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Research for the mechanism of the expression of neuropathic pain

Research Project

Project/Area Number 18GS0319
Research Category

Grant-in-Aid for Creative Scientific Research

Allocation TypeSingle-year Grants
Research InstitutionKyushu University

Principal Investigator

INOUE Kazuhide  Kyushu University, 大学院・薬学研究院, 教授 (80124379)

Co-Investigator(Kenkyū-buntansha) TSUDA Makoto  九州大学, 大学院・薬学研究院, 准教授 (40373394)
SAITOH Hidetoshi  九州大学, 大学院・薬学研究院, 助教 (90444794)
NAKATSUKA Terumasa  関西医療大学, 保健医療学部, 教授 (30380752)
Project Period (FY) 2006 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥508,170,000 (Direct Cost: ¥390,900,000、Indirect Cost: ¥117,270,000)
Fiscal Year 2010: ¥90,350,000 (Direct Cost: ¥69,500,000、Indirect Cost: ¥20,850,000)
Fiscal Year 2009: ¥90,350,000 (Direct Cost: ¥69,500,000、Indirect Cost: ¥20,850,000)
Fiscal Year 2008: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000)
Fiscal Year 2007: ¥106,080,000 (Direct Cost: ¥81,600,000、Indirect Cost: ¥24,480,000)
Fiscal Year 2006: ¥118,430,000 (Direct Cost: ¥91,100,000、Indirect Cost: ¥27,330,000)
Keywords脳神経疾患 / 痛み / シグナル伝達 / ミクログリア / アストロサイト / ATP受容体 / 神経因性疼痛 / P2X4 / サイトカイン / インターフェロン-γ / Lynの活性化 / しぐなる伝達 / みくろぐりあ / あすとろさいと
Research Abstract

We had already reported that activated microglia have a main role for evoking neuropathic pain which is resistant to morphine through the stimulation of P2X4 receptors after nerve damages (Nature, 2003 & 2005). In the present study, we tried to find how microglia receive information of nerve damage and cause the pain. It was clarified that microglia are activated through cytokines such as CCL21 released from the damage nerve, interferon-γ, PDGF. Moreover, transcription factor STAT3 was activated only in astrocytes after nerve damage that is very important for the evoking neuropathic pain.

Report

(6 results)
  • 2010 Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report   Self-evaluation Report ( PDF )
  • 2007 Annual Research Report
  • 2006 Annual Research Report
  • Research Products

    (189 results)

All 2011 2010 2009 2008 2007 2006 Other

All Journal Article (101 results) (of which Peer Reviewed: 46 results) Presentation (60 results) Book (18 results) Remarks (9 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Astrocytic P2Y1 receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia.2011

    • Author(s)
      K.Kuboyama, H.Harada, H.Tozaki-Saitoh, M.Tsuda, K.Ushijima, K.Inoue.
    • Journal Title

      J Cerebral Blood Flow & Metab

    • Related Report
      2010 Final Research Report
  • [Journal Article] JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.2011

    • Author(s)
      M.Tsuda, Y.Kohro, T.Yano, T.Tsujikawa, J.Kitano, H.Tozaki-Saitoh, S.Koyanagi, S.Ohdo, R-R Ji, M.W.Salter, K.Inoue.
    • Journal Title

      Brain 134(4)

      Pages: 1127-1139

    • NAID

      120004951597

    • Related Report
      2010 Final Research Report
  • [Journal Article] P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP.2010

    • Author(s)
      Ohsawa K, Irino Y, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S.
    • Journal Title

      Glia. 58(7)

      Pages: 790-801

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of PAF Receptor in Proinflammatory Cytokine Expression in the Dorsal Root Ganglion and Tactile Allodynia in a Rodent Model of Neuropathic Pain.2010

    • Author(s)
      S.Hasegawa, Y.Kohro, M.Shiratori, S.Ishii, T.Shimizu, M.Tsuda, K.Inoue.
    • Journal Title

      PLoS ONE 3;5(5)

    • Related Report
      2010 Final Research Report
  • [Journal Article] P2×7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways.2010

    • Author(s)
      M.Shiratori, H.Tozaki-Saitoh, M.Yoshitake, M.Tsuda, K.Inoue.
    • Journal Title

      J Neurochem. 114(3)

      Pages: 810-819

    • Related Report
      2010 Final Research Report
  • [Journal Article] Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn.2010

    • Author(s)
      M.Maeda, M Tsuda, H.Tozaki-Saitoh, K.Inoue, H.Kiyama.
    • Journal Title

      Glia 58(15)

      Pages: 1838-1846

    • Related Report
      2010 Final Research Report
  • [Journal Article] Molecular basis for the dosing time-dependency of anti-allodynic effects of gabapentin in a mouse model of neuropathic pain.2010

    • Author(s)
      N.Kusunose, S.Koyanagi, K.Hamamura, N.Matsunaga, M.Yoshida, T.Uchida, M.Tsuda, K.Inoue, S.Ohdo.
    • Journal Title

      Mol Pain 6:83

    • Related Report
      2010 Final Research Report
  • [Journal Article] 痛みの慢性化と脊髄グリア細胞の役割2010

    • Author(s)
      津田誠、井上和秀
    • Journal Title

      臨床麻酔 34

      Pages: 421-430

    • Related Report
      2009 Annual Research Report
  • [Journal Article] equally contributed. Antidepressants inhibit P2×4 receptor function : a possible involvement in neuropathic pain relief.2009

    • Author(s)
      K.Nagata, T.Imai, T.Yamashita, H.Tozaki-Saitoh, M.Tsuda, K.Inoue.
    • Journal Title

      Mol Pain 5:20

    • Related Report
      2010 Final Research Report
  • [Journal Article] Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury.2009

    • Author(s)
      S.Hasegawa, Y.Kohro, M.Tsuda, K.Inoue.
    • Journal Title

      Mol Pain 5:22

    • Related Report
      2010 Final Research Report
  • [Journal Article] Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia.2009

    • Author(s)
      J.Masuda, M.Tsuda, H.Tozaki-Saitoh, K.Inoue.
    • Journal Title

      Mol Pain 5:23

    • Related Report
      2010 Final Research Report
  • [Journal Article] Behavioral phenotypes of mice lacking purinergic P2×4 receptors in acute and chronic pain assays.2009

    • Author(s)
      M.Tsuda, K.Kuboyama, T.Inoue, K.Nagata, H.Tozaki-Saitoh, K.Inoue.
    • Journal Title

      Mol Pain 5:28

    • Related Report
      2010 Final Research Report
  • [Journal Article] IFN-y receptor signaling mediates spinal microglia activation driving neuropathic pain.2009

