K. and Kasuga M
    • Journal Title

      J. Biol. Chem

      Volume: 282 Pages: 2038-2046

    • Related Report
      2010 Final Research Report
  • [Journal Article] Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK12007

    • Author(s)
      Okamoto Y., Ogawa W., Nishizawa A., Inoue H., Teshigawara K., Kinoshita S., Matsuki Y., Watanabe E., Hiramatsu R., Sakaue H., Noda T., Kasuga M
    • Journal Title

      Diabetes

      Volume: 25 Pages: 1000-1009

    • Related Report
      2010 Final Research Report
  • [Journal Article] Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice hepatic deficiency of PDK1.2007

    • Author(s)
      Okamoto, Y. et al.
    • Journal Title

      Diabetes 31 (Epub ahead of print)

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Skp2 controls adipocyte proliferation during the development of obesity.2007

    • Author(s)
      Sakai, T. et al.
    • Journal Title

      J.Biol.Chem. 19;282(3)

      Pages: 2038-2046

    • Related Report
      2006 Annual Research Report
  • [Journal Article] MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity2006

    • Author(s)
      Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K and Kasuga, M
    • Journal Title

      J. Clin. Invest

      Volume: 116 Pages: 1494-1505

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of hepatic STAT3 in brain insulin action on hepatic glucose production2006

    • Author(s)
      Inoue, H., Ogawa, W., Asakawa, A., Okamoto, Y., Nishizawa, A., Matsumoto, M., Teshigawara, K., Matsuki, Y., Watanabe, E., Hiramatsu, R., Notohara, K., Katayose, K., Okamura, H., Kahn, CR., Noda, T., Takeda, K., Akira, S., Inui, A and Kasuga, M
    • Journal Title

      Cell Met

      Volume: 3 Pages: 267-275

    • Related Report
      2010 Final Research Report
  • [Journal Article] Ablation of PDK1 in pancreaticβ-cells induces diabetes as a result of loss ofβ-cell mass2006

    • Author(s)
      Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Tsuchihashi, D., Nishizawa, A., Ogawa, W., Fujimoto, Y., Okamura, H., Arden, KC., Herrera, PL., Noda, T and Kasuga, M
    • Journal Title

      Nature Genet

      Volume: 38 Pages: 589-593

    • Related Report
      2010 Final Research Report
  • [Journal Article] Insulin resistance and pancreatic s cell failure2006

    • Author(s)
      Kasuga, M
    • Journal Title

      J. Clin. Invest

      Volume: 116 Pages: 1756-1760

    • Related Report
      2010 Final Research Report
  • [Journal Article] MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity2006

    • Author(s)
      Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K and Kasuga, M
    • Journal Title

      J. Clin. Invest. 116

      Pages: 1494-1505

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Role of hepatic STAT3 in brain insulin action on hepatic glucose production2006

    • Author(s)
      Inoue, H., Ogawa, W., Asakawa, A., Okamoto, Y., Nishizawa, A., Matsumoto, M., Teshigawara, K., Matsuki, Y., Watanabe, E., Hiramatsu, R., Notohara, K., Katayose, K., Okamura, H., Kahn, CR., Noda, T., Takeda, K., Akira, S., Inui, A and Kasuga, M
    • Journal Title

      Cell Met 3

      Pages: 267-275

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Ablation of PDK1 in pancreatic sscells induces diabetes as a result of loss of ss-cell mass2006

    • Author(s)
      Hashimoto, N., Kido, Y., Uchida, T., Asahara, S., Shigeyama, Y., Matsuda, T., Takeda, A., Tsuchihashi, D., Nishizawa, A., Ogawa, W., Fujimoto, Y., Okamura, H., Arden, KC., Herrera, PL., Noda, T and Kasuga, M
    • Journal Title

      Nature Genet 38

      Pages: 589-593

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity.2006

    • Author(s)
      Kanda, H. et al.
    • Journal Title

      J.Clin.Invest 116(6)

