|Budget Amount *help
¥508,170,000 (Direct Cost: ¥390,900,000、Indirect Cost: ¥117,270,000)
Fiscal Year 2010: ¥90,350,000 (Direct Cost: ¥69,500,000、Indirect Cost: ¥20,850,000)
Fiscal Year 2009: ¥90,350,000 (Direct Cost: ¥69,500,000、Indirect Cost: ¥20,850,000)
Fiscal Year 2008: ¥102,960,000 (Direct Cost: ¥79,200,000、Indirect Cost: ¥23,760,000)
Fiscal Year 2007: ¥106,080,000 (Direct Cost: ¥81,600,000、Indirect Cost: ¥24,480,000)
Fiscal Year 2006: ¥118,430,000 (Direct Cost: ¥91,100,000、Indirect Cost: ¥27,330,000)
We had already reported that activated microglia have a main role for evoking neuropathic pain which is resistant to morphine through the stimulation of P2X4 receptors after nerve damages (Nature, 2003 & 2005). In the present study, we tried to find how microglia receive information of nerve damage and cause the pain. It was clarified that microglia are activated through cytokines such as CCL21 released from the damage nerve, interferon-γ, PDGF. Moreover, transcription factor STAT3 was activated only in astrocytes after nerve damage that is very important for the evoking neuropathic pain.