    • Author(s)
      M.Tsuda, T.Masuda, J.Kitano, H.Shimoyama, H.Tozaki-Saitoh, K.Inoue.
    • Journal Title

      Pro.Natl.Acad.Sci.USA 106(19)

      Pages: 8032-8037

    • Related Report
      2010 Final Research Report
  • [Journal Article] Mechanisms underlying fibronectin-induced upregulation of P2X4R expression in microglia : distinct roles of PI3K-Akt and MEK-ERK signaling pathways2009

    • Author(s)
      M.Tsuda, E.Toyomitsu, M.Kometani, H.Tozaki-Saitoh, K.Inoue
    • Journal Title

      J.Cellular and Molecular Medicine 13

      Pages: 3251-3259

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct observation of ATP-induced conformational changes in single P2X4 receptors2009

    • Author(s)
      Y.Shinozaki, K.Sumitomo, M.Tsuda, S.Koizumi, K.Inoue, K.Torimitsu
    • Journal Title

      PLoS Biology 7

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-Y receptor signaling mediates spinal microglia activation driving neuropathic pain2009

    • Author(s)
      M.Tsuda, T.Masuda, J.Kitano, H.Shimoyama, H.Tozaki-Saitoh, K.Inoue
    • Journal Title

      Pro.Natl.Acad.Sci.USA 106

      Pages: 8032-8037

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antidepressants inhibit P2X4 receptor function : a possible involvement in neuropathic pain relief2009

    • Author(s)
      K.Nagata, T.Imai, T.Yamashita, H.Tozaki-Saitoh, M.Tsuda, K.Inoue
    • Journal Title

      Molecular Pain 5:20(online)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury2009

    • Author(s)
      S.Hasegawa, Y.Kohro, M.Tsuda, K.Inoue
    • Journal Title

      Molecular Pain 5:22(online)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intrathecal delivery of PDGF produces tactile allodynia through its receptors in spinal microglia2009

    • Author(s)
      J.Masuda, M.Tsuda, H.Tozaki-Saitoh, K.Inoue
    • Journal Title

      Molecular Pain 5:23(online)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronicpain assays2009

    • Author(s)
      M.Tsuda, K.Kuboyama, T.Inoue, K.Nagata, H.Tozaki-Saitoh, K.Inoue.
    • Journal Title

      Molecular Pain 5:28(online)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P2Y12 receptor-mediated integrin-betal activation regulates microglial process extension induced by ATP2009

    • Author(s)
      Ohsawa K, Irino Y, Sanagi T, Nakamura Y, Suzuki E, Inoue K, Kohsaka S.
    • Journal Title

      Glia 58(7)

      Pages: 790-801

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経因性疼痛とグリア細胞2009

    • Author(s)
      井上和秀
    • Journal Title

      臨床整形外科 44

      Pages: 57-64

    • NAID

      40016441065

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
  • [Journal Article] 脳内グリア細胞におけるATPセンサーを介した情報伝達2009

    • Author(s)
      小泉修一、井上和秀
    • Journal Title

      生化学 81

      Pages: 35-38

    • NAID

      10024915713

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
  • [Journal Article] ATP受容体2009

    • Author(s)
      井上和秀、津田誠、齊藤秀俊
    • Journal Title

      Clinical Neuroscience 27

      Pages: 503-506

    • NAID

      10018884008

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ミクログリアと神経因性疼痛:エコファーマへの挑戦2009

    • Author(s)
      井上和秀
    • Journal Title

      福岡医誌 99

      Pages: 239-245

    • NAID

      120001101387

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Microglia and neuropathic pain2009

    • Author(s)
      K.Inoue, M.Tsuda
    • Journal Title

      GLIA 57

      Pages: 1469-1479

    • NAID

      40020926787

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痛みとATP受容体2009

    • Author(s)
      井上和秀、津田誠、齊藤秀俊
    • Journal Title

      ペインクリニック 30

      Pages: 339-346

    • Related Report
      2009 Annual Research Report 2008 Annual Research Report
  • [Journal Article] 難治性疼痛治療とエコファーマ2009

    • Author(s)
      井上和秀、大石了三
    • Journal Title

      ペインクリニック 30

      Pages: 673-676

    • Related Report
      2009 Annual Research Report
  • [Journal Article] P2プリン受容体の種類と機能2009

    • Author(s)
      井上和秀
    • Journal Title

      生体の科学「伝達物質と受容体」特集号 60

      Pages: 500-501

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 脊髄ミクログリアのP2プリン受容体と神経障害性疼痛2009

    • Author(s)
      井上和秀、津田誠、齊藤秀俊
    • Journal Title

      生体の科学「伝達物質と受容体」特集号 60

      Pages: 506-508

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 神経因性疼痛とミクログリア活性化2009

    • Author(s)
      井上和秀
    • Journal Title

      慢性疼痛 28

      Pages: 7-13

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 神経障害性疼痛発症メカニズムとその制御2009

    • Author(s)
      井上和秀
    • Journal Title

      臨床神経学 49

      Pages: 779-782

    • NAID

      10026290754

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      K.Inoue, S.Koizumi, A.Kataoka, H.Tozaki-Saitoh, M.Tsuda.
    • Journal Title

      P2Y6-evoked microglial phagocytosis. In International Review of Neurobiology vol.85 : Advances in Neuropharmacology, (ed.by G.Bagetta, M.T.Corasaniti, T.Sakurada, S.Sakurada).(Burlington : Academic Press)

      Pages: 159-163

    • Related Report
      2009 Annual Research Report
  • [Journal Article] P2Y1 receptor signaling enhances neuroprotection by astrocytes against oxidative stress via IL-6 release in hippocampal cultures2009

    • Author(s)
      T. Fujita, H. Tozaki-Saitoh, K. Inoue
    • Journal Title

      Glia 57

      Pages: 244-257

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M. Adenosine modulates excitatory synaptic transmission and suppresses neuronal death induced by ischaemia in rat spinal motoneurones2009

    • Author(s)
      Miyazaki N, Nakatsuka T, Takeda D, Nohda K, Inoue K, Yoshida
    • Journal Title

      Pflugers Arch. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NEAT2009

    • Author(s)
      A. Kataoka, H. Tozaki-Saitoh, Y. Koga, M. Tsuda, K. Inoue
    • Journal Title

      J. Neurochem (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P2Y6 receptor-Ga12/13 signaling in cardiomyocytes triggers pressure overload-induced cardiac fibrosis2009