      Pages: 1494-1505

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action

    • Author(s)
      Takashima M, 他
    • Journal Title

      Diabetes (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cited2 regulates hepatic gluconeogenesis by controlling PGC-1αActivity2010

    • Author(s)
      Sakai M., Matsumoto M., Kasuga M
    • Organizer
      11th International Symposium on Insulin Receptor and Insulin Action
    • Place of Presentation
      Naples Italy
    • Year and Date
      2010-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] STAT3依存性肝糖新生調節における小胞体ストレスの役割2010

    • Author(s)
      山田智子、井上啓
    • Organizer
      日本薬学会
    • Place of Presentation
      就実大学
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Regulation of hepatic lipid metabolism by transcription factor Stra132010

    • Author(s)
      Nomura K, 他
    • Organizer
      14th International Congress of Endocrinology
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Transcriptional regulation of hepatic energy metabolism2010

    • Author(s)
      Ogawa W
    • Organizer
      14^<th> International Congress of Endocrinology
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 摂食・エネルギー代謝調節におけるシグナル伝達分子の視床下部弓状核ニューロン特異的な役割の検討2010

    • Author(s)
      中江淳, 他
    • Organizer
      第24回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-01-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂肪細胞における脂肪滴蓄積形態とエネルギー代謝2009

    • Author(s)
      田守義和
    • Organizer
      第30回日本肥満学会
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Brain PDK1 and TSC2 KO2009

    • Author(s)
      中江淳, 他
    • Organizer
      第30回 日本肥満学会
    • Place of Presentation
      浜松
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] メトホルミンはKLF15の発現抑制を介して肝糖産生を抑制する2009

    • Author(s)
      高嶋基嗣, 他
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] SREBP1cの転写制御におけるStra13の重要性2009

    • Author(s)
      衣斐亜希, 他
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] AMPキナーゼを介したKLF15の細胞内局在制御2009

    • Author(s)
      千賀陽子, 他
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膵β細胞におけるmTORシグナルとミトコンドリア機能の検討2009

    • Author(s)
      小柳真希, 他
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 摂食エネルギー代謝調節におけるPOMCおよびAGRPニューロンTSC2の役割の検討2009

    • Author(s)
      曹永恒, 他
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 摂食エネルギー代謝調節におけるPOMCおよびAGRPニューロンTSC2の役割の検討2009

    • Author(s)
      曹永恒, 他
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂肪滴蛋白FSP27は単房性の脂肪滴形成を介して白色脂肪に効率よく脂肪を蓄積する2008

    • Author(s)
      西野尚延, 他
    • Organizer
      第51回 日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肥満・糖尿病発症における転写因子KLF15の役割2008

    • Author(s)
      永礼智基, 他
    • Organizer
      第51回 日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] mTORシグナルによる膵β細胞数・サイズ調節機構の解明2008

    • Author(s)
      小柳真希, 他
    • Organizer
      第51回 日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] メトホルミン作用によるKLF15の発現制御と肝糖代謝における意義2008

    • Author(s)
      高嶋基嗣, 他
    • Organizer
      第51回 日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] PGC1αによる糖産生系酵素の発現誘導における転写因子Fox01の二つの役割の検討2008

    • Author(s)
      横田一樹, 他
    • Organizer
      第51回 日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] POMCおよびAgRPニューロンにおけるPDK1の摂食調節作用の検討2008

    • Author(s)
      曹永恒, 他
    • Organizer
      第51回 日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膵β細胞における低分子量GタンパクRac1の機能解析2008

    • Author(s)
      浅原俊一郎, 他
    • Organizer
      第51回 日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Role of IL-6/STAT3 in Insulin Action2008

    • Author(s)
      春日 雅人
    • Organizer
      Keystone Symposia
    • Place of Presentation
      カナダ
    • Year and Date
      2008-02-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] MCP-1 can induce systemic insulin resistance in vivo without inflammation in adipose tissue2008

