| Project/Area Number |
18GS0320
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| Research Category |
Grant-in-Aid for Creative Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
AIZAWA Shinichi The Institute of Physical and Chemical Research, ボディプラン研究グループ, グループディレクター (60073011)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAMURA Kenji 熊本大学, 発生医学研究所, 教授 (70301140)
HIRATA Tatsumi 国立遺伝学研究所, 総合遺伝研究系, 准教授 (80260587)
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| Project Period (FY) |
2006 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥394,160,000 (Direct Cost: ¥303,200,000、Indirect Cost: ¥90,960,000)
Fiscal Year 2010: ¥74,360,000 (Direct Cost: ¥57,200,000、Indirect Cost: ¥17,160,000)
Fiscal Year 2009: ¥74,360,000 (Direct Cost: ¥57,200,000、Indirect Cost: ¥17,160,000)
Fiscal Year 2008: ¥74,360,000 (Direct Cost: ¥57,200,000、Indirect Cost: ¥17,160,000)
Fiscal Year 2007: ¥74,360,000 (Direct Cost: ¥57,200,000、Indirect Cost: ¥17,160,000)
Fiscal Year 2006: ¥96,720,000 (Direct Cost: ¥74,400,000、Indirect Cost: ¥22,320,000)
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| Keywords | 脊椎動物系統発生 / 前後軸形成 / オーガナイザー / 頭部誘導 / 脳形成 / 皮質形成 / 比較発生学 / 比較ゲノム解析 / 脊椎動物 / 頭部形成 / 進化 / Otx / microRNA-9 / 頭部ギャップ遺伝子 / エンハンサー / 系統発生 / 胚体外組織 / 脳領域化 / Emx / ヘッドオーガナイザー / 胚体外内胚葉 / EPB41L5 / miR9 / 脊椎動物進化 / 吻側神経外胚葉 / microRNA / Foxg1 / Cajal-Retzius細胞 / 上皮間充織転換 / EPB4.1L5 / Pax6 / 四足動物 / 真骨魚 / ポリプテルス / エイ |
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| Research Abstract |
Comparative analyses of mammalian (mouse, rabbit, pig, suncus), reptile (gekko, turtle), avian (chick), amphibian (Xenopus), actinist (coelacanth), cladist (bichir), teleost (zebrafish, medaka, fugu), cartillaginous fish (skate) and agnatha (lamprey) embryos, developmentally and/or genomically, demonstrated that 1) extraembryonic head organizer tissues in vertebrates are homologous to deep endoderm cells in Xenopus, 2) Otx2 gene cascade was established in ancestral sarcopterigian to suppress poeteriorizing signals, 3) anterior neuroectoderm develops differently between sarcopterigian and actinopterigian, 4) potency to form layer structures in cortical progenitor cells would have been established in reptile stage, not in mammal, and others.
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