    • Author(s)
      M. Nishidal, Y. Sato, A. Uemura, Y. Narita, H. Tozaki-Saitoh, M. Nakayal, T. Ide, K. Suzuki, K. Inoue, T. Nagao, H. Kurose
    • Journal Title

      EMBO (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms underlying fibronectin-induced upregulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signaling pathways2009

    • Author(s)
      M. Tsuda*, E. Toyomitsu*, M. Kometani, H. Tozaki-Saitoh, K. Inoue
    • Journal Title

      J. Cellular and Molecular Medicine (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct observation of ATP-induced conformational changes in single P2X4 receptors2009

    • Author(s)
      Y. Shinozaki, K. Sumitomo, M. Tsuda, S. Koizumi, K. Inoue, K. Torimitsu
    • Journal Title

      PLoS Biology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IFN-Y receptor signaling mediates spinal microglia activation driving neuropathic pain2009

    • Author(s)
      M. Tsuda*, T. Masuda*, J. Kitano, H. Shimoyama, H. Tozaki-Saitoh, K. Inoue
    • Journal Title

      Pro. Natl. Acad. Sci. USA (in press)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ATP受容体2009

    • Author(s)
      井上和秀、津田誠、齊藤秀俊
    • Journal Title

      Clinical Neuroscience (in press)

    • NAID

      10018884008

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ミクログリアと神経因性疼痛:エコファーマヘの挑戦2009

    • Author(s)
      井上和秀
    • Journal Title

      福岡医誌 (in press)

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Microglia and neuropathic pain2009

    • Author(s)
      K. Inoue, M. Tsuda
    • Journal Title

      Glia (in press)

    • NAID

      40020926787

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury.2008

    • Author(s)
      M.Tsuda, H.Tozaki-Saitoh, T.Masuda, E.Toyomitsu, T.Tezuka, T.Yamamoto, K.Inoue.
    • Journal Title

      Glia. 56

      Pages: 50-58

    • Related Report
      2010 Final Research Report
  • [Journal Article] P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.2008

    • Author(s)
      H.Tozaki-Saitoh, M.Tsuda, H.Miyata, K.Ueda, S.Kohsaka, K.Inoue.
    • Journal Title

      J.Neurosci. 28

      Pages: 4949-4956

    • Related Report
      2010 Final Research Report
  • [Journal Article] Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury2008

    • Author(s)
      M.Tsuda, H.Tozaki-Saitoh, T.Masuda, E. Toyomitsu, T. Tezuka, T. Yamamoto, K. Inoue
    • Journal Title

      Glia 56

      Pages: 50-58

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury2008

    • Author(s)
      H. Tozaki-Saitoh, M. Tsuda, H. Miyata, K. Ueda, S. Kohsaka, K. Inoue
    • Journal Title

      J. Neurosci 28

      Pages: 4949-56

    • Related Report
      2008 Annual Research Report 2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury2008

    • Author(s)
      M. Tsuda, H. Tozaki-Saitoh, T. Masuda, E. Toyomitsu, T. Tezuka, T. Yamamoto, K. Inoue
    • Journal Title

      Glia 56

      Pages: 50-58

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling.2008

    • Author(s)
      M. Tsuda*, H. Ueno*, A. Kataoka, H. Tozaki-Saitoh, K. Inoue
    • Journal Title

      Glia 56

      Pages: 378-386

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibronectin/integrin system is involved in P2X4 receptor upregulation in the spinal cord and neuropathic pain after nerve injury2008

    • Author(s)
      M. Tsuda, E. Toyomitsu, T. Komatsu, T. Masuda, E. Kunifusa, K. Nasu-Tada, S. Koizumi, K. Yamamoto, J. Ando, K. Inoue
    • Journal Title

      Glia 56

      Pages: 579-585

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia2008

    • Author(s)
      Irino Y, Nakamura Y, Inoue K, Kohsaka S, Ohsawa K
    • Journal Title

      J Neurosci Res. 86

      Pages: 1511-1519

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin2008

    • Author(s)
      T. Nakatsuka, T. Fujita, K. Inoue, E. Kumamoto
    • Journal Title

      J. Physiol 586

      Pages: 2511-2522

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenosine modulates excitatory synaptic transmission and suppresses neuronal death induced by ischaemia in rat spinal motoneurones2008

    • Author(s)
      N. Miyazaki, T. Nakatsuka, D. Takeda, K. Nohda, K. Inoue, M. Yoshida
    • Journal Title

      Pflugers Arch. (European Journal of Physiology) (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced synaptic activity precedes synaptic stripping in vagal motoneurons after axotomy2008

    • Author(s)
      Yamada J, Hayashi Y, Jinno S, Wu Z, Inoue K, Kohsaka S, Nakanishi H
    • Journal Title

      Glia 56

      Pages: 1448-1462

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective up-regulation of P2X4 receptor gene expression by interferon-Y in vascular endothelial cells2008

    • Author(s)
      Y. Tang, I. Matsuoka, T. Ono, K. Inoue, J. Kimura
    • Journal Title

      J Pharmacol Sci. 107

      Pages: 419-427

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The EXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines2008

    • Author(s)
      T. Nishimaki-Mogami, N. Tamehiro, Y. Sato, K. Okuhira, K. Sail, H. Kagechika, K. Shudo, S. Abe-Dohmae, S. Yokoyama, Y. Ohno, K. Inoue, J. Sawada
    • Journal Title

      Biochem Pharmacol 76

      Pages: 1006-1013

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経障害性疼痛におけるATP受容体の役割2008

    • Author(s)
      津田誠、齊藤秀俊、井上和秀
    • Journal Title

      ペインクリニック 29

      Pages: 164-169

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ニューロン・ミクロクリア相互作用2008

    • Author(s)
      小泉修一、井上和秀
    • Journal Title

      BIO Clinica 23

      Pages: 371-376

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 痛みの生理学2008

    • Author(s)
      井上和秀
    • Journal Title

      臨床精神医学 37

      Pages: 5-10

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 最近の知見から:痛みとグリアの働き2008

    • Author(s)
      井上和秀
    • Journal Title

      理学療法 25

      Pages: 959-966

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Purinergic systems in microglia2008

    • Author(s)
      Inoue K
    • Journal Title

      Cell Mol Life Sci. 65

      Pages: 3074-3080

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 鎮痛薬開発の現状とこれから2008

    • Author(s)
      津田誠、井上和秀
    • Journal Title

      薬事 50

      Pages: 107-111

    • Related Report
      2008 Annual Research Report
  • [Journal Article] ATP・アデノシン受容体2008

    • Author(s)
      井上和秀、南雅文
    • Journal Title

      道薬誌 25

      Pages: 4-8

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Activation of dorsal horn microglia contributes to diabetes-induced tactile allodynia via extracellular signal-regulated protein kinase signaling.2008