    • Author(s)
      Tateya S., Tamori Y., Kanda H., Kasuga M
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Banff, Alberta, Canada
    • Related Report
      2010 Final Research Report
  • [Presentation] Muscle-specific overexpression of heparin-binding EGF-like growth factor increases peripheral glucose disposal and insulin sensitivity2007

    • Author(s)
      Fukatsu Y., Noguchi T., Ogura T., Hosooka T., Shibakusa T., Inoue K., Matsuki Y., Hiramatsu T., Kaku K., Fushiki T., Kasuga M
    • Organizer
      The 67th Annual Meeting of the American Diabetes Association
    • Place of Presentation
      Chicago, IL, U. S. A
    • Related Report
      2010 Final Research Report
  • [Presentation] Accumulation of C/EBPυinduces pancreaticυcell failure by reducing the endoplasmic reticulum function2007

    • Author(s)
      Matsuda T, Kido Y, Hashimoto N, Asahara S, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Uchida T, Kasuga M
    • Organizer
      67^<th> Scientific Session of American Diabetes Association
    • Place of Presentation
      Chicago, IL, U. S. A
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of TSC2 in the regulation of pancreaticυcell mass2007

    • Author(s)
      Sigeyama Y, Kido Y, Hashimoto N, Asahara S, Matsuda T, Takeda A, Inoue T, Shibutani Y, Uchida T, Noda T, Kasuga M
    • Organizer
      67^<th> Scientific Session of American Diabetes Association
    • Place of Presentation
      Chicago, IL, U. S. A
    • Related Report
      2010 Final Research Report
  • [Book] 分子糖尿病学の進歩20072007

    • Author(s)
      井上啓,小川渉,春日雅人
    • Publisher
      金原出版
    • Related Report
      2010 Final Research Report
  • [Book] 糖尿病学基礎と臨床2007

    • Author(s)
      細岡哲也,野口哲也,春日雅人
    • Publisher
      西村書店
    • Related Report
      2010 Final Research Report
  • [Remarks] Nature Medicineに発表した論(Hosooka, T., et al.雑誌論文)について以下のメディアで報道された(2008年1月21日)

    • Related Report
      2010 Final Research Report
  • [Remarks] 読売新聞(大阪)

    • Related Report
      2010 Final Research Report
  • [Remarks] 日本経済新聞

    • Related Report
      2010 Final Research Report
  • [Remarks] 産経新聞(大阪)

    • Related Report
      2010 Final Research Report
  • [Remarks] 神戸新聞

    • Related Report
      2010 Final Research Report
  • [Remarks] Nature Medicineに発表した論(Hosooka, T., et.al. 雑誌論文(2))について以下のメディアで報道された(2008年1月21日)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 読売新聞(大阪)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 日本経済新聞

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 産経新聞(大阪)

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 神戸新聞

    • Related Report
      2008 Self-evaluation Report
  • [Patent(Industrial Property Rights)] 高トリグリセリド血症の予防・治療剤、及びそのスクリーニング法2006

    • Inventor(s)
      春日雅人,小川渉,松木泰,渡辺英二郎
    • Industrial Property Rights Holder
      春日雅人,小川渉,松木泰,渡辺英二郎
    • Filing Date
      2006-10-12
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 2型糖尿病に対する感受性の判定方法2006

    • Inventor(s)
      春日雅人,小川渉,大原毅,廣田勇二,松木泰,渡辺英二郎
    • Industrial Property Rights Holder
      春日雅人,小川渉,大原毅,廣田勇二,松木泰,渡辺英二郎
    • Filing Date
      2006-04-07
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 糖・脂質代謝能の改善剤およびそのスクリーニング方法2006

    • Inventor(s)
      春日雅人,阪上浩,永禮智基,岡田裕子,松木泰
    • Industrial Property Rights Holder
      春日雅人,阪上浩,永禮智基,岡田裕子,松木泰
    • Filing Date
      2006-04-04
    • Related Report
      2010 Final Research Report

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Published: 2006-04-01   Modified: 2016-04-21  

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