    • Author(s)
      M. Tsuda^*, H. Ueno^*, A. Kataoka, H. Tozaki-Saitoh, K. Inoue
    • Journal Title

      Glia 56

      Pages: 378-386

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury.2008

    • Author(s)
      M. Tsuda, H. Tozaki-Saitoh, T. Masuda, E. Toyomitsu, T. Tezuka, T. Yamamoto, K. Inoue.
    • Journal Title

      Glia. 56

      Pages: 50-58

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibronectin/integrin system is involved in P2X4 receptor upregulation in the spinal cord and neuropathic pain after nerve injury.2008

    • Author(s)
      M. Tsuda, E. Toyomitsu, T. Komatsu, T. Masuda, E. Kunifusa, K. Nasu-Tada, S. Koizumi, K. Yamamoto, J. Ando and K. Inoue
    • Journal Title

      Glia. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia.2008

    • Author(s)
      Irino Y, Nakamura Y, Inoue K, Kohsaka S, Ohsawa K
    • Journal Title

      J Neurosci Res. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin.2008

    • Author(s)
      T. Nakatsuka, T. Fujita, K. Inoue and E. Kumamoto.
    • Journal Title

      J. Physiol. (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痛みの生理学2008

    • Author(s)
      井上 和秀
    • Journal Title

      臨床精神医学 37

      Pages: 5-10

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ニューロン・ミクログリア相互作用2008

    • Author(s)
      小泉修一、井上和秀
    • Journal Title

      BIO Clinica 23

      Pages: 371-376

    • Related Report
      2007 Annual Research Report
  • [Journal Article] UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.2007

    • Author(s)
      S.Koizumi, Y.Shigemoto-Mogami, K.Nasu-Tada, Y.Shinozaki, K.Ohsawa, M.Tsuda, B.V.Joshi, K.A.Jacobson, S.Kohsaka, K.Inoue.
    • Journal Title

      Nature 446

      Pages: 1091-1095

    • Related Report
      2010 Final Research Report
  • [Journal Article] UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis2007

    • Author(s)
      S. Koizumi, Y. Shigemoto-Mogami, K. Nasu-Tada, Y. Shinozaki, K. Ohsawa, M. Tsuda, B. V. Joshi, K. A. Jacobson, S. Kohsaka, K. Inoue
    • Journal Title

      Nature 446

      Pages: 1091-1095

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.2007

    • Author(s)
      S. Koizumi, Y. Shigemoto-Mogami, K. Nasu-Tada, Y. Shinozaki, K. Ohsawa, M. Tsuda, B. V. Joshi, K. A. Jacobson, S. Kohsaka, K. Inoue
    • Journal Title

      Nature 446

      Pages: 1091-1095

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn.2007

    • Author(s)
      H. Ikeda, M. Tsuda, K. Inoue, K. Murase
    • Journal Title

      Eur J Neurosci. 25

      Pages: 1297-1306

    • NAID

      120001040175

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Y. Shinozaki, Y. Sato, S. Koizumi, Y. Ohno, T. Nagao and K. Inoue.2007

    • Author(s)
      Y. Shinozaki, Y. Sato, S. Koizumi, Y. Ohno, T. Nagao and K. Inoue.
    • Journal Title

      Neuroscience:, 2007 147

      Pages: 153-63

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced pain behaviors and ERK activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor.2007

    • Author(s)
      M. Tsuda, S. Ishii, T. Masuda, S. Hasegawa, K. Nakamura, K. Nagata, T. Yamashita, H. Furue, H. Tozaki-Saito, M. Yoshimura, S. Koizumi, T. Shimizu & K. Inoue
    • Journal Title

      J Neurochem 102

      Pages: 1658-1668

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P2X receptors-mediated cytosolic phospholipase A2 activation in primary afferent sensory neurons contributes to neuropathic pain.2007

    • Author(s)
      M. Tsuda, S. Hasegawa and K. Inoue
    • Journal Title

      J Neurochem 103

      Pages: 1408-1416

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of P2X(4) and P2Y(12) receptors in ATP-induced microglial chemotaxis.2007

    • Author(s)
      Ohsawa K, Irino Y, Nakamura Y, Akazawa C, Inoue K, Kohsaka S
    • Journal Title

      Glia 55

      Pages: 604-616

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMDA receptor-independent synaptic plasticity in the central amygdala in the rat model of neuropathic pain.2007

    • Author(s)
      Ikeda R, Takahashi Y, Inoue K, Kato F
    • Journal Title

      Pain 127

      Pages: 161-172

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of nucleotides in the neuron-glia communication responsible for the brain functions.2007

    • Author(s)
      K. Inoue, S. Koizumi and M. Tsuda.
    • Journal Title

      J Neurochem (Invited review for 50th aniversary special issue) 102

      Pages: 1447-1458

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] UDP facilitates microglial phagocytosis through P2Y6 receptors.2007

    • Author(s)
      K. Inoue
    • Journal Title

      Cell Adhesion and Migration 1

      Pages: 131-132

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal On and Off signals control microglia2007

    • Author(s)
      K. Biber, H. Neumann, K. Inoue, H. W. G. M. Boddeke
    • Journal Title

      Trends in Neurosciences 30

      Pages: 596-602

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modification of neuropathic pain sensation through microglial ATP receptors2007

    • Author(s)
      K. Inoue, M. Tsuda, H. Tozaki-Saitoh
    • Journal Title

      Purinergic Signalling 3

      Pages: 311-316

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経因性疼痛におけるミクログリアの関与2007

    • Author(s)
      井上 和秀
    • Journal Title

      BRAIN and NERVE 59

      Pages: 739-746

    • Related Report
      2007 Annual Research Report
  • [Journal Article] ATP受容体を介する慢性疼痛発症機構2007

    • Author(s)
      津田誠, 井上和秀
    • Journal Title

      医学のあゆみ 222

      Pages: 892-893

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 神経因性疼痛と脊髄ミクログリアのATP受容体2007

    • Author(s)
      津田誠, 井上和秀
    • Journal Title

      BRAIN and NERVE-神経研究の進歩 59

      Pages: 953-959

    • NAID

      40015625659

    • Related Report
      2007 Annual Research Report
  • [Journal Article] 基礎と臨床のリレーショナル疼痛研究:神経因性疼痛におけるミクログリアとP2X4受容体の関与2007

    • Author(s)
      井上 和秀
    • Journal Title

      Pain Research 22

      Pages: 163-169

    • NAID

      130004651885

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 神経因性疼痛におけるミクログリアとATP受容体の関与2007

    • Author(s)
      井上 和秀
    • Journal Title

      医学の歩み 223

      Pages: 681-686

    • Related Report
      2007 Annual Research Report
  • [Journal Article] NMDA receptor-independent synaptic plasticity in the central amygdala in the rat model of neuropathic pain.2007

    • Author(s)
      Ikeda R, Takahashi Y, Inoue K, Kato F.
    • Journal Title

      Pain 127

      Pages: 161-172

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Involvement of P2X(4) and P2Y(12) receptors in ATP-induced microglial chemotaxis.2007

    • Author(s)
      Ohsawa K, Irino Y, Nakamura Y, Akazawa C, Inoue K, Kohsaka S.
    • Journal Title

      Glia 55

      Pages: 604-616

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn.2007

    • Author(s)
      H.Ikeda, M.Tsuda, K.Inoue, K.Murase.
    • Journal Title

      Eur J Neurosci (In press)

    • NAID

      120001040175

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Alpha-bile alcohols function as farnesoid X receptor antagonisis.2006

    • Author(s)
      Nishimaki-Mogami T, Kawahara Y, Tamehiro N, Yoshida T, Inoue K, Ohno Y, Nagao T, Une M.
    • Journal Title

      Biochem Biophys Res Commun 339

      Pages: 386-391

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia.2006

    • Author(s)
      Nasu-Tada K., Koizumi S., Tsuda M., Kunifusa E., Inoue K
    • Journal Title

      Glia 53

      Pages: 769-775

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of posisynaptic P2X receptors.2006

    • Author(s)
      Shiokawa H, Nakatsuka T, Furue H, Tsuda M, Katafuchi T, Inoue K, Yoshimura M.
    • Journal Title

      J Phisiology 573

      Pages: 753-763

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Retinoic acids increase P2X2 receptor expression through the 5'-flanking region of P2rx2 gene in rat phaeochromocytoma PC-12 cells.2006

    • Author(s)
      Tozaki-Saitoh H, Koizumi S, Sato Y, Tsuda M, Nagao T, Inoue K.
    • Journal Title

      Mol Pharmacol. 70

      Pages: 319-328

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Extracellular ATP counteracts the ERK1/2-mediated death-promoting signaling cascades in astrocytes.2006

    • Author(s)
      Y.Shinozaki, S.Koizumi, Y.Ohno, T.Nagao, K.Inoue
    • Journal Title

      Glia 54

      Pages: 606-618

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Microglial・7nicotinic acetylcholine receptors drive a phospholipase C/IP3 pathway and modulate the cell activation toward a neuroprotectinve role.2006

    • Author(s)
      Suzuki T, Hide I, Matsubara A, Hama C, Harada K, Miyano K, Andra M, Natsubayashi H, Sakai N, Kohsaka S, Inoue K, Nakata Y.
    • Journal Title

      J Neurosci Res 83

      Pages: 1461-1470

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Screening of novel nuclear receptor agonists by a convenient reporter gene assay using green fluorescent protein derivatives.2006

    • Author(s)
      Suzuki T, Nishimaki-Mogami T, Kawai H, Kobayashi T, Shinozaki Y, Sato Y, Hashimoto T, Asakawa Y, Inoue K, Ohno Y, Hayakawa T, Kawanishi T.
    • Journal Title

      Phytomedicine 13

      Pages: 401-411

    • Related Report
      2006 Annual Research Report
  • [Journal Article] Neuronal CCL21 up-regulates microglia P2×4 expression and initiates neuropathic pain development.

    • Author(s)
      Biber K, Tsuda M, Saitoh-Tozaki H, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K.
    • Journal Title

      EMBO J in press

    • Related Report
      2010 Final Research Report
  • [Journal Article] Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kB

    • Author(s)
      M.Nishida, M.Ogushi, R.Suda, M.Toyotaka, S.Saiki, N.Kitajima, M.Nakaya, K.-M.Kim, T.Ide, Y.Sato, K.Inoue, H.Kurose.
    • Journal Title

      PNAS in press

    • Related Report
      2010 Final Research Report
  • [Journal Article] IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain

    • Author(s)
      M. Tsuda, T. Masuda, J. Kitano, H. Shimoyama, H.Tozaki-Saitoh, K.Inoue
    • Journal Title

      Pro. Natl. Acad. Sci. USA (in press)

    • NAID

      120001788298

    • Related Report
      2008 Self-evaluation Report
    • Peer Reviewed
  • [Presentation] The function of microglial P2 purinergic receptors in neuropathic pain.2010

    • Author(s)
      K Inoue.
    • Organizer
      Purine 2010 : Adenine Nucleosides and Nucleotides in Biomedicine, invited syposist
    • Place of Presentation
      Tarragona, Spain
    • Year and Date
      2010-05-31
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of spinal microglia in neuropathic pain.2010

    • Author(s)
      K Inoue.
    • Organizer
      The Lecture to enter as Foreign Academicien member of the Royal Academy of Pharmacy of Spain
    • Place of Presentation
      Special Lecture, Madrid
    • Year and Date
      2010-05-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 痛み情報伝達におけるATP受容体の機能と創薬への展望2010

    • Author(s)
      井上和秀
    • Organizer
      日本薬学会第130年会、特別講演
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ATP受容体研究におけるエコファーマの実践2010

    • Author(s)
      井上和秀
    • Organizer
      日本薬学会第130年会、シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] グリア細胞を標的にした新しい鎮痛薬の可能性2010

    • Author(s)
      津田誠、井上和秀
    • Organizer
      日本薬学会第130年会、年会融合型シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ATP受容体から難治性慢性疼痛メカニズムを探る2010

    • Author(s)
      津田誠、井上和秀
    • Organizer
      日本薬学会第130年会、シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 痛みの慢性化メカニズムにおけるP2Xイォンチャネルの役割2010

    • Author(s)
      津田誠、井上和秀
    • Organizer
      日本薬学会第130年会、シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ATP受容体の生理機能に関する神経薬理学的研究2010

    • Author(s)
      井上和秀
    • Organizer
      第83回日本薬理学会年会、第3回日本薬理学会江橋節郎賞受賞講演
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経障害性疼痛治療薬としてのミクログリア活性化阻害剤2010

    • Author(s)
      井上和秀
    • Organizer
      第83回日本薬理学会年会、シンポジウム招待
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経障害性疼痛発症における interferon regulatory factor-8の役割2010

    • Author(s)
      増田隆博、津田誠、吉永遼平、田村智彦、井上和秀
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCL2はミクログリア細胞膜上でのP2X4受容体発現を増加する(CCL2 increases P2X4 receptor expression on the plasma membrane of microglia)2010

    • Author(s)
      豊満笑加、津田誠、山下智大、齊藤秀俊、井上和秀
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] UDP誘発ミクログリアの貪食反応におけるPKDの関与2010

    • Author(s)
      片岡彩子、齊藤秀俊、古賀結衣、上杉歩未、津田誠、井上和秀
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経障害性疼痛発症時の脊髄CCL3の関与2010

    • Author(s)
      齊藤秀俊、上田和明、津田誠、井上和秀
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミクログリア貪食時における一過性のカルシウム上昇2010

    • Author(s)
      齊藤秀俊、津田誠、井上和秀
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] UDP誘発ミクログリア貪食作用におけるVASPリン酸化の関与2010

    • Author(s)
      古賀結衣、片岡彩子、齊藤秀俊、津田誠、井上和秀
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミクログリアからのATP誘発CXCL2放出メカニズム2010

    • Author(s)
      白鳥美穂、齊藤秀俊、吉武麻衣、津田誠、井上和秀
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Microglia in pain signalling.2010

    • Author(s)
      K Inoue.
    • Organizer
      The 29th Naito Conference : Glia World, invited
    • Place of Presentation
      Kanagawa
    • Related Report
      2010 Final Research Report
  • [Presentation] 神経障害性疼痛におけるミクログリアの役割2009

    • Author(s)
      井上和秀
    • Organizer
      新潟応用薬理シンポジウム、招待
    • Place of Presentation
      新潟
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経障害性疼痛の維持におけるSTAT3の役割2009

    • Author(s)
      高露雄太、津田誠、矢野貴之、辻川智子、北野順子、齊藤秀俊、井上和秀
    • Organizer
      第62回日本薬理学会西南部会
    • Place of Presentation
      松山
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミクログリアからのATP誘発CXCL2放出メカニズム2009

    • Author(s)
      白鳥美穂、齊藤秀俊、吉武麻衣、津田誠、井上和秀
    • Organizer
      第62回日本薬理学会西南部会
    • Place of Presentation
      松山
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] The challenge to the drugs against neuropathic pain refactoring to morphine2009

    • Author(s)
      井上和秀
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミクログリアーATP受容体研究から新規神経障害性疼痛治療薬開発への期待2009

    • Author(s)
      井上和秀
    • Organizer
      第37回薬物活性シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] The function of microglia in neuropathic pain2009

    • Author(s)
      井上和秀
    • Organizer
      2009 European Glial Cell Meeting(Euroglia 2009)invited symposist
    • Place of Presentation
      Paris
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Purinergic signaling in microglia in neuropathic pain2009

    • Author(s)
      井上和秀
    • Organizer
      The 22nd Biennial Meeting of the International Society for Neurochemistry
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2009-08-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Possible involvement of VASP phosphorylation in the P2Y6 receptor-induced phagocytosis of microglia2009

    • Author(s)
      Yui Koga, Ayako Kataoka, Hidetosi Tozaki-Saitoh, Makoto Tsuda, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009 : International Symposium on Purinergic Signalling in New Strategy of Drug Discovery ; a satellite symposium for the 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Activation of JAK2/STAT3 signaling pathway in spinal cord astrocytes induces neuropathic pain after peripheral nerve injury2009

    • Author(s)
      Takayuki Yano, Makoto Tsuda, Tomoko Tsujikawa, Yuta Kohro, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] The possible effect on surface membrane P2X4 receptor expression in microglia by inhibition of V-ATPase activity2009

    • Author(s)
      Tomohiro Yamashita, Makoto Tsuda, Hidetoshi Saitoh, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spinal microglial activation and tactile allodynia after nerve injury are regulated by nitric oxide synthase2009

    • Author(s)
      K.Kuboyama, M.Tsuda, Y.Naraki, M.Tsutsui, Y.Toyohara, H.Tozaki-Saitoh, H.Shimokawa, N.Yanagihara, K.Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanism underlying upregulation of P2Y6 receptors in microglia in kainate-induced injury model2009

    • Author(s)
      Kayoko Fujishita, Atsuhito Nakao, Kazuhide Inoue, Schichi Koizumi
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analgesic action of clomipramine and maprotiline via P2X4 receptor in hibition2009

    • Author(s)
      Miho Kometani, Yuta Matsumura, Kenichiro Nagata, Makoto Tsuda, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fibronectin increases P2X4R protein expression on the surface of micro filial cells2009

    • Author(s)
      Emika Toyomitsu, Makoto Tsuda, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms of remitting neuropathic pain by activation of CB2 receptors2009

    • Author(s)
      Hiroshi Shimoyama, Keiko Tsukamoto, Hidetoshi Saitoh, Makoto Tsuda, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms underlying P2X receptor-dependent regulation of neuropathic pain through cPLA2 in DRG neurons : role of PAF receptor and proinf lammatory cytokines2009

    • Author(s)
      Yuta Kohro, Shigeo Hasegawa, Makoto Tsuda, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechanisms of ATP-induced CXCL2 production and release in mouse microglial cell line, BV22009

    • Author(s)
      Miho Shiratori, Mai Yoshitake, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Interferon-gamma receptor signals are required for spinal microglia activation and neuropathic pain after peripheral nerve injury2009

    • Author(s)
      Takahiro Masuda, Makoto Tsuda, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury2009

    • Author(s)
      Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Hiroyuki Miyata, Kazuaki Ueda, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009, invited
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Spinal microglia mediate PDGF-induced tactile allodynia in rats2009

    • Author(s)
      Junya Masuda, Makoto Tsuda, Hidetoshi Saitoh, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] P2X4 receptor-mediated anti-allodynic effect by paroxetine- drug discovery of P2X4 receptor antagonist2009

    • Author(s)
      Toshiyasu Imai, Eriko Nakata, Toru Kawasaki, Shogo Sakuma, Tomio Yamakawa, Kazuhide Inoue
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Localization of P2X4 receptors in lipid raft-like structure of in vitro model of cell membrane2009

    • Author(s)
      Youichi Shinozaki, Koji Sumitomo, Makoto Tsuda, SchuichiKoizumi, Kazuhide Inoue, Keiichi Torimitsu
    • Organizer
      Fukuoka Purine 2009, invited
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Down-regulation of angiotensin type 1 receptor by purinergic P2Y2 receptor stimulation through S-nitrosylation of nuclear factor κB(NF-κB)2009

    • Author(s)
      Motohiro Nishida, Mariko Ogushi, Reiko Suda, Michio Nakaya, Kazuhide Inoue, Hitoshi Kurose
    • Organizer
      Fukuoka Purine 2009, invited
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Formation of P2Y2 receptor-TRPC5-eNOS signal complex defines ATP-stimulated anti-hypertrophic responses in rat neonatal cardiomyocytes2009

    • Author(s)
      Motohiro Nishida, Yoji Sato, Michio Nakaya, Kazuhide Inoue, Ryuji Inoue, Yasuo Mori, Hitoshi Kurose
    • Organizer
      Fukuoka Purine 2009
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脊髄ミクログリア活性化と神経因性疼痛2009

    • Author(s)
      井上和秀、津田誠
    • Organizer
      第31回日本疼痛学会、シンポジスト招待
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミクログリアと神経因性疼痛2009

    • Author(s)
      井上和秀
    • Organizer
      第7回整形外科痛みを語る会。シンポジスト招待
    • Place of Presentation
      福岡
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] ミクログリアと疼痛2009

    • Author(s)
      津田誠、井上和秀
    • Organizer
      52回日本神経化学会大会・シンポジウム、招待
    • Place of Presentation
      伊香保
    • Year and Date
      2009-06-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経因性疼痛とミクログリア活性化2009

    • Author(s)
      井上和秀
    • Organizer
      第38回日本慢性疼痛学会、特別講演
    • Place of Presentation
      神戸
    • Year and Date
      2009-02-27
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] The function of microglia in neuropathic pain.2009

    • Author(s)
      K Inoue.
    • Organizer
      2009 European Glial Cell Meeting (Euroglia 2009), invited symposist
    • Place of Presentation
      Paris
    • Related Report
      2010 Final Research Report
  • [Presentation] Purinergic signaling in microglia in neuropathic pain.2009

    • Author(s)
      K.Inoue.
    • Organizer
      The 22nd Biennial Meeting of the International Society for Neurochemistry (ISN) 2009/APSN 2009, Plenary lecture, invited
    • Place of Presentation
      Busan, Korea
    • Related Report
      2010 Final Research Report
  • [Presentation] Pain signalling through puri- nergic receptors of microglia.2009

    • Author(s)
      K Inoue.
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences, symposist invited
    • Place of Presentation
      Kyoto
    • Related Report
      2010 Final Research Report
  • [Presentation] Microglia and mechanisms of neuropathic pain. Gordon Research Conferences2009

    • Author(s)
      K.Inoue.
    • Organizer
      Glial Biology : Functional Interactions Among Glia & Neurons, invited
    • Place of Presentation
      Ventura
    • Related Report
      2010 Final Research Report
  • [Presentation] Pain signalling through purinergic receptors of microglia2009

    • Author(s)
      井上和秀
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences, symposist invited
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Microglial purinoceptors in the spinal cord and pathological pain2009

    • Author(s)
      Makoto Tsuda, Hidetoshi Tozaki Saitoh, Kazuhide Inoue
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences, symposist invited
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] 神経因性疼痛でのミクログリアとATP受容体の役割2008

    • Author(s)
      井上和秀
    • Organizer
      日本ペインクリニック学会第42回大会
    • Place of Presentation
      福岡
    • Year and Date
      2008-07-19
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Microglia listening to neurons through purinergic receptors2008

    • Author(s)
      K. Inoue
    • Organizer
      Purines 2008. International Scientific Advisory Bord(Plenary lecture, invited)
    • Place of Presentation
      Copenhagen
    • Year and Date
      2008-07-01
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Neurons talk with microglia through nucleotides2008

    • Author(s)
      K. Inoue
    • Organizer
      7th Dutch Endo-Neuro- Psycho Meeting(Plenary lecture, invited)
    • Place of Presentation
      Doorwerth、オランダ
    • Year and Date
      2008-06-04
    • Related Report
      2008 Self-evaluation Report
  • [Presentation] Neurons talk with microglia through nucleotides2008

    • Author(s)
      K. Inoue
    • Organizer
      7^<th> Dutch Endo-Neuro-Psycho Meeting
    • Place of Presentation
      Doorwerth, Netherland
    • Year and Date
      2008-06-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] Glial-neuronal interactions in neu-ropathic pain.2008

    • Author(s)
      K.Inoue.
    • Organizer
      NeuPSIG Satellite Symposium to the Glasgow 2008 World Congress on Pain. Invited
    • Place of Presentation
      London
    • Related Report
      2010 Final Research Report
  • [Presentation] P2×4 molecules expressed in microglia involving in neuropathic pain.2008

    • Author(s)
      K.Inoue.
    • Organizer
      Glasgow 2008 World Congress on Pain, Organizer, Invited
    • Place of Presentation
      Glasgow
    • Related Report
      2010 Final Research Report
  • [Presentation] Neurons talk with microglia through nucleotides.2008

    • Author(s)
      K.Inoue.
    • Organizer
      7th Dutch Endo-Neuro-Psycho Meeting. Plenary lecture, invited
    • Place of Presentation
      Doorwerth
    • Related Report
      2010 Final Research Report
  • [Presentation] Microglia listening to neurons through purinergic receptors.2008

    • Author(s)
      K.Inoue.
    • Organizer
      Purines 2008. Plenary lecture, invited
    • Place of Presentation
      Copenhagen
    • Related Report
      2010 Final Research Report
  • [Presentation] UDP, P2Y6 and microglial phagocytosis.(invited)2007

    • Author(s)
      K. Inoue
    • Organizer
      Gordon Research Conference"Apoptotic Cell Recognition & Clearance"
    • Place of Presentation
      Lewiston, USA
    • Related Report
      2007 Annual Research Report
  • [Book] P2Y6-evoked microglial phagocytosis.(In International Review of Neurobiology vol.85 : Advances in Neuropharmacology, ed.)(G.Bagetta, M.T.Corasaniti, T.Sakurada, S.Sakurada)2009

    • Author(s)
      K.Inoue, S.Koizumi, A.Kataoka, H.Tozaki-Saitoh, M.Tsuda.
    • Publisher
      Burlington : Academic Press
    • Related Report
      2010 Final Research Report
  • [Book] P2 Purinergic Receptor.(Handbook of Neurochemistry and Molecular Neurobiology : Neural Signaling Mechanisms.)(Volume Editor : K.Mikoshiba, Total editor : Abel Lajtha)2009

    • Author(s)
      井上和秀
    • Publisher
      Springer Sciencep Business Media, New York
    • Related Report
      2010 Final Research Report
  • [Book] P2 Purinergic Receptor.Handbook of Neurochemistry and Molecular Neurobiology : Neural Signaling Mechanisms2009

    • Author(s)
      K.Inoue
    • Total Pages
      14
    • Publisher
      Springer Science
    • Related Report
      2009 Annual Research Report
  • [Book] P2Y6-evoked microglial phagocytosis. In International Review of Neurobiology2009

    • Author(s)
      K. Inoue, S. Koizumi, A. Kataoka, H. Tozaki-Saitoh, M. Tsuda
    • Publisher
      ELSEVIER(In press)
    • Related Report
      2008 Annual Research Report
  • [Book] ATP receptors in the pain signaling : Glial contribution in neuropathic pain.(In Interaction between neurons and glia in aging and disease.)(J.O.Malva.)2007

    • Author(s)
      井上和秀
    • Publisher
      Springer
    • Related Report
      2010 Final Research Report
  • [Book] How DNA microarray technology contributes to the Retinoid Evaluations.(In "Vitamin A: New Research")(Ingrid T.Loesing)2007

    • Author(s)
      Ishida S, Tanabe H, Shinozaki Y, Koyano S, Kagechika H, Shudo K, Ozawa S, Sawada J, Ohno Y, Inoue K.
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2010 Final Research Report
  • [Book] 生理活性ヌクレオチド・ヌクレオシド(In New薬理学)(田中千賀子、加藤隆一編)2007

    • Author(s)
      井上和秀
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report
  • [Book] ATP receptors in the pain signaling : Glial contribution in neuropathic pain(J. O. Malva, In Interaction between neurons and glia in aging and disease)2007

    • Author(s)
      Inoue K
    • Publisher
      Springer
    • Related Report
      2008 Self-evaluation Report
  • [Book] ATP receptors in the pain signaling: Glial contribution in neurop athic pain. In Interaction between neurons and glia in aging and disease.2007

    • Author(s)
      Inoue K
    • Publisher
      Springer
    • Related Report
      2007 Annual Research Report
  • [Book] P2X receptors in Sensory Neurons.(In The Nociceptive Membrane (Current Topics in Membrane, vol.57)(Uhtaek Oh.)2006

    • Author(s)
      Tsuda M, Inoue K.
    • Publisher
      Academic Press, London
    • Related Report
      2010 Final Research Report
  • [Book] ATP receptors of microglia involved in pain.(In Purinergic signaling in neuron-glia interaction (Novartis Foundation Symposium 276))2006

    • Author(s)
      井上和秀
    • Publisher
      John Wiley & Sons, Ltd, Chichester
    • Related Report
      2010 Final Research Report
  • [Book] ATP(痛み研究のアプローチ)(河谷正仁編)2006

    • Author(s)
      井上和秀
    • Publisher
      真興交易(株)医書出版部
    • Related Report
      2010 Final Research Report
  • [Book] ATP receptors of microglia involved in pain(In Purinergic signaling in neuron-glia interaction (Novartis Foundation Symposium 276))2006

    • Author(s)
      Inoue K
    • Publisher
      John Wiley &amp; Sons, Ltd, Chichester
    • Related Report
      2008 Self-evaluation Report
  • [Book] ATP。痛み研究のアプローチ。(河谷正仁編)2006

    • Author(s)
      井上和秀
    • Total Pages
      10
    • Publisher
      真興貿易(株)医書出版部
    • Related Report
      2006 Annual Research Report
  • [Book] Role of P2X receptors in pain.(In Translational Pain Research : From Mouse to Man)

    • Author(s)
      E.Toulme, M.Tsuda, B.S.Khakh, K.Inoue
    • Publisher
      CRC Press, in press
    • Related Report
      2010 Final Research Report
  • [Book] Pain and purinergic signaling. In Synaptic processes in the nervous system : the role of glial cells : BRAIN RESEARCH REVIEWS(edited by Joachim W.Deitmer, Christian Steinhauser.)

    • Author(s)
      M.Tsuda, H.Tozaki-Saitoh, K.Inoue
    • Publisher
      in press
    • Related Report
      2010 Final Research Report
  • [Book] Role of purinergic receptors in neuroprotection.(In Purine and Pyrimidine Receptor : Advances in Pharmacology)(edited by Kenneth A.Jacobson and Joel Linden)

    • Author(s)
      H.Tozaki-Saitoh, M.Tsuda, K.Inoue
    • Publisher
      in press
    • Related Report
      2010 Final Research Report
  • [Book] P2Y6-evoked microglial phagocytosis. In International Review of Neurobiology vol85: Advances in Neuropharmacology(ed. by G. Bagetta, M. T. Corasaniti, T. Sakurada, and S. Sakurada)

    • Author(s)
      K. Inoue, S. Koizumi, A. Kataoka, H. Tozaki-Saitoh, M. Tsuda
    • Publisher
      Elsevier(in press)
    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 2007年のNature論文は、NHK、毎日新聞、読売新聞や、共同通信社、西日本新聞などで紹介され、社会的なインパクトを与えた。

    • Related Report
      2010 Final Research Report
  • [Remarks] 2008年2月19日に共同通信社が、我々の研究成果「抗うつ薬が動物でもヒトでも神経因性疼痛を抑制すること」を発信した。

    • Related Report
      2010 Final Research Report
  • [Remarks] 2009年のProc.Natl.Acad.Sci.USA論文は、NHK、朝日新聞、毎日新聞、読売新聞、共同通信社、西日本新聞などで紹介され、社会的なインパクトを与えた。

    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ

    • URL

      http://yakkou.phar.kyushu-u.ac.jp/

    • Related Report
      2010 Final Research Report
  • [Remarks] 2007年のNature論文は、NHK、毎日新聞、読売新聞や、共同通信社、西日本新聞などで紹介され、社会的なインパクトを与えた。

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 2008年2月19日に共同通信社が、我々の研究成果「抗うつ薬が動物でもヒトでも神経因性疼痛を抑制すること」を発信した。

    • Related Report
      2008 Self-evaluation Report
  • [Remarks] 2009年のProc. Natl. Acad. Sci. USA論文は、NHK、朝日新聞、毎日新聞、読売新聞、共同通信社、西日本新聞などで紹介され、社会的なインパクトを与えた。

    • Related Report
      2008 Self-evaluation Report
  • [Remarks]

    • URL

      http://210.233.60.66/~yakkou/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://210.233.60.66/~yakkou/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] ジアゼピンジオン誘導体2009

    • Inventor(s)
      井上和秀, 他
    • Industrial Property Rights Holder
      日本ケミファ株式会社
    • Industrial Property Number
      2009-022242
    • Filing Date
      2009-02-03
    • Related Report
      2010 Final Research Report 2008 Self-evaluation Report

URL: 

Published: 2006-04-01   Modified: 2016-04-21  

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